LOCUS       NM_031780               3864 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus amyloid beta precursor protein binding family A
            member 2 (Apba2), mRNA.
ACCESSION   NM_031780
VERSION     NM_031780.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3864)
  AUTHORS   Jensen,T.M.T., Albertsen,L., Bartling,C.R.O.,
            Haugaard-Kedstrom,L.M. and Stromgaard,K.
  TITLE     Probing the Mint2 Protein-Protein Interaction Network Relevant to
            the Pathophysiology of Alzheimer's Disease
  JOURNAL   Chembiochem (2018) In press
   PUBMED   29578633
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3864)
  AUTHORS   Xie,X., Yan,X., Wang,Z., Zhou,H., Diao,W., Zhou,W., Long,J. and
            Shen,Y.
  TITLE     Open-closed motion of Mint2 regulates APP metabolism
  JOURNAL   J Mol Cell Biol 5 (1), 48-56 (2013)
   PUBMED   22730553
REFERENCE   3  (bases 1 to 3864)
  AUTHORS   Yao,L.L., Liu,X.Y., Jin,J.Y., Tao,B.B., Chen,Y.J., Yu,Y.C.,
            Bian,W.H., Yu,J., Huang,J. and Wang,Y.G.
  TITLE     Expression and ultrastructural localization of Mint2 in the spinal
            cord of rats
  JOURNAL   Mol Biol Rep 38 (1), 667-673 (2011)
   PUBMED   20369384
  REMARK    GeneRIF: These data suggest that Mint2 may play more important role
            in spinal cord than the other two family members.
REFERENCE   4  (bases 1 to 3864)
  AUTHORS   Zhang,Y., Wang,Y.G., Zhang,Q., Liu,X.J., Liu,X., Jiao,L., Zhu,W.,
            Zhang,Z.H., Zhao,X.L. and He,C.
  TITLE     Interaction of Mint2 with TrkA is involved in regulation of nerve
            growth factor-induced neurite outgrowth
  JOURNAL   J Biol Chem 284 (18), 12469-12479 (2009)
   PUBMED   19265194
  REMARK    GeneRIF: Mint2 is a novel TrkA-regulating protein that affects
            NGF-induced neurite outgrowth, possibly through a mechanism
            involving retention of TrkA in the Golgi apparatus.
REFERENCE   5  (bases 1 to 3864)
  AUTHORS   Yoon,S., Choi,J., Haam,J., Choe,H. and Kim,D.
  TITLE     Reduction of mint-1, mint-2, and APP overexpression in okadaic
            acid-treated neurons
  JOURNAL   Neuroreport 18 (18), 1879-1883 (2007)
   PUBMED   18007179
  REMARK    GeneRIF: Upon neurodegeneration with okadaic acid, mint-1 and
            mint-2 levels were reduced by proteolytic cleavage, and these
            changes were followed by increases in APP levels.
REFERENCE   6  (bases 1 to 3864)
  AUTHORS   Ho,A., Morishita,W., Atasoy,D., Liu,X., Tabuchi,K., Hammer,R.E.,
            Malenka,R.C. and Sudhof,T.C.
  TITLE     Genetic analysis of Mint/X11 proteins: essential presynaptic
            functions of a neuronal adaptor protein family
  JOURNAL   J Neurosci 26 (50), 13089-13101 (2006)
   PUBMED   17167098
REFERENCE   7  (bases 1 to 3864)
  AUTHORS   Kitano,J., Yamazaki,Y., Kimura,K., Masukado,T., Nakajima,Y. and
            Nakanishi,S.
  TITLE     Tamalin is a scaffold protein that interacts with multiple neuronal
            proteins in distinct modes of protein-protein association
  JOURNAL   J Biol Chem 278 (17), 14762-14768 (2003)
   PUBMED   12586822
REFERENCE   8  (bases 1 to 3864)
  AUTHORS   Biederer,T., Cao,X., Sudhof,T.C. and Liu,X.
  TITLE     Regulation of APP-dependent transcription complexes by Mint/X11s:
            differential functions of Mint isoforms
  JOURNAL   J Neurosci 22 (17), 7340-7351 (2002)
   PUBMED   12196555
REFERENCE   9  (bases 1 to 3864)
  AUTHORS   Biederer,T. and Sudhof,T.C.
  TITLE     Mints as adaptors. Direct binding to neurexins and recruitment of
            munc18
  JOURNAL   J Biol Chem 275 (51), 39803-39806 (2000)
   PUBMED   11036064
REFERENCE   10 (bases 1 to 3864)
  AUTHORS   Okamoto,M. and Sudhof,T.C.
