LOCUS       NM_012499               8582 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus APC regulator of WNT signaling pathway (Apc),
            mRNA.
ACCESSION   NM_012499
VERSION     NM_012499.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8582)
  AUTHORS   Shirakami,Y., Nakanishi,T., Ozawa,N., Ideta,T., Kochi,T.,
            Kubota,M., Sakai,H., Ibuka,T., Tanaka,T. and Shimizu,M.
  TITLE     Inhibitory effects of a selective prostaglandin E2 receptor
            antagonist RQ-15986 on inflammation-related colon tumorigenesis in
            APC-mutant rats
  JOURNAL   PLoS One 16 (5), e0251942 (2021)
   PUBMED   34003864
  REMARK    GeneRIF: Inhibitory effects of a selective prostaglandin E2
            receptor antagonist RQ-15986 on inflammation-related colon
            tumorigenesis in APC-mutant rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8582)
  AUTHORS   Yuan,B., Wu,W., Zhang,H., Gu,H., Guo,D., Jiang,J. and Wang,X.
  TITLE     Adenomatous polyposis coli as a predictor of environmental
            chemical-induced transgenerational effects related to male
            infertility
  JOURNAL   J Biochem Mol Toxicol 33 (7), e22331 (2019)
   PUBMED   30934153
  REMARK    GeneRIF: the miR-30 family/APC interaction is a potential mechanism
            for the transgenerational effects induced by the environmental
            chemical.
REFERENCE   3  (bases 1 to 8582)
  AUTHORS   Torricelli,F., Nicoli,D., Bellazzi,R., Ciarrocchi,A., Farnetti,E.,
            Mastrofilippo,V., Zamponi,R., La Sala,G.B., Casali,B. and
            Mandato,V.D.
  TITLE     Computational development of a molecular-based approach to improve
            risk stratification of endometrial cancer patients
  JOURNAL   Oncotarget 9 (39), 25517-25528 (2018)
   PUBMED   29876005
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8582)
  AUTHORS   Arif,M., Pandey,R., Alam,P., Jiang,S., Sadayappan,S., Paul,A. and
            Ahmed,R.P.H.
  TITLE     MicroRNA-210-mediated proliferation, survival, and angiogenesis
            promote cardiac repair post myocardial infarction in rodents
  JOURNAL   J Mol Med (Berl) 95 (12), 1369-1385 (2017)
   PUBMED   28948298
REFERENCE   5  (bases 1 to 8582)
  AUTHORS   Council,L.N., Shanmugam,C., Suswam,E.A., Katkoori,V.R.,
            Heslin,M.J., Hanna,A., Jhala,N.C., Varambally,S. and Manne,U.
  TITLE     Association between Hepatitis C Virus Infection, p53 Phenotypes,
            and Gene Variants of Adenomatous Polyposis Coli in Hepatocellular
            Carcinomas
  JOURNAL   J Dig Dis Hepatol 2016 (5) (2016)
   PUBMED   28203651
REFERENCE   6  (bases 1 to 8582)
  AUTHORS   Clarke,A.R., Cummings,M.C. and Harrison,D.J.
  TITLE     Interaction between murine germline mutations in p53 and APC
            predisposes to pancreatic neoplasia but not to increased intestinal
            malignancy
  JOURNAL   Oncogene 11 (9), 1913-1920 (1995)
   PUBMED   7478622
REFERENCE   7  (bases 1 to 8582)
  AUTHORS   Kakiuchi,H., Watanabe,M., Ushijima,T., Toyota,M., Imai,K.,
            Weisburger,J.H., Sugimura,T. and Nagao,M.
  TITLE     Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat
            colon tumors induced by
            2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
  JOURNAL   Proc Natl Acad Sci U S A 92 (3), 910-914 (1995)
   PUBMED   7846077
REFERENCE   8  (bases 1 to 8582)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
REFERENCE   9  (bases 1 to 8582)
  AUTHORS   Horii,A., Nakatsuru,S., Miyoshi,Y., Ichii,S., Nagase,H., Ando,H.,
            Yanagisawa,A., Tsuchiya,E., Kato,Y. and Nakamura,Y.
  TITLE     Frequent somatic mutations of the APC gene in human pancreatic
            cancer
  JOURNAL   Cancer Res 52 (23), 6696-6698 (1992)
   PUBMED   1423316
REFERENCE   10 (bases 1 to 8582)
  AUTHORS   Moser,A.R., Dove,W.F., Roth,K.A. and Gordon,J.I.
