LOCUS       NM_031781               1939 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus amyloid beta precursor protein binding family A
            member 3 (Apba3), mRNA.
ACCESSION   NM_031781
VERSION     NM_031781.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1939)
  AUTHORS   Hirose,Y., Johnson,Z.I., Schoepflin,Z.R., Markova,D.Z., Chiba,K.,
            Toyama,Y., Shapiro,I.M. and Risbud,M.V.
  TITLE     FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in
            nucleus pulposus cells
  JOURNAL   J Biol Chem 289 (30), 20594-20605 (2014)
   PUBMED   24867948
  REMARK    GeneRIF: FIH-1-Mint3 axis does not control HIF-1 transcriptional
            activity in nucleus pulposus cells.
REFERENCE   2  (bases 1 to 1939)
  AUTHORS   Sakamoto,T. and Seiki,M.
  TITLE     Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1)
            in macrophages by suppressing the activity of factor inhibiting
            HIF-1
  JOURNAL   J Biol Chem 284 (44), 30350-30359 (2009)
   PUBMED   19726677
REFERENCE   3  (bases 1 to 1939)
  AUTHORS   Ho,A., Morishita,W., Atasoy,D., Liu,X., Tabuchi,K., Hammer,R.E.,
            Malenka,R.C. and Sudhof,T.C.
  TITLE     Genetic analysis of Mint/X11 proteins: essential presynaptic
            functions of a neuronal adaptor protein family
  JOURNAL   J Neurosci 26 (50), 13089-13101 (2006)
   PUBMED   17167098
REFERENCE   4  (bases 1 to 1939)
  AUTHORS   Biederer,T., Cao,X., Sudhof,T.C. and Liu,X.
  TITLE     Regulation of APP-dependent transcription complexes by Mint/X11s:
            differential functions of Mint isoforms
  JOURNAL   J Neurosci 22 (17), 7340-7351 (2002)
   PUBMED   12196555
REFERENCE   5  (bases 1 to 1939)
  AUTHORS   Okamoto,M. and Sudhof,T.C.
  TITLE     Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or
            -2
  JOURNAL   Eur J Cell Biol 77 (3), 161-165 (1998)
   PUBMED   9860131
REFERENCE   6  (bases 1 to 1939)
  AUTHORS   Gynther,B.D., Vickery,R.M. and Rowe,M.J.
  TITLE     Responses of slowly adapting type II afferent fibres in cat hairy
            skin to vibrotactile stimuli
  JOURNAL   J Physiol 458, 151-169 (1992)
   PUBMED   1302262
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF029109.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF029109.1, BC161842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1939
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1939
                     /gene="Apba3"
                     /gene_synonym="Mint3"
                     /note="amyloid beta precursor protein binding family A
                     member 3"
                     /db_xref="GeneID:83611"
                     /db_xref="RGD:620846"
     exon            1..645
                     /gene="Apba3"
                     /gene_synonym="Mint3"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1794
                     /gene="Apba3"
                     /gene_synonym="Mint3"
                     /note="mint-3; adapter protein X11gamma; neuron-specific
                     X11L2 protein; neuronal Munc18-1-interacting protein 3;
                     amyloid beta (A4) precursor protein-binding, family A,
                     member 3 (X11-like 2)"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 3"
                     /protein_id="NP_113969.1"
                     /db_xref="GeneID:83611"
                     /db_xref="RGD:620846"
                     /translation="MEFLPEPQHPPGPPTMDLEEPKGPEVPSEDHPSNTQGALGPRGP
                     DTLSEMELDTSSVRALVQQLEALPSDLGGQFPDGAPCPLHIATGQGLATQENLDAGGL
                     LSAEAGGDNLLGLLRCEASLPAQSVPPDPAQAAPRLLQPPEDPGGDPGWMEGTEPADN
                     RSSSSSPELWLETAPLVTHRDPPVGTQSQETLASCPAVSEVPGPCGQEELMDGVLFGA
                     KYLGSTQLLSERNPPPSTRMGQAQEAMDRVKAPEGESQPMTEVDIFISTKRVKVLAAD
                     SQDALMDHALQTISYIADIGPVLVLMARRRLAKRTTSQDRQRQLYKMLCHVFHSEDAQ
                     LIAQAIGQAFSIAYSQFLQENGIDPSQVGMQPSASASHPHNGDLDHFCNSQNCREVCI
