LOCUS       NM_001106769            9594 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus APC regulator of WNT signaling pathway 2 (Apc2),
            mRNA.
ACCESSION   NM_001106769 XM_001076585 XM_234910
VERSION     NM_001106769.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9594)
  AUTHORS   Halit,C., Elif,Y.N., Hasan,M.A., Sacide,P., Yasemin,O., Deniz,D.
            and Mehmet,A.U.
  TITLE     Methylation of APC2, NR3C1, and DRD2 gene promoters in turkish
            patients with tobacco use disorder
  JOURNAL   Niger J Clin Pract 25 (2), 160-166 (2022)
   PUBMED   35170441
REFERENCE   2  (bases 1 to 9594)
  AUTHORS   Gatta,E., Grayson,D.R., Auta,J., Saudagar,V., Dong,E., Chen,Y.,
            Krishnan,H.R., Drnevich,J., Pandey,S.C. and Guidotti,A.
  TITLE     Genome-wide methylation in alcohol use disorder subjects:
            implications for an epigenetic regulation of the cortico-limbic
            glucocorticoid receptors (NR3C1)
  JOURNAL   Mol Psychiatry 26 (3), 1029-1041 (2021)
   PUBMED   31239533
REFERENCE   3  (bases 1 to 9594)
  AUTHORS   Kahn,O.I., Schatzle,P., van de Willige,D., Tas,R.P., Lindhout,F.W.,
            Portegies,S., Kapitein,L.C. and Hoogenraad,C.C.
  TITLE     APC2 controls dendrite development by promoting microtubule
            dynamics
  JOURNAL   Nat Commun 9 (1), 2773 (2018)
   PUBMED   30018294
  REMARK    GeneRIF: It has been found that APC2 localizes as distinct clusters
            along microtubule bundles in dendrites, and that this localization
            is driven by LC8-binding and two separate microtubule-interacting
            domains.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9594)
  AUTHORS   Pronobis,M.I., Rusan,N.M. and Peifer,M.
  TITLE     A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling
            by driving a catalytic cycle of efficient betacatenin destruction
  JOURNAL   Elife 4, e08022 (2015)
   PUBMED   26393419
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9594)
  AUTHORS   Almuriekhi,M., Shintani,T., Fahiminiya,S., Fujikawa,A.,
            Kuboyama,K., Takeuchi,Y., Nawaz,Z., Nadaf,J., Kamel,H., Kitam,A.K.,
            Samiha,Z., Mahmoud,L., Ben-Omran,T., Majewski,J. and Noda,M.
  TITLE     Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features
  JOURNAL   Cell Rep 10 (9), 1585-1598 (2015)
   PUBMED   25753423
REFERENCE   6  (bases 1 to 9594)
  AUTHORS   Jarrett,C.R., Blancato,J., Cao,T., Bressette,D.S., Cepeda,M.,
            Young,P.E., King,C.R. and Byers,S.W.
  TITLE     Human APC2 localization and allelic imbalance
  JOURNAL   Cancer Res 61 (21), 7978-7984 (2001)
   PUBMED   11691822
REFERENCE   7  (bases 1 to 9594)
  AUTHORS   Nakagawa,H., Koyama,K., Murata,Y., Morito,M., Akiyama,T. and
            Nakamura,Y.
  TITLE     EB3, a novel member of the EB1 family preferentially expressed in
            the central nervous system, binds to a CNS-specific APC homologue
  JOURNAL   Oncogene 19 (2), 210-216 (2000)
   PUBMED   10644998
REFERENCE   8  (bases 1 to 9594)
  AUTHORS   Nakagawa,H., Koyama,K., Murata,Y., Morito,M., Akiyama,T. and
            Nakamura,Y.
  TITLE     APCL, a central nervous system-specific homologue of adenomatous
            polyposis coli tumor suppressor, binds to p53-binding protein 2 and
            translocates it to the perinucleus
  JOURNAL   Cancer Res 60 (1), 101-105 (2000)
   PUBMED   10646860
REFERENCE   9  (bases 1 to 9594)
  AUTHORS   van Es,J.H., Kirkpatrick,C., van de Wetering,M., Molenaar,M.,
            Miles,A., Kuipers,J., Destree,O., Peifer,M. and Clevers,H.