  TITLE     The Min (multiple intestinal neoplasia) mutation: its effect on gut
            epithelial cell differentiation and interaction with a modifier
            system
  JOURNAL   J Cell Biol 116 (6), 1517-1526 (1992)
   PUBMED   1541640
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D38629.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344/N"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..8582
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="APC regulator of WNT signaling pathway"
                     /db_xref="GeneID:24205"
                     /db_xref="RGD:2123"
     exon            1..188
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..8582
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="adenomatosis polyposis coli; WNT signaling pathway
                     regulator; APC, WNT signaling pathway regulator"
                     /codon_start=1
                     /product="adenomatous polyposis coli protein"
                     /protein_id="NP_036631.1"
                     /db_xref="GeneID:24205"
                     /db_xref="RGD:2123"
                     /translation="MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTELETEASNM
                     KEVLKQLQGSIEDETMTSGQIDLLERLKEFNLDSNFPGVKLRSKMSLRSYGSREGSVS
                     SRSGECSPVPMGSFPRRAFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQL
                     QNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRAAMEEQLGTCQDMEKRAQRRIAR
                     IQQIEKDILRVRQLLQSQAAEAERSSQSKHETASHEAERQLEGQGVAESNLATSGSGQ
                     SSAARVDHETAGVLSSSGTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLA
                     MSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQ
                     PDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVEHQICPAVCV
                     LMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMHGLTDDHYSVTLRRYAGMALTNLTF
                     GDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGS
                     VKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQT
                     NTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTL
                     WNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANI
                     MSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQNLYGDYV
                     FDASRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGI
                     GLSTYHSATENPGTSSKRGLQLSATAAQIAKVMEEVSALHTSQDDRSPASAAELHCVA
                     EERTAARRSSASHTHPNTHNFAKSESSNRTCSMPYAKVEYKRSSNDSLNSVTSSDGYG
                     KRGQMKPSVESYSEDDEGKFCSYGQYPADLAHKIHSANHMDDNGGELDTPINYSLKYS
                     DEQLNSGRQSPSQNERWARPKHVIEDEIKQNEQRQSRSQNTNFPVYSENTDDKHLKFQ
                     QHFGQQECVSPYRSRGTNGSETNRMGSSHAVNQNVNQSLCQEDDYEDDKPTNYSERYS
                     EEEQHEEEERPTNYSIKYNEEKHHVDQPIDYSLKYATDISSSQKPSFSFSKTPSVQGT
                     KTEHNSPSSEAASAPSSNAKRQSQLHPSSAQRNGQTPKGTACKVPSINQETMQTYCVE
                     DTPICFSRCSSLSSLSSAEDEIGCDQTTQEADSANTLQIAEIKENDVTRSAQDPASDV
                     PAVSQSTRTKPSRLQASGLASESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETP
                     LVFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIVSPSDLPDSPGQTMPPSRSKTP
                     PPPPPPQPVQTKREVPKTKVPAAEQREGGPKQTAVSAAVQRVQVLPDADTLLHFATES
                     TPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETEPEQPEESNENQDKEV
