LOCUS       NM_001107646            3712 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus adaptor related protein complex 3 subunit beta 1
            (Ap3b1), mRNA.
ACCESSION   NM_001107646 XM_001067082 XM_226666
VERSION     NM_001107646.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3712)
  AUTHORS   Vallejo,M.O., Niemeyer,G.P., Vaglenov,A., Hock,T., Urie,B.,
            Christopherson,P. and Lothrop,C.D. Jr.
  TITLE     Decreased hematopoietic progenitor cell mobilization in pearl mice
  JOURNAL   Exp Hematol 41 (10), 848-857 (2013)
   PUBMED   23748140
REFERENCE   2  (bases 1 to 3712)
  AUTHORS   Bultema,J.J., Ambrosio,A.L., Burek,C.L. and Di Pietro,S.M.
  TITLE     BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and
            Rab32 proteins to mediate protein trafficking to lysosome-related
            organelles
  JOURNAL   J Biol Chem 287 (23), 19550-19563 (2012)
   PUBMED   22511774
REFERENCE   3  (bases 1 to 3712)
  AUTHORS   Gochuico,B.R., Huizing,M., Golas,G.A., Scher,C.D., Tsokos,M.,
            Denver,S.D., Frei-Jones,M.J. and Gahl,W.A.
  TITLE     Interstitial lung disease and pulmonary fibrosis in
            Hermansky-Pudlak syndrome type 2, an adaptor protein-3 complex
            disease
  JOURNAL   Mol Med 18 (1), 56-64 (2012)
   PUBMED   22009278
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3712)
  AUTHORS   Larimore,J., Tornieri,K., Ryder,P.V., Gokhale,A., Zlatic,S.A.,
            Craige,B., Lee,J.D., Talbot,K., Pare,J.F., Smith,Y. and Faundez,V.
  TITLE     The schizophrenia susceptibility factor dysbindin and its
            associated complex sort cargoes from cell bodies to the synapse
  JOURNAL   Mol Biol Cell 22 (24), 4854-4867 (2011)
   PUBMED   21998198
REFERENCE   5  (bases 1 to 3712)
  AUTHORS   Sasai,M., Linehan,M.M. and Iwasaki,A.
  TITLE     Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3
  JOURNAL   Science 329 (5998), 1530-1534 (2010)
   PUBMED   20847273
REFERENCE   6  (bases 1 to 3712)
  AUTHORS   Huizing,M., Sarangarajan,R., Strovel,E., Zhao,Y., Gahl,W.A. and
            Boissy,R.E.
  TITLE     AP-3 mediates tyrosinase but not TRP-1 trafficking in human
            melanocytes
  JOURNAL   Mol Biol Cell 12 (7), 2075-2085 (2001)
   PUBMED   11452004
REFERENCE   7  (bases 1 to 3712)
  AUTHORS   Feng,L., Rigatti,B.W., Novak,E.K., Gorin,M.B. and Swank,R.T.
  TITLE     Genomic structure of the mouse Ap3b1 gene in normal and pearl mice
  JOURNAL   Genomics 69 (3), 370-379 (2000)
   PUBMED   11056055
REFERENCE   8  (bases 1 to 3712)
  AUTHORS   Yang,W., Li,C., Ward,D.M., Kaplan,J. and Mansour,S.L.
  TITLE     Defective organellar membrane protein trafficking in
            Ap3b1-deficient cells
  JOURNAL   J Cell Sci 113 (Pt 22), 4077-4086 (2000)
   PUBMED   11058094
REFERENCE   9  (bases 1 to 3712)
  AUTHORS   Feng,L., Seymour,A.B., Jiang,S., To,A., Peden,A.A., Novak,E.K.,
            Zhen,L., Rusiniak,M.E., Eicher,E.M., Robinson,M.S., Gorin,M.B. and
            Swank,R.T.
  TITLE     The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is
            altered in the mouse hypopigmentation mutant pearl, a model for
            Hermansky-Pudlak syndrome and night blindness
  JOURNAL   Hum Mol Genet 8 (2), 323-330 (1999)
   PUBMED   9931340
REFERENCE   10 (bases 1 to 3712)
  AUTHORS   Novak,E.K., Hui,S.W. and Swank,R.T.