  TITLE     Mints, Munc18-interacting proteins in synaptic vesicle exocytosis
  JOURNAL   J Biol Chem 272 (50), 31459-31464 (1997)
   PUBMED   9395480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 30, 2020 this sequence version replaced NM_031780.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF029107.1, SRR26360176.275206.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               JAXUCZ010000001.1  127514500-127514617
            119-172             JAXUCZ010000001.1  127579354-127579407
            173-1166            JAXUCZ010000001.1  127640212-127641205
            1167-1247           JAXUCZ010000001.1  127659381-127659461
            1248-1284           JAXUCZ010000001.1  127660433-127660469
            1285-1430           JAXUCZ010000001.1  127678640-127678785
            1431-1466           JAXUCZ010000001.1  127679682-127679717
            1467-1553           JAXUCZ010000001.1  127681647-127681733
            1554-1739           JAXUCZ010000001.1  127683646-127683831
            1740-1919           JAXUCZ010000001.1  127687175-127687354
            1920-2132           JAXUCZ010000001.1  127688346-127688558
            2133-2252           JAXUCZ010000001.1  127689633-127689752
            2253-2393           JAXUCZ010000001.1  127694668-127694808
            2394-3864           JAXUCZ010000001.1  127696654-127698124
FEATURES             Location/Qualifiers
     source          1..3864
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3864
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /note="amyloid beta precursor protein binding family A
                     member 2"
                     /db_xref="GeneID:83610"
                     /db_xref="RGD:620845"
     exon            1..118
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     exon            119..172
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     exon            173..1166
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..2465
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /function="putative function in synaptic vesicle
                     exocytosis by binding to munc18-1, an essential component
                     of the synaptic vesicle exocytotic machinery"
                     /note="adapter protein X11beta; neuron-specific X11L
                     protein; neuronal Munc18-1-interacting protein 2; amyloid
                     beta (A4) precursor protein-binding, family A, member 2
                     (X11-like)"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2"
                     /protein_id="NP_113968.1"
                     /db_xref="GeneID:83610"
                     /db_xref="RGD:620845"
                     /translation="MAHRKRQSTASSMLDHRARPGPIPHDQEPENEDTELPLESYVPT
                     GLELGTLRPDSPTPEEQECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGVTYYIR
                     YCPEDDSYLEGMDCNGEEYLAHGAHPVDTDECQEAVEDWTDSVGPHTHSHGAENSQEY
                     PDSHLPIPEDDPTVLEVHDQEEDGHYCPSKESYQDYYPPETNGNTGGASPYRMRRGDG
                     DLEEQEEDIDQIVAEIKMSLSMTSITSASEASPEHMPELDPGDSTEACSPSDTGRGPS
                     RQEARPKSLNLPPEVKHSGDPQRGLKTKTRTPEERPKWPQEQVCNGLEQPRKQQRSDL
                     NGPTDNNNIPETKKVASFPSFVAVPGPCEPEDLIDGIIFAANYLGSTQLLSERNPSKN
                     IRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTLTEVDLFISTQRIKVLNADTQETM
                     MDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPGAQEGKKQYKMICHVFESE
                     DAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDIINTQEMYNDDLIHFSNSEN
                     CKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSING
                     TSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIIC
                     SLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRL
                     LTGQETPLYI"
     exon            1167..1247
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1284
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1430
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1466
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1553
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1739
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1919
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2132
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2252
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2393
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..3864
                     /gene="Apba2"
                     /gene_synonym="Mint2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagttctctg gagactgagg cactgctgaa gctcagccag gtgacacccc cgccccgtcg
       61 cagtagactt tcctgcagac aggagcaggg agagccatcc tgtgtgtgga gactgccgga