  TITLE     Identification of APC2, a homologue of the adenomatous polyposis
            coli tumour suppressor
  JOURNAL   Curr Biol 9 (2), 105-108 (1999)
   PUBMED   10021369
REFERENCE   10 (bases 1 to 9594)
  AUTHORS   Nakagawa,H., Murata,Y., Koyama,K., Fujiyama,A., Miyoshi,Y.,
            Monden,M., Akiyama,T. and Nakamura,Y.
  TITLE     Identification of a brain-specific APC homologue, APCL, and its
            interaction with beta-catenin
  JOURNAL   Cancer Res 58 (22), 5176-5181 (1998)
   PUBMED   9823329
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000007.1.
            
            On Oct 12, 2007 this sequence version replaced NM_001106769.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               JAXUCZ010000007.1  10059205-10059345   c
            142-232             JAXUCZ010000007.1  10058947-10059037   c
            233-413             JAXUCZ010000007.1  10058683-10058863   c
            414-522             JAXUCZ010000007.1  10056811-10056919   c
            523-639             JAXUCZ010000007.1  10056594-10056710   c
            640-717             JAXUCZ010000007.1  10056330-10056407   c
            718-813             JAXUCZ010000007.1  10056088-10056183   c
            814-1201            JAXUCZ010000007.1  10055004-10055391   c
            1202-1297           JAXUCZ010000007.1  10054223-10054318   c
            1298-1437           JAXUCZ010000007.1  10053865-10054004   c
            1438-1515           JAXUCZ010000007.1  10053443-10053520   c
            1516-1632           JAXUCZ010000007.1  10053121-10053237   c
            1633-1847           JAXUCZ010000007.1  10052340-10052554   c
            1848-9594           JAXUCZ010000007.1  10043010-10050756   c
FEATURES             Location/Qualifiers
     source          1..9594
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..9594
                     /gene="Apc2"
                     /note="APC regulator of WNT signaling pathway 2"
                     /db_xref="GeneID:299611"
                     /db_xref="RGD:1308256"
     CDS             1..6846
                     /gene="Apc2"
                     /note="adenomatosis polyposis coli 2; APC2, WNT signaling
                     pathway regulator"
                     /codon_start=1
                     /product="adenomatous polyposis coli protein 2"
                     /protein_id="NP_001100239.2"
                     /db_xref="GeneID:299611"
                     /db_xref="RGD:1308256"
                     /translation="MASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETS
                     GMKEVLKHLQGKLEQEARVLVSSGQTEVLEQLKALQTDISSLYNLKFHAPALGPEPAA
                     QTPEGSPVHGPAPSKDSFGELSRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQ
                     GLSKRLDELPHVDTQFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASR
                     LEQIDKELLEAQDRVQQTEPQALLAVKPVAVEEQEAEVPTHPEDVTPQPGNSKVEVVF
                     WLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGSVGRTGTP
                     GAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDS
                     GTESGTGDTPVPIEPQICQAACAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMHK
