LOCUS       NM_012500               2381 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus acylaminoacyl-peptide hydrolase (Apeh), mRNA.
ACCESSION   NM_012500
VERSION     NM_012500.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2381)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2381)
  AUTHORS   Sandoval,R., Navarro,S., Garcia-Rojo,G., Calderon,R., Pedrero,A.,
            Sandoval,S., Wyneken,U. and Pancetti,F.
  TITLE     Synaptic localization of acylpeptide hydrolase in adult rat
            telencephalon
  JOURNAL   Neurosci Lett 520 (1), 98-103 (2012)
   PUBMED   22640895
  REMARK    GeneRIF: ACPH protein levels are significantly increased at the
            synapse; ACPH is preferentially located at the pre-synaptic side
REFERENCE   3  (bases 1 to 2381)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2381)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 2381)
  AUTHORS   Yamin,R., Bagchi,S., Hildebrant,R., Scaloni,A., Widom,R.L. and
            Abraham,C.R.
  TITLE     Acyl peptide hydrolase, a serine proteinase isolated from
            conditioned medium of neuroblastoma cells, degrades the
            amyloid-beta peptide
  JOURNAL   J Neurochem 100 (2), 458-467 (2007)
   PUBMED   17241160
REFERENCE   6  (bases 1 to 2381)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 2381)
  AUTHORS   Lin,L.W., Lee,F.J. and Smith,J.A.
  TITLE     Structural organization of the rat acyl-peptide hydrolase gene
  JOURNAL   Nucleic Acids Res 17 (11), 4397-4400 (1989)
   PUBMED   2578023
REFERENCE   8  (bases 1 to 2381)
  AUTHORS   Kobayashi,K., Lin,L.W., Yeadon,J.E., Klickstein,L.B. and Smith,J.A.
  TITLE     Cloning and sequence analysis of a rat liver cDNA encoding
            acyl-peptide hydrolase
  JOURNAL   J Biol Chem 264 (15), 8892-8899 (1989)
   PUBMED   2722805
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J04733.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04733.1, BC107565.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2381
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="CD"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2381
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /note="acylaminoacyl-peptide hydrolase"
                     /db_xref="GeneID:24206"
                     /db_xref="RGD:2125"
     exon            1..17
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..2204
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /EC_number="3.4.19.1"
                     /note="APH; AARE; acyl-peptide hydrolase;
                     acylaminoacyl-peptidase; acylpeptide hydrolase;
                     N-acylaminoacyl-peptide hydrolase"
                     /codon_start=1
                     /product="acylamino-acid-releasing enzyme"
                     /protein_id="NP_036632.1"
                     /db_xref="GeneID:24206"
                     /db_xref="RGD:2125"
                     /translation="MERQVLLSEPQEAAALYRGLSRQPSLSAACLGPEVTTQYGGLYR
                     TVHTEWTQRDLERMENIRFCRQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSGTM
                     KAVLRKAGGTVSGEEKQFLEVWEKNRKLKSFNLSALEKHGPVYEDDCFGCLSWSHSET
                     HLLYVAEKKRPKAESFFQTKALDISASDDEMARPKKPDQAIKGDQFVFYEDWGETMVS
                     KSIPVLCVLDIDSGNISVLEGVPENVSPGQAFWAPGDTGVVFVGWWHEPFRLGIRYCT
                     NRRSALYYVDLSGGKCELLSDGSLAICSPRLSPDQCRIVYLQYPCLAPHHQCSQLCLY
                     DWYTKVTSVVVDIVPRQLGESFSGIYCSLLPLGCWSADSQRVVFDSAQRSRQDLFAVD
                     TQTGSITSLTAAGSAGSWKLLTIDKDLMVAQFSTPSLPPSLKVGFLPPPGKEQSVSWV
                     SLEEAEPIPGIHWGVRVLHPPPDQENVQYADLDFEAILLQPSNPPDKTQVPMVVMPHG
                     GPHSSFVTAWMLFPAMLCKMGFAVLLVNYRGSTGFGQDSILSLPGNVGHQDVKDVQFA
                     VEQVLQEEHFDARRVALMGGSHGGFLSCHLIGQYPETYSACIARNPVINIASMMGSTD
                     IPDWCMVETGFPYSNSCLPDLNVWEEMLDKSPIKYIPQVKTPVLLMLGQEDRRVPFKQ
                     GMEYYRALKARNVPVRLLLYPKSNHALSEVEAESDSFMNAVLWLHTHLGS"
     exon            18..150
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            151..277
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            278..371
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            372..447
