LOCUS       NM_031779               6621 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus amyloid beta precursor protein binding family A
            member 1 (Apba1), mRNA.
ACCESSION   NM_031779
VERSION     NM_031779.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6621)
  AUTHORS   Zhang,K., Wang,T., Liu,X., Yuan,Q., Xiao,T., Yuan,X., Zhang,Y.,
            Yuan,L. and Wang,Y.
  TITLE     CASK, APBA1, and STXBP1 collaborate during insulin secretion
  JOURNAL   Mol Cell Endocrinol 520, 111076 (2021)
   PUBMED   33159991
  REMARK    GeneRIF: CASK, APBA1, and STXBP1 collaborate during insulin
            secretion.
REFERENCE   2  (bases 1 to 6621)
  AUTHORS   Jones,K.A., Eng,A.G., Raval,P., Srivastava,D.P. and Penzes,P.
  TITLE     Scaffold protein X11alpha interacts with kalirin-7 in dendrites and
            recruits it to Golgi outposts
  JOURNAL   J Biol Chem 289 (51), 35517-35529 (2014)
   PUBMED   25378388
  REMARK    GeneRIF: Data show that scaffold protein X11alpha modulates
            kalirin-7 localization in dendrites and recruits it to Golgi
            outposts.
REFERENCE   3  (bases 1 to 6621)
  AUTHORS   Liu,W., Wen,W., Wei,Z., Yu,J., Ye,F., Liu,C.H., Hardie,R.C. and
            Zhang,M.
  TITLE     The INAD scaffold is a dynamic, redox-regulated modulator of
            signaling in the Drosophila eye
  JOURNAL   Cell 145 (7), 1088-1101 (2011)
   PUBMED   21703451
REFERENCE   4  (bases 1 to 6621)
  AUTHORS   Samuels,B.A., Hsueh,Y.P., Shu,T., Liang,H., Tseng,H.C., Hong,C.J.,
            Su,S.C., Volker,J., Neve,R.L., Yue,D.T. and Tsai,L.H.
  TITLE     Cdk5 promotes synaptogenesis by regulating the subcellular
            distribution of the MAGUK family member CASK
  JOURNAL   Neuron 56 (5), 823-837 (2007)
   PUBMED   18054859
REFERENCE   5  (bases 1 to 6621)
  AUTHORS   Yoon,S., Choi,J., Haam,J., Choe,H. and Kim,D.
  TITLE     Reduction of mint-1, mint-2, and APP overexpression in okadaic
            acid-treated neurons
  JOURNAL   Neuroreport 18 (18), 1879-1883 (2007)
   PUBMED   18007179
  REMARK    GeneRIF: Upon neurodegeneration with okadaic acid, mint-1 and
            mint-2 levels were reduced by proteolytic cleavage, and these
            changes were followed by increases in APP levels.
REFERENCE   6  (bases 1 to 6621)
  AUTHORS   Maximov,A., Sudhof,T.C. and Bezprozvanny,I.
  TITLE     Association of neuronal calcium channels with modular adaptor
            proteins
  JOURNAL   J Biol Chem 274 (35), 24453-24456 (1999)
   PUBMED   10455105
REFERENCE   7  (bases 1 to 6621)
  AUTHORS   Borg,J.P., Straight,S.W., Kaech,S.M., de Taddeo-Borg,M.,
            Kroon,D.E., Karnak,D., Turner,R.S., Kim,S.K. and Margolis,B.
  TITLE     Identification of an evolutionarily conserved heterotrimeric
            protein complex involved in protein targeting
  JOURNAL   J Biol Chem 273 (48), 31633-31636 (1998)
   PUBMED   9822620
REFERENCE   8  (bases 1 to 6621)
  AUTHORS   Butz,S., Okamoto,M. and Sudhof,T.C.
