LOCUS       NM_001173382            2572 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus aprataxin and PNKP like factor (Aplf), mRNA.
ACCESSION   NM_001173382 XM_001075022 XM_002726429 XM_002729393 XM_575597
VERSION     NM_001173382.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2572)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   2  (bases 1 to 2572)
  AUTHORS   Burgess,R.J. and Zhang,Z.
  TITLE     Histone chaperones in nucleosome assembly and human disease
  JOURNAL   Nat Struct Mol Biol 20 (1), 14-22 (2013)
   PUBMED   23288364
  REMARK    Review article
REFERENCE   3  (bases 1 to 2572)
  AUTHORS   Rulten,S.L., Fisher,A.E., Robert,I., Zuma,M.C., Rouleau,M., Ju,L.,
            Poirier,G., Reina-San-Martin,B. and Caldecott,K.W.
  TITLE     PARP-3 and APLF function together to accelerate nonhomologous
            end-joining
  JOURNAL   Mol Cell 41 (1), 33-45 (2011)
   PUBMED   21211721
REFERENCE   4  (bases 1 to 2572)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   5  (bases 1 to 2572)
  AUTHORS   Ahel,I., Ahel,D., Matsusaka,T., Clark,A.J., Pines,J., Boulton,S.J.
            and West,S.C.
  TITLE     Poly(ADP-ribose)-binding zinc finger motifs in DNA
            repair/checkpoint proteins
  JOURNAL   Nature 451 (7174), 81-85 (2008)
   PUBMED   18172500
REFERENCE   6  (bases 1 to 2572)
  AUTHORS   Kanno,S., Kuzuoka,H., Sasao,S., Hong,Z., Lan,L., Nakajima,S. and
            Yasui,A.
  TITLE     A novel human AP endonuclease with conserved zinc-finger-like
            motifs involved in DNA strand break responses
  JOURNAL   EMBO J 26 (8), 2094-2103 (2007)
   PUBMED   17396150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_575597.3, XM_002726429.1, XM_001075022.2, XM_002729393.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000004.1  121679627-121679932 c
            307-378             JAXUCZ010000004.1  121677174-121677245 c
            379-551             JAXUCZ010000004.1  121665497-121665669 c
            552-699             JAXUCZ010000004.1  121661693-121661840 c
            700-835             JAXUCZ010000004.1  121661282-121661417 c
            836-1020            JAXUCZ010000004.1  121657474-121657658 c
            1021-1376           JAXUCZ010000004.1  121647595-121647950 c
            1377-1502           JAXUCZ010000004.1  121643046-121643171 c
            1503-1549           JAXUCZ010000004.1  121637904-121637950 c
            1550-2572           JAXUCZ010000004.1  121627800-121628822 c
FEATURES             Location/Qualifiers
     source          1..2572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2572
                     /gene="Aplf"
                     /gene_synonym="RGD1565557"
                     /note="aprataxin and PNKP like factor"
                     /db_xref="GeneID:500247"
                     /db_xref="RGD:1565557"
     exon            1..306
                     /gene="Aplf"
                     /gene_synonym="RGD1565557"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1734
                     /gene="Aplf"
                     /gene_synonym="RGD1565557"
                     /EC_number="4.2.99.18"
                     /codon_start=1
                     /product="aprataxin and PNK-like factor"
                     /protein_id="NP_001166853.1"
                     /db_xref="GeneID:500247"
                     /db_xref="RGD:1565557"
                     /translation="MSSEFFLHPLDGGPRVPVGPGQTVIGRGPLLGITDKRVSRRHAI
                     LEVVDSQLRIKPVHKNPCFHQSSEKSQLSPMETHVWSRLHPGDSFSLLLDKYAFRVSS
                     TQSEVEVESTLRNSQMLDEDDILNEMRKSPVVNLPDKAAGASQLQGSPEVTKTKCPPI
                     DPMSSSGDCRAFSEHQPDPAHRKRILPAWMLAGSLSDQNLSTPAEGGGDKDAIQRDGK
                     EGTHEDKTPVNTSWRGRKRFIPPGNSKSVSPKQDPGKKWRRSDQEGLAVSPEDVPESS
                     SSITVSDPDMDIVKANKLSDTISAEELGEAPKHKAVTKPTTNDKDKTMSHPKCRAGVQ
                     SKTFLEKSQGCHPESSSAPSSPGASHTDTADSVLGCSEESKVRRTSCMYGANCYRKNP
                     LHFQHFSHPGDSDYGAVPVTDEGVTGDRPECPYGASCYRKNPQHRMEYRHSALPARVA
                     VDEDDDDVGQPSDSDKDEEDYAPTDEDSDWQPGKDDEEKEDVDELLKEAKRFMRRKT"
     exon            307..378
                     /gene="Aplf"
                     /gene_synonym="RGD1565557"
                     /inference="alignment:Splign:2.1.0"
     exon            379..551
                     /gene="Aplf"
                     /gene_synonym="RGD1565557"
