LOCUS       NM_031349               3670 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus apelin receptor (Aplnr), mRNA.
ACCESSION   NM_031349
VERSION     NM_031349.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3670)
  AUTHORS   Lei,J., Zheng,F., Chen,L., Zhang,R., Yang,Y., Yin,Z. and Luo,L.
  TITLE     Gstp1 negatively regulates blood pressure in hypertensive rat via
            promoting APLNR ubiquitination degradation mediated by Nedd4
  JOURNAL   Clin Sci (Lond) 138 (14), 883-900 (2024)
   PUBMED   38959295
  REMARK    GeneRIF: Gstp1 negatively regulates blood pressure in hypertensive
            rat via promoting APLNR ubiquitination degradation mediated by
            Nedd4.
REFERENCE   2  (bases 1 to 3670)
  AUTHORS   Gemici,B., Birsen,I. and Izgut-Uysal,V.N.
  TITLE     The apelin-apela receptor APJ is necessary for formation and
            healing of ischemia reperfusion-induced gastric ulcer in rats
  JOURNAL   Peptides 166, 171027 (2023)
   PUBMED   37245722
  REMARK    GeneRIF: The apelin-apela receptor APJ is necessary for formation
            and healing of ischemia reperfusion-induced gastric ulcer in rats.
REFERENCE   3  (bases 1 to 3670)
  AUTHORS   Xi,Y., Li,Y., Ren,W., Bo,W., Ma,Y., Pan,S., Gong,D.W. and Tian,Z.
  TITLE     ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic
            Exercise in Cardioprotection of Myocardial Infarction Rats
  JOURNAL   Med Sci Sports Exerc 55 (7), 1172-1183 (2023)
   PUBMED   36878020
  REMARK    GeneRIF: ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of
            Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats.
REFERENCE   4  (bases 1 to 3670)
  AUTHORS   Akkan,S.S., Izgut-Uysal,V.N., Cakir,T., Ozbey,O. and Ustunel,I.
  TITLE     The effect of experimental varicocele on the apelin and APJ
            expressions in rat testis tissue
  JOURNAL   Tissue Cell 63, 101318 (2020)
   PUBMED   32223946
  REMARK    GeneRIF: The effect of experimental varicocele on the apelin and
            APJ expressions in rat testis tissue.
REFERENCE   5  (bases 1 to 3670)
  AUTHORS   Zhao,Y., Li,Y., Li,Z., Xu,B., Chen,P. and Yang,X.
  TITLE     Superoxide anions modulate the performance of apelin in the
            paraventricular nucleus on sympathetic activity and blood pressure
            in spontaneously hypertensive rats
  JOURNAL   Peptides 121, 170051 (2019)
   PUBMED   30582943
  REMARK    GeneRIF: The enhanced activity of endogenous apelin and APJ
            receptor in paraventricular nucleus contributes to sympathetic
            activation in hypertension.
REFERENCE   6  (bases 1 to 3670)
  AUTHORS   Medhurst,A.D., Jennings,C.A., Robbins,M.J., Davis,R.P., Ellis,C.,
            Winborn,K.Y., Lawrie,K.W., Hervieu,G., Riley,G., Bolaky,J.E.,
            Herrity,N.C., Murdock,P. and Darker,J.G.
  TITLE     Pharmacological and immunohistochemical characterization of the APJ
            receptor and its endogenous ligand apelin
  JOURNAL   J Neurochem 84 (5), 1162-1172 (2003)
   PUBMED   12603839
  REMARK    GeneRIF: Organ specificity of APJ receptor mRNA and distribution of
            the APJ receptor in rat brain and spinal cord was determined
REFERENCE   7  (bases 1 to 3670)
  AUTHORS   Reaux,A., De Mota,N., Skultetyova,I., Lenkei,Z., El Messari,S.,
            Gallatz,K., Corvol,P., Palkovits,M. and Llorens-Cortes,C.
  TITLE     Physiological role of a novel neuropeptide, apelin, and its
            receptor in the rat brain
  JOURNAL   J Neurochem 77 (4), 1085-1096 (2001)
   PUBMED   11359874
REFERENCE   8  (bases 1 to 3670)
  AUTHORS   De Mota,N., Lenkei,Z. and Llorens-Cortes,C.
  TITLE     Cloning, pharmacological characterization and brain distribution of
            the rat apelin receptor
  JOURNAL   Neuroendocrinology 72 (6), 400-407 (2000)
   PUBMED   11146423
REFERENCE   9  (bases 1 to 3670)
  AUTHORS   Hosoya,M., Kawamata,Y., Fukusumi,S., Fujii,R., Habata,Y.,
            Hinuma,S., Kitada,C., Honda,S., Kurokawa,T., Onda,H., Nishimura,O.
            and Fujino,M.