  TITLE     A tripartite protein complex with the potential to couple synaptic
            vesicle exocytosis to cell adhesion in brain
  JOURNAL   Cell 94 (6), 773-782 (1998)
   PUBMED   9753324
REFERENCE   9  (bases 1 to 6621)
  AUTHORS   Okamoto,M. and Sudhof,T.C.
  TITLE     Mints, Munc18-interacting proteins in synaptic vesicle exocytosis
  JOURNAL   J Biol Chem 272 (50), 31459-31464 (1997)
   PUBMED   9395480
REFERENCE   10 (bases 1 to 6621)
  AUTHORS   Ushkaryov,Y.A., Petrenko,A.G., Geppert,M. and Sudhof,T.C.
  TITLE     Neurexins: synaptic cell surface proteins related to the
            alpha-latrotoxin receptor and laminin
  JOURNAL   Science 257 (5066), 50-56 (1992)
   PUBMED   1621094
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 5, 2020 this sequence version replaced NM_031779.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF029105.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               JAXUCZ010000001.1  230790297-230790564
            269-1551            JAXUCZ010000001.1  230928052-230929334
            1552-1647           JAXUCZ010000001.1  230958486-230958581
            1648-1687           JAXUCZ010000001.1  230962117-230962156
            1688-1833           JAXUCZ010000001.1  230963874-230964019
            1834-1866           JAXUCZ010000001.1  230979033-230979065
            1867-1953           JAXUCZ010000001.1  230980018-230980104
            1954-2139           JAXUCZ010000001.1  230981071-230981256
            2140-2319           JAXUCZ010000001.1  230982494-230982673
            2320-2532           JAXUCZ010000001.1  230983473-230983685
            2533-2652           JAXUCZ010000001.1  230990122-230990241
            2653-2793           JAXUCZ010000001.1  230991337-230991477
            2794-6621           JAXUCZ010000001.1  230992159-230995986
FEATURES             Location/Qualifiers
     source          1..6621
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..6621
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /note="amyloid beta precursor protein binding family A
                     member 1"
                     /db_xref="GeneID:83589"
                     /db_xref="RGD:620844"
     exon            1..268
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
     exon            269..1551
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..2865
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /note="amyloid beta (A4) precursor protein-binding, family
                     A, APBA1: amyloid beta (A4) precursor protein-binding,
                     family A, member 1 (X11); mint-1; adapter protein
                     X11alpha; neuron-specific X11 protein; neuronal
                     Munc18-1-interacting protein 1"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 1"
                     /protein_id="NP_113967.2"
                     /db_xref="GeneID:83589"
                     /db_xref="RGD:620844"
                     /translation="MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPQPSP
                     PPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAA
                     ARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEH
                     EEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRL
                     YERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQI
