LOCUS       NP_001033066             453 aa            linear   ROD 03-APR-2024
DEFINITION  AP-4 complex subunit mu-1 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001033066 XP_222003
VERSION     NP_001033066.1
DBSOURCE    REFSEQ: accession NM_001037977.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 453)
  AUTHORS   Raza,M.H., Mattera,R., Morell,R., Sainz,E., Rahn,R., Gutierrez,J.,
            Paris,E., Root,J., Solomon,B., Brewer,C., Basra,M.A., Khan,S.,
            Riazuddin,S., Braun,A., Bonifacino,J.S. and Drayna,D.
  TITLE     Association between Rare Variants in AP4E1, a Component of
            Intracellular Trafficking, and Persistent Stuttering
  JOURNAL   Am J Hum Genet 97 (5), 715-725 (2015)
   PUBMED   26544806
REFERENCE   2  (residues 1 to 453)
  AUTHORS   Zhang,J., Cheng,X.Y. and Sheng,G.Y.
  TITLE     AP4M1 is abnormally expressed in oxygen-glucose deprived
            hippocampal neurons
  JOURNAL   Neurosci Lett 563, 85-89 (2014)
   PUBMED   24486887
  REMARK    GeneRIF: AP4M1 is not only down-regulated at both the mRNA and
            protein levels, but also redistributed from dendrites to axons in
            oxygen-glucose deprived hippocampal neurons.
REFERENCE   3  (residues 1 to 453)
  AUTHORS   Burgos,P.V., Mardones,G.A., Rojas,A.L., daSilva,L.L., Prabhu,Y.,
            Hurley,J.H. and Bonifacino,J.S.
  TITLE     Sorting of the Alzheimer's disease amyloid precursor protein
            mediated by the AP-4 complex
  JOURNAL   Dev Cell 18 (3), 425-436 (2010)
   PUBMED   20230749
REFERENCE   4  (residues 1 to 453)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (residues 1 to 453)
  AUTHORS   Matsuda,S., Miura,E., Matsuda,K., Kakegawa,W., Kohda,K.,
            Watanabe,M. and Yuzaki,M.
  TITLE     Accumulation of AMPA receptors in autophagosomes in neuronal axons
            lacking adaptor protein AP-4
  JOURNAL   Neuron 57 (5), 730-745 (2008)
   PUBMED   18341993
REFERENCE   6  (residues 1 to 453)
  AUTHORS   Yap,C.C., Murate,M., Kishigami,S., Muto,Y., Kishida,H.,
            Hashikawa,T. and Yano,R.
  TITLE     Adaptor protein complex-4 (AP-4) is expressed in the central
            nervous system neurons and interacts with glutamate receptor delta2
  JOURNAL   Mol Cell Neurosci 24 (2), 283-295 (2003)
   PUBMED   14572453
REFERENCE   7  (residues 1 to 453)
  AUTHORS   Simmen,T., Honing,S., Icking,A., Tikkanen,R. and Hunziker,W.
  TITLE     AP-4 binds basolateral signals and participates in basolateral
            sorting in epithelial MDCK cells
  JOURNAL   Nat Cell Biol 4 (2), 154-159 (2002)
   PUBMED   11802162
REFERENCE   8  (residues 1 to 453)
  AUTHORS   Aguilar,R.C., Boehm,M., Gorshkova,I., Crouch,R.J., Tomita,K.,
            Saito,T., Ohno,H. and Bonifacino,J.S.
  TITLE     Signal-binding specificity of the mu4 subunit of the adaptor
            protein complex AP-4
  JOURNAL   J Biol Chem 276 (16), 13145-13152 (2001)
   PUBMED   11139587
REFERENCE   9  (residues 1 to 453)
  AUTHORS   Dell'Angelica,E.C., Mullins,C. and Bonifacino,J.S.
  TITLE     AP-4, a novel protein complex related to clathrin adaptors
  JOURNAL   J Biol Chem 274 (11), 7278-7285 (1999)
   PUBMED   10066790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Dec 23, 2005 this sequence version replaced XP_222003.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ298439.1, SRR26643429.42681.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     Protein         1..453
                     /product="AP-4 complex subunit mu-1 isoform 1"
                     /function="intracellular transport of membrane protein
                     from TGN to plasma membrane"
                     /note="AP-4 complex subunit mu-1; mu4; mu-ARP2;
                     mu4-adaptin; mu subunit of AP-4; mu-adaptin-related
                     protein 2; AP-4 adapter complex mu subunit;
                     adaptor-related protein complex 4, mu 1 subunit;
                     adapter-related protein complex 4 mu-1 subunit;
                     adaptor-related protein complex AP-4, mu 1;
                     adapter-related protein complex 4 subunit mu-1; AP-4
                     adaptor complex mu subunit"
                     /calculated_mol_wt=49722
     Region          3..141
                     /region_name="AP4_Mu_N"
                     /note="AP-4 complex subunit mu N-terminal domain; cd14838"
                     /db_xref="CDD:341442"
     Site            order(18,21,45..46,55,57,59,71..73,75..77,80,84,110..111,
                     114..115,117..119,121..124,133,135..136)
                     /site_type="other"
                     /note="putative AP-4 beta interface [polypeptide binding]"
                     /db_xref="CDD:341442"
     Region          175..453
                     /region_name="AP-4_Mu4_Cterm"
                     /note="C-terminal domain of medium Mu4 subunit in adaptor
                     protein (AP) complex AP-4; cd09253"
                     /db_xref="CDD:271161"
     Site            order(188..190,217,328,410,412,421,438..441,443)
                     /site_type="other"
                     /note="putative signal peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271161"
     Site            order(254..257,259,261,264..265,280,283)
                     /site_type="other"
                     /note="signal peptide binding site [polypeptide binding]"
                     /db_xref="CDD:271161"
     Region          383..403
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2PWT8.1)"
     CDS             1..453
                     /gene="Ap4m1"
                     /coded_by="NM_001037977.3:73..1434"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:304344"
                     /db_xref="RGD:1310233"
ORIGIN      
        1 misqffilss kgdpliykdf rgdsggrdva elfyrkltgl pggespvvmy hddrhfihir
       61 hsglylvatt senvspfsll ellsrlatll gdycgslneg tisrnvalvy elldevldyg
      121 yvqttstdml rnfiqteaav skpfslfdls svglfgaetq qnrvapssaa srpvlssrsd
      181 qsqknevfld vverlsvlia sngsllkvdv qgeirlksfl pssseicigl teefcvgkse
      241 lrgygpgirv devsfhssvn ldefeshril hlqppqgelt vmryqlsddl psplpfrlfp
      301 svqwdqgsgr lqvylklrcd lppksqalni hlhlplprgv vslsqelssp dqkaelgega
      361 lhwdlprvqg gsqlsglfqm dvpglqgpps rgpspsappl glgpaslsfe lprhtcsglq
      421 vrflrlsfsa cgnanphkwv rhlshsnayv iri
//