                     EKPDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKLAQTASKLPPPVARKPSQL
                     PVYKLLPSQSRLQAQKHVSFTPGDDVPRVYCVEGTPINFSTATSLSDLTIESPPNELA
                     AGDGVRASVQSGEFEKRDTIPTEGRSTDEAQRGKVSSIAIPDLDGSKAEEGDILAECI
                     NSALPKGRSHKPFRVKKIMDQVQQASMTSSGTNKNQIDTKKKKPTSPVKPMPQNTEYR
                     TRVRKNTDSKVNVNTEETFSDNKDSKKQSLKNNPKDLNDKLPDNEDRVRGGFTFDSPH
                     HYAPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKGKESKDSEAKVTCHTEPSS
                     SQQSARKAQASTKHPVNRGPSKPLLQEQPTFPQSSKDVPDRGAATDEKLQNFAIENTP
                     VCFSRNSSLSSLSDVDQENNNNEETGPVRDAEPANAQGQPGKPQASGYAPKSFHVEDT
                     PVCFSRNSSLSSLSIDSEDDLLRECISSAMPKKRRPSRLKGEGEWQSPRKVGSVLAED
                     LTLDLKDIQRPESEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAAACLSRQASSDS
                     DSILSLKSGVSLGSPFHLTPDQEEKPFTSHKGPRILKPGEKSTLEAKKIESENKGIKG
                     GKKVYKSLITGKIRSNSEISSQMKQPLQTNMPSISRGRTMIHIPGVRNSSSSTSPVSK
                     KGPPLKTPASKSPSEGPVATTSPRGTKPAVKSELSPITRQTSHISGSNKGPSRSGSRD
                     STPSRPTQQPLSRPMQSPGRNSISPGRNGISTPNKLSQLPRTSSPSTASTKSSGSGKM
                     SYTSPGRQLSQQNLSKQTGLSKNASSIPRSESASKGLNQMNNSNGSNKKVELSRMSST
                     KSSGSESDRSERPALVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPDSPTRSQAQ
                     TPVLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYSDGRPSKRHDIARSHSESPSR
                     LPVNRAGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSVP
                     GPRQMKENQVPTKGTWRKIKESEISPTNTVSQTTSSGAASGAESKTLIYQMAPAVSRT
                     EDVWVRIEDCPINNPRSGRSPTGNTPPVIDSISEKGNPSIKDSKDTQGKQSVGSGSPV
                     QTVGLENRLNSFIQVEAPEQKGTETKAGQGSPAPVAETGETCMAERTPFSSSSSSKHS
                     SPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVGSSTKKRDSKTDSTESSGAQ
                     SPKRHSGSYLVTSV"
     exon            189..270
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            271..469
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            470..578
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            579..692
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            693..776
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            777..881
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            882..980
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1359
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1455
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1595
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1673
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1790
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..2005
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..8582
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagtgaat ttcaaaatcc tttttaacct tataggtcca agggtagcca aggatggcag
       61 cagcctcata tgatcagttg ttaaagcaag ttgaggccct gaagatggag aactcaaatc
      121 ttcgacaaga gctcgaagat aattccaatc accttacaga actggaaact gaggcatcta
      181 acatgaagga agtacttaag cagctgcagg gaagtattga agatgagact atgacttccg
      241 gacagattga tttactagag cgccttaaag aatttaactt agatagcaat ttccccggag
      301 tgaaactacg ctcgaaaatg tccctccgat cctatggaag tcgggaagga tctgtatcaa
      361 gccgttcagg agaatgcagt cctgtcccca tggggtcatt cccaagaaga gcatttgtaa
      421 atggaagcag agaaagcact ggatacttag aagagcttga gaaagagaga tcattactcc
