LOCUS       NM_001047090            1284 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus aph-1 homolog B, gamma secretase subunit (Aph1b),
            mRNA.
ACCESSION   NM_001047090 XM_001076887 XM_217185
VERSION     NM_001047090.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Jiang,F., Sun,F.X. and Xu,S.M.
  TITLE     [Effect of betasheet blocking peptide H102 on APP metabolic enzymes
            in hippocampal brain of double transgenic AD mice]
  JOURNAL   Zhongguo Ying Yong Sheng Li Xue Za Zhi 33 (4), 299-303 (2017)
   PUBMED   29926633
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Simic,D., Simutis,F., Euler,C., Thurby,C., Peden,W.M., Bunch,R.T.,
            Pilcher,G., Sanderson,T. and Van Vleet,T.
  TITLE     Determination of relative Notch1 and gamma-secretase-related gene
            expression in puromycin-treated microdissected rat kidneys
  JOURNAL   Gene Expr 16 (1), 39-47 (2013)
   PUBMED   24397211
  REMARK    GeneRIF: Notch ligand binding leads to gamma-secretase-mediated
            proteolytic cleavage of the Notch receptor releasing the Notch
            intracellular domain, resulting in its subsequent translocation
            into the nucleus and gene expression regulation
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Van Schijndel,J.E., Van Zweeden,M., Van Loo,K.M. and Martens,G.J.
  TITLE     Gene expression profiling in brain regions of a rat model
            displaying schizophrenia-related features
  JOURNAL   Behav Brain Res 207 (2), 476-479 (2010)
   PUBMED   19896980
  REMARK    GeneRIF: Aph1b and KCnIP1 are significantly differentially
            expressed in a number of brain tissues of a schizophrenia model;
            KCnIP1 is an attractive novel candidate gene that may play a role
            in the complex phenotype
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   van Loo,K.M., van Schijndel,J.E., van Zweeden,M., van Manen,D.,
            Trip,M.D., Petersen,D.C., Schuitemaker,H., Hayes,V.M. and
            Martens,G.J.
  TITLE     Correlation between HIV-1 seropositivity and prevalence of a
            gamma-secretase polymorphism in two distinct ethnic populations
  JOURNAL   J Med Virol 81 (11), 1847-1851 (2009)
   PUBMED   19774691
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   van Loo,K.M., Dejaegere,T., van Zweeden,M., van Schijndel,J.E.,
            Wijmenga,C., Trip,M.D. and Martens,G.J.
  TITLE     Male-specific association between a gamma-secretase polymorphism
            and premature coronary atherosclerosis
  JOURNAL   PLoS One 3 (11), e3662 (2008)
   PUBMED   18987747
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Coolen,M.W., van Loo,K.M., Ellenbroek,B.A., Cools,A.R. and
            Martens,G.J.
  TITLE     Ontogenic reduction of Aph-1b mRNA and gamma-secretase activity in
            rats with a complex neurodevelopmental phenotype
  JOURNAL   Mol Psychiatry 11 (8), 787-793 (2006)
   PUBMED   16718279
  REMARK    GeneRIF: low levels of Aph-1b mRNA and gamma-secretase activity
            observed in the I/I and II/II rats during the entire developmental
            period may well underlie their complex phenotype
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Coolen,M.W., van Loo,K.M., van Bakel,N.N., Ellenbroek,B.A.,
            Cools,A.R. and Martens,G.J.
  TITLE     Reduced Aph-1b expression causes tissue- and substrate-specific
            changes in gamma-secretase activity in rats with a complex
            phenotype
  JOURNAL   FASEB J 20 (1), 175-177 (2006)
   PUBMED   16249316
  REMARK    GeneRIF: Pharmacogenetically bred apomorphine-susceptible Wistar
            rats have only one or two copies of the Aph-1b gene; in these rats,
            gamma-secretase activity is altered, leading to a complex
            phenotype.
REFERENCE   8  (bases 1 to 1284)
  AUTHORS   Coolen,M.W., Van Loo,K.M., Van Bakel,N.N., Pulford,D.J.,
            Serneels,L., De Strooper,B., Ellenbroek,B.A., Cools,A.R. and
            Martens,G.J.
  TITLE     Gene dosage effect on gamma-secretase component Aph-1b in a rat
            model for neurodevelopmental disorders
  JOURNAL   Neuron 45 (4), 497-503 (2005)
   PUBMED   15721236
REFERENCE   9  (bases 1 to 1284)
  AUTHORS   Ma,G., Li,T., Price,D.L. and Wong,P.C.
  TITLE     APH-1a is the principal mammalian APH-1 isoform present in
            gamma-secretase complexes during embryonic development
  JOURNAL   J Neurosci 25 (1), 192-198 (2005)
   PUBMED   15634781
REFERENCE   10 (bases 1 to 1284)
  AUTHORS   Lee,S.F., Shah,S., Li,H., Yu,C., Han,W. and Yu,G.
