LOCUS       NM_023979               6112 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus apoptotic peptidase activating factor 1 (Apaf1),
            mRNA.
ACCESSION   NM_023979
VERSION     NM_023979.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6112)
  AUTHORS   Bai,L., Yang,J., Zhang,H., Liao,W. and Cen,Y.
  TITLE     PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial
            ischemia/hypoxia-reperfusion injury via inactivation of apoptotic
            protease activating factor-1 (APAF-1)/Caspase9 signaling pathway
  JOURNAL   Bioengineered 12 (1), 4385-4396 (2021)
   PUBMED   34304702
  REMARK    GeneRIF: PTB domain and leucine zipper motif 1 (APPL1) inhibits
            myocardial ischemia/hypoxia-reperfusion injury via inactivation of
            apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling
            pathway.
REFERENCE   2  (bases 1 to 6112)
  AUTHORS   Li,Y., Liang,P., Jiang,B., Tang,Y., Lv,Q., Hao,H., Liu,Z. and
            Xiao,X.
  TITLE     CARD9 inhibits mitochondria-dependent apoptosis of cardiomyocytes
            under oxidative stress via interacting with Apaf-1
  JOURNAL   Free Radic Biol Med 141, 172-181 (2019)
   PUBMED   31212066
  REMARK    GeneRIF: CARD9 protects cardiomyocytes from apoptosis by
            interacting with Apaf-1 and interfering with apoptosome formation
            following myocardial ischemia/reperfusion injury in vivo and in
            vitro
REFERENCE   3  (bases 1 to 6112)
  AUTHORS   Li,T., Ding,Z.L., Zheng,Y.L. and Wang,W.
  TITLE     MiR-484 promotes non-small-cell lung cancer (NSCLC) progression
            through inhibiting Apaf-1 associated with the suppression of
            apoptosis
  JOURNAL   Biomed Pharmacother 96, 153-164 (2017)
   PUBMED   28982084
REFERENCE   4  (bases 1 to 6112)
  AUTHORS   Erol,B., Sari,U., Amasyali,A.S., Ozkanli,S., Sogut,S., Hanci,V.,
            Efiloglu,O., Danacioglu,Y.O., Engin,P., Yencilek,F., Atis,G.,
            Yildirim,A., Alkoc,O.A. and Caskurlu,T.
  TITLE     Comparison of combined antioxidants and thymoquinone in the
            prevention of testis ischemia - reperfusion injury
  JOURNAL   Andrology 5 (1), 119-124 (2017)
   PUBMED   27748062
REFERENCE   5  (bases 1 to 6112)
  AUTHORS   Song,X.F., Tian,H., Zhang,P. and Zhang,Z.X.
  TITLE     Expression of Cyt-c-Mediated Mitochondrial Apoptosis-Related
            Proteins in Rat Renal Proximal Tubules during Development
  JOURNAL   Nephron 135 (1), 77-86 (2017)
   PUBMED   27665619
REFERENCE   6  (bases 1 to 6112)
  AUTHORS   Li,K., Li,Y., Shelton,J.M., Richardson,J.A., Spencer,E., Chen,Z.J.,
            Wang,X. and Williams,R.S.
  TITLE     Cytochrome c deficiency causes embryonic lethality and attenuates
            stress-induced apoptosis
  JOURNAL   Cell 101 (4), 389-399 (2000)
   PUBMED   10830166
REFERENCE   7  (bases 1 to 6112)
  AUTHORS   Yoshida,H., Kong,Y.Y., Yoshida,R., Elia,A.J., Hakem,A., Hakem,R.,
            Penninger,J.M. and Mak,T.W.
  TITLE     Apaf1 is required for mitochondrial pathways of apoptosis and brain
            development
  JOURNAL   Cell 94 (6), 739-750 (1998)
   PUBMED   9753321
REFERENCE   8  (bases 1 to 6112)
  AUTHORS   Cecconi,F., Alvarez-Bolado,G., Meyer,B.I., Roth,K.A. and Gruss,P.
  TITLE     Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian
            development
  JOURNAL   Cell 94 (6), 727-737 (1998)
   PUBMED   9753320
REFERENCE   9  (bases 1 to 6112)
  AUTHORS   Zou,H., Henzel,W.J., Liu,X., Lutschg,A. and Wang,X.