                     VAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPG
                     GSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPT
                     RDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEV
                     PGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRK
                     KAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRR
                     MPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANG
                     INPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGS
                     ILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVK
                     LNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQ
                     SVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI"
     exon            1552..1647
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1687
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1833
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1866
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1953
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2139
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2319
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2532
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2652
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2793
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..6621
                     /gene="Apba1"
                     /gene_synonym="Mint1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgcagcc gcccggccct ggcgcgcgtc acgagggcga gcgggcggcg agcagggggt
       61 ggggccgcgg ccggaggggc ccgagcggct gccgagcaaa agccggagga acggggcgcg
      121 ggcggctgcg gtcccggtgg cggcggggga agatggtggc gctggagacg ggagcagctg
      181 gagagcagct ttattcccag gcttggcacg gtcgctgtca ctagcgccgc ctgctcccgc
      241 gggcccgcgg acccagctgt caggcaaggc cccgtgaagc caaaatgagc acacagtgag
      301 ccagcgcagc ctctcgccag ccatcccccg acgcccacca tgaaccactt ggagggctcc
      361 gcggaggtgg aggtggccga cgaggcgcca ggaggggagg tgaacgagtc cgtggaggcc
      421 gacctggagc accccgaggt ggaggaagag cagcagccgc agccgtcgcc cccgccgccc
      481 gcaggtcacg cacccgagga ccaccgcgcg catccggcgc cgccgccgcc gccaccaccg
      541 caggaggagg aggaggagcg cggcgagtgc ctggctcgct cggccagcac cgagagcggc
      601 ttccacaacc acacggacac cgctgagggc gacgtgctcg ccgcggcccg agacggctac
      661 gaggcggagc gcgcgcagga cgccgacgat gagagcgcct acgccgtgca gtaccggccc
      721 gaggccgagg agtacacgga gcaggcggag gccgagcacg ccgaggcggc gcagcggcgc
      781 gcgctgccca accacctgca cttccactcg ctggagcacg aggaagccat gaacgccgcc
      841 tactcgggct atgtctacac gcaccggctc ttccaccgcg ccgaggacga gccctacgcc
      901 gagccctacg ccgactacgg cggcctccag gagcacgtgt acgaggagat cggggacgcg
      961 cctgagctgg aggcgcgcga cggcctgcgg ctctatgagc gggagcgcga cgaggcggcc
     1021 gcctaccgcc aggaggccct aggcgcgcgg ctgcaccact acgacgagcg ctccgacggc
     1081 gagtccgaca gccccgagaa ggaggcggag ttcgcgccct acccgcgcat ggacagttat
     1141 gagcaggaag aggacatcga ccagatcgtg gccgaggtca agcagagcat gagctcgcag
     1201 agcctcgaca aggcggccga agacatgccc gaggcggagc aggacctgga gcgcgccccg
     1261 accccgggag ggggacaccc cgacagccct gggctgccag cacctgccgg gcagcagcag
     1321 cgagttgtgg gaaccccggg aggcagcgag gttggtcagc ggtacagcaa ggaaaagagg
