LOCUS       NM_053957               2072 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus amyloid beta precursor protein binding family B
            member 3 (Apbb3), mRNA.
ACCESSION   NM_053957 XM_006254495
VERSION     NM_053957.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2072)
  AUTHORS   Bruni,P., Minopoli,G., Brancaccio,T., Napolitano,M., Faraonio,R.,
            Zambrano,N., Hansen,U. and Russo,T.
  TITLE     Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein,
            blocks cell cycle progression by down-regulating thymidylate
            synthase expression
  JOURNAL   J Biol Chem 277 (38), 35481-35488 (2002)
   PUBMED   12089154
REFERENCE   2  (bases 1 to 2072)
  AUTHORS   Duilio,A., Faraonio,R., Minopoli,G., Zambrano,N. and Russo,T.
  TITLE     Fe65L2: a new member of the Fe65 protein family interacting with
            the intracellular domain of the Alzheimer's beta-amyloid precursor
            protein
  JOURNAL   Biochem J 330 (Pt 1) (Pt 1), 513-519 (1998)
   PUBMED   9461550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Dec 1, 2020 this sequence version replaced
            XM_006254495.1, NM_053957.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13413.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN12840110,
                                           SAMN12840131 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               JAXUCZ010000018.1  28554005-28554383   c
            380-537             JAXUCZ010000018.1  28553569-28553726   c
            538-614             JAXUCZ010000018.1  28553411-28553487   c
            615-675             JAXUCZ010000018.1  28552411-28552471   c
            676-822             JAXUCZ010000018.1  28552099-28552245   c
            823-950             JAXUCZ010000018.1  28551854-28551981   c
            951-956             JAXUCZ010000018.1  28551600-28551605   c
            957-1071            JAXUCZ010000018.1  28551345-28551459   c
            1072-1156           JAXUCZ010000018.1  28551155-28551239   c
            1157-1240           JAXUCZ010000018.1  28550667-28550750   c
            1241-1356           JAXUCZ010000018.1  28550295-28550410   c
            1357-1548           JAXUCZ010000018.1  28549963-28550154   c
            1549-2072           JAXUCZ010000018.1  28547205-28547728   c
FEATURES             Location/Qualifiers
     source          1..2072
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..2072
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /note="amyloid beta precursor protein binding family B
                     member 3"
                     /db_xref="GeneID:117026"
                     /db_xref="RGD:620853"
     exon            1..379
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1785
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /note="fe65-like protein 2; protein Fe65-like 2; amyloid
                     beta (A4) precursor protein-binding, family B, member 3"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     B member 3"
                     /protein_id="NP_446409.2"
                     /db_xref="GeneID:117026"
                     /db_xref="RGD:620853"
                     /translation="MLGKDYMLAIILVNCDDDLWGDQNLEGETGLPPGWRKIRDAAGT
                     YYWHVPSGSTQWQRPTWELAEDPGTGKEGIWELRPPKGRSFSSLDSSLNRSNSLTWYN
                     EDSYVRSLEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRNRSQPHDG
                     AWGEGQNMLMVLKKDAMSLLNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVAGDK
                     DSCMLKCHVFRCDVPAKAIASALQGLCAQILSERVGLSGEAACCSPDPISPEDFPRQV