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            448..611
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            612..749
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            750..841
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            842..882
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1004
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1065
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1163
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1215
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1304
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1443
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1527
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1608
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1697
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1888
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1991
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2098
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2361
                     /gene="Apeh"
                     /gene_synonym="Apeh14; Apeh17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgactatgga gcgtcaggtg ctgctgagtg agccccagga ggcggcagcg ctgtaccggg
       61 gccttagccg ccagccttcg ctgagcgccg cctgcctggg tccggaggtc accacgcagt
      121 atgggggcct ctatcggacc gtgcacactg agtggactca gagggacttg gagcgaatgg
      181 agaacatccg attctgccgc cagtacctag tgtttcatga cggagactcg gtggtgtttg
      241 ccgggcctgc aggcaacagt gtggaaaccc ggggggagct gctgagcaga gagtctcctt
      301 caggcaccat gaaagctgtg cttcgcaagg ccggaggcac agtctcagga gaggaaaaac
      361 agttcttgga ggtctgggag aagaaccgga agctcaagag tttcaacctg tcagcgctgg
      421 agaagcatgg gcctgtctat gaggatgact gctttggctg cctttcctgg tcacactcag
      481 agacacactt gttgtatgtg gcggagaaga agcgtcccaa ggctgagtcc ttctttcaga
      541 ccaaagcctt ggacatcagt gccagcgatg atgagatggc caggccgaag aagccagacc
      601 aggccatcaa gggggaccag tttgtatttt atgaagactg gggagaaacg atggtttcca
      661 aaagcatccc tgtgctctgc gtgctagata tcgacagtgg caacatctct gtgcttgagg
      721 gagtccctga aaatgtgtca cctggtcagg ctttttgggc ccctggagac acgggggtgg
      781 tgtttgtggg ctggtggcat gaacccttca ggctcggcat ccgctattgc accaatcgca
      841 gatcagctct gtactatgtg gacctgagcg gagggaagtg tgaactactc tcggatggtt
      901 ccctggccat ctgttctcct cggctcagcc cagaccagtg tcgcatcgtc tacctacagt
      961 atccatgtct agcccctcat caccaatgca gccagctctg cctgtacgac tggtacacca
     1021 aggtcacctc agtggtggtg gacattgtac cccggcagct gggagagagc ttctctggaa
     1081 tctactgcag tcttcttcct ttgggatgct ggtcagctga cagccagaga gtagtctttg
     1141 actctgccca gcgcagtcgg caggacctgt ttgctgtgga cacccagacg ggcagcatca
     1201 cctccctgac agctgcgggg tcagcaggaa gctggaagct gcttacaatt gacaaagacc
     1261 ttatggttgc ccagttctcc acacccagtt tgcccccaag cctgaaagtt gggttcctgc
     1321 ctcctcctgg gaaggagcag tctgtgtcat gggtgtccct ggaggaggct gaacctattc
     1381 ctggcatcca ctggggcgtc cgtgtgctac acccacctcc agaccaagag aatgtacaat
     1441 atgctgacct tgactttgaa gcaatccttt tgcagcccag caatcctcca gataagaccc
     1501 aggtccccat ggtagtcatg ccccatgggg gaccccattc gtccttcgtc actgcctgga
     1561 tgctgttccc agccatgctc tgcaagatgg gctttgcagt acttctggtg aactatcgtg
     1621 gctccactgg ctttggccaa gacagcatcc tttctctccc aggcaatgtg ggccaccagg
     1681 atgtgaagga tgtccagttt gcagtggagc aggtactcca ggaggaacac tttgatgcaa
     1741 gacgcgtggc ccttatgggt ggttcccatg gtgggttcct ctcctgccac ctgattggtc
     1801 aatacccgga gacctacagt gcttgtatag cccggaaccc agtgatcaac attgcctcca
     1861 tgatgggctc cactgacatc cctgattggt gtatggtgga gactggcttc ccttatagca
     1921 acagctgcct cccagatctg aatgtgtggg aggagatgct ggataagtca cccatcaaat
     1981 acatccctca ggtaaagaca ccagtgttac tgatgctggg ccaggaggac cgacgggtac
     2041 ccttcaagca gggtatggag tattaccgtg ccctcaaggc ccggaatgtg cctgtccggc
     2101 tcctgctgta ccccaagagc aaccacgcgc tgtcagaggt ggaggcggag tcagacagct
     2161 tcatgaacgc tgtgctttgg ctgcacacac acttgggcag ctgaagccct atgttcttct
     2221 tgagctgggc agcccgtctt gcactttgct cttggtaagc tccaggatct gaccgaacag
     2281 ccaaacagtc tcctaggctg tggactcagt gaatgggcag aggactaaga actatgttat
     2341 cataataaag gaagacacag aaaaaaaaaa aaaaaaaaaa a
//