      121 agactggatc accaggagag ttctcaggac attatcaagg cactcatttc tgtggctgct
      181 tccaggtaac aatggctgtg tgagtgtcta ccatggccca ccgcaagcgc cagagcactg
      241 caagcagcat gttggaccac agggcccggc caggtcctat cccccatgac caggagcctg
      301 agaatgagga tacagaactg cctctggaga gctatgtacc cacaggcctg gagctaggca
      361 ctctgagacc agacagcccc acgcctgagg aacaggagtg ccacaaccat agccctgatg
      421 gggactccag ctctgactat gtgaacaaca cgtctgagga ggaggactat gacgagggcc
      481 tccctgagga ggaggaaggt gtcacctact acatccgcta ttgtcctgag gatgacagct
      541 acctggaggg catggactgt aatggggagg agtacctagc ccatggtgca catcctgtgg
      601 acactgatga gtgtcaggag gcggtagagg actggacgga ctcagtgggt cctcatactc
      661 atagccacgg ggctgaaaac agccaagagt atccagacag ccacctgcct atcccagagg
      721 atgaccctac tgtcctggag gtccatgacc aggaagaaga tggccactac tgtcccagca
      781 aggagagcta ccaggactat tatcccccag agaccaatgg gaacacgggt ggcgcttctc
      841 cctatcgcat gaggcgtggg gatggggacc tagaggagca ggaggaagac atcgaccaga
      901 tagtggctga gatcaagatg agcctgagca tgaccagtat taccagtgcc agtgaggcca
      961 gccctgagca catgcctgag ctggaccctg gggactccac tgaggcctgt tcacccagtg
     1021 acactggccg tggacccagt aggcaagaag cgaggcccaa gtcgctgaac cttccccctg
     1081 aggttaagca ctccggagac ccccaaagag gactcaagac caagaccagg accccagagg
     1141 agaggccaaa gtggccccaa gagcaggttt gcaatggctt ggaacagccg aggaagcagc
     1201 agcgctctga tctcaatgga cccactgaca ataacaacat cccagagaca aagaaggtgg
     1261 cctcgtttcc aagctttgta gctgttccag ggccctgtga gccagaagac ctcatcgatg
     1321 gcatcatctt tgcagccaac tacctgggct ccacccagct gctctctgag cgcaacccct
     1381 ccaaaaacat ccgaatgatg caagctcaag aagctgtcag cagggtcaag aggatgcaga
     1441 aggctgctaa gatcaagaaa aaagcgaatt ctgagggtga tgctcagaca ctgacagaag
     1501 tagacctctt catttctacc cagaggatca aagtcttaaa cgctgacaca caggaaacca
     1561 tgatggacca tgccttgcgc accatctcct acattgcaga cattgggaac atcgtggttc
     1621 tgatggccag gcgccgcatg cccaggtcag cctctcagga ctgcatcgag accacgcctg
     1681 gggcccagga agggaagaag cagtacaaga tgatctgtca cgtgttcgag tcagaggatg
     1741 cccagctgat agcccagtca attgggcagg ccttcagtgt ggcctaccag gagttcctga
     1801 gggccaacgg catcaaccct gaggacctga gccagaagga atacagtgat atcataaata
     1861 cccaggagat gtataatgat gaccttatcc acttctcaaa ctcggagaac tgcaaggagc
     1921 tgcagctgga gaagcacaag ggtgagattt tgggtgtggt ggtcgtggag tcaggctggg
     1981 gctccatcct gcccactgtg atcctggcga acatgatgaa cggcggccca gcagctcgct
     2041 cggggaagct gagcattggc gaccagatca tgtccatcaa tggcaccagc ctggtggggc
     2101 tgcccctcgc tacctgccag ggtatcatca agggcctgaa gaaccaaaca caggtaaagc
     2161 tcaacatcgt cagctgtccc ccagtcacca cagtcctcat caaacgtcca gatctcaagt
     2221 accagctggg tttcagcgtg caaaatggaa tcatttgcag cctcatgaga gggggtattg
     2281 cagagcgagg tggtgtccga gtcggccacc gtatcatcga gatcaacgga cagagtgtgg
     2341 tagccacagc ccacgagaag atagtccagg ctctgtctaa ctcagttgga gagattcaca
     2401 tgaagaccat gcctgcagcc atgttcaggc tcctcacagg ccaggagaca ccgctgtaca
     2461 tctaggtaca ccctgcctcg ccaaggagca gggactccag gcagacccac ctgggcccag
     2521 aggagccaga agccaggaca aagccctgac ccctgacccc gcagcccaac caagaactct
     2581 ggctctcccc cctccccacc cccaagggtg tgtccttgtc acctaggttt tttttttgtt
     2641 tgtttggttg gttggtttgg ggtttttttt ttgtttgttt gttttatttt gttttgggtt
     2701 ttgctaaaaa aagaaaaggg aaaaaaaaaa gctatgtcct tactgaaggg gagtcacagg
     2761 acaatccttt gtaaaactta ccagtcttct gccatatttt cattgcggct gatgaagggt
     2821 gctcacaggt agttctatgt gtggtgtgct gtgtctctac tccctgaggc tatggaatgt
     2881 gaatgtggcg cccaccccgc ccgcacatct gtgtggctgt gaagggagcc ctctgtgatg
     2941 cagctgcagc cttttctgcc cttggctggg acacctgggg tccagtggtg tcctaaaagg
     3001 gcccccatgt gctggccttg cctcctctac acaggcacag ggggcagcct ggctcccagg
     3061 ctgagacttg tgccgtgtgg gaacgtgtga ttgattgtaa gtatttacgc agcaagggga
     3121 tgctcccaag ttaaataaaa aatcatggtc acgatgtcaa aactccatat ttatttagca
     3181 acaaatactg tttggacttt gaccttggca agccattctc tggatgttta ggttttctga
     3241 caatctgtga ccactgctgc ttctcctgtc ctagcctgtt ctgagacccc tgagaccctg
     3301 tgaacttccc tgggcatcct taccttgact gactccttct ccaccacagg gcttcctgtt
     3361 agggggcaac gtcctgctgg ggacaaaggc agaggcatgg gaaatgttcc tatttaaata
     3421 gcaacaacaa aactctacct acacatatgt acacacacac acacacacac acacacacac
     3481 acacccctct gtccccaaca aaggaagccc acaccagaaa accccacctc tacccttcca
     3541 gaagggacca gcaagagtgc aaattacgtg tcaagtgagc tgctccgcca tcactcccag
     3601 agcagtgtta gtggttatag accaaggaac gcagtggctg gctcagcgcg ttagagatca
     3661 atgttaactg acgtcatttt gtctggcagc ctcttttttt ggctcaagcc ttgaagaata
     3721 cactgtgact taagaagcct taccacacag taactaaaga tttaggatta ctgtactcga
     3781 ggaataacct gtgtgttgca tgcagctgac cctaggaaga cttcgtgcat attgctaata
     3841 aacctgaagt catgatcaaa agca
//