  TITLE     Apaf-1, a human protein homologous to C. elegans CED-4,
            participates in cytochrome c-dependent activation of caspase-3
  JOURNAL   Cell 90 (3), 405-413 (1997)
   PUBMED   9267021
REFERENCE   10 (bases 1 to 6112)
  AUTHORS   Harris,B.S., Franz,T., Ullrich,S., Cook,S., Bronson,R.T. and
            Davisson,M.T.
  TITLE     Forebrain overgrowth (fog): a new mutation in the mouse affecting
            neural tube development
  JOURNAL   Teratology 55 (4), 231-240 (1997)
   PUBMED   9216040
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_023979.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF320222.1, AF218388.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               JAXUCZ010000007.1  27466197-27466772   c
            577-755             JAXUCZ010000007.1  27464357-27464535   c
            756-945             JAXUCZ010000007.1  27463843-27464032   c
            946-1143            JAXUCZ010000007.1  27462480-27462677   c
            1144-1327           JAXUCZ010000007.1  27451692-27451875   c
            1328-1440           JAXUCZ010000007.1  27446828-27446940   c
            1441-1572           JAXUCZ010000007.1  27446578-27446709   c
            1573-1811           JAXUCZ010000007.1  27445398-27445636   c
            1812-1979           JAXUCZ010000007.1  27444719-27444886   c
            1980-2111           JAXUCZ010000007.1  27443667-27443798   c
            2112-2225           JAXUCZ010000007.1  27439912-27440025   c
            2226-2410           JAXUCZ010000007.1  27438048-27438232   c
            2411-2537           JAXUCZ010000007.1  27432905-27433031   c
            2538-2663           JAXUCZ010000007.1  27431637-27431762   c
            2664-2795           JAXUCZ010000007.1  27425072-27425203   c
            2796-2921           JAXUCZ010000007.1  27422372-27422497   c
            2922-3083           JAXUCZ010000007.1  27416994-27417155   c
            3084-3212           JAXUCZ010000007.1  27412503-27412631   c
            3213-3338           JAXUCZ010000007.1  27410766-27410891   c
            3339-3458           JAXUCZ010000007.1  27407264-27407383   c
            3459-3575           JAXUCZ010000007.1  27401962-27402078   c
            3576-3701           JAXUCZ010000007.1  27399300-27399425   c
            3702-3821           JAXUCZ010000007.1  27392658-27392777   c
            3822-3947           JAXUCZ010000007.1  27391362-27391487   c
            3948-4073           JAXUCZ010000007.1  27388753-27388878   c
            4074-4220           JAXUCZ010000007.1  27386959-27387105   c
            4221-6112           JAXUCZ010000007.1  27381842-27383733   c
FEATURES             Location/Qualifiers
     source          1..6112
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..6112
                     /gene="Apaf1"
                     /note="apoptotic peptidase activating factor 1"
                     /db_xref="GeneID:78963"
                     /db_xref="RGD:620575"
     exon            1..576
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..755
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             618..4367
                     /gene="Apaf1"
                     /note="apaf-1"
                     /codon_start=1
                     /product="apoptotic protease-activating factor 1"
                     /protein_id="NP_076469.1"
                     /db_xref="GeneID:78963"
                     /db_xref="RGD:620575"
                     /translation="MDAKARNCLLQHKEALEKDIKTSYIMDHMISNGVLTVVEEEKVK
                     SQATQYQRAAALIKMILNKDNYAYISFYNALLHEGYKDLAGLLHSGLPLVSSSSGKDT
