LOCUS       NM_080478               2537 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus amyloid beta precursor protein binding family B
            member 1 (Apbb1), mRNA.
ACCESSION   NM_080478
VERSION     NM_080478.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2537)
  AUTHORS   Strecker,P., Ludewig,S., Rust,M., Mundinger,T.A., Gorlich,A.,
            Krachan,E.G., Mehrfeld,C., Herz,J., Korte,M., Guenette,S.Y. and
            Kins,S.
  TITLE     FE65 and FE65L1 share common synaptic functions and genetically
            interact with the APP family in neuromuscular junction formation
  JOURNAL   Sci Rep 6, 25652 (2016)
   PUBMED   27734846
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2537)
  AUTHORS   Matz,A., Lee,S.J., Schwedhelm-Domeyer,N., Zanini,D., Holubowska,A.,
            Kannan,M., Farnworth,M., Jahn,O., Gopfert,M.C. and Stegmuller,J.
  TITLE     Regulation of neuronal survival and morphology by the E3 ubiquitin
            ligase RNF157
  JOURNAL   Cell Death Differ 22 (4), 626-642 (2015)
   PUBMED   25342469
REFERENCE   3  (bases 1 to 2537)
  AUTHORS   Cheung,H.N., Dunbar,C., Morotz,G.M., Cheng,W.H., Chan,H.Y.,
            Miller,C.C. and Lau,K.F.
  TITLE     FE65 interacts with ADP-ribosylation factor 6 to promote neurite
            outgrowth
  JOURNAL   FASEB J 28 (1), 337-349 (2014)
   PUBMED   24056087
REFERENCE   4  (bases 1 to 2537)
  AUTHORS   Rebelo,S., Domingues,S.C., Santos,M., Fardilha,M., Esteves,S.L.,
            Vieira,S.I., Vintem,A.P., Wu,W., da Cruz E Silva,E.F. and da Cruz E
            Silva,O.A.
  TITLE     Identification of a novel complex AbetaPP:Fe65:PP1 that regulates
            AbetaPP Thr668 phosphorylation levels
  JOURNAL   J Alzheimers Dis 35 (4), 761-775 (2013)
   PUBMED   23531501
  REMARK    GeneRIF: Fe65 is the bridging protein to amyloid-beta protein
            precursor in the complex formed and thus we simultaneously describe
            another PP1 binding protein
REFERENCE   5  (bases 1 to 2537)
  AUTHORS   Dumanis,S.B., Chamberlain,K.A., Jin Sohn,Y., Jin Lee,Y.,
            Guenette,S.Y., Suzuki,T., Mathews,P.M., Pak,D.Ts., Rebeck,G.W.,
            Suh,Y.H., Park,H.S. and Hoe,H.S.
  TITLE     FE65 as a link between VLDLR and APP to regulate their trafficking
            and processing
  JOURNAL   Mol Neurodegener 7, 9 (2012)
   PUBMED   22429478
  REMARK    GeneRIF: our data suggest that FE65 serves as a link between VLDLR
            and APP
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2537)
  AUTHORS   Zambrano,N., Buxbaum,J.D., Minopoli,G., Fiore,F., De Candia,P., De
            Renzis,S., Faraonio,R., Sabo,S., Cheetham,J., Sudol,M. and Russo,T.
  TITLE     Interaction of the phosphotyrosine interaction/phosphotyrosine
            binding-related domains of Fe65 with wild-type and mutant
            Alzheimer's beta-amyloid precursor proteins
  JOURNAL   J Biol Chem 272 (10), 6399-6405 (1997)
   PUBMED   9045663
REFERENCE   7  (bases 1 to 2537)
  AUTHORS   Borg,J.P., Ooi,J., Levy,E. and Margolis,B.
  TITLE     The phosphotyrosine interaction domains of X11 and FE65 bind to
            distinct sites on the YENPTY motif of amyloid precursor protein
  JOURNAL   Mol Cell Biol 16 (11), 6229-6241 (1996)
   PUBMED   8887653
REFERENCE   8  (bases 1 to 2537)
  AUTHORS   Fiore,F., Zambrano,N., Minopoli,G., Donini,V., Duilio,A. and
            Russo,T.