  TITLE     Molecular and functional characteristics of APJ. Tissue
            distribution of mRNA and interaction with the endogenous ligand
            apelin
  JOURNAL   J Biol Chem 275 (28), 21061-21067 (2000)
   PUBMED   10777510
REFERENCE   10 (bases 1 to 3670)
  AUTHORS   O'Carroll,A.M., Selby,T.L., Palkovits,M. and Lolait,S.J.
  TITLE     Distribution of mRNA encoding B78/apj, the rat homologue of the
            human APJ receptor, and its endogenous ligand apelin in brain and
            peripheral tissues
  JOURNAL   Biochim Biophys Acta 1492 (1), 72-80 (2000)
   PUBMED   11004481
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072494.1.
            
            On Jun 13, 2004 this sequence version replaced NM_031349.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC072494.1, AB033170.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..3670
                     /gene="Aplnr"
                     /gene_synonym="Agtrl1; Apj"
                     /note="apelin receptor"
                     /db_xref="GeneID:83518"
                     /db_xref="RGD:621645"
     exon            1..3646
                     /gene="Aplnr"
                     /gene_synonym="Agtrl1; Apj"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1357
                     /gene="Aplnr"
                     /gene_synonym="Agtrl1; Apj"
                     /note="B78; GPCR34; G-protein coupled receptor APJ;
                     angiotensin receptor-like 1"
                     /codon_start=1
                     /product="apelin receptor"
                     /protein_id="NP_112639.1"
                     /db_xref="GeneID:83518"
                     /db_xref="RGD:621645"
                     /translation="MEDDGYNYYGADNQSECDYADWTPSGALIPAIYILVFLLGTTGN
                     GLVLWTVFWSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKL
                     SSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAV
                     PVMVFRSTDIPENSTKTQCYMDYSMVATSNSEWAWEVGLGVSSTAVGFVVPFIIMLTC
                     YFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGNLLH
                     WPCDFDSFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRRACTSMLCCDQSGCKGSPH
                     SSSAEKSASYSSGHSQGPGPNMCKGGEPMHEKSIPYSQETLVD"
ORIGIN      
        1 gctaggacca ggaaggtaga ggtgcagccg cctgagaagc acatcctgct gggtctgagc
       61 tcccagagag gctagttctg catgccggga agggctctaa gcaccctcag accacttact
      121 ctgaggtttg agccaagcct ccagggtgct tgctgagttg ctgagataac tttggagctg
      181 gtgtccctgg gactcactgc ccagcttccc tccattcacc accatggaag atgatggtta
      241 caactactac ggggctgaca accagtctga atgtgactac gcagactgga cgccctctgg
      301 agctctcatc cctgccatct acattctggt tttccttcta ggcaccacag gcaatggcct
      361 ggtgctctgg accgtgtttt ggagcagccg agaaaagaga cgctcagctg acatcttcat
      421 tgccagcctg gctgtggctg acttgacctt tgtggtgact ttgccactgt gggccactta
      481 tacctaccgg gagtttgact ggccttttgg aaccttctct tgcaagctca gcagctacct
      541 catctttgtc aacatgtacg ccagtgtctt ttgcctcacc ggcctcagct ttgaccgata
      601 cctggccatt gtcaggccag tggctaacgc tcgactaagg ctgcgagtca gcggggccgt
      661 ggccacagca gtcttgtggg tgctggctgc ccttctagct gtgcccgtca tggtgttccg
      721 ttccactgac atcccggaaa acagcaccaa gacccagtgc tacatggact actctatggt
      781 ggccacttca aactcagagt gggcctggga ggtgggcctt ggggtgtcct ccactgctgt
      841 gggctttgtg gtgcccttca tcatcatgct gacctgttac ttcttcattg cccaaaccat
      901 cgctggccat ttccgaaagg agcgcatcga gggcctgcgg aagaggcgcc ggctgctgag
