LOCUS       NM_001079892            1878 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus apurinic/apyrimidinic endodeoxyribonuclease 2
            (Apex2), mRNA.
ACCESSION   NM_001079892 XM_001061562
VERSION     NM_001079892.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Ide,Y., Tsuchimoto,D., Tominaga,Y., Nakashima,M., Watanabe,T.,
            Sakumi,K., Ohno,M. and Nakabeppu,Y.
  TITLE     Growth retardation and dyslymphopoiesis accompanied by G2/M arrest
            in APEX2-null mice
  JOURNAL   Blood 104 (13), 4097-4103 (2004)
   PUBMED   15319281
  REMARK    GeneRIF: Apex1 does not compensate for loss of Apex2 in mouse.
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 1878)
  AUTHORS   Ide,Y., Tsuchimoto,D., Tominaga,Y., Iwamoto,Y. and Nakabeppu,Y.
  TITLE     Characterization of the genomic structure and expression of the
            mouse Apex2 gene
  JOURNAL   Genomics 81 (1), 47-57 (2003)
   PUBMED   12573260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC127530.1.
            
            On Jan 5, 2007 this sequence version replaced XM_001061562.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127530.1, CK471482.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1878
                     /gene="Apex2"
                     /note="apurinic/apyrimidinic endodeoxyribonuclease 2"
                     /db_xref="GeneID:317628"
                     /db_xref="RGD:1565983"
     exon            1..169
                     /gene="Apex2"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1566
                     /gene="Apex2"
                     /EC_number="4.2.99.18"
                     /note="DNA-(apurinic or apyrimidinic site) lyase 2; APEX
                     nuclease (apurinic/apyrimidinic endonuclease) 2"
                     /codon_start=1
                     /product="DNA-(apurinic or apyrimidinic site) endonuclease
                     2"
                     /protein_id="NP_001073361.1"
                     /db_xref="GeneID:317628"
                     /db_xref="RGD:1565983"
                     /translation="MLRVVSWNINGIRSPLQGLAGQEPSNSPTALRRVLDELDADIVC
                     LQETKVTRDVLTEPLAIVEGYNSYFSFSRSRSGYSGVATFCKDSATPVAAEEGLSGVF
                     ATLNGDIGCYGNTDEFTQEELRVLDSEGRAFLTQHKIRTLEGKEKTLTLINVYCPHAD
                     PGKPERLTFKMRFYRLLQIRAEALLAAGSHVIILGDLNTAHRPIDHCDASSLECFEED
                     PGRKWMDGLLSNPGNEAGPHIGHFMDSFRYFHPKQQRAFTCWSVVSGARHLNYGSRLD
                     YVLGDRSLVIDTFQASFLLPEVMGSDHCPVGAVLNVSCVPAKQCPALCTRFLPEFAGT
                     QLKILRFLVPLEQEPVKEQPVLQPSHQIQAQKQPSKARIHSTRLRKTQGVPKRNQKSL
                     MSYFQPSSNLSQTSDVELPTLPLVSPLTSTKTAEEVAMATVVKEKNKVPEAKDEKEVR
                     TAFWKSMLSGPSPMPLCGGHREPCVMRTVKKAGPNFGRHFYMCARPRGPPSDPSSRCN
                     FFLWSRPS"
     exon            170..253
                     /gene="Apex2"
                     /inference="alignment:Splign:2.1.0"
     exon            254..434
                     /gene="Apex2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..581
                     /gene="Apex2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..651
                     /gene="Apex2"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1854
                     /gene="Apex2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtatagttta ctaaaatgct gcgtgtggta agctggaaca tcaatgggat ccggagtccc
       61 ctgcaagggc ttgcgggcca ggaaccgagc aacagtccca cggccttgcg acgcgttttg
      121 gacgagctgg atgctgatat tgtctgtctc caggagacca aagtaaccag agatgtactg
      181 acagagcctc tggctattgt tgagggttat aactcctatt tcagcttcag ccgcagccgt
      241 agtggctatt ctggtgtggc taccttttgt aaggacagtg ctaccccagt agctgctgaa
      301 gaaggtctga gtggtgtgtt tgctacccta aatggggata ttggttgcta tggaaacacg
      361 gacgagttca cgcaagaaga actccgggtt ctggatagtg agggccgggc cttccttaca
      421 cagcacaaga tccgcacatt ggaagggaag gagaagacct tgactctgat caatgtgtac
      481 tgccctcacg cggatcctgg gaagcctgag cggctgacct ttaagatgcg cttctatcgc
      541 ctgctgcaga tccgagcaga agcactcctg gcagctggca gtcatgtgat aatcctgggg
      601 gacctgaata cagcccaccg acccattgac cactgtgatg caagtagtct ggaatgcttt
      661 gaagaggacc cagggcgtaa gtggatggat ggcttgctca gtaacccagg gaatgaggct
      721 ggaccccaca tagggcactt catggatagt ttccgctact tccatccaaa acagcagagg
      781 gctttcacct gctggtcagt ggtcagtggg gcacgccatc tcaactatgg ctctcgactt
      841 gattatgtcc tgggagatag gagcttggtc atagatacct tccaggcctc ctttctactc
      901 cctgaagtga tgggctctga ccactgcccc gtgggagctg tcttaaatgt atcctgtgtg
      961 ccagcaaaac agtgcccagc tctgtgtacc cgcttcctcc ctgagtttgc aggtacccag
     1021 ctcaagattc ttcgcttcct agttcctctt gaacaagaac ctgtgaagga acagccagtc
     1081 ctgcagccca gtcatcaaat ccaggcacag aaacagccaa gcaaagcccg catacattca
     1141 accaggcttc ggaaaactca aggtgtcccc aaaagaaacc agaaaagcct gatgagttac
     1201 ttccagcctt cctctaacct ttcccaaact tctgatgtag aactgcctac cctgcctctg
     1261 gtgagccctc ttacaagcac aaagactgca gaagaggtgg caatggccac agtggtaaaa
     1321 gagaagaaca aggttccaga ggccaaagat gagaaggaag taaggactgc cttctggaag
     1381 tctatgctga gtgggccctc accaatgccc ctctgtggag gccacaggga gccatgtgta
     1441 atgcgtactg taaaaaaagc aggacccaac tttggccgcc atttctatat gtgtgctaga
     1501 ccccgaggtc ctcccagtga cccctcctcc cgctgtaact tcttcctctg gagtaggccc
     1561 agctgaacag accgaggcat agggatatct gcgtattcac cccatacaca gggtcgatac
     1621 caggtccctg cctttgaaga tgtcttccca ccgagacttc ttttcctttg ctttctcttc
     1681 tcttggttca ctcccttcct tcccttcttc ccctaatgcc tctcccattc tcatatctct
     1741 gtttcttcct ctttgtaact tgtaggagca aggtactaag ttaacccctt ctgctcttgc
     1801 tggggtataa ataacatttt gttcataaat aaagttcata tttttgtttc agtaaaaaaa
     1861 aaaaaaaaaa aaaaaaaa
//