  TITLE     Platelet storage pool deficiency in mouse pigment mutations
            associated with seven distinct genetic loci
  JOURNAL   Blood 63 (3), 536-544 (1984)
   PUBMED   6696991
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473955.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_226666.4, XM_001067082.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3712
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..3712
                     /gene="Ap3b1"
                     /note="adaptor related protein complex 3 subunit beta 1"
                     /db_xref="GeneID:309969"
                     /db_xref="RGD:1310256"
     exon            1..200
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            201..296
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..457
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..524
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..707
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..757
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..855
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             764..3148
                     /gene="Ap3b1"
                     /note="adaptor-related protein complex 3, beta 1 subunit"
                     /codon_start=1
                     /product="AP-3 complex subunit beta-1"
                     /protein_id="NP_001101116.1"
                     /db_xref="GeneID:309969"
                     /db_xref="RGD:1310256"
                     /translation="MAVAQLYWHISPRSEAGVISKSLVRLLRSHREVQYIVLQNIATM
                     SIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVRSQDK
                     QFAAATIQTIGRCATSIAEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQH
                     GEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKL
                     QILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNEKSGALSK
                     YAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNVKASGYLELSNWPEVAPDPSVRN
                     VEVIESAKEWTPLGKTKKEKPEKKFYSESEEEEEEEEEDEEDEEEDPSDSSSDSESGS
                     GRESGDSGSSSEDSSEDSSSGQDSETGSEAEAEHQRVAKTNSKTKRKSASEDREKKNG
                     KSQASESSSEESSSTEESSSESESGSDSEPAPRKTAKAKERKPQQERHPPSKDVFLLD
                     LDDFNPVSTPVALPTPALSPSLIADLEGLNLSTSSSIINVSTPVFVPTKTHELLHRMR
                     GKGLAAHYCFPRQPCIFGDKMVSVQITLTNTSDGKIENIHVGGKKLAVGVQMHVFHPI
                     ESLEPEGSVTVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFK
                     KEQGMLTGMNETSATLIAAPQNFTPSMILQKVVNVANLGAVPSSQDNIHRYERLKFQV
                     LQERFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPVLSQG"
     exon            856..910
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..982
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1045
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1178
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1288
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1465
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1652
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1783
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1928
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2082
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2224
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2297
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2404
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2636
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2721
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2819
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2958
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..2994
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3712
                     /gene="Ap3b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaacgcca gccacccgga gagaaccccg caagctcccg cccgcacccg cccgctggcc
       61 ggcaccgccg caatgtctag caacagtttc gcctacaacg agcagtccgg aggaggggag
      121 gcggcggagc tggggcagga ggccacctcg accatctctt cctcgggcgc cttcggcctc
      181 ttcagcagcg attggaagaa atcaagaagc tggtgtatgt ttacctcgtc cgatacgctg
      241 aggaacagca ggacttggct ctcctgtcca taagcacttt ccagcgtgct ttgaaggacc
      301 caaatcaact aatccgcgca agtgccttga gagttttgtc aagtattaga gtgccgatta
