LOCUS       NM_001399814            2328 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus amyloid beta precursor like protein 1 (Aplp1),
            transcript variant 1, mRNA.
ACCESSION   NM_001399814 XM_039088313
VERSION     NM_001399814.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2328)
  AUTHORS   Xue,Y., Lee,S. and Ha,Y.
  TITLE     Crystal structure of amyloid precursor-like protein 1 and heparin
            complex suggests a dual role of heparin in E2 dimerization
  JOURNAL   Proc Natl Acad Sci U S A 108 (39), 16229-16234 (2011)
   PUBMED   21930949
REFERENCE   2  (bases 1 to 2328)
  AUTHORS   Weber,B., Schaper,C., Scholz,J., Bein,B., Rodde,C. and H Tonner,P.
  TITLE     Interaction of the amyloid precursor like protein 1 with the
            alpha2A-adrenergic receptor increases agonist-mediated inhibition
            of adenylate cyclase
  JOURNAL   Cell Signal 18 (10), 1748-1757 (2006)
   PUBMED   16531006
REFERENCE   3  (bases 1 to 2328)
  AUTHORS   Cao,Q., Huang,Y.S., Kan,M.C. and Richter,J.D.
  TITLE     Amyloid precursor proteins anchor CPEB to membranes and promote
            polyadenylation-induced translation
  JOURNAL   Mol Cell Biol 25 (24), 10930-10939 (2005)
   PUBMED   16314516
REFERENCE   4  (bases 1 to 2328)
  AUTHORS   Soba,P., Eggert,S., Wagner,K., Zentgraf,H., Siehl,K., Kreger,S.,
            Lower,A., Langer,A., Merdes,G., Paro,R., Masters,C.L., Muller,U.,
            Kins,S. and Beyreuther,K.
  TITLE     Homo- and heterodimerization of APP family members promotes
            intercellular adhesion
  JOURNAL   EMBO J 24 (20), 3624-3634 (2005)
   PUBMED   16193067
  REMARK    Erratum:[EMBO J. 2006 Feb 8;25(3):653]
REFERENCE   5  (bases 1 to 2328)
  AUTHORS   Herms,J., Anliker,B., Heber,S., Ring,S., Fuhrmann,M.,
            Kretzschmar,H., Sisodia,S. and Muller,U.
  TITLE     Cortical dysplasia resembling human type 2 lissencephaly in mice
            lacking all three APP family members
  JOURNAL   EMBO J 23 (20), 4106-4115 (2004)
   PUBMED   15385965
REFERENCE   6  (bases 1 to 2328)
  AUTHORS   Duilio,A., Faraonio,R., Minopoli,G., Zambrano,N. and Russo,T.
  TITLE     Fe65L2: a new member of the Fe65 protein family interacting with
            the intracellular domain of the Alzheimer's beta-amyloid precursor
            protein
  JOURNAL   Biochem J 330 (Pt 1) (Pt 1), 513-519 (1998)
   PUBMED   9461550
REFERENCE   7  (bases 1 to 2328)
  AUTHORS   Lee,N.H., Weinstock,K.G., Kirkness,E.F., Earle-Hughes,J.A.,
            Fuldner,R.A., Marmaros,S., Glodek,A., Gocayne,J.D., Adams,M.D.,
            Kerlavage,A.R. et al.
  TITLE     Comparative expressed-sequence-tag analysis of differential gene
            expression profiles in PC-12 cells before and after nerve growth
            factor treatment
  JOURNAL   Proc Natl Acad Sci U S A 92 (18), 8303-8307 (1995)
   PUBMED   7667285
REFERENCE   8  (bases 1 to 2328)
  AUTHORS   Wasco,W., Bupp,K., Magendantz,M., Gusella,J.F., Tanzi,R.E. and
            Solomon,F.
