LOCUS       NM_001399424             961 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus apelin receptor early endogenous ligand (Apela),
            mRNA.
ACCESSION   NM_001399424 XM_039095067
VERSION     NM_001399424.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 961)
  AUTHORS   Xi,Y., Li,Y., Ren,W., Bo,W., Ma,Y., Pan,S., Gong,D.W. and Tian,Z.
  TITLE     ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic
            Exercise in Cardioprotection of Myocardial Infarction Rats
  JOURNAL   Med Sci Sports Exerc 55 (7), 1172-1183 (2023)
   PUBMED   36878020
  REMARK    GeneRIF: ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of
            Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats.
REFERENCE   2  (bases 1 to 961)
  AUTHORS   Sahinturk,S., Demirel,S., Ozyener,F. and Isbil,N.
  TITLE     Vascular Functional Effect Mechanisms of Elabela in Rat Thoracic
            Aorta
  JOURNAL   Ann Vasc Surg 84, 381-397 (2022)
   PUBMED   35472496
  REMARK    GeneRIF: Vascular Functional Effect Mechanisms of Elabela in Rat
            Thoracic Aorta.
REFERENCE   3  (bases 1 to 961)
  AUTHORS   Song,J.J., Yang,M., Liu,Y., Song,J.W., Liu,X.Y., Miao,R.,
            Zhang,Z.Z., Liu,Y., Fan,Y.F., Zhang,Q., Dong,Y., Yang,X.C. and
            Zhong,J.C.
  TITLE     Elabela prevents angiotensin II-induced apoptosis and inflammation
            in rat aortic adventitial fibroblasts via the activation of
            FGF21-ACE2 signaling
  JOURNAL   J Mol Histol 52 (5), 905-918 (2021)
   PUBMED   34453661
  REMARK    GeneRIF: Elabela prevents angiotensin II-induced apoptosis and
            inflammation in rat aortic adventitial fibroblasts via the
            activation of FGF21-ACE2 signaling.
REFERENCE   4  (bases 1 to 961)
  AUTHORS   Perjes,A., Kilpio,T., Ulvila,J., Magga,J., Alakoski,T., Szabo,Z.,
            Vainio,L., Halmetoja,E., Vuolteenaho,O., Petaja-Repo,U., Szokodi,I.
            and Kerkela,R.
  TITLE     Characterization of apela, a novel endogenous ligand of apelin
            receptor, in the adult heart
  JOURNAL   Basic Res Cardiol 111 (1), 2 (2016)
   PUBMED   26611206
  REMARK    GeneRIF: conclude that apela is present in the adult heart, is
            upregulated in post-infarction cardiac remodeling, and increases
            cardiac contractility in an ERK1/2-dependent manner
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jan 7, 2022 this sequence version replaced XM_039095067.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214304.1, FM060468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               JAXUCZ010000016.1  29460855-29461153
            300-389             JAXUCZ010000016.1  29462406-29462495
            390-961             JAXUCZ010000016.1  29469391-29469962
FEATURES             Location/Qualifiers
     source          1..961
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p13"
     gene            1..961
                     /gene="Apela"
                     /gene_synonym="ELA; Tdl"
                     /note="apelin receptor early endogenous ligand"
                     /db_xref="GeneID:103693925"
                     /db_xref="RGD:9299863"
     exon            1..299
                     /gene="Apela"
                     /gene_synonym="ELA; Tdl"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..388
                     /gene="Apela"
                     /gene_synonym="ELA; Tdl"
                     /note="Protein Elabela; Protein Toddler"
                     /codon_start=1
                     /product="apelin receptor early endogenous ligand
                     precursor"
                     /protein_id="NP_001386353.1"
                     /db_xref="GeneID:103693925"
                     /db_xref="RGD:9299863"
                     /translation="MRFQPLFWVFFIFAMSLLFITEEKSVNFPRRRKLYRHNCFRRRC
                     ISLHSRVPFP"
     exon            300..389
                     /gene="Apela"
                     /gene_synonym="ELA; Tdl"
                     /inference="alignment:Splign:2.1.0"
     exon            390..961
                     /gene="Apela"
                     /gene_synonym="ELA; Tdl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcattaacc ttttcaggaa aaagcagctg gcagccctct gaggtctggc cataggatgt
       61 ggggtgagcc ggacagatac tgcccaggcg ctttacagac aatttcttta cttggagagc
      121 tattgttcac ttgcgtgtaa aaagaaaaac agaaaaaaag aaaaagaaga aaagaaaaag
      181 caaaaggaaa gaaaaaagga aagaaaaaaa gaaaagaaaa aagatgagat tccagcccct
      241 tttttgggta ttttttatct ttgcgatgag tctccttttt atcacggaag agaaatcagt
      301 taattttccc aggagaagaa aactatacag acacaactgc tttcgccgga gatgcatttc
      361 acttcattct cgagtgccct tcccatgaga aagtcactga tctccttggt taccagaaga
      421 agggtgaaag cagacatacc cagtcacctg gaaacgtcct caggatggca acagtgcggc
      481 agcttgggag ttactatgca acagaagctg tttcaaagta ccttggatgg cttttcggat
      541 ccagagactg ctcttcctgg attttcttcg ataagaaagt aatagacatg gaagacagac
      601 tagactagag cacactcacc tgcctgaata acaatctctc atccgtttct gcacattatt
      661 tgcatatgac atatgcatga tccatagtgg tgggtttcat gaaggcattt acatacaagt
      721 acatcatgtc ctgtgactat aattgcacac atgtacatca cattacacta tttacacaca
      781 tgtatgccat gtgcactatt tacacacatt tactttcctc tttctctccc ttcaccctcc
      841 tgctggtccc tttcattcgc ctggacagtt ttgtttctat tttagtggca tgtacacatg
      901 aatgatttta ttgcacatta ttattctgac atgtattaaa aagaaaacta ctttaatatt
      961 a
//
