LOCUS       NM_001014255            2069 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  Rattus norvegicus aph-1 homolog A, gamma secretase subunit (Aph1a),
            mRNA.
ACCESSION   NM_001014255 XM_345251
VERSION     NM_001014255.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2069)
  AUTHORS   Jiang F, Sun FX and Xu SM.
  TITLE     [Effect of betasheet blocking peptide H102 on APP metabolic enzymes
            in hippocampal brain of double transgenic AD mice]
  JOURNAL   Zhongguo Ying Yong Sheng Li Xue Za Zhi 33 (4), 299-303 (2017)
   PUBMED   29926633
REFERENCE   2  (bases 1 to 2069)
  AUTHORS   Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SHW and
            Shi Y.
  TITLE     An atomic structure of human gamma-secretase
  JOURNAL   Nature 525 (7568), 212-217 (2015)
   PUBMED   26280335
REFERENCE   3  (bases 1 to 2069)
  AUTHORS   Lu P, Bai XC, Ma D, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R,
            Scheres SHW and Shi Y.
  TITLE     Three-dimensional structure of human gamma-secretase
  JOURNAL   Nature 512 (7513), 166-170 (2014)
   PUBMED   25043039
REFERENCE   4  (bases 1 to 2069)
  AUTHORS   Chen AC, Guo LY, Ostaszewski BL, Selkoe DJ and LaVoie MJ.
  TITLE     Aph-1 associates directly with full-length and C-terminal fragments
            of gamma-secretase substrates
  JOURNAL   J Biol Chem 285 (15), 11378-11391 (2010)
   PUBMED   20145246
  REMARK    GeneRIF: Aph-1 associates directly with full-length and C-terminal
            fragments of gamma-secretase substrates
REFERENCE   5  (bases 1 to 2069)
  AUTHORS   Zhao G, Liu Z, Ilagan MX and Kopan R.
  TITLE     Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and
            amyloid precursor protein in the absence of nicastrin
  JOURNAL   J Neurosci 30 (5), 1648-1656 (2010)
   PUBMED   20130175
REFERENCE   6  (bases 1 to 2069)
  AUTHORS   Ma G, Li T, Price DL and Wong PC.
  TITLE     APH-1a is the principal mammalian APH-1 isoform present in
            gamma-secretase complexes during embryonic development
  JOURNAL   J Neurosci 25 (1), 192-198 (2005)
   PUBMED   15634781
REFERENCE   7  (bases 1 to 2069)
  AUTHORS   Hansson CA, Frykman S, Farmery MR, Tjernberg LO, Nilsberth C,
            Pursglove SE, Ito A, Winblad B, Cowburn RF, Thyberg J and
            Ankarcrona M.
  TITLE     Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase
            complexes in mitochondria
  JOURNAL   J Biol Chem 279 (49), 51654-51660 (2004)
   PUBMED   15456764
  REMARK    GeneRIF: Nicastrin, presenilin 1, APH-1, and PEN-2 form an active
            gamma-secretase complex expressed in mitochondria.
REFERENCE   8  (bases 1 to 2069)
  AUTHORS   Fraering PC, Ye W, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL,
            van Dorsselaer A, Wang R, Selkoe DJ and Wolfe MS.
  TITLE     Purification and characterization of the human gamma-secretase
            complex
  JOURNAL   Biochemistry 43 (30), 9774-9789 (2004)
   PUBMED   15274632
REFERENCE   9  (bases 1 to 2069)
  AUTHORS   Cheng HT, Miner JH, Lin M, Tansey MG, Roth K and Kopan R.
  TITLE     Gamma-secretase activity is dispensable for
            mesenchyme-to-epithelium transition but required for podocyte and
            proximal tubule formation in developing mouse kidney
  JOURNAL   Development 130 (20), 5031-5042 (2003)
   PUBMED   12952904
REFERENCE   10 (bases 1 to 2069)
  AUTHORS   Lee SF, Shah S, Li H, Yu C, Han W and Yu G.
  TITLE     Mammalian APH-1 interacts with presenilin and nicastrin and is
            required for intramembrane proteolysis of amyloid-beta precursor
            protein and Notch
  JOURNAL   J Biol Chem 277 (47), 45013-45019 (2002)
   PUBMED   12297508
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087081.1.