                     /inference="alignment:Splign:2.1.0"
     exon            552..699
                     /gene="Aplf"
                     /gene_synonym="RGD1565557"
                     /inference="alignment:Splign:2.1.0"
     exon            700..835
                     /gene="Aplf"
                     /gene_synonym="RGD1565557"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1020
                     /gene="Aplf"
                     /gene_synonym="RGD1565557"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1376
                     /gene="Aplf"
                     /gene_synonym="RGD1565557"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1502
                     /gene="Aplf"
                     /gene_synonym="RGD1565557"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1549
                     /gene="Aplf"
                     /gene_synonym="RGD1565557"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..2572
                     /gene="Aplf"
                     /gene_synonym="RGD1565557"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttacagttt taagctgtag tttggcggtg agctgacagg taattcctgc acgaatcaca
       61 agctctcaag aagtagggat tccggaaagg gaagaagttc actcactaga aaaggagcct
      121 cgggtctcac acccctttgg gacttgcgcg gcgtgtctga gggaggtggc tacgaggtat
      181 ctccaggcga aggaatctga ttttaccacc atgtcttcgg agttctttct gcatcctctg
      241 gacggcggtc cccgcgtgcc cgtggggccg gggcagactg tgataggccg cgggccgctg
      301 ctgggaataa cagataaaag agtatccaga aggcatgcca ttcttgaagt ggttgatagt
      361 cagctccgaa tcaaaccagt ccacaagaac ccatgtttcc accagtcctc ggagaagagc
      421 cagctctcgc caatggagac ccacgtgtgg agccggttgc atcctgggga cagcttttcc
      481 ttgttacttg acaagtacgc tttccgtgtt tcctctacac aatctgaagt ggaagtggag
      541 agtactctga gaaacagtca gatgctcgat gaagatgata tattgaatga gatgcggaag
      601 tcccctgtgg ttaacttacc tgataaggcg gctggtgcct cacagctgca aggaagcccc
      661 gaagtaacga agaccaagtg tccccccata gatcctatgt cctcttcagg tgactgccga
      721 gctttcagtg agcaccagcc agatcctgcc cacaggaaaa gaatcctccc agcatggatg
      781 ttagcaggaa gtctaagtga tcaaaacctt tccacacctg ctgagggtgg aggagataag
      841 gatgccatcc agagggatgg gaaagaagga acccatgaag ataaaacccc agtaaataca
      901 tcgtggcgtg ggagaaagcg gtttattcca ccaggaaatt caaaaagtgt gtcaccaaaa
      961 caagaccctg ggaagaaatg gagaaggtct gaccaagaag gactggctgt ttcacccgag
     1021 gatgtgccag aatcatcgtc ttcaatcaca gtaagtgacc cggatatgga tattgtgaag
     1081 gcaaataaac tgagtgacac aatttcagca gaggaactag gtgaggcccc taaacataaa
     1141 gctgtcacca aaccaaccac gaatgacaag gacaagacta tgagccatcc caagtgtcgt
     1201 gcaggtgtcc aaagtaagac atttcttgag aaatcccaag gatgccatcc cgagtccagc
     1261 tctgctccct ccagtcctgg tgcttcgcac acagacaccg ccgattcagt gctaggctgt
     1321 tcagaggaaa gcaaggtccg gaggacgtcc tgcatgtatg gggccaactg ctacaggaag
     1381 aatccgctcc attttcaaca cttcagccac cctggtgata gtgactatgg agctgtacct
     1441 gtcacagacg aaggcgtgac tggtgacagg cctgagtgtc cctatggggc atcttgttac
     1501 aggaagaatc cccagcacag gatggaatat aggcacagtg cacttccggc cagggttgct
     1561 gtggatgaag atgacgatga tgttgggcaa ccgagtgaca gtgacaagga tgaggaagac
     1621 tatgcgccga cagatgaaga ttctgactgg caaccaggaa aggatgatga ggagaaggaa
     1681 gatgtggatg agcttttgaa agaagcaaag cggttcatga gaaggaaaac gtagcttttc
     1741 tgcaacgacg gaacacacac tcacatttgc ttttctccgt gggaaacata gtcgcttccc
     1801 tcttccacta gttctctgca cttgaagcct tggaacaccg gccttcagtg aaggtgggga
     1861 gtgaatgccg gctgctgcct gttttagtgt ctattatgca cccgtcattg gaagcgggtg
     1921 gagttgggca gactgatctt tgtcatatcc tttacatact gctaataaaa agccagaggt
     1981 tgcacaaacc tttggtcttc tgcccagagg tctttatagt ttaccctgcg agcttagcca
     2041 ggcgattgca gaggagtggg agagcctagc cccacactgc tgttgaaaga gtccctcaca
     2101 aagctggact tgaacaaatg acagccagca gtgtgctatg tctgtaatgt attagatgtg
     2161 gctgtgtgat ttcatttaca gcatttgtcc tttgaatcct gggaaaacaa atggatgctg
     2221 agaatgatcc tattagctcc agggcagcgt tcctggcctt gcaaggaaat gggctttgtg
     2281 catccacgac tgcatatgtg tgtctgcgag agaacaaagc acacggctac ggaacacttc
     2341 ggttcctctc ccgattactt tgcctgcact gcgcaccttt acactgagga tgcagagaag
     2401 gttctagcca cagtctcctt ttcattcttc aagaggaaat aaaatgtgca tcttagaaca
     2461 ggaggtgttg catatgtttc cttagtactt atgggtctct atgtacttgt acaatgttaa
     2521 catttactta acctgaagac agacagaata aatatttctc tgttatcatt ac
//