                     MTQDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLASESEELHQVVS
                     SILRNLSWRADINSKKVLREVGSMTALMECVLRASKESTLKSVLSALWNLSAHSTENK
                     AAICQVDGALGFLVSTLTYRCQGNSLAVIESGGGILRNVSSLIATREDYRQVLRDHNC
                     LQTLLQHLTSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVGMLRNLVHSKHKMIA
                     MGSAAALRNLLAHRPAKYQAAAMAVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHL
                     EKQGLPEAETTSKKPLPPLRHLDGLVQDYASDSGCFDDDDAPSLAAAATTAEPASPAV
                     MSMFLGGPFLQGQALARTPPARQGGLEAEKETGGEAAVAAKAKAKLALAVARIDRLVE
                     DISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGTEGGRREAGSRAHPLLRLKA
                     AHTSLSNDSLNSGSTSDGYCTREHMTPCPLAVLTEHRDGPVCGQTRPSRLDLDLPSRA
                     ELPARDTAATDARVRTIKLSPTYQHVPLLDGAPGAGVRPLVGLGTSPGTRKQAWIPAD
                     SLSKVPEKLVASPLPVTSKVLQKLVAQDGPMSLSRCSSLSSLSSTGHAVPSQVENLDD
                     SDSSLEELEEAGPGEAELDRAWRASGSTSLPVSIPAPQRGRSRGLGVEDATPSSSSEN
                     CVQETPLVLSRCSSVSSLGSFESRSIASSIPSDPCSALGSGTVSPSELPDSPGQTMPP
                     SRSRTPPAPPGQPEASQFSLQWESYVKRFLDIADCRERCQPPSELDAGSVRFTVEKPD
                     ENFSCASSLSALALHELYVQQDVELRLRPPACPERAVGGGGGHRRRDEATSRLDGPAP
                     AGSRARSAADKELEALRECLGAAMPARLRKVASALVPGRRALPVPVYMLVPAPARGDD
                     SGTDSAEGTPVNFSSAASLSDETLQGPSRDKPARPGDRQKPTGRAAPARQTRGHRPKA
                     AGAGAGKSTEHTRGANRNRAGLELPLSRPQSARSNRDGSCQTRTRGDGALQSLCLTTP
                     TEEAVYCFYDSDEEPPATAPPTRRASAIPRALKREKPAGRKETPTRATQPATLPVRAQ
                     PRLIVDETPPCYSLTSSASSLSEPEASEQPACHPRVEEQGSKQDSSPRAEEELLQRCI
                     SLAMPRRRTQVPSSRRRKPRAVRSDIRPTELPQKCREEVPGSDPASDLDSVEWQAIQE
                     GANSIVTWLHQAAAKASLEASSESDSLLSLVSGLSASSTLQPSKLRKGRKPVAEAGGA
                     WRPEKRGTTSTKGSGSPRFPSGPEKAKGTQKTMAGESAMLRGRTVIYTASPASRAQSK
                     GISGPCSAPKKMGTSGTTQPETATKTPSPEQQRSRSLHRPGKISELAALSHPPRSATP
                     PARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPKSPARALLAKQHK
                     TQKSPVRIPFMQRPARRVPPPLARPSPEPGSRGRAGAEGTPGARGSRLGLVRVASTRS
                     SGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTVSTSQTASPCRGRPALPAVF
                     LCSSRCDELRASPRQPLAAQRVPQAKPGLAPRAPRRTSSESPSRLPVRATPGRPETVK
                     RYASLPHISVSRRPDSAVSVPTTQANATRRGSDGEARPLPRVAAPGTTWRRIKDEDVP
                     HILRSTLPATALPLRGSSPEDSPAGTPHRKTSDAVVQTEDVATSKTNSSTSPSLESRD
                     PPQAPISGPVAPLGSDVDGPVLAKPPASAPFTHEGLSVVTGGFPTSRHGSPSRAARVP
                     PFNYVPSPMVVATMTSDSAVEKAPVTSPASLLE"
     exon            1..141
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            142..232
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            233..413
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..522
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..639
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..717
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..813
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1201