  TITLE     Identification of a mouse brain cDNA that encodes a protein related
            to the Alzheimer disease-associated amyloid beta protein precursor
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10758-10762 (1992)
   PUBMED   1279693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 14, 2022 this sequence version replaced XM_039088313.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213451.1, FQ212221.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000001.1  94834397-94834610   c
            215-358             JAXUCZ010000001.1  94833393-94833536   c
            359-491             JAXUCZ010000001.1  94832368-94832500   c
            492-604             JAXUCZ010000001.1  94832081-94832193   c
            605-738             JAXUCZ010000001.1  94831771-94831904   c
            739-929             JAXUCZ010000001.1  94831465-94831655   c
            930-1060            JAXUCZ010000001.1  94830956-94831086   c
            1061-1135           JAXUCZ010000001.1  94830353-94830427   c
            1136-1294           JAXUCZ010000001.1  94829408-94829566   c
            1295-1423           JAXUCZ010000001.1  94829199-94829327   c
            1424-1523           JAXUCZ010000001.1  94827533-94827632   c
            1524-1631           JAXUCZ010000001.1  94826146-94826253   c
            1632-1655           JAXUCZ010000001.1  94825515-94825538   c
            1656-1726           JAXUCZ010000001.1  94825302-94825372   c
            1727-1789           JAXUCZ010000001.1  94825075-94825137   c
            1790-1933           JAXUCZ010000001.1  94824809-94824952   c
            1934-2328           JAXUCZ010000001.1  94824330-94824724   c
FEATURES             Location/Qualifiers
     source          1..2328
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2328
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /note="amyloid beta precursor like protein 1"
                     /db_xref="GeneID:502317"
                     /db_xref="RGD:69257"
     exon            1..214
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2032
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /note="isoform 1 is encoded by transcript variant 1;
                     amyloid-like protein 1; amyloid beta (A4) precursor-like
                     protein 1"
                     /codon_start=1
                     /product="amyloid beta precursor like protein 1 isoform 1"
                     /protein_id="NP_001386743.1"
                     /db_xref="GeneID:502317"
                     /db_xref="RGD:69257"
                     /translation="MGPSSPTTRGQGRRRGPPPLPLLLPLSLLLLRAQLAVGNLAGGS
                     PSAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLLDPQRVLEYCRQMYPEL
                     HIARVEQAAQAIPMERWCGGTRSGRCAHPHHEVVPFHCLPGEFVSEALLVPEGCRFLH
                     QERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPATPNP
                     SGMAVGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEPPQAEEEEEEEEERAPP
                     PSSHTPVMVSRVTPTPRPTDGVDVYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMR
                     EWAMADSQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQR
                     RAALEGFLAALQGDPPQAERVLMALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMR
                     FQVQTHLQVVQERMNQSLGLLDQNPHLAQELRPQIQELLHAEHLGPSELEASVPGSSS
                     EDKGSLQPPESKDDAPVTLPKGSTDQESSSSGREKLTPLEQYEQKVNASAPRGFPFHS
                     SDIQRDELAPAGTGVSREALSGLLIMGAGGGSLIVLSLLLLRKKKPYGTISHGVVEVD
                     PMLTLEEQQLRELQRHGYENPTYRFLEERP"
     exon            215..358
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            359..491
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            492..604
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            605..738
