LOCUS       NM_024148               1213 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus apurinic/apyrimidinic endodeoxyribonuclease 1
            (Apex1), mRNA.
ACCESSION   NM_024148
VERSION     NM_024148.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1213)
  AUTHORS   Fan,J., Liu,M., Li,X., Gao,S., Wang,Y., Li,A., Chen,L., Zhou,D.,
            Chen,H., Xu,Z., Wu,Z. and Wu,K.
  TITLE     Apurinic/apyrimidinic endonuclease 1 regulates palmitic
            acid-mediated apoptosis in cardiomyocytes via endoplasmic reticulum
            stress
  JOURNAL   Biochem Biophys Res Commun 650, 123-131 (2023)
   PUBMED   36791545
  REMARK    GeneRIF: Apurinic/apyrimidinic endonuclease 1 regulates palmitic
            acid-mediated apoptosis in cardiomyocytes via endoplasmic reticulum
            stress.
REFERENCE   2  (bases 1 to 1213)
  AUTHORS   Sadek,K., Abouzed,T., Nasr,S. and Shoukry,M.
  TITLE     Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic
            Genes, DNA Repair Systems, and Cell Cycle Control
  JOURNAL   Iran J Pharm Res 19 (4), 372-386 (2020)
   PUBMED   33841550
REFERENCE   3  (bases 1 to 1213)
  AUTHORS   Tang,W., Lin,D., Chen,M., Li,Z., Zhang,W., Hu,W. and Li,F.
  TITLE     PTEN-mediated mitophagy and APE1 overexpression protects against
            cardiac hypoxia/reoxygenation injury
  JOURNAL   In Vitro Cell Dev Biol Anim 55 (9), 741-748 (2019)
   PUBMED   31432320
  REMARK    GeneRIF: Our findings provide an insight into the PTEN and APE1
            overexpression protects against cardiac hypoxia/reoxygenation
            injury, which may be through inducing the PINK1/Parkin-mediated
            mitophagy.
REFERENCE   4  (bases 1 to 1213)
  AUTHORS   Zaky,A., Bouali-Benazzouz,R., Favereaux,A., Tell,G. and Landry,M.
  TITLE     APE1/Ref-1 redox function contributes to inflammatory pain
            sensitization
  JOURNAL   Exp Neurol 307, 1-11 (2018)
   PUBMED   29772245
  REMARK    GeneRIF: Changes in APE1 expression and sub-cellular distribution
            are implicated in inflammatory pain mechanisms mediated by APE1
            redox functions.
REFERENCE   5  (bases 1 to 1213)
  AUTHORS   Fehrenbacher,J.C., Guo,C., Kelley,M.R. and Vasko,M.R.
  TITLE     DNA damage mediates changes in neuronal sensitivity induced by the
            inflammatory mediators, MCP-1 and LPS, and can be reversed by
            enhancing the DNA repair function of APE1
  JOURNAL   Neuroscience 366, 23-35 (2017)
   PUBMED   28965839
  REMARK    GeneRIF: Study shows that genetically enhancing
            apurinic/apyrimidinic endonuclease expression or treatment with the
            small molecule, E3330, increases DNA repair.
REFERENCE   6  (bases 1 to 1213)
  AUTHORS   Walton,M., Lawlor,P., Sirimanne,E., Williams,C., Gluckman,P. and
            Dragunow,M.
  TITLE     Loss of Ref-1 protein expression precedes DNA fragmentation in
            apoptotic neurons
  JOURNAL   Brain Res Mol Brain Res 44 (1), 167-170 (1997)
   PUBMED   9030714
REFERENCE   7  (bases 1 to 1213)
  AUTHORS   Yacoub,A., Kelley,M.R. and Deutsch,W.A.
  TITLE     Drosophila ribosomal protein PO contains apurinic/apyrimidinic
            endonuclease activity
  JOURNAL   Nucleic Acids Res 24 (21), 4298-4303 (1996)
   PUBMED   8932386
REFERENCE   8  (bases 1 to 1213)
  AUTHORS   Tan,Y., Nakagawa,Y., Akiyama,K., Wakabayashi,H., Sarker,A.H. and
            Seki,S.
  TITLE     cDNA cloning of rat major AP endonuclease (APEX nuclease) and
            analyses of its mRNA expression in rat tissues
  JOURNAL   Acta Med Okayama 50 (1), 53-60 (1996)
   PUBMED   8701782
REFERENCE   9  (bases 1 to 1213)
  AUTHORS   Akiyama,K., Seki,S., Oshida,T. and Yoshida,M.C.