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1297
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1437
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1515
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1632
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1847
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..9594
                     /gene="Apc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccagct ccgtggcctc gtacgagcag ctggtgcgcc aggtggaggc cttgaaggcg
       61 gagaacactc acttaagaca ggagctgagg gataactcta gccatctctc caagctggag
      121 acagagactt ctggcatgaa ggaggtcctg aaacaccttc agggcaagct ggagcaggag
      181 gcgagagtgc tggtatcctc cgggcagaca gaagtgttag agcaactgaa agctcttcag
      241 actgacatca gtagcctcta taacctgaag ttccatgccc cggccctggg ccctgagcct
      301 gctgcccaga ctccagaggg aagcccagta catggccctg caccgtccaa ggacagcttc
      361 ggagagctga gccgggccac catccgcctg ctggaagaac tagaccagga gagatgcttc
      421 ctgctgagcg agatagagaa agaggagaag gagaagctgt ggtattactc tcagctccag
      481 ggcctctcta agcgcttgga tgaactgcca cacgtagaca cgcagttttc gatgcagatg
      541 gatctaattc ggcagcagct ggagttcgaa gcccagcaca tccgctcgtt gatggaggag
      601 cgcttcggta cctcagacga gatggtgcag cgggctcaga tccgggcttc acgcctggag
      661 cagattgaca aggagctgtt ggaagcccag gaccgggtgc agcagacgga gccccaggcg
      721 ctgctggcgg tgaagcctgt ggcagtggag gagcaggagg cagaagttcc cacacaccct
      781 gaggatgtca ccccccagcc tggcaacagc aaggtggagg tcgtgttctg gcttctatct
      841 atgttggcaa cgcgcgacca ggaagatact gcgcgcacgc tgctcgccat gtccagctcg
      901 ccagagagct gcgtagccat gcgccgctcg ggatgtctgc cactgctgct ccagatcctt
      961 catggcactg aggctgggtc tgtggggcgc acaggaaccc ccggagcgcc tggtgccaaa
     1021 gatgcacgca tgcgtgccaa cgcggccctg cacaacatag tcttctccca gccggatcag
     1081 ggcctggcac gcaaggagat gcgtgtgctg cacgtgctgg agcagatccg agcctactgc
     1141 gagacctgct gggactggct tcaggcgcgg gacagcggga cagagagtgg tacaggagac
     1201 actcctgtcc ctatcgagcc tcagatctgc caggccgcct gtgcagtgat gaagctgtca
     1261 tttgacgagg aataccgtcg ggctatgaat gagctagggg ggctgcaggc tgtggccgag
     1321 ctactgcagg tggattatga gatgcacaag atgacccagg atccactcaa cctcgccctg
     1381 cgccgctacg ctggcatgac cctcaccaac ctcaccttcg gagacgttgc caacaaggcc
     1441 actctgtgtg cccgccgagg ctgcatggaa gccattgtgg cccagctggc ctctgagagc
     1501 gaggagctgc atcaggttgt ttccagtatt ctgcgtaacc tgtcgtggag ggcggacatc
     1561 aacagcaaga aggtgctgag ggaggttggc agcatgaccg ctttgatgga atgtgtgctg
     1621 cgggcctcca aggagtccac tctaaagagc gtgctcagtg ctctgtggaa cctgtcggca
     1681 cacagcacag agaacaaggc agctatctgc caggtggatg gcgcgctggg tttcctggtg
     1741 agcaccctaa cataccgttg ccaagggaac tccctagcag tcatcgagag tggcggtggg
     1801 atcctgcgca acgtgtcaag cctcattgcc acgcgggagg actacaggca ggtgctccgt
     1861 gaccacaact gcctacagac actgctgcag cacctcacgt cgcacagctt gactatcgtg
     1921 agcaatgcct gcggcaccct ttggaacctg tctgcccgca gcccccgcga ccaggaactg
     1981 ttgtgggacc tgggggctgt gggcatgcta cgaaacctcg tccactccaa acacaagatg
     2041 atcgccatgg gtagcgctgc cgctctgcgg aacctgctgg cccaccgacc ggccaagtat
     2101 caggccgcag ccatggcagt ctccccaggc acctgcgtgc ccagtctgta cgtccgcaag
