LOCUS       NM_001399729            3694 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus apoptosis inhibitor 5 (Api5), transcript variant
            1, mRNA.
ACCESSION   NM_001399729 XM_006234586
VERSION     NM_001399729.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3694)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 3694)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 3694)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3694)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   5  (bases 1 to 3694)
  AUTHORS   Van den Berghe,L., Laurell,H., Huez,I., Zanibellato,C., Prats,H.
            and Bugler,B.
  TITLE     FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a
            nuclear putatively antiapoptotic factor, interacts specifically
            with FGF-2
  JOURNAL   Mol Endocrinol 14 (11), 1709-1724 (2000)
   PUBMED   11075807
REFERENCE   6  (bases 1 to 3694)
  AUTHORS   Kim,J.W., Cho,H.S., Kim,J.H., Hur,S.Y., Kim,T.E., Lee,J.M.,
            Kim,I.K. and Namkoong,S.E.
  TITLE     AAC-11 overexpression induces invasion and protects cervical cancer
            cells from apoptosis
  JOURNAL   Lab Invest 80 (4), 587-594 (2000)
   PUBMED   10780674
REFERENCE   7  (bases 1 to 3694)
  AUTHORS   Tewari,M., Yu,M., Ross,B., Dean,C., Giordano,A. and Rubin,R.
  TITLE     AAC-11, a novel cDNA that inhibits apoptosis after growth factor
            withdrawal
  JOURNAL   Cancer Res 57 (18), 4063-4069 (1997)
   PUBMED   9307294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 13, 2022 this sequence version replaced XM_006234586.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.391083.1,
                                           SRR26360194.1087354.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               JAXUCZ010000003.1  100858359-100858580 c
            223-384             JAXUCZ010000003.1  100849128-100849289 c
            385-478             JAXUCZ010000003.1  100847510-100847603 c
            479-544             JAXUCZ010000003.1  100847036-100847101 c
            545-696             JAXUCZ010000003.1  100846370-100846521 c
            697-903             JAXUCZ010000003.1  100844849-100845055 c
            904-1008            JAXUCZ010000003.1  100844227-100844331 c
            1009-1098           JAXUCZ010000003.1  100842962-100843051 c
            1099-1280           JAXUCZ010000003.1  100841819-100842000 c
            1281-1374           JAXUCZ010000003.1  100840927-100841020 c
            1375-1431           JAXUCZ010000003.1  100840473-100840529 c
            1432-1508           JAXUCZ010000003.1  100838686-100838762 c
            1509-1645           JAXUCZ010000003.1  100838103-100838239 c
            1646-3694           JAXUCZ010000003.1  100833417-100835465 c
FEATURES             Location/Qualifiers
     source          1..3694
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q31"
     gene            1..3694
                     /gene="Api5"
                     /note="apoptosis inhibitor 5"
                     /db_xref="GeneID:362170"
                     /db_xref="RGD:1309772"
     exon            1..222
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1728
                     /gene="Api5"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="apoptosis inhibitor 5 isoform 1"
                     /protein_id="NP_001386658.1"
                     /db_xref="GeneID:362170"
                     /db_xref="RGD:1309772"
                     /translation="MPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRL
                     AAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADIL
                     TQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLK
                     TLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVA
                     EQADLEQTFSPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLSTLTTP
                     VEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNE
                     EPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLR
                     LALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVE
                     IGQKRTSEDTSSGSPPKKSPGGPKRDARQIYNPPSGKYSSNLGNFNYEQRGAFRGSRG
                     GRGWGTRGNRSRGRLY"
     exon            223..384
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     exon            385..478
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     exon            479..544
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     exon            545..696
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     exon            697..903
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1008
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1098
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1280
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1374
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1431
