LOCUS       NM_001037977            1651 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus adaptor related protein complex 4 subunit mu 1
            (Ap4m1), transcript variant 1, mRNA.
ACCESSION   NM_001037977 XM_222003
VERSION     NM_001037977.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1651)
  AUTHORS   Raza,M.H., Mattera,R., Morell,R., Sainz,E., Rahn,R., Gutierrez,J.,
            Paris,E., Root,J., Solomon,B., Brewer,C., Basra,M.A., Khan,S.,
            Riazuddin,S., Braun,A., Bonifacino,J.S. and Drayna,D.
  TITLE     Association between Rare Variants in AP4E1, a Component of
            Intracellular Trafficking, and Persistent Stuttering
  JOURNAL   Am J Hum Genet 97 (5), 715-725 (2015)
   PUBMED   26544806
REFERENCE   2  (bases 1 to 1651)
  AUTHORS   Zhang,J., Cheng,X.Y. and Sheng,G.Y.
  TITLE     AP4M1 is abnormally expressed in oxygen-glucose deprived
            hippocampal neurons
  JOURNAL   Neurosci Lett 563, 85-89 (2014)
   PUBMED   24486887
  REMARK    GeneRIF: AP4M1 is not only down-regulated at both the mRNA and
            protein levels, but also redistributed from dendrites to axons in
            oxygen-glucose deprived hippocampal neurons.
REFERENCE   3  (bases 1 to 1651)
  AUTHORS   Burgos,P.V., Mardones,G.A., Rojas,A.L., daSilva,L.L., Prabhu,Y.,
            Hurley,J.H. and Bonifacino,J.S.
  TITLE     Sorting of the Alzheimer's disease amyloid precursor protein
            mediated by the AP-4 complex
  JOURNAL   Dev Cell 18 (3), 425-436 (2010)
   PUBMED   20230749
REFERENCE   4  (bases 1 to 1651)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1651)
  AUTHORS   Matsuda,S., Miura,E., Matsuda,K., Kakegawa,W., Kohda,K.,
            Watanabe,M. and Yuzaki,M.
  TITLE     Accumulation of AMPA receptors in autophagosomes in neuronal axons
            lacking adaptor protein AP-4
  JOURNAL   Neuron 57 (5), 730-745 (2008)
   PUBMED   18341993
REFERENCE   6  (bases 1 to 1651)
  AUTHORS   Yap,C.C., Murate,M., Kishigami,S., Muto,Y., Kishida,H.,
            Hashikawa,T. and Yano,R.
  TITLE     Adaptor protein complex-4 (AP-4) is expressed in the central
            nervous system neurons and interacts with glutamate receptor delta2
  JOURNAL   Mol Cell Neurosci 24 (2), 283-295 (2003)
   PUBMED   14572453
REFERENCE   7  (bases 1 to 1651)
  AUTHORS   Simmen,T., Honing,S., Icking,A., Tikkanen,R. and Hunziker,W.
  TITLE     AP-4 binds basolateral signals and participates in basolateral
            sorting in epithelial MDCK cells
  JOURNAL   Nat Cell Biol 4 (2), 154-159 (2002)
   PUBMED   11802162
REFERENCE   8  (bases 1 to 1651)
  AUTHORS   Aguilar,R.C., Boehm,M., Gorshkova,I., Crouch,R.J., Tomita,K.,
            Saito,T., Ohno,H. and Bonifacino,J.S.
  TITLE     Signal-binding specificity of the mu4 subunit of the adaptor
            protein complex AP-4
  JOURNAL   J Biol Chem 276 (16), 13145-13152 (2001)
   PUBMED   11139587
REFERENCE   9  (bases 1 to 1651)
  AUTHORS   Dell'Angelica,E.C., Mullins,C. and Bonifacino,J.S.
  TITLE     AP-4, a novel protein complex related to clathrin adaptors
  JOURNAL   J Biol Chem 274 (11), 7278-7285 (1999)
   PUBMED   10066790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000225.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001037977.3.