     2161 cagagggccc tggaggccga gctggacact cggcacctgg tgcatgcgct cggtcacttg
     2221 gagaagcagg gtctgcctga ggcagagacc acttcaaaga agcccctgcc acccctccgc
     2281 cacctggacg ggctggtgca ggactatgcc tctgattctg gctgctttga tgatgatgat
     2341 gcaccatccc tggctgctgc ggccaccaca gctgagcccg ccagcccagc agtgatgtct
     2401 atgttccttg gtggtccctt ccttcagggc caggcactgg cccgcacccc acctgcccgc
     2461 cagggtggcc tagaagctga gaaggagact ggtggggagg cagctgtggc tgctaaagcc
     2521 aaggccaagc tagcgttggc tgtggctcgc atcgaccgac tggtggagga catctctgcc
     2581 ctgcacacct catcagacga cagcttcagt ctcagctcgg gggacccggg gcaggaggcg
     2641 ccaagggagg gccgtgcgca gtcctgctct ccatgccggg gcacagaggg tgggcggcgt
     2701 gaggctggca gccgggcgca ccctctgctg aggctcaagg cggcccacac cagcctctcc
     2761 aacgacagcc tgaacagtgg tagcaccagc gatggctact gtacccggga acacatgacg
     2821 ccttgcccac tggccgtgtt gaccgagcac cgcgatggcc cagtatgcgg acagactcgg
     2881 cccagccgac tggacctaga ccttcccagc cgggctgagc ttcctgcccg ggacacagca
     2941 gccactgatg cccgagtgcg caccattaag ttatccccaa cctatcagca cgtgccactg
     3001 cttgatgggg ccccgggggc aggtgtcaga cccctggttg ggcttggaac ctccccgggg
     3061 actcggaaac aggcatggat acctgcagat agtttgagta aagtccccga gaagctggtg
     3121 gcctccccac tgccggtgac tagcaaggtg ctgcagaagc tggtggcaca ggatgggccg
     3181 atgtccctct ccaggtgcag ttccctgtct tctctgtctt ccacgggcca tgcagtcccc
     3241 agccaggtgg agaaccttga tgacagcgat tcatccctgg aagagcttga ggaggctggt
     3301 cctggcgagg ccgagctaga cagggcgtgg agagcatccg ggtccacctc tcttccggtg
     3361 tccatcccgg ccccacagcg gggtcgaagt cgaggtcttg gggtggagga tgctacacca
     3421 tccagttcat ctgagaactg cgtccaggag acacccttgg tcctgagccg ctgtagctct
     3481 gtgagctccc tgggcagctt cgagagccgt tccatcgcca gctccatccc gagcgacccc
     3541 tgcagtgcgc tgggcagtgg tacagtgagt cccagcgagc tgccagacag ccccggccag
     3601 acaatgccac ccagccgcag caggactcca ccggcacctc ccgggcagcc cgaggccagc
     3661 cagttcagcc tgcagtggga aagttacgtg aagcgcttcc tggacatcgc agactgtcgg
     3721 gaaagatgcc agccgccctc ggagctggac gcgggcagcg tacgcttcac ggtggagaag
     3781 ccggacgaga atttctcttg tgcttccagc ctcagcgcac tggccctgca tgagctgtat
     3841 gtccagcagg acgtggaact gcggctgagg ccaccagcct gtccagaacg tgcggtgggt
     3901 ggtggtgggg gccaccgtcg gagggacgag gctaccagcc gcctggatgg cccagcacca
     3961 gctggctcta gggctcggtc agcggctgat aaagaactag aggcgctgcg tgaatgtctg
     4021 ggggcagcca tgccggcccg gctccgcaag gtggcctcgg ccttggtgcc tggccgccgt
     4081 gcactgccgg tccccgtgta catgttagtg cccgccccgg ctcggggtga tgactcgggc
     4141 acagactctg cagagggcac gcctgtcaac ttttccagtg cagcctctct cagtgacgag
     4201 accttacagg gaccctccag ggataagccg gccaggcctg gggacaggca gaaacctaca
     4261 ggccgagctg ctcctgccag gcagacccgt gggcaccggc ccaaggcagc aggagcaggt
     4321 gctggtaaga gcacagagca cacacggggg gctaatagga accgggcagg attggaacta
     4381 cccctcagcc ggccccagag tgctcggtcc aacagggatg gctcatgcca gacccggacc
     4441 cgtggagacg gtgccctgca gtcgctatgc ctcacgacac ccacagagga agctgtgtac
     4501 tgcttctatg actctgacga ggagccacca gccacagcac caccaactcg gcgggcgtcc
     4561 gccatccctc gggctcttaa acgtgagaaa cccgcaggca ggaaagagac cccaaccagg
