LOCUS       NM_012906               3644 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus amyloid beta precursor like protein 2 (Aplp2),
            transcript variant 1, mRNA.
ACCESSION   NM_012906
VERSION     NM_012906.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3644)
  AUTHORS   Trillaud-Doppia,E., Paradis-Isler,N. and Boehm,J.
  TITLE     A single amino acid difference between the intracellular domains of
            amyloid precursor protein and amyloid-like precursor protein 2
            enables induction of synaptic depression and block of long-term
            potentiation
  JOURNAL   Neurobiol Dis 91, 94-104 (2016)
   PUBMED   26921470
  REMARK    GeneRIF: alanine in APP- intracellular domain(ICD) and the proline
            in APLP2-ICD lie directly behind a conserved caspase cleavage site
REFERENCE   2  (bases 1 to 3644)
  AUTHORS   Pluta,R., Kocki,J., Ulamek-Koziol,M., Petniak,A., Gil-Kulik,P.,
            Januszewski,S., Bogucki,J., Jablonski,M., Brzozowska,J.,
            Furmaga-Jablonska,W., Bogucka-Kocka,A. and Czuczwar,S.J.
  TITLE     Discrepancy in Expression of beta-Secretase and Amyloid-beta
            Protein Precursor in Alzheimer-Related Genes in the Rat Medial
            Temporal Lobe Cortex Following Transient Global Brain Ischemia
  JOURNAL   J Alzheimers Dis 51 (4), 1023-1031 (2016)
   PUBMED   26890784
  REMARK    GeneRIF: This study demonstrated that the downregulation of amyloid
            beta precursor in Rat Medial Temporal Lobe Cortex Following
            Transient Global Brain ischemia.
REFERENCE   3  (bases 1 to 3644)
  AUTHORS   Santha,P., Pakaski,M., Fazekas,O., Szucs,S., Fodor,E.K., Kalman,J.
            Jr., Kalman,S., Szabo,G., Janka,Z. and Kalman,J.
  TITLE     [Acute and chronic stress induced changes in gene transcriptions
            related to Alzheimer's disease]
  JOURNAL   Ideggyogy Sz 65 (5-6), 195-200 (2012)
   PUBMED   22724288
  REMARK    GeneRIF: Findings demonstrate that both acute and chronic
            Immobilization Stress lead to gene transcriptional changes of
            beta-actin, APP and MAPK-1. These changes may lead to cognitive
            deterioration, and the development of Alzheimer disease.
REFERENCE   4  (bases 1 to 3644)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 3644)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 3644)
  AUTHORS   Duilio,A., Faraonio,R., Minopoli,G., Zambrano,N. and Russo,T.
  TITLE     Fe65L2: a new member of the Fe65 protein family interacting with
            the intracellular domain of the Alzheimer's beta-amyloid precursor
            protein
  JOURNAL   Biochem J 330 (Pt 1) (Pt 1), 513-519 (1998)
   PUBMED   9461550
REFERENCE   7  (bases 1 to 3644)
  AUTHORS   von Koch,C.S., Zheng,H., Chen,H., Trumbauer,M., Thinakaran,G., van
            der Ploeg,L.H., Price,D.L. and Sisodia,S.S.
  TITLE     Generation of APLP2 KO mice and early postnatal lethality in
            APLP2/APP double KO mice
  JOURNAL   Neurobiol Aging 18 (6), 661-669 (1997)
   PUBMED   9461064
REFERENCE   8  (bases 1 to 3644)
  AUTHORS   von der Kammer,H., Hanes,J., Klaudiny,J. and Scheit,K.H.
  TITLE     A human amyloid precursor-like protein is highly homologous to a
            mouse sequence-specific DNA-binding protein
  JOURNAL   DNA Cell Biol 13 (11), 1137-1143 (1994)
   PUBMED   7702756
REFERENCE   9  (bases 1 to 3644)
  AUTHORS   Sandbrink,R., Masters,C.L. and Beyreuther,K.
  TITLE     Complete nucleotide and deduced amino acid sequence of rat amyloid
            protein precursor-like protein 2 (APLP2/APPH): two amino acids
            length difference to human and murine homologues
  JOURNAL   Biochim Biophys Acta 1219 (1), 167-170 (1994)
   PUBMED   8086458
REFERENCE   10 (bases 1 to 3644)
  AUTHORS   Yan,Y.C., Bai,Y., Wang,L.F., Miao,S.Y. and Koide,S.S.
  TITLE     Characterization of cDNA encoding a human sperm membrane protein
            related to A4 amyloid protein
  JOURNAL   Proc Natl Acad Sci U S A 87 (7), 2405-2408 (1990)
   PUBMED   1690887
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM044356.1, FM029818.1, CA340752.1, CB795867.1, FM030557.1,
            FM039816.1, CB700594.1, FM112636.1, FM104554.1, FM041002.1 and
            BP497339.1.
