LOCUS       NP_112639                377 aa            linear   ROD 10-FEB-2025
DEFINITION  apelin receptor [Rattus norvegicus].
ACCESSION   NP_112639
VERSION     NP_112639.1
DBSOURCE    REFSEQ: accession NM_031349.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 377)
  AUTHORS   Lei,J., Zheng,F., Chen,L., Zhang,R., Yang,Y., Yin,Z. and Luo,L.
  TITLE     Gstp1 negatively regulates blood pressure in hypertensive rat via
            promoting APLNR ubiquitination degradation mediated by Nedd4
  JOURNAL   Clin Sci (Lond) 138 (14), 883-900 (2024)
   PUBMED   38959295
  REMARK    GeneRIF: Gstp1 negatively regulates blood pressure in hypertensive
            rat via promoting APLNR ubiquitination degradation mediated by
            Nedd4.
REFERENCE   2  (residues 1 to 377)
  AUTHORS   Gemici,B., Birsen,I. and Izgut-Uysal,V.N.
  TITLE     The apelin-apela receptor APJ is necessary for formation and
            healing of ischemia reperfusion-induced gastric ulcer in rats
  JOURNAL   Peptides 166, 171027 (2023)
   PUBMED   37245722
  REMARK    GeneRIF: The apelin-apela receptor APJ is necessary for formation
            and healing of ischemia reperfusion-induced gastric ulcer in rats.
REFERENCE   3  (residues 1 to 377)
  AUTHORS   Xi,Y., Li,Y., Ren,W., Bo,W., Ma,Y., Pan,S., Gong,D.W. and Tian,Z.
  TITLE     ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic
            Exercise in Cardioprotection of Myocardial Infarction Rats
  JOURNAL   Med Sci Sports Exerc 55 (7), 1172-1183 (2023)
   PUBMED   36878020
  REMARK    GeneRIF: ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of
            Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats.
REFERENCE   4  (residues 1 to 377)
  AUTHORS   Akkan,S.S., Izgut-Uysal,V.N., Cakir,T., Ozbey,O. and Ustunel,I.
  TITLE     The effect of experimental varicocele on the apelin and APJ
            expressions in rat testis tissue
  JOURNAL   Tissue Cell 63, 101318 (2020)
   PUBMED   32223946
  REMARK    GeneRIF: The effect of experimental varicocele on the apelin and
            APJ expressions in rat testis tissue.
REFERENCE   5  (residues 1 to 377)
  AUTHORS   Zhao,Y., Li,Y., Li,Z., Xu,B., Chen,P. and Yang,X.
  TITLE     Superoxide anions modulate the performance of apelin in the
            paraventricular nucleus on sympathetic activity and blood pressure
            in spontaneously hypertensive rats
  JOURNAL   Peptides 121, 170051 (2019)
   PUBMED   30582943
  REMARK    GeneRIF: The enhanced activity of endogenous apelin and APJ
            receptor in paraventricular nucleus contributes to sympathetic
            activation in hypertension.
REFERENCE   6  (residues 1 to 377)
  AUTHORS   Medhurst,A.D., Jennings,C.A., Robbins,M.J., Davis,R.P., Ellis,C.,
            Winborn,K.Y., Lawrie,K.W., Hervieu,G., Riley,G., Bolaky,J.E.,
            Herrity,N.C., Murdock,P. and Darker,J.G.
  TITLE     Pharmacological and immunohistochemical characterization of the APJ
            receptor and its endogenous ligand apelin
  JOURNAL   J Neurochem 84 (5), 1162-1172 (2003)
   PUBMED   12603839
  REMARK    GeneRIF: Organ specificity of APJ receptor mRNA and distribution of
            the APJ receptor in rat brain and spinal cord was determined
REFERENCE   7  (residues 1 to 377)
  AUTHORS   Reaux,A., De Mota,N., Skultetyova,I., Lenkei,Z., El Messari,S.,
            Gallatz,K., Corvol,P., Palkovits,M. and Llorens-Cortes,C.
  TITLE     Physiological role of a novel neuropeptide, apelin, and its
            receptor in the rat brain
  JOURNAL   J Neurochem 77 (4), 1085-1096 (2001)
   PUBMED   11359874
REFERENCE   8  (residues 1 to 377)
  AUTHORS   De Mota,N., Lenkei,Z. and Llorens-Cortes,C.