  TITLE     Structure, promoter analysis and chromosomal assignment of the
            human APEX gene
  JOURNAL   Biochim Biophys Acta 1219 (1), 15-25 (1994)
   PUBMED   8086453
REFERENCE   10 (bases 1 to 1213)
  AUTHORS   Wilson,T.M., Carney,J.P. and Kelley,M.R.
  TITLE     Cloning of the multifunctional rat apurinic/apyrimidinic
            endonuclease (rAPEN)/redox factor from an immature T cell line
  JOURNAL   Nucleic Acids Res 22 (3), 530-531 (1994)
   PUBMED   7510394
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D44495.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D44495.1, BC078816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1213
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; REF-1"
                     /note="apurinic/apyrimidinic endodeoxyribonuclease 1"
                     /db_xref="GeneID:79116"
                     /db_xref="RGD:2126"
     exon            1..50
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; REF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            51..162
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; REF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1061
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; REF-1"
                     /EC_number="3.1.11.2"
                     /note="apurinic/apyrimidinic endonuclease 1; APEX nuclease
                     1; DNA-(apurinic or apyrimidinic site) lyase; APEN; AP
                     endonuclease 1; DNA-(apurinic or apyrimidinic site)
                     endonuclease; redox factor-1; APEX nuclease
                     (multifunctional DNA repair enzyme) 1"
                     /codon_start=1
                     /product="DNA repair nuclease/redox regulator APEX1"
                     /protein_id="NP_077062.1"
                     /db_xref="GeneID:79116"
                     /db_xref="RGD:2126"
                     /translation="MPKRGKRAAAEDGEEPKSEPETKKSKGAAKKTEKEAAGEGPVLY
                     EDPPDQKTSASGKSATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENK
                     LPAELQELPGLTHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAE
                     FESFILVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKDLASRKPLVLCGDLNVAHEEID
                     LRNPKGNKKNAGFTPQERQGFGEMLQAVPLADSFRHLYPNTAYAYTFWTYMMNARSKN
                     VGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL"
     exon            163..350
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; REF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..543
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; REF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1213
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; REF-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacagactc cattctttgt gcagtgaggg gctccctgcc tcgttgggag gcagcgtagt
       61 aaacactgct tcggtgctcc agacgcctaa gggctttcgt tacagcgatg ccgaagcggg
      121 ggaagagagc ggcagcggaa gacggggaag aacccaagtc cgagccagag accaagaaga
      181 gtaagggggc agcaaagaaa actgagaagg aggccgcagg agagggccct gtcctgtatg
      241 aggaccctcc agatcagaaa acgtcagcca gtggcaaatc tgccacactc aagatatgct
      301 cctggaatgt ggatgggctt cgagcctgga ttaaaaagaa aggcttggat tgggtaaagg
      361 aagaagcacc agacatcttg tgcctccaag agaccaaatg ctcagagaac aaactcccgg
      421 ctgaactgca agagctgcct ggactcaccc atcagtactg gtcagctcca tcagacaaag
      481 aaggatatag tggtgtgggc ctactttccc gccaatgccc gctcaaagtc tcttatggca
      541 ttggtgagga agaacatgat caagaaggcc gggtgattgt ggctgaattt gagtccttta
      601 tcttggtaac agcctatgtt ccgaacgcag gaaggggtct ggtaagactg gagtaccgac
      661 agcgatggga tgaagccttc agaaagtttc taaaggactt ggcttcccgg aaacctcttg
      721 tgctgtgtgg ggatctcaat gtggctcatg aagaaataga ccttcgtaac cccaaaggaa
      781 acaaaaagaa tgctggtttt actccccagg agcgccaagg ctttggggaa atgctacagg
      841 ctgtaccact ggctgacagc ttccggcatc tctaccccaa cactgcctac gcttatactt
      901 tctggactta catgatgaat gcccgctcta agaatgttgg ttggcgcctt gattactttt
      961 tgctgtctca ctctctttta cctgctttgt gcgacagcaa gatccggtcc aaggctcttg
     1021 gcagtgacca ctgtcccatc accctttacc tagcactgtg acactcccct caagtagctt
     1081 catgctggga aatagcctcc tctcctccag gagaccagtg cgttatctct tcttcaggtg
     1141 tttactcccc tctaaaccaa acttctggtt tcctttaaac aatccaagtg aaataaaagt
     1201 cctacttttc aac
//
