LOCUS       NM_012738                889 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Rattus norvegicus apolipoprotein A1 (Apoa1), mRNA.
ACCESSION   NM_012738
VERSION     NM_012738.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 889)
  AUTHORS   Wang,J., Zhang,Y., Liu,Y.M., Yang,X.C., Chen,Y.Y., Wu,G.J.,
            He,X.H., Duan,L., Dong,Y. and Ma,R.F.
  TITLE     Uncovering the protective mechanism of Huoxue Anxin Recipe against
            coronary heart disease by network analysis and experimental
            validation
  JOURNAL   Biomed Pharmacother 121, 109655 (2020)
   PUBMED   31734577
REFERENCE   2  (bases 1 to 889)
  AUTHORS   Wang,X., Gong,Y., Deng,T., Zhang,L., Liao,X., Han,C., Yang,C.,
            Huang,J., Wang,Q., Song,X., Zhang,T., Yu,T., Zhu,G., Ye,X. and
            Peng,T.
  TITLE     Diagnostic and prognostic significance of mRNA expressions of
            apolipoprotein A and C family genes in hepatitis B virus-related
            hepatocellular carcinoma
  JOURNAL   J Cell Biochem 120 (10), 18246-18265 (2019)
   PUBMED   31211449
REFERENCE   3  (bases 1 to 889)
  AUTHORS   Dominguez-Avila,J.A., Astiazaran-Garcia,H., Wall-Medrano,A., de la
            Rosa,L.A., Alvarez-Parrilla,E. and Gonzalez-Aguilar,G.A.
  TITLE     Mango phenolics increase the serum apolipoprotein A1/B ratio in
            rats fed high cholesterol and sodium cholate diets
  JOURNAL   J Sci Food Agric 99 (4), 1604-1612 (2019)
   PUBMED   30187493
REFERENCE   4  (bases 1 to 889)
  AUTHORS   Gao,L., Lin,Z., Liu,Y., Wang,X., Wan,L., Zhang,L. and Liu,X.
  TITLE     Hypolipidemic effect of Fragarianilgerrensis Schlecht. medicine
            compound on hyperlipidemic rats
  JOURNAL   Lipids Health Dis 17 (1), 222 (2018)
   PUBMED   30231880
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 889)
  AUTHORS   Kareinen,I., Baumann,M., Nguyen,S.D., Maaninka,K., Anisimov,A.,
            Tozuka,M., Jauhiainen,M., Lee-Rueckert,M. and Kovanen,P.T.
  TITLE     Chymase released from hypoxia-activated cardiac mast cells cleaves
            human apoA-I at Tyr192 and compromises its cardioprotective
            activity
  JOURNAL   J Lipid Res 59 (6), 945-957 (2018)
   PUBMED   29581158
  REMARK    GeneRIF: C-terminal truncation of apoA-I by chymase released from
            cardiac mast cells during ischemia impairs the ability of apoA-I to
            heal damaged endothelium in the ischemic myocardium
REFERENCE   6  (bases 1 to 889)
  AUTHORS   Strobl,W., Chan,L. and Patsch,W.
  TITLE     Differential regulation of hepatic apolipoprotein A-I and A-II gene
            expression by thyroid hormone in rat liver
  JOURNAL   Atherosclerosis 97 (2-3), 161-170 (1992)
   PUBMED   1466661
REFERENCE   7  (bases 1 to 889)
  AUTHORS   Williamson,R., Lee,D., Hagaman,J. and Maeda,N.
  TITLE     Marked reduction of high density lipoprotein cholesterol in mice
            genetically modified to lack apolipoprotein A-I
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 7134-7138 (1992)
   PUBMED   1496008
REFERENCE   8  (bases 1 to 889)
  AUTHORS   Mahlberg,F.H. and Rothblat,G.H.
  TITLE     Cellular cholesterol efflux. Role of cell membrane kinetic pools
            and interaction with apolipoproteins AI, AII, and Cs
  JOURNAL   J Biol Chem 267 (7), 4541-4550 (1992)
   PUBMED   1537840
REFERENCE   9  (bases 1 to 889)
  AUTHORS   Weisgraber,K.H. and Mahley,R.W.
  TITLE     Apoprotein (E--A-II) complex of human plasma lipoproteins. I.