      481 ttgctgatct tgacaaagaa gaaaaggaaa aggactggta ttatgctcag cttcagaacc
      541 tcacgaaaag aatagatagc ctgcccttga ctgagaactt ttccttacag acagacatga
      601 caagacggca gctggagtat gaagcacggc agatcagggc cgcaatggag gagcagcttg
      661 gcacctgcca ggacatggag aaacgagcac agcgaagaat agccaggatt cagcaaatag
      721 agaaggacat tcttcgtgta cggcagctct tacagtccca agcggctgaa gcagagaggt
      781 catctcagag caagcatgaa actgcctccc atgaagctga gcggcagctt gaaggtcaag
      841 gagtggcaga aagcaacttg gcaacttctg gtagtggcca gagttcagct gcacgtgtgg
      901 atcatgaaac agccggtgtt ttgagttcta gcggcacaca ctctgctcct cgaaggctga
      961 cgagtcacct gggaacgaag gtggaaatgg tgtattcatt gttgtccatg cttggtactc
     1021 atgataagga cgatatgtca cgaactttgc tagctatgtc tagctcccaa gacagctgta
     1081 tatccatgcg acagtctgga tgtcttcctc tcctcatcca gcttttacat ggcaatgaca
     1141 aagactctgt gttgttggga aattcccggg gcagtaaaga ggctcgggcc agggccagtg
     1201 cagccctcca caacatcatt cactcacagc ctgatgacaa gagaggcagg cgtgaaatcc
     1261 gggtccttca tcttttggaa cagatacgag cttactgcga aacctgttgg gagtggcagg
     1321 aagcccatga acaaggcatg gaccaggaca aaaatccaat gccagctcct gttgagcatc
     1381 agatctgccc tgcggtgtgt gttctgatga aactctcatt tgatgaggag cacagacatg
     1441 cgatgaatga gcttgggggg ctgcaggcta ttgcagagtt actgcaggtg gactgtgaga
     1501 tgcacgggct cactgatgac cactacagtg tcactctacg acggtacgct ggaatggcct
     1561 tgacaaacct gacctttgga gatgttgcca acaaggctac gctgtgttct atgaaaggct
     1621 gcatgagggc actcgtggcc cagttaaaat ccgaaagtga agacttacag caggttattg
     1681 caagtgtttt gcggaatttg tcttggcgag cagatgtaaa tagcaaaaag acgttgagag
     1741 aagttggaag tgtgaaagcg ttgatggaat gtgctttgga agttaaaaag gaatcaactc
     1801 tcaaaagcgt cttgagtgcc ttatggaatc tgtccgcaca ctgcactgag aataaggctg
     1861 acatatgtgc tgtggacggg gcactggcat ttctggttgg caccctcact taccggagcc
     1921 agacaaatac gttagccatc attgaaagtg gaggtgggat attacggaat gtgtccagct
     1981 tgatagctac caacgaagac cacagacaaa tcctaagaga gaacaactgc ctacaaactt
     2041 tattacagca cttgaaatct cacagcttga caatagtcag taatgcatgt ggaactctgt
     2101 ggaatctctc agcgagaaat cctaaagacc aggaggctct gtgggacatg ggggcggtga
     2161 gcatgctcaa gaacctcatt cattccaagc acaaaatgat cgctatgggg agcgcagcag
     2221 ctttaaggaa tctcatggca aacagacctg caaagtataa ggatgccaac atcatgtctc
     2281 ctggctcaag tttgccatcc cttcacgtta ggaaacaaaa agctctagaa gcagaattag
     2341 acgctcagca tttatcagaa acctttgaca atattgacaa tttaagtccc aaggcatctc
     2401 atcgcagtaa gcagagacac aagcagaatc tttatggtga ctatgtcttt gacgccagtc
     2461 gacatgatga caataggtca gacaacttta acactggaaa catgactgtt ctttcaccat
     2521 acttaaatac cacagtattg cccagctctt cttcatcaag gggaagttta gacagttctc
     2581 gttctgagaa agacagaagt ttggagagag aacgaggtat tggcctcagc acttaccatt
     2641 cagcaacaga aaatccggga acctcttcca aacggggttt gcagctctct gccactgcag
     2701 cccagatagc caaagtgatg gaagaagtgt ccgccctcca cacctcccag gacgacagaa
     2761 gccccgcctc tgccgctgag ctccactgtg tggcggagga gaggactgca gcacgaagaa
     2821 gctctgcgtc ccacacacat ccaaacacac acaacttcgc taagtcggaa agctcaaaca
     2881 ggacatgctc catgccttat gccaaggtgg aatataagag atcttcaaat gacagcttaa
     2941 acagtgtcac tagtagtgat ggctatggta aaaggggcca gatgaagccc tcggttgagt
     3001 cctactcaga agatgatgaa ggtaagtttt gcagttatgg gcagtatcct gccgacctag
     3061 cccataagat acacagtgca aatcatatgg atgataatgg tggggagctg gacacaccaa
     3121 taaactacag cctcaagtac tcagatgagc agctgaactc aggaaggcag agcccctcac