  TITLE     Mammalian APH-1 interacts with presenilin and nicastrin and is
            required for intramembrane proteolysis of amyloid-beta precursor
            protein and Notch
  JOURNAL   J Biol Chem 277 (47), 45013-45019 (2002)
   PUBMED   12297508
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 25, 2020 this sequence version replaced NM_001047090.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ672552.1, BC098711.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840111 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               JAXUCZ010000008.1  76331179-76331428   c
            251-421             JAXUCZ010000008.1  76329784-76329954   c
            422-492             JAXUCZ010000008.1  76325405-76325475   c
            493-615             JAXUCZ010000008.1  76324462-76324584   c
            616-743             JAXUCZ010000008.1  76317865-76317992   c
            744-1284            JAXUCZ010000008.1  76310380-76310920   c
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1284
                     /gene="Aph1b"
                     /gene_synonym="APH-1B'"
                     /note="aph-1 homolog B, gamma secretase subunit"
                     /db_xref="GeneID:300802"
                     /db_xref="RGD:1562468"
     exon            1..250
                     /gene="Aph1b"
                     /gene_synonym="APH-1B'"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..911
                     /gene="Aph1b"
                     /gene_synonym="APH-1B'"
                     /note="anterior pharynx defective 1b homolog; anterior
                     pharynx defective 1 homolog B; APH1B gamma secretase
                     subunit; gamma-secretase subunit APH-1B-like"
                     /codon_start=1
                     /product="gamma-secretase subunit APH-1B"
                     /protein_id="NP_001040555.1"
                     /db_xref="GeneID:300802"
                     /db_xref="RGD:1562468"
                     /translation="MTAPVFFGCAFIAFGPALALYLFTIATDPLRVIFLIAGAFFWLV
                     SLLLSSVFWFLVRVITDNRDGPVQNYLLIFGVLLSVCIQELFRLAYYRLLKKASEGLK
                     SINPEETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSNALGPGTVGIHGDSPQFFLNSA
                     FMTLVIIMLHVFWGIVFFDGCEKNKWYILLTVLLTHLLVSTQTLLSPHYEVNLVTAYI
                     IMVLMGIWAFCVAGGSRRSLKLCLLCQDKDFLLYNQRSR"
     exon            251..421
                     /gene="Aph1b"
                     /gene_synonym="APH-1B'"
                     /inference="alignment:Splign:2.1.0"
     exon            422..492
                     /gene="Aph1b"
                     /gene_synonym="APH-1B'"
                     /inference="alignment:Splign:2.1.0"
     exon            493..615
                     /gene="Aph1b"
                     /gene_synonym="APH-1B'"
                     /inference="alignment:Splign:2.1.0"
     exon            616..743
                     /gene="Aph1b"
                     /gene_synonym="APH-1B'"
                     /inference="alignment:Splign:2.1.0"
     exon            744..1284
                     /gene="Aph1b"
                     /gene_synonym="APH-1B'"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccgcctcc tgggctctgc tccgccctct tctctaattg cgctcggagc acctggcagg
       61 cgtgtccggt cccatatccc gctaagacag cgtcccatgc accttggatc cacccgggac
      121 tgacttctgc gggtaccatg acagcgcccg tgttcttcgg ttgcgccttc atcgccttcg
      181 ggcccgcgct cgctctctac ctcttcacca tcgccaccga ccctttgcga gtcatcttcc
      241 tcatcgccgg tgccttcttc tggttggtgt ctctgctgct ttcgtctgtt ttctggttcc
      301 tagtgagagt catcactgac aacagagatg gaccagtaca gaattacctg ctcatctttg
      361 gagtgttgct ctctgtctgt atccaagagc tgttcaggct cgcatattat aggctgttaa
      421 aaaaagccag cgagggtttg aaaagcataa accctgagga gacagcacct tcgatgcgac
      481 tgttggccta tgtttctggc ttgggctttg gaatcatgag tggagtgttt tcctttgtga
      541 acaccctgtc taatgccttg gggccaggca cagtgggcat tcatggtgat tctcctcagt
      601 tcttccttaa ttcagctttc atgacgctgg ttatcataat gctgcacgtg ttctggggca
      661 tcgtgttttt tgacggctgt gagaagaata agtggtacat cctcctcaca gttctcctga
      721 cccacctgct ggtgtccacc cagactttac taagtcctca ctatgaagtg aatctggtga
      781 cagcatatat aatcatggtg ctcatgggca tctgggcatt ctgtgttgct ggaggcagcc
      841 gccgaagcct gaaactctgt ctgctctgcc aagacaagga ctttcttctt tacaaccagc
      901 gctccagata acctctgacg gtcagcacct ccaaacagca gcctgtgtgc cagaggaagg
      961 gcagccgggc cctgttctaa aatgaccctt ttcttctgga gctttggagc agcagagctt
     1021 ctagcctgca actgtcctgt gctttcatgc agcagcctct ggaagagctg cagtgtggcc
     1081 tgcagcctgg ctgcacattt gaggcatctg gggaaacaaa gaccgatgct tctgggcctc
     1141 ccctctagac tcgagtatcc cagatgtgca atacagctga gtcactgggg tccaatggga
     1201 agtttcagag aacccaaagg cagttctgta tttgtctcct aagccaacct ctgctgagca
     1261 agtaaatttc tgaaaacctg ggta
//
