LOCUS       NM_022952                804 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus adaptor related protein complex 2 subunit sigma 1
            (Ap2s1), mRNA.
ACCESSION   NM_022952 XM_346534
VERSION     NM_022952.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 804)
  AUTHORS   Taoufiq,Z., Ninov,M., Villar-Briones,A., Wang,H.Y., Sasaki,T.,
            Roy,M.C., Beauchain,F., Mori,Y., Yoshida,T., Takamori,S., Jahn,R.
            and Takahashi,T.
  TITLE     Hidden proteome of synaptic vesicles in the mammalian brain
  JOURNAL   Proc Natl Acad Sci U S A 117 (52), 33586-33596 (2020)
   PUBMED   33376223
REFERENCE   2  (bases 1 to 804)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 804)
  AUTHORS   Kastning,K., Kukhtina,V., Kittler,J.T., Chen,G., Pechstein,A.,
            Enders,S., Lee,S.H., Sheng,M., Yan,Z. and Haucke,V.
  TITLE     Molecular determinants for the interaction between AMPA receptors
            and the clathrin adaptor complex AP-2
  JOURNAL   Proc Natl Acad Sci U S A 104 (8), 2991-2996 (2007)
   PUBMED   17289840
REFERENCE   4  (bases 1 to 804)
  AUTHORS   Collins,B.M., McCoy,A.J., Kent,H.M., Evans,P.R. and Owen,D.J.
  TITLE     Molecular architecture and functional model of the endocytic AP2
            complex
  JOURNAL   Cell 109 (4), 523-535 (2002)
   PUBMED   12086608
REFERENCE   5  (bases 1 to 804)
  AUTHORS   Zhang,Y., Moheban,D.B., Conway,B.R., Bhattacharyya,A. and
            Segal,R.A.
  TITLE     Cell surface Trk receptors mediate NGF-induced survival while
            internalized receptors regulate NGF-induced differentiation
  JOURNAL   J Neurosci 20 (15), 5671-5678 (2000)
   PUBMED   10908605
REFERENCE   6  (bases 1 to 804)
  AUTHORS   Adams,L.D., Lemire,J.M. and Schwartz,S.M.
  TITLE     A systematic analysis of 40 random genes in cultured vascular
            smooth muscle subtypes reveals a heterogeneity of gene expression
            and identifies the tight junction gene zonula occludens 2 as a
            marker of epithelioid 'pup' smooth muscle cells and a participant
            in carotid neointimal formation
  JOURNAL   Arterioscler Thromb Vasc Biol 19 (11), 2600-2608 (1999)
   PUBMED   10559001
REFERENCE   7  (bases 1 to 804)
  AUTHORS   Tsuchida,S., Matsusaka,T., Chen,X., Okubo,S., Niimura,F.,
            Nishimura,H., Fogo,A., Utsunomiya,H., Inagami,T. and Ichikawa,I.
  TITLE     Murine double nullizygotes of the angiotensin type 1A and 1B
            receptor genes duplicate severe abnormal phenotypes of
            angiotensinogen nullizygotes
  JOURNAL   J Clin Invest 101 (4), 755-760 (1998)
   PUBMED   9466969
REFERENCE   8  (bases 1 to 804)
  AUTHORS   Takei,K., Mundigl,O., Daniell,L. and De Camilli,P.
  TITLE     The synaptic vesicle cycle: a single vesicle budding step involving
            clathrin and dynamin
  JOURNAL   J Cell Biol 133 (6), 1237-1250 (1996)
   PUBMED   8682861
REFERENCE   9  (bases 1 to 804)
  AUTHORS   Page,L.J. and Robinson,M.S.
  TITLE     Targeting signals and subunit interactions in coated vesicle
            adaptor complexes
  JOURNAL   J Cell Biol 131 (3), 619-630 (1995)
   PUBMED   7593184
REFERENCE   10 (bases 1 to 804)
  AUTHORS   Kirchhausen,T., Davis,A.C., Frucht,S., Greco,B.O., Payne,G.S. and
            Tubb,B.