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-541               FM044356.1         1-541
            542-668             FM029818.1         511-637
            669-1041            CA340752.1         298-670
            1042-1320           CB795867.1         146-424
            1321-1723           FM030557.1         187-589
            1724-2065           FM039816.1         116-457
            2066-2168           CB700594.1         200-302
            2169-2788           FM112636.1         75-694
            2789-3248           FM104554.1         199-658
            3249-3532           FM041002.1         287-570
            3533-3644           BP497339.1         1-112               c
FEATURES             Location/Qualifiers
     source          1..3644
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3644
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /note="amyloid beta precursor like protein 2"
                     /db_xref="GeneID:64312"
                     /db_xref="RGD:2128"
     exon            1..205
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2398
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sperm membrane protein (YWK-II); amyloid-like
                     protein 2; amyloid beta (A4) precursor-like protein
                     2-like; Amyloid protein precursor-like protein 2; amyloid
                     protein homolog; CDEI box-binding protein"
                     /codon_start=1
                     /product="amyloid beta precursor like protein 2 isoform 1
                     precursor"
                     /protein_id="NP_037038.1"
                     /db_xref="GeneID:64312"
                     /db_xref="RGD:2128"
                     /translation="MAATGTAAAAATGKLLVLLLLGLTAPAAALAGYIEALAANAGTG
                     FAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITN
                     VMEANQPVNIDSWCRRDKKQCRSHIVIPFKCLVGEFVSDVLLVPENCQFFHQERMEVC
                     EKHQRWHTVVKEACLTEGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKVVDSDSTMSKE
                     EEEEEEEDEEEDYALDKSEFPTEADLEDFTEAAADEDEDEEEEEEEEGEEVVEDRDYY
                     YDSFKGDDYNEENPTEPSSDGTISDKEIAHDVKAVCSQEAMTGPCRAVMPRWYFDLSK
                     GKCVRFIYGGCGGNRNNFESEDYCMAVCKTMIPPTPLPTNDVDVYFETSADDNEHARF
                     QKAKEQLEIRHRSRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASE
                     KQQLVETHLARVEAMLNDRRRIALENYLAALQSDPPRPHRILQALRRYVRAENKDRLH
                     TIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDEL
                     LQEQRADMDQFTSSISENPVDVRVSSEESEEIPPFHPFHPFPSLSENEDTQPELYHPM
                     KKGSGMAEQDGGLIGAEEKVINSKNKMDENMVIDETLDVKEMIFNAERVGGLEEEPDS
                     VGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPE
                     ERHLNKMQNHGYENPTYKYLEQMQI"
     exon            206..379
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..503
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            504..616
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..807
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1028
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1196
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1327
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1402
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1561
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1690
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1790
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1943
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..1979
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2065
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2140
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2296
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..3642
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; Apph; CDEBP; WALPLP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaacgggct tcagacgctt ttgggtcgcg ttagggagac gctctggtcc ggttgtgcgt
       61 gagaggagga gagcccagcg ccacagcgac ccggagaggg atggcggcca ccgggaccgc
      121 ggccgctgcg gccaccggca agcttcttgt cctgctgctg ctcgggctca cggcacccgc
      181 agcggctctg gctggctata tcgaggctct cgcagccaat gctggaacag gctttgcggt
      241 tgctgaacct cagattgcca tgttctgtgg gaagctgaac atgcatgtga acattcagac