            
            On Apr 20, 2005 this sequence version replaced XM_345251.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087081.1, CK476803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2069
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2069
                     /gene="Aph1a"
                     /gene_synonym="RGD1311546"
                     /note="aph-1 homolog A, gamma secretase subunit"
                     /db_xref="GeneID:365872"
                     /db_xref="RGD:1311546"
     exon            1..305
                     /gene="Aph1a"
                     /gene_synonym="RGD1311546"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..936
                     /gene="Aph1a"
                     /gene_synonym="RGD1311546"
                     /note="anterior pharynx defective 1a homolog; anterior
                     pharynx defective 1 homolog A; APH1A gamma secretase
                     subunit"
                     /codon_start=1
                     /product="gamma-secretase subunit APH-1A"
                     /protein_id="NP_001014277.1"
                     /db_xref="GeneID:365872"
                     /db_xref="RGD:1311546"
                     /translation="MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLV
                     SLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLA
                     SLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTS
                     AFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIY
                     AVTVSMGLWAFVTAGGSLRSIQRSLSCKD"
     exon            306..476
                     /gene="Aph1a"
                     /gene_synonym="RGD1311546"
                     /inference="alignment:Splign:2.1.0"
     exon            477..550
                     /gene="Aph1a"
                     /gene_synonym="RGD1311546"
                     /inference="alignment:Splign:2.1.0"
     exon            551..673
                     /gene="Aph1a"
                     /gene_synonym="RGD1311546"
                     /inference="alignment:Splign:2.1.0"
     exon            674..801
                     /gene="Aph1a"
                     /gene_synonym="RGD1311546"
                     /inference="alignment:Splign:2.1.0"
     exon            802..2039
                     /gene="Aph1a"
                     /gene_synonym="RGD1311546"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtagacgag gtcgggcgga ccttcgtctg gggtttcggc accccccctt ccccttcccc
       61 ggggtccggg ggtgacattg caccgcgccc ctcctggggt tgcgtcgctg ccccacgcgg
      121 actccccctc ggagcgctgc tcccattcgc ctcccttggc cgggtctcct tccctccccc
      181 agctgtccag tcatgggggc tgctgtgttt ttcggatgca ccttcgtcgc gttcggccca
      241 gccttcgccc ttttcctgat tactgtagcc ggagaccctc ttcgggttat catcctggtg
      301 gcgggagcct ttttctggct ggtttccctg ctcttggcct ctgtggtctg gttcatcttg
      361 gtccatgtga cagaccgatc agatgcacgg ctccagtatg gcctcctgat ttttggtgct
      421 gctgtctctg tccttctaca ggaagtgttc cgttttgcct actacaagct ccttaagaag
      481 gcagatgagg gcttagcatc actaagtgag gacggaagat cgcccatctc catccgacag
      541 atggcctatg tttctggtct gtccttcggt atcatcagtg gtgtcttctc tgttatcaat
      601 attttggctg atgcacttgg gccaggtgtg gttgggatcc atggagactc accctattac
      661 ttcctgactt cagcttttct gacagcagcc attatcctgc tccatacctt ttggggagtt
      721 gtgttctttg atgcctgtga gaggagacgg tactgggctt tgggcctggt agttgggagt
      781 caccttctga cttcaggact gacattcctg aacccctggt atgaggccag cctgctgccc
      841 atctatgcag tcaccgtttc catggggctc tgggcattcg tcacagccgg aggctccctc
      901 cggagtatcc agcgcagcct ttcgtgtaag gactgactac ctggactgat cgcccgacag
      961 ctcccatctg cctgtccact gcccatgact gaacccagcc ccagcccggg tccattgccc
     1021 tcatcctccg tctcctcgct gatgtgtccc acttccttcc gggtttggcg ttgtccattt
     1081 gtgacctgta gtctctaagc tttctcagga gcagcttggg tgcagcccgt cagggactgg
     1141 tgggcttgaa tctgcatctc tccccaccac ctggggaccc ccttgttgtc caggtctccc
     1201 catgtgtcag tgctctatcc ccaccctgcc catgactcac cccacttccc ctctgcaggc
     1261 cgacggcagg aggacagtcg ggtgatggtg tactctgccc tgcgcatccc acccgaggac
     1321 tgagggaaca tgggggggac ccctgggcct ggggtgccct cccgacctcc tcgtcctgta
     1381 tttctccatc tccagttctg gacagtgcag gttgtcaaga aaagggacct agtttaggca
     1441 tggccctgga gatgaagttc ctggaggctc aagggtagat gagttcagtg cagtttctcc
     1501 tgcccagact ggacatcttg gtctttttct caggtctgaa aggaaccatt tttttttggt
     1561 atgataaaga ccccaaaaat gccttttttt taaatggggg agagggagga ggtgtgccgg
     1621 gagcctcctt gacctcctgt aggctgtgtc tctgctcctg aatctgctga ttgtggctca
     1681 cttctatcct attatccctt tggtccaggc cctggggaaa aggaaggaag tgcatgtgtg
     1741 ggaacgggta ccactggaac tcctatttta acgcctgtga ccattagcac ccctcctttc
     1801 cccaaggtga agtggagggt gctgtggggg ccagcccact ccatggcagt gccccagagg
     1861 agtcagacta ccatggcatc gcagcccaag aggacaggca ttttttctag tttttaattg
     1921 gggtgtggga gggctgggga ggttttctat cactgtattg ttttttctgc tgagggtggg
     1981 atattccatc cttttaatca aggtgattgt gattttgatt aataaaaagg actttataaa
     2041 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