            
            On Oct 29, 2022 this sequence version replaced NM_001037977.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ298439.1, SRR8487226.46512.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JACYVU010000225.1  3749124-3749253
            131-219             JACYVU010000225.1  3749354-3749442
            220-326             JACYVU010000225.1  3749938-3750044
            327-423             JACYVU010000225.1  3750121-3750217
            424-534             JACYVU010000225.1  3751634-3751744
            535-615             JACYVU010000225.1  3751827-3751907
            616-678             JACYVU010000225.1  3752779-3752841
            679-745             JACYVU010000225.1  3752922-3752988
            746-799             JACYVU010000225.1  3753079-3753132
            800-906             JACYVU010000225.1  3753235-3753341
            907-1001            JACYVU010000225.1  3753440-3753534
            1002-1046           JACYVU010000225.1  3753768-3753812
            1047-1097           JACYVU010000225.1  3754524-3754574
            1098-1209           JACYVU010000225.1  3754671-3754782
            1210-1651           JACYVU010000225.1  3754865-3755306
FEATURES             Location/Qualifiers
     source          1..1651
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1651
                     /gene="Ap4m1"
                     /note="adaptor related protein complex 4 subunit mu 1"
                     /db_xref="GeneID:304344"
                     /db_xref="RGD:1310233"
     exon            1..130
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1434
                     /gene="Ap4m1"
                     /function="intracellular transport of membrane protein
                     from TGN to plasma membrane"
                     /note="isoform 1 is encoded by transcript variant 1; AP-4
                     complex subunit mu-1; mu4; mu-ARP2; mu4-adaptin; mu
                     subunit of AP-4; mu-adaptin-related protein 2; AP-4
                     adapter complex mu subunit; adaptor-related protein
                     complex 4, mu 1 subunit; adapter-related protein complex 4
                     mu-1 subunit; adaptor-related protein complex AP-4, mu 1;
                     adapter-related protein complex 4 subunit mu-1; AP-4
                     adaptor complex mu subunit"
                     /codon_start=1
                     /product="AP-4 complex subunit mu-1 isoform 1"
                     /protein_id="NP_001033066.1"
                     /db_xref="GeneID:304344"
                     /db_xref="RGD:1310233"
                     /translation="MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGGE
                     SPVVMYHDDRHFIHIRHSGLYLVATTSENVSPFSLLELLSRLATLLGDYCGSLNEGTI
                     SRNVALVYELLDEVLDYGYVQTTSTDMLRNFIQTEAAVSKPFSLFDLSSVGLFGAETQ
                     QNRVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKS
                     FLPSSSEICIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILHLQPPQ
                     GELTVMRYQLSDDLPSPLPFRLFPSVQWDQGSGRLQVYLKLRCDLPPKSQALNIHLHL
                     PLPRGVVSLSQELSSPDQKAELGEGALHWDLPRVQGGSQLSGLFQMDVPGLQGPPSRG
                     PSPSAPPLGLGPASLSFELPRHTCSGLQVRFLRLSFSACGNANPHKWVRHLSHSNAYV
                     IRI"
     exon            131..219
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            220..326
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..423
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..534
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..615
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..678
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..745
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..799
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..906
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1001
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1046
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1097
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1209
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1651
                     /gene="Ap4m1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttgttcc gtgtccgcaa ggcggggtgg gttcaacttt caccgtcttc ttgtctatcc
       61 ttcagaacgg ccatgatttc ccagttcttc attctgtctt ccaaggggga tccgctcatc
      121 tataaagact tccgagggga tagtggtggt cgtgatgtgg ccgagctctt ctaccggaag
      181 ctgacgggac tgccgggagg cgagtccccg gttgtcatgt atcacgatga tcgtcatttt
      241 attcacatca gacacagtgg tctctatttg gtggccacaa cttcagaaaa tgtctctcct
      301 ttcagcctcc tggagctact ttccaggtta gccactctct tgggtgacta ctgtggctca
      361 ctcaatgagg ggaccatctc acggaatgtg gcgcttgtct acgaactcct ggatgaagtg
      421 ctggattacg gctatgtgca gactacgtcc acagacatgc tgaggaactt catccaaact
      481 gaagccgcgg tcagcaagcc tttcagcctc ttcgacctca gcagcgtcgg tctgtttggg
      541 gcagagacgc agcagaacag agtggcccca agcagtgcag ccagccgccc tgtcctgtcc
      601 agtcgttctg accagagcca aaagaatgaa gtgtttttag atgtggtcga aaggctgtct
      661 gttctgattg catctaatgg ctccctgttg aaggtggatg tccaaggaga gatccggctc
      721 aagagcttcc tccccagcag ttctgagata tgcattggct tgacagaaga attctgtgtt
      781 ggaaagtcag aactgagagg ttatgggcca gggattcgag ttgatgaggt gtcattccat
      841 agctctgtca atctagatga gtttgaatct catcggatcc tccacctgca gccgcctcag
      901 ggcgagctga ctgtgatgag ataccagctc tctgatgacc tcccctcacc acttcccttc
      961 cggctgtttc cctctgtaca atgggaccaa ggctcaggcc ggctccaggt ttacctgaag
     1021 ttacggtgtg acctgccccc aaagagccaa gctctcaaca ttcatctgca ccttcccctg
     1081 cctcgagggg tcgtcagcct gtctcaggaa ctgagcagcc cagatcagaa ggcagagctg
     1141 ggagaaggag cccttcactg ggacctgccc cgggtacaag gaggttctca actctctggc
     1201 cttttccaga tggatgtccc tggcttgcag ggacctccca gccgtgggcc gtccccctca
     1261 gcacccccct tggggctggg tcctgccagc ctctcctttg aactccctcg gcacacatgc
     1321 tctggcctcc aggttcgatt cctcagactg tcctttagcg cctgtggtaa tgctaaccct
     1381 cacaagtggg ttcgacatct aagccacagc aacgcctacg taattcggat ttgaatctcc
     1441 tcaaagaagg atatggacag caatgtcagc aggcattttc tttcttgtga ctttggatct
     1501 ggacaggaag gttccacaga ctcacccctt ctgttttgtg acacagggag gctcacaaag
     1561 ttacaaatcc aacttttatt ctgaggaact tactgttaca gaatctaaaa agaaagtcac
     1621 tggggaaaac atctttcttc ttcctccctc a
//