                     DGGNTSFVRTVLCEGGVPQRPVIFVTRKKLVSAIQQKLWKLNGEPGWVTIYGMAGCGK
                     SVLAAEAVRDHALLEGCFSGGVHWVSIGKQDKSGLLMKLQNLCTRLGQEESFSQRLPL
                     NIEEAKDRLRVLMLRKHPRSLLILDDVWDPWVLKAFDNQCQILLTTRDKSVTDSVMGP
                     KYVIPVESGLGKEKGLEILSLFVNMKKEDLPVEAHSIIKECKGSPLVVSLVGALLRDF
                     PNRWAYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKD
                     VKVPTKVLCVLWDLETEEVEDILQEFVNKSLLFCNRNGKSFCYYLHDLQVDFLTEKNR
                     SQLQDLHRKMVTQFQRYHQPHTLSPGQEDCMYWYNFLAYHMASAGMHKELCALMFSLD
                     WIKAKTELVGPAHLIHEFVEYRHILDEKDCAVCENFQEFLSLNGHLLGRQPFPNIVQL
                     GLCEPETSEVYQQAKLQAKQEVDTGRLYLEWINKKTIKNLSRLVVRPHTDAVYHACFS
                     QDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVK
                     IWDSGTGKLVHTYEEHSEQVNCCHFTNKSNHLLLATGSNDSFLKLWDLNQKECRNTMF
                     GHTNSVTHCRFSPDDELLASCSADGTLKLWDVRSANEKKSINVKRFFLSSEDPPEDVE
                     VIVKCCSWSADGDRIIVAAKNKVLLLDIHTSGLLTEIHTGHHSTIQYCDFSPYDHLAV
                     IALSQYCVELWNIDSRVKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETRKV
                     CKNSAIVLKQEIDVVFQENEMMVLAVDNIRGLQLIAGKTGQIDYLPEAQVSCCCLSPH
                     LEYVAFGDEEGAIKIIELPNNRVFSSGIGHKKAVRHIQFTADGKTLISSSEDSVIQVW
                     NWQTEEYVFLQAHQETVKDFRLLRDSRLLSWSFDGTVKVWNVITGRIERDFTCHQGTV
                     LSCAISSDATKFSSTSADKTAKIWSFELPSPLHELKGHNSCVRCSAFSLDGILLATGD
                     DNGEIRIWNVSDGQLLHLCAPISIEEGTATHGGWVTDVCFSPDRKMLVSAGGYLKWWN
                     VVTGESSQTFYTNGTNLKKIHVSPDFRTYVTVDNLGILYILQVLE"
     exon            756..945
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1143
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1327
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1440
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1572
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1811
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1979
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2111
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2225
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2410
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2537
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2663
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2795
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2921
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3083
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3212
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3338
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3458
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3575
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3701
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3821
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3822..3947
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4073
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4220
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            4221..6112
                     /gene="Apaf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggacgggg cgggcccagc tgtgtttgag tgctccgcgg tcctgggagc cagagacctg
       61 gaggaagcga gctgggtaga cggctttctc cgctcgcgga agggtgtgag aggagtgtgt
      121 gggggtcggc agctagaggt gtgtgcagtc agccaccggc gaggagctga gacagtcgcc
      181 gcagctttcc gagccgcatc cgcttcccgc ccggggcagc tccggctgga ggggtgaagc
      241 ggcggctgga gtggccgtgc ttttgtgtcc tggatccggg taccctccct cccctggtgc
      301 tgcccgaggc aagtccatcg aggtgatcac tcctcgacgc cgctcggaaa tcctgggcat
      361 cccccctgcg ccccgagcgg ctgataccca ggtgaggcac ctgaggtgtc aggacctgcc