     1381 gatgccatct cgctggccat caaggacatc aaggaggcca tcgaagaagt gaaaaccagg
     1441 accatccgtt cgccttacac ccccgacgaa cccaaagagc ccatctgggt catgcgccag
     1501 gacattagcc ccacaaggga ctgtgacgac cagaggcccg tggacggaga ttctccgtct
     1561 cctggcagtt cctcacccct gggtgctgag tcatcaatca caccccttca tcccggtgac
     1621 cccacggaag cctccactaa taaagagtca agaaaaagct tggcttcatt cccaacctac
     1681 gttgaagttc ctggaccctg cgaccctgaa gacttgatcg atggaattat ttttgctgcc
     1741 aattaccttg gttccactca gctactctca gacaaaactc cctccaaaaa cgtgcgcatg
     1801 atgcaggccc aggaagcagt aagccggatc aagacggccc agaaattagc caaaagcagg
     1861 aagaaggctc ctgaaggcga atctcagcca atgactgagg tggacctctt catctccacc
     1921 cagaggatca aagtgttgaa tgcagataca caggagccta tgatggacca ccctctgagg
     1981 accatttcct acatcgcaga cattgggaac atcgtcgtgc tgatggcccg caggcggatg
     2041 ccccgctcca actcccagga gaatgtggag gcctctcacc catcccagga tgcaaaacgg
     2101 cagtacaaga tgatctgtca tgtctttgag tctgaggacg cccagctgat cgcacagtcc
     2161 atcgggcagg ccttcagcgt tgcataccag gagttcctca gggccaacgg gattaaccca
     2221 gaagacctga gccaaaagga gtacagcgac ctgctcaaca cccaggacat gtacaacgat
     2281 gacctgatcc acttctccaa gtcggaaaac tgcaaagatg tcttcataga gaagcagaaa
     2341 ggagaaatcc tgggagttgt gattgtggag tctggctggg gatccattct gccaaccgtg
     2401 atcattgcca acatgatgca cggaggcccc gccgagaagt cggggaagct gaacatcggg
     2461 gaccagatca tgtccattaa cggcaccagc ctggtgggcc tgcccctgtc cacctgccag
     2521 agcatcatta agggcttaaa gaaccagtcc cgcgtgaagc tgaacatcgt gaggtgcccc
     2581 ccagtgacca cagtgctaat taggaggccg gaccttcgct accagctggg tttcagcgtg
     2641 cagaatggaa ttatctgtag cctcatgaga gggggaatag ctgagagagg aggtgtccgc
     2701 gtgggacatc ggatcattga aatcaacggc cagagtgtcg tagccacacc acacgagaag
     2761 atcgtccaca tactctccaa tgctgttggg gagatccaca tgaagacaat gccagcagcc
     2821 atgtacagac tgctgacagc ccaggagcag cccgtttaca tctgagccgc acctccgcgg
     2881 cgtggcagca tgcatggagg actctcctca ccgtggttgt gtttcttgtg ctgcatctgt
     2941 gtgtccactg agacattccc ctctcgcacc caacgtttgg ttttacacag gaagagaaga
     3001 atcggcaagg gcctctttgc tctctgtctc tctccagttc gcttttttat gttccatcct
     3061 taacaccagg gaagtttggt gtgtgccctc ctgagggtgg agagcagcta atatacctag
     3121 gatcatggtg gaggcctttg ggggatctta aagtggttgt tactgcccaa ggaggcatca
     3181 tccctcccca agagacacac acttccctga aggagctctc agaggcagca caggagatga
     3241 ctgagcagtg cctaaaactc acttgctgat ctctccgccc tcctcacctc actgatggaa
     3301 agatggttgg tgacaggtga cagcactgaa tatccttaaa gcccacatct ttaaggatgt
     3361 ttgctgcctg ctgtgtagtt ggagccccgc acattatttc tgcccagaat ttctgagcca
     3421 cttttaaatc ccttccctag tttcttttag ttgcaatgtg tgtgctaatt caggcctaac
     3481 ttctgagaaa caaggacaag gatgctgtga cacccacctc agaggtcctg gcaagtcaca
     3541 gggcctccaa ggttccccag gtttccaagg ttaccaattg gaggataacc actggcaggt
     3601 actgtcctaa cgtacttgca caggcgctta tgtgtaacac acacacacac acacacacac
     3661 acacacacac acacacacga gccctgctca gtgtttcatt tgccctctgc ctgtatccaa
     3721 gcaggctaaa aacctagcac acagactctg tggagaaccc cccagcacct ctctggaaga
     3781 tctcccctcc cctagcataa ggttgaccta ggcagaaagc tgcaggcctt gtcctaagac
     3841 agacactctc ctggccttct ctatcccaat tggctcagag tcccctccag gactccccca
     3901 ccccatgtac acaactggag gttgttcttg agggacaaac cgtgatgggg gtgccctagt
     3961 gtcatgcttt cctgcctgaa ggctaagcca gcctgggcct gttcaccact accagtgagg