  TITLE     The regions of the Fe65 protein homologous to the phosphotyrosine
            interaction/phosphotyrosine binding domain of Shc bind the
            intracellular domain of the Alzheimer's amyloid precursor protein
  JOURNAL   J Biol Chem 270 (52), 30853-30856 (1995)
   PUBMED   8537337
REFERENCE   9  (bases 1 to 2537)
  AUTHORS   Faraonio,R., Minopoli,G., Porcellini,A., Costanzo,F., Cimino,F. and
            Russo,T.
  TITLE     The DNA sequence encompassing the transcription start site of a
            TATA-less promoter contains enough information to drive
            neuron-specific transcription
  JOURNAL   Nucleic Acids Res 22 (23), 4876-4883 (1994)
   PUBMED   7800475
REFERENCE   10 (bases 1 to 2537)
  AUTHORS   Duilio,A., Zambrano,N., Mogavero,A.R., Ammendola,R., Cimino,F. and
            Russo,T.
  TITLE     A rat brain mRNA encoding a transcriptional activator homologous to
            the DNA binding domain of retroviral integrases
  JOURNAL   Nucleic Acids Res 19 (19), 5269-5274 (1991)
   PUBMED   1923810
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_080478.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF333983.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-724               JAXUCZ010000001.1  169324412-169325135 c
            725-900             JAXUCZ010000001.1  169318102-169318277 c
            901-957             JAXUCZ010000001.1  169317951-169318007 c
            958-1043            JAXUCZ010000001.1  169317780-169317865 c
            1044-1107           JAXUCZ010000001.1  169317608-169317671 c
            1108-1257           JAXUCZ010000001.1  169317077-169317226 c
            1258-1385           JAXUCZ010000001.1  169316583-169316710 c
            1386-1391           JAXUCZ010000001.1  169316479-169316484 c
            1392-1506           JAXUCZ010000001.1  169316073-169316187 c
            1507-1591           JAXUCZ010000001.1  169315842-169315926 c
            1592-1675           JAXUCZ010000001.1  169315505-169315588 c
            1676-1791           JAXUCZ010000001.1  169309666-169309781 c
            1792-1968           JAXUCZ010000001.1  169309370-169309546 c
            1969-2537           JAXUCZ010000001.1  169308720-169309288 c
FEATURES             Location/Qualifiers
     source          1..2537
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2537
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /note="amyloid beta precursor protein binding family B
                     member 1"
                     /db_xref="GeneID:29722"
                     /db_xref="RGD:2122"
     CDS             1..2136
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /note="amyloid beta A4 precursor protein-binding family B
                     member 1; amyloid beta (A4) precursor protein-binding,
                     family B, member 1 (Fe65)"
                     /codon_start=1
                     /product="amyloid beta precursor protein binding family B
                     member 1"
                     /protein_id="NP_536726.1"
                     /db_xref="GeneID:29722"
                     /db_xref="RGD:2122"
                     /translation="MSVPSSLSQSAINANSHGGPALSFPFPLHAAHNQLLNAKLQATA
                     VVPKDLRSAMGEGSVPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQE
                     AETAPLGPKGLMHLYSELELSAHNAANRGLHGSALIINTQGLGPDEGEEKAAGEVEEE
                     DEDEEEEDEEEEDLSSPQGLPEPLENVEVPSGPQVLTDGPREHSKSASLLFGMRNSAA
                     SDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPT
                     GTTQWEPPGRASPSQGNSPQEESQLTWTGFAHQEGFEEGEFWKDEPSEEAPMELGLKD
                     PEEGTLPFSAQSLSPEPVPQEEENLPQRNANPGIKCFAVRSLGWVEMTEEELAPGRSS
                     VAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQNQTLLHAQPIVS
                     IRVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMSERR
                     NARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGA
                     LESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAF
                     IMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQTSTSCLPAPPAESV
                     ARRVGWTVRRGVQSLWGSLKPKRLGSQTP"