     3181 aaaatgaaag gtgggcaaga cccaagcatg tgatagaaga tgaaataaag caaaacgagc
     3241 aaaggcaatc aagaagccag aacaccaatt ttcccgtcta ctctgagaac actgatgaca
     3301 aacacctcaa gttccaacag cattttgggc aacaagagtg cgtttcccca tataggtcca
     3361 ggggaaccaa tggttcagaa acaaatcgaa tgggttctag tcatgcagtt aatcaaaatg
     3421 tgaaccagtc tttgtgtcag gaagacgact atgaagatga caagcctacc aactacagtg
     3481 aacgttattc tgaggaagaa cagcatgaag aagaagagag accgacaaat tacagcataa
     3541 agtataatga agagaaacac catgtggatc agcctattga ttatagtcta aaatatgcca
     3601 ctgacatatc ttcatcccag aagccatcat tttcattctc aaagactcca tcagtacagg
     3661 gcactaaaac tgaacataac tctccaagca gtgaggctgc atctgcacct tcatctaacg
     3721 ccaaaaggca gagtcagctg catccaagtt cagcacaaag aaatggtcag actccaaaag
     3781 ggactgcctg caaagtcccc tccatcaacc aagagacaat gcagacttac tgtgtagaag
     3841 acaccccaat atgtttctca aggtgtagtt ccttatcatc gctatcatca gctgaggatg
     3901 aaataggctg tgatcagaca acacaggagg cagactctgc gaatactctg caaatagcag
     3961 agataaaaga gaatgatgtg acgcggtcag ctcaagaccc tgcgagtgac gtcccagccg
     4021 tgtcccagag tactagaacc aagcccagca gactccaggc ttccggctta gcttcagaat
     4081 ccgccaggca taaagctgtt gagttttctt caggagccaa gtctccctcc aaaagcggtg
     4141 ctcagacacc caaaagtccc ccagaacact atgtccagga gacgcccctt gtattcagca
     4201 ggtgtacttc tgtcagctcc ctggacagtt ttgagagtcg ctccatcgcc agctctgttc
     4261 agagtgagcc atgtagtgga atggtgagtg ggattgtcag ccccagtgac cttccagaca
     4321 gcccagggca gaccatgcca ccaagcagaa gcaagacccc tccccctccc cctcccccac
     4381 agccagtgca gaccaagaga gaggtgccaa aaactaaggt gcctgctgcc gagcagagag
     4441 agggtgggcc taagcagacg gccgtgagtg cggctgtgca gagggtgcag gtcctcccgg
     4501 atgccgacac tctgttacac tttgccacag agagtactcc agatgggttt tcttgttcct
     4561 ctagcctaag tgctctgagt ctggatgagc cctttataca gaaagatgtg gaattaagaa
     4621 taatgcctcc agttcaggaa aacgacaatg ggaatgaaac tgaaccagaa cagcctgaag
     4681 aatctaatga aaaccaggat aaagaggtag aaaagcctga ctctgaaaaa gacttattag
     4741 atgattccga tgatgatgat attgaaatat tagaagaatg tattatttca gccatgccaa
     4801 caaagtcatc acgcaaagcc aaaaagctag cccagactgc ttcaaaatta cctcctcctg
     4861 tggcaaggaa accgagtcag ctgcctgtgt acaaacttct gccgtcacag agcaggctgc
     4921 aggcacaaaa acatgtcagc tttacaccag gggacgatgt gccccgagtg tactgtgtgg
     4981 aagggacgcc tataaacttc tccacagcaa catctctgag tgatctcaca atagaatccc
     5041 ctccgaatga gctggctgct ggagatgggg ttagagcaag tgtacagtca ggtgagtttg
     5101 aaaaacgaga taccattcct acagagggca gaagtacaga tgaggctcag agaggaaaag
     5161 tctcctctat agctatacca gacctggatg gtagcaaagc agaggaagga gatattcttg
     5221 cagaatgcat caattctgcc ctgcccaaag gaagaagcca caagcctttc cgagtgaaaa
     5281 agataatgga ccaagtccaa caggcatcca tgacttcatc cggaactaac aaaaatcaaa
     5341 tagacactaa gaaaaagaag cctacttcac cagtaaagcc catgccacaa aatactgaat
     5401 acagaactcg tgtgagaaag aatacagact caaaagttaa cgtaaatact gaagaaactt
     5461 tctcagacaa taaagactca aagaaacaga gcttaaaaaa caaccccaag gacttgaatg
     5521 acaagctacc ggacaatgag gacagggtcc ggggaggctt tactttcgat tcaccgcatc
     5581 attacgcacc cattgaaggg actccttact gcttctcacg aaatgactct ttgagttctc
     5641 tagattttga tgatgacgat gttgacctct ccagggaaaa ggctgagtta agaaagggca
     5701 aagaaagtaa ggactccgaa gccaaagtta cctgccacac agaaccaagc tcaagccaac
     5761 agtcggctag gaaggcacag gctagtacaa aacatccagt gaacagaggg ccgtctaaac
     5821 cactgctgca ggaacaaccc actttccccc agtcctctaa agacgtacca gacagagggg