      301 tgggaagtgg gagcctgacc caaccggcac caagagctgc ctgggaacaa aggaggaagt
      361 tcttcagtac tgccaggaga tatatccaga gctgcagatc acaaatgtga tggaagcaaa
      421 ccagccagtc aatattgata gttggtgccg aagggacaaa aaacagtgca ggagtcacat
      481 tgttatacca ttcaagtgtc ttgtgggtga atttgtaagt gatgttctgc tagttccaga
      541 aaactgccag tttttccacc aagagcggat ggaggtgtgt gagaagcatc agcggtggca
      601 cacagtcgtc aaggaggcat gtctgactga ggggatgacc ttatatagct atggcatgct
      661 gctgccctgt ggggtagacc agttccatgg cactgagtat gtgtgctgcc ctcagacaaa
      721 ggttgttgac tctgactcca ctatgtccaa agaagaggag gaagaagagg aagaggatga
      781 agaagaagac tatgctcttg ataaaagtga atttcctacc gaagcagatc tggaagactt
      841 cacagaagca gctgcagatg aggacgagga tgaggaggag gaggaggagg aggaagggga
      901 ggaagtggta gaagaccgtg attactacta tgactccttt aaaggagatg attacaatga
      961 ggagaaccca actgaaccca gcagcgatgg caccatctca gacaaggaga ttgctcacga
     1021 tgttaaagct gtctgctccc aggaggccat gacggggccc tgccgggccg tgatgcctcg
     1081 ttggtacttc gacctctcca agggaaagtg cgtacgcttt atatatggcg gctgcggcgg
     1141 caacaggaac aattttgagt ctgaggatta ttgtatggct gtgtgtaaaa cgatgattcc
     1201 cccgactccc ctgccaacca atgatgtgga cgtgtatttt gagacgtcgg ctgatgacaa
     1261 tgagcacgcc cgctttcaga aggctaagga gcagttggaa attcggcatc gcagccgaat
     1321 ggacagggta aaaaaggagt gggaagaagc agaacttcaa gccaagaacc tccccaaggc
     1381 agagcgacag accctcattc agcatttcca agctatggtt aaagccttag agaaggaagc
     1441 agccagtgag aagcagcagc ttgtggagac ccatttggcc cgagtagaag caatgctgaa
     1501 tgaccgtcgg cgcatagctc tggaaaacta cctggctgcc ctgcagtctg accctcctcg
     1561 gccacatcgc attcttcaag ctcttcgtcg ttacgtccgt gctgagaaca aagatcgcct
     1621 gcacaccatt cgtcattacc aacatgtgtt ggctgttgac ccagaaaagg ctgcgcagat
     1681 gaaatcccag gtgatgacac acctccatgt cattgaagaa agaaggaacc aaagtctctc
     1741 tctgctgtac aaagtgcctt atgtggctca agagattcag gaggaaattg atgagctcct
     1801 tcaggaacag cgagcagata tggaccagtt tacctcctcc atctcagaga accctgtgga
     1861 tgtccgggtg agctctgagg aaagtgagga gatcccgccg ttccaccctt tccatccctt
     1921 cccatccttg tctgagaacg aagacactca gccggagttg taccacccaa tgaaaaaagg
     1981 atctggaatg gcagagcaag atgggggcct gattggtgca gaagaaaagg tgatcaacag
     2041 taagaataaa atggatgaaa atatggtcat tgacgagact ctggatgtta aggaaatgat
     2101 tttcaatgct gagagagttg ggggtctgga ggaagagccg gactctgtgg ggcctctacg
     2161 ggaggacttc agtttgagca gcagtgccct tattggcttg ctggtcatcg cggtggccat
     2221 tgctacagtc atcgtcatca gcctggtgat gctgaggaag aggcaatacg gcaccatcag
     2281 ccatggcatt gtggaggttg atccaatgct caccccagaa gagcgtcact tgaacaagat
     2341 gcagaaccac ggctatgaaa acccaaccta caaatacctg gagcagatgc agatttaagg
     2401 acagcagcgt gtgcgacacc ctggctgagg ctgctgcagg tgggctggaa gagcctcagc
     2461 gtttgtgctt gactgctgac caccagcggt gccagaggcc tcatcctaca tcctgctctc
     2521 ctggattgtt aagactataa agtactactg taggattgca atttccattc ttttaaatgg
     2581 gtttaaaaga tgttaatata acaatatatg atatataaac cttaagtgaa aaaaagatct
     2641 attgcagata tctgatggat gtagttttct ttttttaaat tagaaatgcc acttctattg
     2701 tattgtctca cacatgctct atataaatgg aaaatgttga tttttcaatg atagactata
     2761 tacacaggct gttcccgtta tgtaagtctg ttctttaggc tcgtttgctg ggctggtttt
     2821 gtcgtcattt gttttaatgt ataaaggcag tattcccctt ttcaggttgc tgagaaatgt
     2881 aagtggaact gaagtacatt gtatgcagtt actgactgtt ttaggcatag tctccttgga
     2941 agcctagtgc ttccagtgcc gggtgtccag tgctgtcacc aagcaaggct aagtcacctt
     3001 gagctagctg gatgcaaaac tagatccact gtgctttcct tcaaatccag ttcttccaca
     3061 gcaaccagcc catagttgtt ctgtgttctt ccacagctgt ttacggtagc ctcctagcca
     3121 ctctcctcag caagtgcatc caagagtgca ccaccccctt ctttggacgt ctccgtccca
     3181 tgcactgacc ctctgcttgc cttcgtacct cacttcctcc accgctcttc agcccctttg
     3241 atgtcccctc agagaatacc gatatacaca tggctaagga cccaggagac ttcacgggag
     3301 gcctcattag gtgaaaggac gatgttctgg gctgtacatg aaattggatc tgtagacact
     3361 gtgtttcctt cactgacttg taatgtcacg cagctggagt tgatgccaca gcccttagtg
     3421 ctttgttgct gttttgtttt tcagggttct ggtaacctgc tactgttttt gttttggttt
     3481 tggtttggtt ttttttgtat ttttctgtga tttccctccc cttccccccc atgcctcttc
     3541 ccactatgca cagatggaaa ctttacctac aaactccttc gtatgatctg tggagaatgt
     3601 acagaactta ttacatcaat aaaacacttt aacttccccc gaaa
//