      421 cggggcgcgg ggtgtccgga agccaggcgg gagccccggc tgctttttgg caatcgattc
      481 ccatctgtga ccctccccga gctgttttct atcgaatctc atctgtgatc ctcccccggc
      541 tgctcttccc aggacaactc cggtgcaaag gcttggctca tgctcgacgg cgaggggaga
      601 aaaaaagctg agggacaatg gatgcaaagg cccgaaattg tttgcttcaa cataaagaag
      661 ctctggaaaa ggacatcaaa acatcctaca tcatggatca catgatcagt aatggcgtct
      721 taacagtagt agaggaggaa aaggtcaaaa gtcaggccac tcaatatcaa cgagcagctg
      781 ctttaattaa aatgatactt aataaagaca attatgccta catttcattc tacaacgctc
      841 tactacacga gggctataaa gaccttgctg gacttctgca tagcggcctt cctcttgtgt
      901 cttcttccag cggcaaggac acagacggtg gaaacacttc atttgtaagg acagtgctgt
      961 gtgaaggtgg agtgccacag aggccagtca tctttgtcac taggaagaag ctggtcagtg
     1021 cgattcagca gaagctctgg aaactgaatg gggagccagg gtgggtcacc atctatggaa
     1081 tggcaggctg tggcaagtct gtattagctg cggaagctgt tcgcgaccat gccctcctag
     1141 aaggttgttt ttcagggggc gtacactggg tttccatcgg aaaacaagac aagtccgggc
     1201 ttctaatgaa gctgcagaat ctttgcacgc ggttgggtca agaagagagt ttctctcaga
     1261 ggctcccgct taacattgag gaggccaaag accgtctccg tgttctgatg ctgcgaaaac
     1321 acccaaggtc tctgttgatc ttggatgacg tttgggatcc ttgggtgtta aaggcttttg
     1381 acaaccagtg tcagattctt cttaccacca gagataagag tgttaccgat tcagtaatgg
     1441 gtcctaagta tgttatccct gtggagagtg gtctagggaa agagaaggga cttgaaatct
     1501 tgtcactttt tgttaatatg aagaaagaag atctgccagt ggaggctcac agtattataa
     1561 aggagtgcaa aggctctcct ctcgtcgtgt ctttagttgg tgcgctttta cgggattttc
     1621 ccaatcgctg ggcatactac ctcaggcagc ttcagaataa gcagtttaag agaataagga
     1681 aatcttcatc ttatgactac gaggctctgg atgaagccat gtccataagt gtggagatgc
     1741 tcagagaaga catcaaggac tactacacag acctctccat ccttcagaag gatgtcaagg
     1801 tgcctacgaa ggtgctgtgt gttctctggg acttggaaac ggaagaagtt gaagacatct
     1861 tgcaggagtt cgttaataag tctctcttat tctgtaatcg gaatgggaag tcattttgtt
     1921 attatttaca cgatcttcaa gtagatttcc ttacagagaa gaatcgaagt cagctccagg
     1981 atctgcacag gaagatggtc actcaatttc agaggtatca ccagccgcat acgctgtctc
     2041 caggtcagga ggactgcatg tactggtaca acttcctggc ctatcatatg gccagtgccg
     2101 gtatgcacaa agaactttgt gctttaatgt tttccctgga ttggattaaa gcaaaaacag
     2161 aacttgtcgg ccctgcgcat ctgattcatg agttcgtgga atataggcat atactggatg
     2221 aaaaggattg tgcagtctgt gagaattttc aggagttttt atctttaaac ggacaccttc
     2281 ttggacgaca gccatttcct aacattgtgc aactgggcct ctgtgaacca gagacttccg
     2341 aagtttatca acaagcaaag ctgcaggcca agcaggaggt ggataccggg cggctttacc
     2401 tggaatggat caacaaaaaa accatcaaga atctgtcccg cttagtcgtt cgcccccata
     2461 cagacgccgt gtaccatgcg tgtttttctc aggatggtca gagaatagct tcttgtggag
     2521 ctgataaaac cttgcaggtg tttaaagccg agacaggaga gaaacttctt gacattaaag
     2581 ctcatgaaga tgaggtgctt tgctgtgcgt tctcctcaga tgacagttac atagcaacct
     2641 gctcagtgga taagaaagtt aagatttggg attctgggac tgggaagcta gtgcacacct
     2701 acgaagaaca ctcagagcag gtcaattgct gccatttcac caataagagc aaccaccttc
     2761 ttttggccac cgggtcaaat gactccttcc ttaagctctg ggatttgaat caaaaagaat
     2821 gccgaaatac catgttcggt cacacgaact cagtcaccca ctgcaggttc tcaccagacg
     2881 atgagctctt ggcgagttgc tcagccgacg ggactttaaa gctttgggat gtgagatcag
     2941 caaacgagaa gaaaagcatt aatgtgaagc gcttcttcct gagttcagaa gacccaccag
     3001 aggacgtgga ggtgatcgtg aaatgttgct cctggtctgc agatggcgac agaataatag
     3061 tggcagcaaa aaacaaagtc ctccttcttg atattcatac tagtggcctg ctgactgaga
     3121 tccacacagg tcatcacagc accatccagt actgtgactt ctccccctac gaccatttgg
     3181 cagtgattgc cctgtctcag tactgtgtgg agttgtggaa catagactcc cgggtaaagg