     4021 atgtgatatt ataaaggcta ggacagataa gccactacat caggcagaat taacaattgg
     4081 tgttgggcct taggaatccc caactgtgcc ccagacacat cctctactgt cttgcagatc
     4141 tgggagtttg cagctggtat gggaggctcg tggtctcccc cagatgcctc acgttttaga
     4201 tcacgtctca gtccgtgcat gttttaataa tgccattctg agccagtttc cacttattct
     4261 tggtccaaag agcagtttgt ttccatgtgg aatgtggctc ttttttttct tttctttttt
     4321 tttttttttt tttttctgtt cttgttttgt ttcatcgatg acctcagtag agacagggga
     4381 agaaaaacta atatattttg tagtatggat ataatccctg ttctctgcat ctgggatatt
     4441 tatattgtgt ctttggaaat gggagttcag tgagcagtgt tggggaggat ggatttatgg
     4501 agggaagaga gggatctagg ggagggagag atgtgaatag aagagaggga acaggagact
     4561 tcagccaggg tgggaaacag tcaacccctg ttgacttgat gagttgtcta gagagactct
     4621 ggagagcccg gtgcttgctg ggaactgcag tgagccctca gttttactct agcacaaaaa
     4681 gtcccagcga tatgagactc cggctgccca gatggctgcc tgagaagggc tgggcctgct
     4741 gctgtgagaa ctatgtggag ttgggaccct aggagccagg ccgtctggac ttgatgttaa
     4801 ggctgtctaa ccaaatgctc ctgcatgacc aggcccaagg tcaaacccca ggaaaggtgg
     4861 agagcaggag ccatggcttg ggttttcttt acatctcctg aaataactga tctgtcaggt
     4921 atctaatata atacacgctg aggggtgaga cccatctctg ccagagagga cagctagaac
     4981 aaagagagac gttattgctg ccatttctgg cattgggaac ctgggtaaag tcacttgaca
     5041 ggcttatgtc cgtccgtctg gcccagggtg gccaccatgg gcaggcacct aagcacctgg
     5101 acaggaaggc agaagcagga cctcagaggc taactgggac cagtcagggg tagaccccac
     5161 agacctcact cccagtaatc accccagggg aagaggaaag agaaagtgtt ttctattctt
     5221 gttgctccca accctggaag ccttaagagg ggctgaaaag caaggctttt cttgtgagct
     5281 ctcctaggga actaatagtt tagcacgatt gtaaggatta cttaggcttt tgtgttaagg
     5341 agggttcctc cctcccagag gaaagcctgg tccaggcccc ctgctgaagc atgttcttcc
     5401 tcttttgagc atcagactga atgattaaac ttggggtcag gtctcatctg gcatcctcat
     5461 atacatagtt acatatgtaa atatctcata gctcccagta atggggccag ctacacacag
     5521 agctgccccc acagcaagca aggcacaagc cactctgccc actcagctgg aacccgctgg
     5581 tgacttggct ttggggcagg tttccagatc cacacccctc cccccagtcc aatgaggttg
     5641 cactagaacc cactctgcct ctgccttctc ctcgggagca cttcagggag ccaccatcag
     5701 ccttgagttc acgagaggag gaaagcctca cagatccagg ccaggagccc acttcctgag
     5761 cgatcccttc cttcacagca ggctctgtgg gagtccaggg gcgggggtag agcagagcag
     5821 gcggcaggct gccatctccc tgcacacagg tttgctttct gaactttgcc cgtcaacatt
     5881 ggccttcagg gagtcagagt aacctactac ctcccccatc gctcccctcc ctcctcctgc
     5941 ggccccaccc acacctatgc tccccttggc acactgatga aaacccaccc acagagccct
     6001 gctcaggtct ctccacccac tggtgtagct gtcaccaatg tttacaacca agggccacct
     6061 cttcctgatg ttttaactct caccttcaca aggctacctg ttagtttgag tttcacctct
     6121 gtctgctcct tccctggtta gggtccactg agtacacaac tctgatttta tcttccctcc
     6181 atctaaggca gtgtgtgatg tgggaatgaa atctcttgta catacttagc acagcacctg
     6241 gagtacgaac tcgcacccct gttctgtaac ggggtgcatt agcgcttact gtaaaacatc
     6301 gggagaagta tagtattgta tttgtaacaa tatcgttctt tgtatacatg aaactcaatg
     6361 atctctatat ataaatataa atatatataa ataaaatata tctacacgtg agcctggaat
     6421 gttgatactg cacacccact gaatgtattt cctctgacag tctaatcacc ggtcctggcc
     6481 caccctcccc ttcttcatgc cgtagtggca gttgtctggt ttggggttgt gacgtattta
     6541 atgtgctctc tccttattta actgaacgct aatgtctgta taagaattgc tggaacaata
     6601 aacaaggact tcaccccctt g
//