                     ELLDAVSQAAQKYEALYMGILPVTKAMGMDVLNEAIGTLTGRGDRKTWVPAMLSVSDS
                     LMTAHPIQAEAGAEEEPLWQCPVRLVTFIGVGHDPHTFGLIADLGCQSFQCAAFWCQP
                     HAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGPLPPPL
                     LKGGVGGAGAAPRKRGVFSFLDAFRLKPSLLHMS"
     exon            380..537
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..614
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..675
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..822
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
     exon            823..950
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..956
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1071
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1156
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1240
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1356
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1548
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..2072
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatctcattc gcgccctggt gcacagtgtg cacgttctcc ttgccggtct tccgccgtcg
       61 gaggaactct tagttaccga ccggtgcgga gttcatcgtg tcagtacgct tcgtaggaca
      121 cacgcaccga aacacgcgag gactcgggaa accagacgca caggcagctc aggcccgcct
      181 ctgccctccc ccaaggccgt ccctatcccg cccagtgttt gtttgcgcgg tgccagttgg
      241 cccggcggtc tccggcgcag agaggctggg cttgtgtgcc ctgcagctcc ggaggtcgcc
      301 ttgggctgag aacgcaggcc agtcgagact atgctgggca aggattatat gctggccatc
      361 attctggtca actgcgatga tgacttgtgg ggggaccaaa atctggaggg ggaaacaggc
      421 ctaccccctg gctggagaaa gatccgtgat gctgcaggaa cttattattg gcatgtaccc
      481 agcggtagca ctcagtggca gcgcccaacc tgggaactag cagaggaccc aggaacggga
      541 aaagagggga tttgggaact acgacctccc aaggggagat ctttctccag cctggacagc
      601 tcattgaacc gaagtaactc tctaacatgg tataatgaag attcctatgt ccggagcctg
      661 gagccaggag ctaagtgctt tgcagtccgc tctctgggct gggtagaggt ccctgaggag
      721 gacctggcac cagggaagag cagtattgct gtcaataact gtatccagca gctagcccag
      781 acccgaaacc ggagccagcc tcatgatggt gcctggggtg agggccagaa catgctgatg
      841 gtcctgaaaa aagatgccat gagcttgctg aatcccctgg accacagtct gatccattgt
      901 cagcctctgg ttcacatccg tgtatggggt gtgggcagct ccaagggccg tgacagggac
      961 tttgcttttg ttgcgggtga caaagacagc tgtatgctca aatgtcatgt gtttcgctgt
     1021 gatgtgcccg caaaagccat agcaagtgct ctacaggggc tctgtgcaca gatcttgtca
     1081 gagagggtag gactcagtgg agaagctgct tgttgttccc cagatcctat ttcccctgaa
     1141 gacttcccaa ggcaagtgga attgctggat gcagtgagcc aggctgctca gaagtatgag
     1201 gcactgtaca tggggatcct accagtcacc aaagccatgg gtatggatgt gctgaatgag
     1261 gccattggta ccctcactgg ccgtggggac cggaaaacct gggtccccgc tatgctcagt
     1321 gtgtctgact ctctgatgac tgcacatcct attcaggcag aggctggtgc agaggaagag
     1381 ccactgtggc agtgtcctgt tcgccttgta acctttattg gtgttggcca tgatccgcat
     1441 acctttggcc tcatcgctga tcttggttgt cagagcttcc agtgtgcagc tttctggtgc
     1501 caacctcatg ctgggggact ctctgaagct gtgcaagctg cctgcatggt tcagtaccag
     1561 aagtgtctag tggcctcagc agctcggggt aaggcctggg gtgctcaggc tcgcgctcgc
     1621 ctgcggctca agcggaccag ctccatggac tccccaggcg gcccccttcc tccccctcta
     1681 ctcaaaggag gggttggggg tgctggagca gctcctcgaa agcggggtgt cttctcattt
     1741 cttgatgcct tcaggctaaa accttctctt ctccatatgt cctaaattga tcttagaggg
     1801 ctggggaaag aggctctata ctcttccagt ccctagggtt ctgtagcctc tcaccttcct
     1861 gccatccctg atccttgcct actctgtatt tatgaccaag ttcgttgttt atatggatga
     1921 ctgagaggcc ctgcactcta acttaggcct gtagcaccac tttcctttgg tccttttgtt
     1981 ccttgcccct gtccagccct ggacaattgg ctctacctca tcaactttat agcagaatca
     2041 gtgaaaataa aaatccctca gtaatctcac ta
//