     4621 gcgacacagc ctgccacact ccctgtgagg gcgcagccga gactgatagt agatgagacc
     4681 ccaccctgct attccctgac ttcctcggct agttccctca gcgagcctga ggcctctgaa
     4741 cagccagcct gccaccctcg agtggaggag cagggcagta aacaagatag tagcccaagg
     4801 gcagaagagg agctcctgca gagatgtatc agtttagcta tgcccaggcg ccggacccag
     4861 gtacccagct cacggcgtcg caagcccaga gctgtgaggt cagacataag gcccactgag
     4921 ttaccacaga aatgccgtga agaggttcct ggttctgatc cagcctctga cctagatagc
     4981 gtcgagtggc aggctatcca agagggcgca aactccattg tcacgtggct gcatcaggca
     5041 gcggccaaag ccagcctgga agcttcttct gagtctgact ccctcttgtc tttggtgtct
     5101 gggctgtcag caagctccac cctccagccc tccaagctca gaaaagggcg aaagccagtg
     5161 gctgaggctg ggggtgcctg gcgtcctgag aaacggggca caacttccac taagggcagt
     5221 gggagtcccc ggtttcctag tggccctgag aaggcaaagg gtacccagaa aacgatggca
     5281 ggggagtcag ccatgctccg gggaaggaca gtgatctaca ctgccagccc tgcttcccgg
     5341 gctcagtcca aaggtatttc tggaccttgt tccgcaccta agaagatggg gacatctggt
     5401 accactcagc cagaaactgc caccaaaacc cccagccctg agcaacaacg ttctcggagc
     5461 ctgcaccgac caggcaagat ctctgagttg gcagccttga gccacccgcc caggagtgct
     5521 actcctccag cccgcctcac caagaccccg tcttcaagct cttcacagac ctccccggca
     5581 tcccagtccc tgcctaggcg gtccccactg gccactccaa caggagggcc tctgcctgga
     5641 cctggggggt ccccggtgcc caagtcacca gcccgggctc ttctggctaa gcaacacaag
     5701 acccagaagt cacccgtgcg tatcccattc atgcaaaggc cagccaggcg agtgccacct
     5761 ccactggcca ggccatcccc agagcctggc tccaggggcc gagctggggc tgagggaact
     5821 cctggggcac gtggcagccg cctgggcctg gtacgtgtgg cctcaactcg ctctagcggc
     5881 agtgagtcct cagaccgctc cggcttcaga aggcagctga ccttcattaa ggagtcccca
     5941 ggtctcctcc ggcgccgtag atcggagctg tcctctgcgg actccacggt ctccacctcc
     6001 cagaccgctt cgccctgccg cggacggccc gcactccccg ctgtctttct ctgctcctct
     6061 cgctgtgatg agctgcgagc gtctccacgg cagcccctgg cagcacagag ggtcccgcag
     6121 gccaagccag gtcttgcccc acgtgcgccc agacgcacca gctccgagag cccctcacgc
     6181 ctgcctgtac gggcgacccc tgggcggccc gagacagtca agaggtacgc ctccctgcca
     6241 catattagtg tgtcccgcag gcccgatagc gctgtctctg tgcccaccac ccaggccaat
     6301 gccactcgca ggggaagtga tggcgaggcc aggccgctgc ccagggtggc tgcgccgggt
     6361 acgacctggc gtcgtatcaa agatgaagat gtcccccaca tcctgcgcag cacactgccg
     6421 gccactgccc tgcctctcag gggctcatca cccgaagaca gtcctgctgg aactccacac
     6481 cgcaagacta gcgacgcagt ggtacagaca gaggatgtgg ccacctctaa aaccaactcc
     6541 agcacgtcgc ccagcctgga gagcagggat cccccacagg ccccgatcag tggccctgtt
     6601 gctccactgg gcagcgatgt ggatggacca gtacttgcca agcctcctgc ctcagcgccc
     6661 ttcacccatg agggtctgag tgttgtcacg gggggctttc ctactagcag gcatggctcc
     6721 cccagtaggg ctgcacgggt tccccccttc aactacgtgc ccagccctat ggtagtggct
     6781 acaatgacca gtgactcagc tgtggagaaa gcccctgtta cctctccagc cagcctcctg
     6841 gagtagtggt tataggcctg ccttctggaa ctctctcctc accctgtggc ccaggctggc
     6901 tgcgctgtgg gcctgctctc tagctgctct gattaggcac atgtgtgccc ttagagcccc
     6961 catccagctc gcatctctgc accttagggc cagcccttgc ttctatgccc ggggctcgag
     7021 ggaatcggct gtagactggc catagggcac atgcagcgcc attttctgag gtcggcctgg
     7081 gaaggggtgg acagccagtc tctgaaagtc actagatgtg gggctgtgag ctgcacccgg