                     QKRPGEGLGVALVESGWGSLLPTAVIANLLHGGPAERCGALSIGDRVTAINGTSLVGL
                     SLAACQAAVREVRRHSSVTLSIIHCPPVTTAVIHRPHVREQLGFCVENGIICSLLRGS
                     AAERGGVRVGHRIIEVNGQSVVAMPHARIIQLLTETREIHIKTMPAATYRLLTGQEQP
                     VYL"
     exon            646..685
                     /gene="Apba3"
                     /gene_synonym="Mint3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..831
                     /gene="Apba3"
                     /gene_synonym="Mint3"
                     /inference="alignment:Splign:2.1.0"
     exon            832..918
                     /gene="Apba3"
                     /gene_synonym="Mint3"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1080
                     /gene="Apba3"
                     /gene_synonym="Mint3"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1251
                     /gene="Apba3"
                     /gene_synonym="Mint3"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1464
                     /gene="Apba3"
                     /gene_synonym="Mint3"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1584
                     /gene="Apba3"
                     /gene_synonym="Mint3"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1722
                     /gene="Apba3"
                     /gene_synonym="Mint3"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1939
                     /gene="Apba3"
                     /gene_synonym="Mint3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accatggctt gtctacgagt tccgcactca gagccctcgt cttccagctt ggtgacaatg
       61 ccggcctgaa cctggatccc agacatggag ttcctgccag aaccccagca tcccccaggg
      121 cccccgacca tggacttgga ggagcccaaa ggccccgagg ttccctctga ggaccatccc
      181 tctaacacgc agggggcctt agggcccaga ggccccgata ccctgagcga gatggagctg
      241 gacacatcca gtgtgcgggc gctggttcag cagttggaag ctttgcccag cgacctgggt
      301 ggccagttcc cagatggagc cccctgtccc ctgcacattg ccactggcca aggcctagcc
      361 acccaggaga atttggatgc tggtgggctc ctgtcagccg aggcaggtgg ggacaacctt
      421 ctgggtctgc tgaggtgtga ggcctctttg cctgctcaat ccgttccccc agatcctgca
      481 caggctgcac cccgccttct gcagccacca gaggaccccg gtggggaccc tggatggatg
      541 gaagggacag agccagcaga caacaggagt tccagcagct ccccggagct gtggctagag
      601 acagcacccc tggtgacaca tcgagatcca cccgtgggta cccagagcca ggagaccctg
      661 gcttcgtgcc ctgccgtctc cgaggttcca ggtccctgtg gacaggagga gctcatggac
      721 ggagtcctct tcggggcgaa atacctgggc tccacccagc tgctgtctga gcgcaacccg
      781 ccgcccagca cacgcatggg gcaggcgcag gaggccatgg atcgggtcaa ggcccctgaa
      841 ggtgagagcc agcccatgac cgaggtagac atctttatct ccactaagcg cgtgaaagtg
      901 ctggctgctg actcccagga tgccctgatg gaccatgccc tgcagaccat ctcctacatc
      961 gcggacattg ggcctgtgct ggtcttgatg gcgcgcaggc ggctggccaa gaggacaact
     1021 tctcaggacc gccagcggca gctctacaag atgctatgcc atgtcttcca ttcagaggat
     1081 gcccagctca ttgcgcaagc catcggtcag gccttcagta tcgcctacag ccagttcctg
     1141 caggagaacg gaatcgaccc cagccaggtg ggcatgcagc cttcagcctc tgccagtcac
     1201 ccacacaatg gcgacctgga ccacttctgc aacagccaga actgcaggga ggtttgcatc
     1261 cagaagcggc ctggggaggg cctgggtgtc gcgctggttg agtcaggctg gggctcgctg
     1321 ctgcccaccg cggtcattgc caacctcctc cacgggggcc ctgccgagcg ctgcggggcc
     1381 ctgagcatag gggaccgtgt cactgccatc aacggaacca gcctggtggg gctgtcgctg
     1441 gccgcctgcc aggccgctgt gcgcgaggta cggcgacact catccgtgac gctgagtatc
     1501 atccattgcc caccagtcac cacggccgtc atccaccggc cccacgtgcg cgagcagctg
     1561 ggcttctgtg tggagaacgg cattatttgc agcctgctgc gtgggagtgc ggctgagcgt
     1621 ggtggagtcc gcgttggaca ccgcatcatt gaggtcaatg ggcagagtgt ggtggccatg
     1681 ccccacgcgc gcattatcca gctgctcaca gagacaagag aaatccacat caagaccatg
     1741 ccagctgcca cctaccgact gctcacggga caggaacagc cagtatacct gtgatcgccc
     1801 cgcccacatg tgccttcgcc ccgcccacgt gtgccttcgc cccgccaccg tcacccctcg
     1861 gccggcgggg accaaagaat cctcagtctt gtgctatttt ctaatgtaaa aaatactttt
     1921 aaagatttat taaatggtc
//