     exon            1..724
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            725..900
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            901..957
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1043
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1107
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1257
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1385
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1391
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1506
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1591
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1675
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1791
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1968
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2537
                     /gene="Apbb1"
                     /gene_synonym="FE65"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtctgttc catcatccct gagccagtcg gccattaatg ctaacagcca cggaggccct
       61 gcactcagct tccccttccc cttgcatgct gcccataacc agctgctcaa cgccaagctg
      121 caagccacag ctgtggtacc caaggacctt cgaagtgcca tgggagaggg tagtgtgcct
      181 gaaccaggcc ctgccaatgc caagtggtta aaggaaggcc agaaccagct tcggagggct
      241 gccacagccc atcgagacca gaaccgaaat gtgaccttga ccttggcgga ggaggccagc
      301 caggaggctg agacagcacc tttgggtccc aaaggcttaa tgcatctata ctctgagctg
      361 gagctctcgg cccacaatgc agccaaccga gggcttcatg gatccgcctt gatcatcaac
      421 acccagggac tgggaccaga tgaaggagag gagaaggcag caggagaagt tgaggaggag
      481 gatgaagatg aggaggaaga ggatgaggag gaggaggact tgtcttctcc tcaagggcta
      541 cctgagcctc tggagaatgt ggaagtcccc tctggacccc aggtcctcac agatggcccc
      601 cgggaacata gcaagagtgc tagcctccta tttggcatgc gaaacagtgc agccagtgac
      661 gaggactcaa gctgggccac cttatcgcag ggcagcccct cctatggctc tccggaggac
      721 acagattcct tctggaaccc caacgctttc gagacggatt ccgatctacc ggctggatgg
      781 atgagggtcc aagacacctc agggacctac tactggcaca tcccaacagg gaccacccag
      841 tgggaacccc caggccgggc ctccccatcg caggggaaca gtccccaaga agagtcccag
      901 ctcacctgga ctggctttgc tcaccaagaa ggctttgagg aaggagagtt ttggaaggat
      961 gaacctagtg aagaggcccc aatggagttg ggactgaagg accctgagga ggggacattg
     1021 cccttctcag ctcagagcct cagcccagag ccagtgcccc aggaggagga gaatctgccc
     1081 caacggaacg ccaatccagg gatcaagtgt ttcgctgtgc gctccctagg ctgggtagag
     1141 atgactgagg aggagctggc cccaggacgc agcagtgtgg cagtcaacaa ttgtatccgc
     1201 cagctctcct accacaaaaa caatctacat gatccgatgt ctggaggctg gggagaggga
     1261 aaggatctgc tgctccagct ggaggatgag acgctaaagt tggtggagcc acagaaccag
     1321 acactgctgc atgcccagcc catcgtcagc attcgcgtgt ggggcgttgg gcgggacagt
     1381 ggaagagaga gggactttgc ctacgtagct cgagataagc tgacccagat gctcaagtgc
     1441 cacgtgtttc gctgtgaggc acctgccaag aacatcgcca ccagcctgca tgagatctgc
     1501 tccaagatca tgtctgaacg gcgcaatgct cgctgcttgg taaatggact ctccctggac
     1561 cactctaaac ttgtggatgt ccctttccaa gtggaattcc cagcaccaaa gaatgaactg
     1621 gtgcagaagt ttcaagtcta ttacctaggg aacgtgcctg tggctaaacc cgttggggta
     1681 gatgtgatta atggagccct ggagtcagtc ctgtcttcca gtagtcgtga gcagtggacc
     1741 ccaagtcacg tcagcgtggc ccctgccacc ctcaccatct tgcaccagca gacagaagca
     1801 gtgctggggg agtgtcgagt gcggttcctc tccttcctgg ctgtgggcag agatgtgcac
     1861 acgttcgcat tcatcatggc tgccggccca gcctccttct gctgtcacat gttttggtgc
     1921 gagcccaatg ctgccagtct ctcggaggct gtgcaggctg catgcatgct ccgctaccag
     1981 aagtgtctgg atgctcgttc ccagacctcc acctcctgcc tcccagcacc ccctgcggag
     2041 tcagttgcga gacgtgtagg gtggactgtc cgcaggggtg ttcagtctct gtggggttcc
     2101 ctcaagccca aacgtctagg atcccagacc ccatgaagag ctcccatcct ccctctacct
     2161 gcttgttttg ggccccaggg aactcaaggg tttggggcag gtaggggctg tggatgttct
     2221 tcctacaccc catgtccccc gggctgcccc tcctcagtag ctggggttcc ctacctaggg
     2281 gctgggagag agaaattgaa ttccttcaca gaagtcatta cactggactg atgacatggg
     2341 gggccagaag caaagccagc cttgggctct ccatccccag tgtttgaggt ggagcaggag
     2401 gaactggtcc aagccaggcc ccatcctcaa aggcccaata agggcaggag gggactggtc
     2461 tcggcatgga tcccctgtcc cctgttctgc ggacacctcc actgtactga tatcactaat
     2521 aaagtctgtc tgcgctg
//