     5881 cagcaactga cgaaaaactg cagaattttg ctattgaaaa tacaccggtt tgcttttctc
     5941 gaaattcttc tctgagctcc cttagtgacg ttgaccaaga aaacaacaat aacgaagaaa
     6001 ctggaccagt cagagacgct gagcctgcca acgcgcaagg acagccaggc aagcctcagg
     6061 catctgggta tgcgcccaag tcctttcatg tggaagacac ccctgtgtgc ttctccagaa
     6121 acagctctct cagctctctg agcattgatt ctgaggacga cctgttgcga gagtgcataa
     6181 gctctgctat gccaaaaaag aggaggcctt ccagactcaa gggtgagggt gagtggcaga
     6241 gtcctaggaa agtgggcagc gtgttagccg aagatctgac actcgacttg aaagatatac
     6301 agaggccaga gtcagaacac ggtttatccc ccgattcaga aaatttcgac tggaaagcta
     6361 ttcaggaagg tgcaaactcc atagtaagta gtctgcacca agctgccgcc gccgccgcgt
     6421 gtctgtccag acaagcgtcg tcggactcag actccatcct gtccctgaag tcgggcgtct
     6481 ccctggggtc gccttttcac cttacacctg accaagagga gaagccattc acaagtcata
     6541 aaggcccaag aattctcaaa cctggggaga aaagcacatt agaagcaaaa aaaatagaat
     6601 ccgaaaacaa aggaatcaaa ggtggaaaaa aggtttataa aagcttgatt acaggaaaga
     6661 ttcgatctaa ttcagaaatc tccagccaaa tgaaacaacc ccttcagaca aacatgcctt
     6721 caatctcaag aggcaggaca atgattcaca tcccgggagt tcggaacagc tcctcaagta
     6781 caagccctgt ctctaaaaaa ggcccacccc tcaagactcc agcctctaaa agccccagtg
     6841 aaggtcctgt agctaccact tctcctcgtg gaactaagcc agcagtgaag tcagagctga
     6901 gccctattac caggcaaact tcccacatta gtgggtcaaa taaggggccc tctaggtcag
     6961 ggtctagaga ctccactccc tcgagaccca cacagcagcc attaagtagg ccgatgcagt
     7021 cgccagggcg gaactcgatc tcccccggta gaaatggaat aagcactcct aacaaactct
     7081 ctcagctgcc cagaacatcg tctcccagta ctgcttcgac caagtcctcg gggtcgggga
     7141 aaatgtccta cacatcccca ggccggcagc tgagccagca aaacctcagc aaacaaacag
     7201 gcttgtccaa gaacgccagc agcatcccca gaagtgagtc agcatccaaa ggactgaatc
     7261 agatgaataa cagcaatggg tctaataaaa aggtagaact ttctagaatg tcttcaacta
     7321 agtcaagtgg aagtgaatca gacaggtcag aaagacctgc attagtacgc cagtccactt
     7381 tcatcaaaga agccccaagc ccaaccctaa ggaggaaact ggaggaatct gcctcatttg
     7441 aatccctttc tccatcttct agaccagatt ctcccaccag gtcccaggca cagaccccag
     7501 ttttaagccc ttcccttccc gatatgtctc tgtccacaca tccatctgtt caggcaggtg
     7561 gatggcgcaa gctcccacct aacctcagcc ccactataga gtacagtgac ggaaggccct
     7621 caaagcggca tgatatcgca cgctcccatt ctgaaagtcc gtccagacta ccagtcaacc
     7681 gagcgggaac ctggaagcgt gaacacagca aacattcctc atcccttcct cgagtgagca
     7741 cttggagaag aactggaagc tcatcttcta ttctttctgc ttcttcagag tccagtgaaa
     7801 aagcaaaaag tgaggatgaa aagcatgtga actctgtgcc aggacccaga caaatgaaag
     7861 aaaaccaggt acccacaaaa ggaacatgga ggaaaataaa ggaaagtgaa atttctccca
     7921 caaacacggt ttctcagacc acttcctcag gtgctgccag tggtgctgaa tcaaagactc
     7981 tgatctatca gatggcacct gctgtttcta gaacagagga cgtttgggtg agaattgagg
     8041 actgccccat taacaaccct agatctggaa gatctcccac aggtaacacc cccccagtga
     8101 ttgacagcat ttcagaaaag ggaaatccaa gcattaaaga ttcaaaagac acccaaggaa
     8161 aacaaagtgt gggcagtggc agtcctgtgc aaaccgtggg tctagaaaac cgcctgaact
     8221 cctttattca ggtagaggcc ccggaacaga aaggaactga gactaaagca ggacagggta
     8281 gccctgcccc tgtagcagag actggtgaga cctgcatggc agagcgcacc cctttcagtt
     8341 caagtagctc cagcaagcac agttctccca gtgggacggt cgctgccaga gtgacgcctt
     8401 ttaattacaa cccaagccct aggaaaagca gcgcagacag cacttcagcc cggccatctc
     8461 agatccccac tccggtgggc agcagcacaa agaagagaga ctcgaagact gacagcactg
     8521 aatctagtgg agcccagagt cctaaacgcc attctgggtc ttacctcgtg acgtctgttt
     8581 aa
//