            Characterization of this mixed disulfide and its identification in
            a high density lipoprotein subfraction
  JOURNAL   J Biol Chem 253 (17), 6281-6288 (1978)
   PUBMED   210174
REFERENCE   10 (bases 1 to 889)
  AUTHORS   Ritter,M.C. and Scanus,A.M.
  TITLE     Role of apolipoprotein A-I in the structure of human serum high
            density lipoproteins. Reconstitution studies
  JOURNAL   J Biol Chem 252 (4), 1208-1216 (1977)
   PUBMED   190223
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012738.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210987.1, FQ211267.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                JAXUCZ010000008.1  55423945-55423969
            26-87               JAXUCZ010000008.1  55424167-55424228
            88-241              JAXUCZ010000008.1  55424379-55424532
            242-889             JAXUCZ010000008.1  55425082-55425729
FEATURES             Location/Qualifiers
     source          1..889
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..889
                     /gene="Apoa1"
                     /gene_synonym="apoA-I"
                     /note="apolipoprotein A1"
                     /db_xref="GeneID:25081"
                     /db_xref="RGD:2130"
     exon            1..25
                     /gene="Apoa1"
                     /gene_synonym="apoA-I"
                     /inference="alignment:Splign:2.1.0"
     exon            26..87
                     /gene="Apoa1"
                     /gene_synonym="apoA-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..824
                     /gene="Apoa1"
                     /gene_synonym="apoA-I"
                     /note="preproapolipoprotein A-I; apo-AI; apolipoprotein
                     A-1; apolipoprotein A-I"
                     /codon_start=1
                     /product="apolipoprotein A-I preproprotein"
                     /protein_id="NP_036870.1"
                     /db_xref="GeneID:25081"
                     /db_xref="RGD:2130"
                     /translation="MKAAVLAVALVFLTGCQAWEFWQQDEPQSQWDRVKDFATVYVDA
                     VKDSGRDYVSQFESSTLGKQLNLNLLDNWDTLGSTVGRLQEQLGPVTQEFWANLEKET
                     DWLRNEMNKDLENVKQKMQPHLDEFQEKWNEEVEAYRQKLEPLGTELHKNAKEMQRHL
                     KVVAEEFRDRMRVNADALRAKFGLYSDQMRENLAQRLTEIKNHPTLIEYHTKASDHLK
                     TLGEKAKPALDDLGQGLMPVLEAWKAKIMSMIDEAKKKLNA"
     exon            88..241
                     /gene="Apoa1"
                     /gene_synonym="apoA-I"
                     /inference="alignment:Splign:2.1.0"
     exon            242..889
                     /gene="Apoa1"
                     /gene_synonym="apoA-I"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgttgg agagctccgg gggaggtcgc ccacatcctt caggatgaaa gctgcagtgt
       61 tggctgtggc cctggtcttc ctgacaggtt gccaagcttg ggagttctgg cagcaagatg
      121 agccccagtc ccaatgggac agggtgaagg atttcgccac tgtgtatgtg gatgcagtca
      181 aggacagcgg cagagactat gtgtcccagt ttgaatcctc cactttgggc aaacagctga
      241 acctgaatct cctggacaac tgggacactc tgggttcaac tgttggtcgc ctacaggaac
      301 agctaggccc agtgactcag gagttctggg ctaacctgga gaaagaaaca gattggctga
      361 gaaacgagat gaacaaggac ctggagaatg tgaaacagaa gatgcagccc cacctggatg
      421 aattccagga gaagtggaac gaggaggtcg aggcctaccg ccagaagctg gagcctctgg
      481 gcaccgagct tcacaaaaac gcgaaggaga tgcaaaggca tctaaaggtt gtggccgagg
      541 agtttcgaga ccgcatgcgt gtgaatgcag acgcgctgcg cgcaaagttt gggctctaca
      601 gcgatcagat gcgcgagaac ctggcccagc gcctgaccga gatcaagaac caccctaccc
      661 tgatcgagta tcataccaag gccagcgacc acctgaagac acttggtgag aaagccaaac
      721 ccgcgctgga tgacctgggc cagggcctga tgccggtgct ggaagcctgg aaggccaaaa
      781 tcatgagtat gatcgatgag gccaaaaaga agctgaacgc ttagtgaggc gcccgtcacc
      841 actccccacc cctgaattgg ctttcttaca ataaacgttt ccaaagtgg
//