  TITLE     Cloning, pharmacological characterization and brain distribution of
            the rat apelin receptor
  JOURNAL   Neuroendocrinology 72 (6), 400-407 (2000)
   PUBMED   11146423
REFERENCE   9  (residues 1 to 377)
  AUTHORS   Hosoya,M., Kawamata,Y., Fukusumi,S., Fujii,R., Habata,Y.,
            Hinuma,S., Kitada,C., Honda,S., Kurokawa,T., Onda,H., Nishimura,O.
            and Fujino,M.
  TITLE     Molecular and functional characteristics of APJ. Tissue
            distribution of mRNA and interaction with the endogenous ligand
            apelin
  JOURNAL   J Biol Chem 275 (28), 21061-21067 (2000)
   PUBMED   10777510
REFERENCE   10 (residues 1 to 377)
  AUTHORS   O'Carroll,A.M., Selby,T.L., Palkovits,M. and Lolait,S.J.
  TITLE     Distribution of mRNA encoding B78/apj, the rat homologue of the
            human APJ receptor, and its endogenous ligand apelin in brain and
            peripheral tissues
  JOURNAL   Biochim Biophys Acta 1492 (1), 72-80 (2000)
   PUBMED   11004481
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072494.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC072494.1, AB033170.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     Protein         1..377
                     /product="apelin receptor"
                     /note="B78; GPCR34; G-protein coupled receptor APJ;
                     angiotensin receptor-like 1"
                     /calculated_mol_wt=42218
     Site            13
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JHG3.1)"
     Region          17..318
                     /region_name="7tmA_Apelin_R"
                     /note="apelin receptor, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15190"
                     /db_xref="CDD:341340"
     Site            order(18..22,83,86..87,89,91,108,166,171..175,181,183,196,
                     262,266,269,289,293,297)
                     /site_type="other"
                     /note="peptide ligand binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:341340"
     Region          28..54
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:341340"
     Site            29..52
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHG3.1)"
     Region          62..87
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:341340"
     Site            63..84
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHG3.1)"
     Site            83
                     /site_type="other"
                     /note="Required for APELA and APLN/apelin-13 interaction
                     and signaling. /evidence=ECO:0000250|UniProtKB:P35414;
                     propagated from UniProtKB/Swiss-Prot (Q9JHG3.1)"
     Site            98..123
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHG3.1)"
     Region          100..130
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:341340"
     Region          143..164
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:341340"
     Site            145..162
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHG3.1)"
     Site            166
                     /site_type="other"
                     /note="Required for APELA and APLN/apelin-13 interaction
                     and signaling. /evidence=ECO:0000250|UniProtKB:P35414;
                     propagated from UniProtKB/Swiss-Prot (Q9JHG3.1)"
     Site            173
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JHG3.1)"
     Region          196..225
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:341340"
     Site            197..221
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHG3.1)"
     Region          239..269
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:341340"
     Site            245..268
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHG3.1)"
     Region          286..311
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:341340"
     Site            288..310
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHG3.1)"
     Region          335..377
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHG3.1)"
     CDS             1..377
                     /gene="Aplnr"
                     /gene_synonym="Agtrl1; Apj"
                     /coded_by="NM_031349.2:224..1357"
                     /db_xref="GeneID:83518"
                     /db_xref="RGD:621645"
ORIGIN      
        1 meddgynyyg adnqsecdya dwtpsgalip aiyilvfllg ttgnglvlwt vfwssrekrr
       61 sadifiasla vadltfvvtl plwatytyre fdwpfgtfsc klssylifvn myasvfcltg
      121 lsfdrylaiv rpvanarlrl rvsgavatav lwvlaallav pvmvfrstdi penstktqcy
      181 mdysmvatsn sewawevglg vsstavgfvv pfiimltcyf fiaqtiaghf rkerieglrk
      241 rrrllsiivv lvvtfalcwm pyhlvktlym lgnllhwpcd fdsflmnvfp yctcisyvns
      301 clnpflyaff dprfrracts mlccdqsgck gsphsssaek sasyssghsq gpgpnmckgg
      361 epmheksipy sqetlvd
//