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            739..929
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1060
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1135
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1294
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1423
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1523
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1631
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1655
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1726
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1789
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1933
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2328
                     /gene="Aplp1"
                     /gene_synonym="Aplp1_retired; RGD1561211"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtcaccgc tggggccggg cagggccggg cgggagcgca ggggacctga gggcccgagg
       61 cccggacatg gggccctcca gccccaccac tcgcggtcag ggtcgccgcc ggggcccgcc
      121 gccgctgccg ctgttgctac cactgtcgct gctgcttctg cgcgcgcagc tcgccgtcgg
      181 gaacctggct ggtgggagcc ccagcgcggc cgaggctccg gggtcggctc aagtggctgg
      241 actatgtggg cgtctcaccc ttcaccgaga cctgcgcacc ggccgctggg aaccagaccc
      301 acagcgatca cgacgctgtc ttctggaccc gcagcgcgtg ctggagtact gcagacagat
      361 gtacccagag ctgcacatag ctcgtgtgga gcaggctgca caggccatcc cgatggagcg
      421 ctggtgtggg ggtacccgaa gtggcagatg tgcccacccc caccatgagg ttgtgccctt
      481 ccattgcctg cctggcgaat tcgtgagtga agccctgctg gtgcccgaag gctgtaggtt
      541 cttgcaccag gagcgaatgg accaatgtga gagttcaacc aggaggcacc aggaggctca
      601 agaggcctgc agctcccagg gcctcatcct gcacggttct ggtatgcttt tgccctgtgg
      661 ctctgatcgg ttccgaggtg tggagtatgt atgctgtcca cctcccgcaa ctcccaaccc
      721 atctgggatg gcagttggtg acccctctac ccggtcctgg cccctggggg gcagagcaga
      781 gggaggtgag gatgaagagg aggtggaatc cttccctcag ccagtagacg attacttcgt
      841 agagccccct caggccgaag aagaagagga agaagaggag gaaagggccc cacctcccag
      901 ctcccacacc cctgtcatgg tcagcagagt cactcccacc ccgagaccca ctgatggtgt
      961 ggatgtttac tttggcatgc ctggggagat cagcgagcac gagggtttcc tgagggccaa
     1021 gatggacctg gaggaacgta ggatgcgtca gattaatgag gtgatgcgtg agtgggccat
     1081 ggctgacagc caatctaaga acctgccaaa agccgacagg caggccctga atgagcactt
     1141 ccagtccatt ctgcagaccc tggaagaaca agtgtctggt gagcgacagc gcctggtgga
     1201 gacccacgcc accagagtca tcgctctgat caacgaccag cgccgagctg ccctggaagg
     1261 tttcctggca gcattacagg gcgatccgcc tcaggctgag agagttctga tggccctgag
     1321 gcgctacctg cgagcggagc agaaggagca gaggcacacc ctgaggcact accagcacgt
     1381 ggccgccgtg gaccctgaga aggcccagca gatgcgcttt caggtccaga cccaccttca
     1441 ggtggttcaa gaacgaatga atcagagcct ggggctgctc gaccagaacc ctcacctggc
     1501 tcaggagctg cggccacaga tccaggagct tctccatgcg gaacacttgg gacctagtga
     1561 actggaagcc tctgtgcccg ggagcagcag tgaggacaaa ggtagccttc agcctcctga
     1621 atccaaggat gatgccccag tgacccttcc aaaagggtcc acagatcaag agtcttcctc
     1681 ctctgggaga gagaagctaa ccccactgga gcaatatgag caaaaggtga atgcatctgc
     1741 cccaaggggg tttcccttcc actcatcaga tattcagcgg gatgaactgg caccagctgg
     1801 gactggagtg tcccgagagg ccttgtcagg tctgctgatc atgggagctg gaggaggctc
     1861 cctcattgtc ctatccttgc tgcttctgcg caagaagaaa ccctatggca ctatcagcca
     1921 tggagtggtg gaggtggacc ccatgctgac cctggaggag cagcagctcc gggaacttca
     1981 gaggcatggc tatgagaacc ccacctaccg cttcctggaa gaacgacctt gaccccaacc
     2041 ctagctgcct tcagctgaac cctactgccc ttcttccggt cccctaatcc caactcccag
     2101 cttccggtgg gggagggaga tcttgacaaa ttcattccaa attccacccc cttagaaatt
     2161 cccagttcct gccccaccag ggaccttctc accttaattt attttacgtt aatttattgc
     2221 tccttaaggt gaccaccatc tgggtcccag tgtatgtcac cccctggaat tcaccgtccc
     2281 acgtttcttc actaacatcc caataaagtc ctcttcccca cccggcca
//