     3241 tggctgactg caggggacat ttaagttggg tccacggtgt gatgttttct cctgatggct
     3301 cctcgttctt gacagcttct gatgaccaaa caataagggt ctgggagaca agaaaggtgt
     3361 gcaagaactc tgccattgtg ttaaagcagg aaatagatgt cgtgtttcaa gaaaacgaaa
     3421 tgatggtcct tgcagttgac aacataagag gcctacaact cattgctgga aaaacaggcc
     3481 agattgatta cctgcctgaa gcccaagtga gttgctgctg cctaagtcca catcttgagt
     3541 acgttgcatt tggagatgaa gagggagcca ttaagattat agaacttcca aacaacagag
     3601 ttttcagctc tgggattggg cacaagaaag ctgtacggca catccagttc acagctgatg
     3661 ggaagacact gatttcaagt tctgaagact ctgtgattca ggtgtggaat tggcagacag
     3721 aggagtatgt atttctgcaa gcccatcagg aaacagtaaa ggacttcaga ctcctgagag
     3781 attcacgatt gctttcctgg tcattcgatg gaacggtgaa ggtgtggaat gtcattaccg
     3841 gaagaattga aagagacttt acttgtcatc agggcacagt gctttcctgt gctatctctt
     3901 ctgatgccac caagttttca tctacctcag ctgataagac cgccaagatc tggagttttg
     3961 aactcccttc ccctcttcat gagctgaagg gccataacag ctgtgtccgc tgctctgcct
     4021 tctcgctgga tggcatcctg ttagcaactg gagatgacaa tggagaaatc aggatatgga
     4081 atgtctcaga tggccagctt cttcatttgt gtgctccgat ttccatagaa gaaggaacgg
     4141 ctacccacgg aggctgggtg actgatgttt gcttctctcc tgacagaaaa atgcttgtct
     4201 ctgccggagg ataccttaag tggtggaatg ttgttactgg ggagtcctca cagaccttct
     4261 acaccaatgg aacaaacctc aagaaaatac atgtgtcccc tgacttcaga acatatgtga
     4321 ccgttgataa tcttggtatt ttatatattt tacaggtttt agagtaaagt gactgagcct
     4381 taatgtagct cagcccctta attttaaatt gaaaaaaaat tgaaactgtg catcaacttt
     4441 cgataaagct gtgaattgta ctgcagtatt gcaaacattg tttacagccg gatcaataat
     4501 gcatatagta taatagtata tctccacaaa cacacaggct tttactgttt tttaaataca
     4561 atcattgtta ttaacagttt gtcctcaaca tgcaaatgaa tgtaaatatg taccttgtta
     4621 ggctatgggt aaactctttg atgcattcag attggttggc aaaattaatg ccaattgttt
     4681 gaaggattct atatgttgaa gctgtcatta tgcaggctat gccgcagggt gatagtggtc
     4741 agtatggtgg gtgggttttt tgacccatgc ttaccccagg ggtctggctt tccaaatcag
     4801 tcaattgtgt tgcgtcttca cactctttaa atttgcttta aggtattgca tcctggtgca
     4861 cagtctgcgg catgatttct gataacccag ttctttctct gagcgagtca tgtgttagag
     4921 agatctctct gtaccacaag gtagctgtgc atttggctgg actctggccc tcagagtctt
     4981 tgaactggac accaccctgc actcccttag ttgttttgtt tggtctttaa agagaggcta
     5041 tcttggcatc aatatgtaga ccaggttagc cttgaactca gagatcagcc tgcctctgcc
     5101 tcctgagttc tgggattgaa ggtatgggcc accactgcct ttctctctca gttttatact
     5161 tactacttta ctaagcttga cctcttttaa cctcttctcc atagctaggt gttagtaagc
     5221 cagtgaaata gtaccacaca ttcccctttg atcccttgta tgtcatcacc aaggccgtac
     5281 tctttatgac tttcaagagt cacagaaaac cctcccccca tacacccatg tctccctggg
     5341 aaatgagagc tcattgcgtt atgcagtgat tttgatcctc ctgcatcaga ctcctaagta
     5401 tctgggagag gtgtcttttg atgcagaaaa aaaccaaacc aaaacaaaac tgtgcaacac
     5461 cactaccaag tttttttttt taaacctcct tttagggtct ttaattgaag cttgtttaat
     5521 cactgtcccc tgaaatatta ctaagggcaa tagagataaa ttagtagtag atgtagtttt
     5581 tatataaata aaaaaatcaa atatcttcat tttgcaatag gaattaatgt gtcttagcaa
     5641 tagtagtcga tagtgaagct gtttgtgtgg tcgtgcatat tgccagctgt ggtgtgggca
     5701 gagggaagga agcacaagtg tgttttagag tttacttctc tatggtgctg aagattgaaa
     5761 ccagggcctt gcacacacta gacaagccct ctaccacccg gctgcactcc tggcccttag
     5821 gtggatttca gattagatat tcccagggcg ttttcaggag ctgtaaatag agtgaacaaa
     5881 atcttgtata gagttcagga agtttgttct tttctaacct tttttgttag gttgaggaac
     5941 cactttacct acttactgtg atataagcca atgtgattag tggaaatctt aattttataa
     6001 aataaatatt agaagaagta tgtcggggtt ggggatttag ctcagtggta gagcgcttgc
     6061 ctaggaagcg caaggccctg ggttcggtcc ccagctccga aaaaaaagaa cc
//