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1508
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1645
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..3694
                     /gene="Api5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggggccgt gctgtacgag gtgactggtg gcggcccggc ggcggctgcc ggcgtaatag
       61 tgcggtcgac cgcttagata agttccgtgg aggcggtggt ggcgccgaag aggtgttggg
      121 cgacgggagc gggcccggaa cttggcgctc agcatgccga cggtggagga gctgtaccgc
      181 aactacggca tcctcgccga tgccacggag caagtgggcc agcataaaga tgcctaccaa
      241 gtgatattgg atggtgtgaa aggcgggacc aaggaaaagc gattagcagc tcagtttata
      301 ccaaaattct ttaagcattt tccagagctg gctgattctg ctatcaacgc acagttagac
      361 ctctgtgagg atgaagatgt gtcaatacga cgccaagcaa ttaaagaact gcctcagttt
      421 gccacaggag aaaaccttcc gcgagtagca gatatactga cccagcttct gcagacagat
      481 gactctgcag aatttaactt ggtgaacaat gctctgttaa gtatatttaa gatggacgca
      541 aaaggaacat taggtggctt gtttagccag attcttcaag gagaagacat tgttagagaa
      601 cgagcaatta aattcctgtc cacaaaactc aagacgctcc cagatgaagt gttaactaag
      661 gaagtagagg agctcatact caccgagtcc aaaaaggtcc tagaagatgt gactggtgaa
      721 gagtttgttt tgttcatgaa gatcctgtct gggttaaaaa gcttgcagac agtgagtgga
      781 aggcagcagc tggtagagct ggtggcagaa caggctgacc tggagcagac cttcagcccc
      841 tcagaccctg actgcgtgga caggctgctg cagtgcactc ggcaggctgt gcctctcttc
      901 tctaaaaatg ttcattctac aagatttgtg acatatttct gtgagcaggt cctccctaat
      961 ctcagtaccc taactacccc agtggaaggt ctggatatac agttggaggt attaaagttg
     1021 ttggcagaga tgagttcatt ttgtggtgac atggaaaaac tagaaacaaa tttaagaaaa
     1081 ctgtttgata agttattgga gtatatgcct ctccctccag aagaagcaga aaatggagag
     1141 aacgctggga atgaagagcc caagctacag ttcagttatg tggagtgctt attatatagt
     1201 tttcatcagt tgggccgaaa acttccggac ttcctaacag ccaaactgaa tgcagaaaag
     1261 ctcaaagatt tcaaaattag gttgcagtac tttgcacggg gccttcaggt ttatatcaga
     1321 caacttcgat tggctctcca gggtaaaaca ggcgaggcct taaaaacaga ggagaacaag
     1381 ataaaagttg ttgcattgaa aataacaaac aatatcaatg ttttaatcaa ggatctcttt
     1441 cacattcctc cttcttataa gagcacggta acattgtcct ggaaacctgt acagaaagtt
     1501 gagattgggc aaaagagaac cagtgaagat acaagttcag gttcaccacc taagaaatct
     1561 ccaggaggac caaaaaggga tgccagacag atttacaatc ctcctagtgg gaagtacagc
     1621 agcaatttgg gcaactttaa ttatgagcag agaggagcct tcaggggaag tagaggtggc
     1681 cgaggttggg gaacaagagg aaatcgtagt cgaggacgac tctactgatt gcgacatcac
     1741 actcttgagc attgtcgtga gattaatata cttaaatcta ctactactca ttggattgcc
     1801 ggggatgtcc ctttaaaagg actgctgcct tcagctgaaa acgtaatgtt ctttctacct
     1861 ttgtatgtat gatctacttt tgtaaaagac catggttgtg tccaaggtaa aaccacaaca
     1921 atatttttgg atgctttgtc tgcagccttg acttgttttc acaatatcct cattatccag
     1981 acttcatctt gtgaatcttg cttttacaca tcttgataat ttgttattga gaactgactc
     2041 taatgggaaa ttcagtctag cttgtgatct ggtaaagatg atcacttttt gaagcgttac
     2101 ttattttcct ccccattctg ttacagtttc ttgcccaata catggagaag agtagtaatc
     2161 agtcttaacc ttttgcttcc attgttttct aatgaagctg ctaggcagtg ttgtaacatt
     2221 cctgccaagg gtcatagaaa ttaaacacca gcttctcaca gtgtacaagt gacatcaggc
     2281 ttttagaaag aagttgcttt gcattgctcc cttcactctt ctccatattt tggaatacag
     2341 ctttgaacgc agggtcttat tatttgaata agagtacatg tgcataatat acgtacagac
     2401 ataagcatat gttgtgtgtg tatatatgca tgctatggaa cttgagtata caacaaatca
     2461 atactttaaa ttctcagaat gggtcatctg atatagtgat tatccctttg agactgaatc
     2521 cattactgac ttggtatcta ggtttctact ccagtaggga ggaatttcag tcagttgaac
     2581 tcacatgatt attattgttt aaaactaaaa agaaagtctc ttttttcaga gacaaatcta
     2641 aagacccttg ttggtgaaat acagccagat ctgatgtaca tacaggatgt gatagtgtat
     2701 ttaggatttg gagacttaat aaccagggct acccaggaaa gtgacttgat gacatagtac
     2761 ctaccataag agttgttcac tcagcttgct tttgccactt tcaaaattta acttctcagg
     2821 ttattaatca gattattgta tgttagccaa tagtctttag attaagacaa cagatgggag
     2881 gtttgtggag tgtcttgtgt tgggcatttt tagtagccca gactctgttc ttcatttgaa
     2941 tgtttcataa atttttgttc cacagttact cttccttctc caagtttgct attcaaatca
     3001 gaaattcaga tgacattttt agtggtttgt tgttttggtt tttttgaggt tttgattcct
     3061 acacaggtgt cttcattacc atcacttcta cactgggaaa aaaaaaataa tctcctttgt
     3121 gagaaccact gcacgtattt atggcaaaaa tatttctgaa agtctagaat gatggaaatg
     3181 agcacgggaa gttggtcagc ttgactaagg agtgctggca ataaactctg agcattccac
     3241 aggactgagc tgaacctagg ctcccttgga atctgaacag acaggaacat gggattgcca
     3301 gttgactact ctgaccatct agttatggac ttcagagata aatcagccat ggcctaaagc
     3361 catttcaaga acaaaaatga attgggacta tagcaatata agtttgaaca cagtaatgtt
     3421 tcctctcttg tctgagggta tttgtaaact cagcagaagt aacttgacct catgtctact
     3481 acagaactcc ctgcattcat cccttcctta tccttttgct tcctttccct tgcctagtca
     3541 gtagttcatg acttagtatt ctttttgctt cagaaatttg aaagaaaatc tttatgccat
     3601 gaatcttttt cttccacaag gacacctgtt taccaccttg tttaaatgta aatgttccct
     3661 tatgcttttg aaataaattt ccttttgtaa tttt
//
