LOCUS       NM_001106492             930 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus APAF1 interacting protein (Apip), mRNA.
ACCESSION   NM_001106492 XM_001072220 XM_215785
VERSION     NM_001106492.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 930)
  AUTHORS   Kang,W., Hong,S.H., Lee,H.M., Kim,N.Y., Lim,Y.C., Le le,T.M.,
            Lim,B., Kim,H.C., Kim,T.Y., Ashida,H., Yokota,A., Hah,S.S.,
            Chun,K.H., Jung,Y.K. and Yang,J.K.
  TITLE     Structural and biochemical basis for the inhibition of cell death
            by APIP, a methionine salvage enzyme
  JOURNAL   Proc Natl Acad Sci U S A 111 (1), E54-E61 (2014)
   PUBMED   24367089
REFERENCE   3  (bases 1 to 930)
  AUTHORS   Ko,D.C., Gamazon,E.R., Shukla,K.P., Pfuetzner,R.A., Whittington,D.,
            Holden,T.D., Brittnacher,M.J., Fong,C., Radey,M., Ogohara,C.,
            Stark,A.L., Akey,J.M., Dolan,M.E., Wurfel,M.M. and Miller,S.I.
  TITLE     Functional genetic screen of human diversity reveals that a
            methionine salvage enzyme regulates inflammatory cell death
  JOURNAL   Proc Natl Acad Sci U S A 109 (35), E2343-E2352 (2012)
   PUBMED   22837397
REFERENCE   4  (bases 1 to 930)
  AUTHORS   Mary,C., Duek,P., Salleron,L., Tienz,P., Bumann,D., Bairoch,A. and
            Lane,L.
  TITLE     Functional identification of APIP as human mtnB, a key enzyme in
            the methionine salvage pathway
  JOURNAL   PLoS One 7 (12), e52877 (2012)
   PUBMED   23285211
REFERENCE   5  (bases 1 to 930)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   6  (bases 1 to 930)
  AUTHORS   Cho,D.H., Lee,H.J., Kim,H.J., Hong,S.H., Pyo,J.O., Cho,C. and
            Jung,Y.K.
  TITLE     Suppression of hypoxic cell death by APIP-induced sustained
            activation of AKT and ERK1/2
  JOURNAL   Oncogene 26 (19), 2809-2814 (2007)
   PUBMED   17086211
REFERENCE   7  (bases 1 to 930)
  AUTHORS   Cho,D.H., Hong,Y.M., Lee,H.J., Woo,H.N., Pyo,J.O., Mak,T.W. and
            Jung,Y.K.
  TITLE     Induced inhibition of ischemic/hypoxic injury by APIP, a novel
            Apaf-1-interacting protein
  JOURNAL   J Biol Chem 279 (38), 39942-39950 (2004)
   PUBMED   15262985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 10, 2021 this sequence version replaced NM_001106492.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM103133.1, SRR22582416.228662.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000003.1  109886919-109887096
            179-279             JAXUCZ010000003.1  109904152-109904252
            280-328             JAXUCZ010000003.1  109907594-109907642
            329-446             JAXUCZ010000003.1  109909066-109909183
            447-582             JAXUCZ010000003.1  109909894-109910029
            583-750             JAXUCZ010000003.1  109912251-109912418
            751-930             JAXUCZ010000003.1  109912776-109912955
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q32"
     gene            1..930
                     /gene="Apip"
                     /gene_synonym="RGD1564562"
                     /note="APAF1 interacting protein"
                     /db_xref="GeneID:295961"
                     /db_xref="RGD:1564562"
     exon            1..178
                     /gene="Apip"
                     /gene_synonym="RGD1564562"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..850
                     /gene="Apip"
                     /gene_synonym="RGD1564562"
                     /EC_number="4.2.1.109"
                     /note="probable methylthioribulose-1-phosphate
                     dehydratase"
                     /codon_start=1
                     /product="methylthioribulose-1-phosphate dehydratase"
                     /protein_id="NP_001099962.2"
                     /db_xref="GeneID:295961"
                     /db_xref="RGD:1564562"
                     /translation="MSGCQAQGDCCSRPYGAQDKEHPRFLIPELCKQFYHLGWVTGTG
                     GGISLKHGNEIYIAPSGVQKERIQPEDMFVCDINEQDISGPPASKNLKKSQCTPLFMN
                     AYTMRGAGAVIHTHSKAAVMATLLFPGQEFKITHQEMIKGIRKCTSGGYYRYDDILVV
                     PIIENTPEEKDLKERMARAMNEYPDSCAVLVRRHGVYVWGETWEKAKTMCECYDYLFD
                     IAVSMKKMGLDPTQFPVGEHGIV"
     exon            179..279
                     /gene="Apip"
                     /gene_synonym="RGD1564562"
                     /inference="alignment:Splign:2.1.0"
     exon            280..328
                     /gene="Apip"
                     /gene_synonym="RGD1564562"
                     /inference="alignment:Splign:2.1.0"
     exon            329..446
                     /gene="Apip"
                     /gene_synonym="RGD1564562"
                     /inference="alignment:Splign:2.1.0"
     exon            447..582
                     /gene="Apip"
                     /gene_synonym="RGD1564562"
                     /inference="alignment:Splign:2.1.0"
     exon            583..750
                     /gene="Apip"
                     /gene_synonym="RGD1564562"
                     /inference="alignment:Splign:2.1.0"
     exon            751..930
                     /gene="Apip"
                     /gene_synonym="RGD1564562"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagatctt gcttctcgct cttgctccgc ccccagactg cccgctttgc agactaatag
       61 cgttcttgtg gaccacttag acgtagaacg tgctcggggt ggctaactga gcggagttag
      121 aaccatgtct ggctgtcaag cgcaaggaga ctgttgctcg cggccgtatg gcgcgcagga
      181 caaggaacat cccagattcc tgatcccaga actttgcaaa cagttttacc atctgggctg
      241 ggtcactggc actggaggag gaatcagctt gaagcatggc aatgaaatct acattgctcc
      301 ctcaggcgtg caaaaggagc gcattcagcc agaagacatg tttgtttgtg acatcaatga
      361 gcaggacata agtgggcctc cagcatctaa gaatcttaag aaaagccagt gtacgcctct
      421 tttcatgaac gcttacacca tgagaggagc aggcgcagtg attcataccc actctaaagc
      481 tgctgtgatg gctacccttc tgtttccagg acaggagttt aaaattacac atcaagagat
      541 gatcaaagga ataaggaaat gtacctctgg agggtattac agatacgatg atatattagt
      601 ggtacccatt attgagaaca ctcctgaaga gaaggacctc aaagaacgga tggctcgtgc
      661 catgaatgaa tacccagact cctgtgcagt tctagtcagg cgtcacgggg tgtacgtgtg
      721 gggagaaaca tgggagaaag caaaaaccat gtgtgagtgt tatgattacc tgtttgacat
      781 tgctgtctcc atgaagaaga tggggctgga tccaacgcag ttcccagttg gagaacatgg
      841 aatcgtataa gccaagtgga cgcctaagaa tctccaaaaa taaaacaaac tcaattacgc
      901 cttaaataaa actctgctac ttttaaatga
//