     7141 caggagagtg gacatggctt ctcaggtgac tgagctttcc tgctggaggt ggggacaggc
     7201 tgggggatgg ggcagggagc ctctgcttgg cagctgggga cgcctcagcc ctgcactgtg
     7261 gaagcctgta attagtgctg gggtaattgg ttaatgatga ctctgccagg ggtgtttgcc
     7321 ttctccgagg cggctgagga gcactgggtg aggggtagta gacaagcttc tctctcaccc
     7381 agcactcgtc atagccatga gagactgctg agggtgaaca gccctcctga cgcaggagct
     7441 atggagcagc ccatactctg tccctttact gataggaggg actctaatcc caaggccacc
     7501 tggctaggct ccagggccca ggcaggcagg caggcaggca ggcaggcagg ccggccggcc
     7561 tgaagggagg caggtccatc tgcgggagcc tggtccttcc cagccctggc tgccttaaga
     7621 tgatgaaggc atcaggacca gaacagttcc tcgggcctca ctcagtcaca gcctggaatc
     7681 aaaacaggga cttggtgacg gtgtggggag cctggagctg ctatggaggg cagggaccca
     7741 ggtggagagc aggatgcaga tgtgaggtag ccgagccttc gagcacctgg gcggtgggtc
     7801 tgtgtgccaa ccacagggac ccagggcaga gtcttcctgc agagccaaca acctcctgtg
     7861 ggaccccagg ctgctctttg taaggggagc catggacacc tgcacgagct gtccccagag
     7921 aacggactgt cccttgagct ggcctcaagt ccctcttctg agatgaggga agtggctttg
     7981 agaaccgggg gtgggaggcg gccttgggag gaactgataa ttctgctgcc cttcccaagg
     8041 gtccccttta aggcagggag ttgacagacc caagcttgcc aactcccagg ggcaggctga
     8101 cttgaggaca ccatttgtgg gctacaccta ttacacctgt ccagtgcttt gcgatgcctg
     8161 atgtttcctt gtctggggct ctggccctaa ttgtggggac agtgtcacag cagaaactcc
     8221 agacactaaa tgctcaatgc caggatcttg cctgccagac aaggccgctg gcctttgggt
     8281 gactggtagg gaggggacaa ggaaggccct tttcagaaca gagcaaagtg gctctaggac
     8341 accctctcta gaacacctaa gacacactcc aggatggccc tgtgctgggg accacaatgc
     8401 acagattggc ggctggggtc ggacggcgaa cctcatcttt gtagactgag cctgtgtacc
     8461 atgcactgtg agagctcagg tggcactcgc gctgctctga gccttggttt ccccatgtgg
     8521 gccgtgggga ggactcaggg tggagcagca gggacgtcta ggctgcagca ccagcatgca
     8581 agggccatct ttctcccagc cacctcctcc catcctgtca gccttgggcc cagcagccat
     8641 gtttgccttc tccaccccac acagtggggg acacaagaca cagtggaact tccagcccag
     8701 ggtaggtaag ctctgttgaa gggcagcagc ttctggagtg tccttagaga ccgagcagga
     8761 gatctgccac ctgccaggct gctgatggct gctagctccc tgagctggac accagtggtc
     8821 tactggagac taaccactgg gtgcttgacc agggcaccat gcccaccagt tacctcactg
     8881 tgtgtctgtc tgtcgcactg tcccatggcc aatgtcattc ccttgctcac agctggtcag
     8941 tgtgttctct gctgccgtac tgtttccgcc tgttctgtag tgtacactct gcaccctgat
     9001 gtacagtgta cacttctgca ccctgatgta cagtgtacac ttctgcaccc tgatgtacag
     9061 tgtacacttc tgcaccctga tctacagtgt acactctgca ccctgatcta cagtgtacac
     9121 ttctgcaccc tgatctacag tgtacactct gcaccctgat ctagtgtaca ctctgtaacc
     9181 tgatctacag tgtacactct gcaccctgat ctacagtgta cactctgtaa cctgatctac
     9241 agtgtacact ctgcaccctg atctacagtg tacactctgc accctgatct agtgtacact
     9301 ctgtaacctg atctacagtg tacactctgc accctgatct acagtgtaca ctctgtaacc
     9361 tgatctacag tgtacactct gcaccctgat ctacagtgta cactctgtaa cctgatctac
     9421 agtgtacact ctgcaccctg atctacagtg tacactctgt aacctgatct acagtgtaca
     9481 cttctgcacc ctgatctaca gtgtacactt ctgtacatac tgaccccgga ggacgcccag
     9541 cctggcttct gattctttgt tcatatcttt aataaagcga gacatttggc tgct
//