      961 catcatcgtg gtgctggtgg tgacctttgc cctgtgctgg atgccttacc acctggtgaa
     1021 gactctctac atgctgggca atttgctgca ctggccctgt gactttgaca gcttcctcat
     1081 gaatgtcttt ccctattgca cctgcatcag ttacgtcaac agctgcctca accccttcct
     1141 ctatgccttc tttgaccccc gatttcgccg agcctgcacc tccatgctct gctgtgacca
     1201 gagcgggtgc aaaggcagcc ctcacagcag cagtgcagag aaatctgcca gttattcttc
     1261 tgggcacagc cagggccccg gccccaacat gtgcaaggga ggagaaccga tgcatgagaa
     1321 atctatcccc tatagccaag aaacccttgt ggactagggc tgggaccaga gggaagcctg
     1381 gtgcctcggg gcctgaccca aacttcatcc tcacgctctg agaaccaggt agcatggctt
     1441 ctcctggact ccgaattccc ttctctgctc acctccaagc tctctgcctt gctcctctct
     1501 tctcacgctt gtggtttagt ggaaagggaa ggagccttgc aaacagctca gctgttcagt
     1561 acttctgagg ttgaccttgc acaagtctct taacttcttg aaacctcagt cactttgttt
     1621 gtagtaaatg ggtcaatgtt aaccctaaag tgttgaagtg tgagtcctga cccaatttgt
     1681 ttctttctgt ttgctcagcc ctctgagctt tggttttctc tgttgcagaa attgtttctg
     1741 tcagctactc actttcttct ttctttcttt ctttctttct ttctttcttt ctttctttct
     1801 ttctttcttt ctttctttct tttttttttc cggagctggg gaccgaaccc agggccttcc
     1861 gcttgctagg caagcgctct accactgagc taaatcccca accccagcta ctcactttct
     1921 agcgctaact ctttctcttc tagtggcttc ctccccctca aaccttcctg cctatactca
     1981 gtgccttctc ccctgctggg cttttaaggg taaagaaccc tgaaaattga agagtaactt
     2041 atcttttgag ttcttgtcct gttttctgag agccagcagg tggctgtatg taggcaaaca
     2101 atgaatactc tagtccccac agctccgatc tttccaaaaa gttggatgag ttcattgttg
     2161 gttcagccac cagggctaga ctgatctttg attctttggc agaatctcta tgatgcttag
     2221 tgaataatgc atcctaccaa taaccaagta tccttcccat cactttttaa aattgtctgt
     2281 gagaattgca aggcagcagg gctgaggtgg ctttggatga agggggagtt gggaagggaa
     2341 aacagagaaa gggtgagagg ggaatctgta tttagtctgt atgctgcttg cctcccctcc
     2401 cccaatcctt gcctctccac ctcctacaga actgtgaact gtagagcaga tctttctcct
     2461 gtgtcctccc ccaccctacc ttctctatag gttttggtgc tatttggcac taagagtcac
     2521 ttggttaggt aaggctattt ggtttttgtc aatatgggta tatataaata tatatgcatg
     2581 tgtgtgtatg tgtgtgtgtg cgcgacacac acccagaaga gtatcacata agcttcattg
     2641 atgaaggact ggggtgaacc cccactcact ttctcctgtg ctcctatagg tctcacagac
     2701 cacttgggga agaaggacat atggagggag tgtagaatag atatgggtcc acccccactg
     2761 gatttgggga actccgacgg ctggtccgta tttaggaaag aagtctatgt ttgtgctagg
     2821 ctttctgtag ggagctgttt cctcagtagc atctggttct aaggctggag aaatctggag
     2881 ctgggcccca gttcctctcc ccattccaca atggcaagaa cagacttata gactatatca
     2941 cggcccttct cctgtgtcct tccctggctc tgacttattt cccatccctc tctcttcggg
     3001 gtctgtgtcc ctcttcctaa ggaggacact ttcttgccac aggataaaga atacagggtg
     3061 agcttttggt ctcttctctg tcaggactga gcctcttggc ttcgctggct cctcttgctc
     3121 ctttgtgtgt gtgtgtgtgg ggggggtaag gttgtgaaag agtgactgaa gccgctgtgg
     3181 ggctctcaag gatcaaatta atagcggggc ctctgtgagc tggaaatggg tgtgtgtatt
     3241 ccgggttttg ttcttggagg gctctggaaa ccaaggacaa gacatgtgcc attggacagg
     3301 aagagcctgg cttgatgcag ttggaccatc tctggcaggg atcctgctcc tggggcagaa
     3361 aagggggttg tggtggtggg ggatggagaa aacagctttt cttagctgag ctctgcatgt
     3421 ctcaggccag aaactttcac acagcgtctt catctgccag gccatcctca aagcagccag
     3481 tacaggctgt aggaggcttc tgggagacag gaatctcaac catgactggg acagacagca
     3541 gcggaggcag gctctcttcc ccacccccat cccaccttca gaatgcgctt ttttttcctg
     3601 atcttgttag tcactgtggt tcatcaaata aaaactgttt tgtgtaaaaa aaaaaaaaaa
     3661 aaaaaaaaaa
//