  TITLE     AP17 and AP19, the mammalian small chains of the
            clathrin-associated protein complexes show homology to Yap17p,
            their putative homolog in yeast
  JOURNAL   J Biol Chem 266 (17), 11153-11157 (1991)
   PUBMED   2040623
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088138.1.
            
            On or before Jan 3, 2005 this sequence version replaced
            XM_346534.1, NM_022952.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088138.1, FQ134472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..804
                     /gene="Ap2s1"
                     /gene_synonym="Ap17"
                     /note="adaptor related protein complex 2 subunit sigma 1"
                     /db_xref="GeneID:65046"
                     /db_xref="RGD:620188"
     exon            1..70
                     /gene="Ap2s1"
                     /gene_synonym="Ap17"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..496
                     /gene="Ap2s1"
                     /gene_synonym="Ap17"
                     /note="sigma2-adaptin; sigma-adaptin 3b; clathrin coat
                     assembly protein AP17; clathrin coat-associated protein
                     AP17; clathrin assembly protein 2 small chain;
                     adaptor-related protein complex 2, sigma 1 subunit;
                     adaptor protein complex AP-2 subunit sigma; plasma
                     membrane adaptor AP-2 17 kDa protein; adapter-related
                     protein complex 2 sigma subunit; clathrin-associated
                     protein 17; clathrin assembly protein 2 sigma small chain;
                     adapter-related protein complex 2 subunit sigma;
                     adaptor-related protein complex 2 subunit sigma"
                     /codon_start=1
                     /product="AP-2 complex subunit sigma"
                     /protein_id="NP_075241.2"
                     /db_xref="GeneID:65046"
                     /db_xref="RGD:620188"
                     /translation="MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDA
                     KHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELD
                     LVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLMLQSLE"
     exon            71..220
                     /gene="Ap2s1"
                     /gene_synonym="Ap17"
                     /inference="alignment:Splign:2.1.0"
     exon            221..334
                     /gene="Ap2s1"
                     /gene_synonym="Ap17"
                     /inference="alignment:Splign:2.1.0"
     exon            335..394
                     /gene="Ap2s1"
                     /gene_synonym="Ap17"
                     /inference="alignment:Splign:2.1.0"
     exon            395..772
                     /gene="Ap2s1"
                     /gene_synonym="Ap17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaagcagag ccggagccgc ccagttacag cgggacccgg gcctctgggg tccagacagg
       61 ggtcgccatg atccgattca ttctcatcca gaaccgggca ggcaagacac gcctggccaa
      121 gtggtatatg cagttcgatg atgacgagaa gcagaagttg atcgaggaag tgcacgccgt
      181 ggtcaccgtc agggatgcca agcacaccaa ctttgtggag ttccggaact tcaagatcat
      241 ctaccggcgc tacgctggcc tctacttctg catctgcgtt gacgtcaacg acaacaatct
      301 ggcctatctt gaggccatcc acaacttcgt agaagtgtta aatgaatact tccacaatgt
      361 ctgtgaactg gacctggtgt tcaacttcta caaggtttac acggtggtag atgagatgtt
      421 cctggcagga gagatccgag agacgagcca gacgaaggtg ctgaagcagc tgctgatgct
      481 gcagtcgctg gagtgaggcg ggcctccgcc cagcccggcc tgctgggcca acctgcctgc
      541 tcgtcccctg ccaggctcga ggcccacccc agcagccccc tcccttcctc agctggccca
      601 gaggagtgac ccagcagggt ctaggccaca ggggaggagg ccagaaccca ctgcctctgg
      661 gccctacgtg gatggcagag gccaccgtga tgtcccgagt aactgtgcca ttattgtgtg
      721 atgctgtgag tgtgcgtgtg tgcagccccc aataaacctg tggtcctgcc tgaaaaaaaa
      781 aaaaaaaaaa aaaaaaaaaa aaaa
//