      361 tcgtgcctgt catgatgctg gctatcaagg aggcatcagc tgacctgtcg ccctatgtta
      421 ggaagaatgc agcccatgct atccagaagc tgtacagtct tgaccctgag cagaaggaga
      481 tgctgattga ggtcatcgag aaactcctga aggataagag cacgctggtg gctggcagtg
      541 tggtgatggc ttttgaagag gtgtgcccag atcgaatcga tctgatccac aggaattacc
      601 gcaagctttg taacctactg gttgatgttg aagagtgggg gcaggtggtc ataatccata
      661 tgctaacacg atacgctcgg acccagttcg ttagtccttg gagagaggat gatggtgtag
      721 aagacaatga aaagaatttc tatgattctg acgatgagtg gttatggctg tcgctcagct
      781 gtactggcac atctcaccca ggtcggaggc tggtgtcatt tctaaatcgc tggtgcgcct
      841 acttcgcagc catagggagg tgcagtatat tgtattgcaa aatatcgcaa ctatgtcaat
      901 tcagagaaag ggtatgtttg aaccttacct gaagagcttc tatgtccggt ccactgatcc
      961 aactatgatc aagactctga agcttgaaat cttgacaaac ttggcaaatg aagccaacat
     1021 atcaactctt cttcgagaat ttcagaccta cgtgagaagc caggacaaac agtttgcagc
     1081 ggccactatt cagaccatag gcagatgtgc aaccagcatt gccgaggtca ctgacacatg
     1141 cctcaatggc ctggtctgcc tgctgtccaa cagggatgaa atagttgttg ctgaaagtgt
     1201 ggttgttata aagaaattgt tgcaaatgca gcctgcacag catggtgaga ttattaagca
     1261 catggcgaag ctgttggaca gcatcactgt ccctgtggct cgagcaagca ttctttggct
     1321 gattggagaa aactgtgaac gcgttcctaa aattgctcct gatgttttga gaaaaatggc
     1381 taaaagtttc actagtgaag atgatctggt gaaactgcag attttaaatc ttggagcaaa
     1441 attgtattta actaattcca aacagacaaa attgcttacc cagtacatat taaatctcgg
     1501 caagtatgat cagaactacg acatcagaga ccgcacaaga tttattaggc agcttattgt
     1561 tccgaacgag aagagtggag ctctaagtaa atatgccaaa aaaatctttc tagcacagaa
     1621 gcctgcacca ctgctggagt ctccctttaa agacagggat catttccagc ttggcacctt
     1681 atctcatact ctcaacgtta aagcgtccgg gtacctggaa ttatctaatt ggccagaggt
     1741 ggcgcctgac ccatcggttc gcaatgtaga agtaatagag tcagcaaaag agtggacccc
     1801 acttggaaaa acaaagaaag aaaaacctga gaagaaattt tattcagaat ctgaggagga
     1861 ggaggaggaa gaagaggaag atgaagaaga tgaggaggag gatccctctg atagcagcag
     1921 tgacagtgag agtgggtctg gacgtgagag tggagactca ggcagcagca gcgaggacag
     1981 cagcgaggac tcctccagtg gacaagacag cgagaccgga agcgaggcag aagcagaaca
     2041 ccagagggtg gccaagacga actccaaaac caagaggaaa agtgcctcag aagacaggga
     2101 gaagaaaaat ggaaaatctc aggcctcgga gtcgtccagt gaggagtcca gttccacaga
     2161 agaaagttct tcagagtcag agtcaggctc tgacagtgag cctgcaccca gaaaaacagc
     2221 taaggcaaaa gaaagaaaac cccagcaaga aagacatcct ccctccaaag atgttttcct
     2281 tctcgatctg gatgacttta acccagtatc caccccagtt gcccttccta caccagccct
     2341 ttctccaagc ttgatagctg atcttgaagg tctaaacctg tcaacttcct catccatcat
     2401 caacgtcagt acacctgtct tcgtgcccac aaaaacacat gagctgcttc accgcatgcg
     2461 tgggaaagga ctggctgccc actactgctt cccaagacag ccttgcatct tcggtgacaa
     2521 gatggtctct gtacagataa ccctgaccaa tacttccgat gggaagatag agaacatcca
     2581 cgtaggcggg aagaagcttg ctgtgggcgt gcagatgcac gtcttccatc ccatagagtc
     2641 tctggagcct gagggatccg ttactgtctc gatgggtatt gacttctgtg attctacaca
     2701 gacggccagt tttcagctgt gcaccaagga tgattgcttc aacgtcaaca tccagccacc
     2761 tgttggggag ctgcttttac ctgtggccat gtcagagaaa gactttaaga aggagcaagg
     2821 gatgctcact gggatgaatg agacgtcggc aacgctcatc gccgctccgc agaacttcac
     2881 cccctccatg atcctccaga aggttgtaaa cgtcgccaac ctcggtgcag tgccttccag
     2941 ccaagataac atacacagat atgagagatt aaaattccaa gttcttcaag aaaggtttgc
     3001 agctaaaact gtgcacagtg ggtcactgat gctagtcacc gtggaactga aggaaggttc
     3061 cacagcccaa cttatcatca acaccgagaa aaccgtgatt ggctctgtgc tgctgaggga
     3121 gctgaagcct gtcctgtccc aggggtaacc tgcttacatc tggacttcag aacctggcac
     3181 agaacaaagt gcctggcatc cacgactgct gcctttcatt tataataata gcccttccat
     3241 ctggcagcgg ggaagagcgc actctcgaca ttcttgtctc tgctttagaa tgctgctatg
     3301 tctgtcatgt acacgctcct ctccctcctc gctttgctaa ccaaagaaca tatattttac
     3361 tgtccatttt ctcaactcct caatccacgg ggcatctcct ctgcccgccg acatcttttg
     3421 acctcatctt ccttctggtg tttgagaatg atggatgtgc atcagatact gagaatgtat
     3481 tggaaatcgt ccttcctatg gcaggaggca aaaattagca aggaaatgat ctgaatggcc
     3541 tctcagctcg gtatatgaaa aggaaatgcc atacttttta aattaaatgc aaaaaaaatg
     3601 gcctctctga aaatcccatt ctttgaactt tctggtgtta caattggtta tcgacaattg
     3661 tcatcatgaa atcccctgaa catcagggtg aataaaggag cacatgaata gc
//
