LOCUS       NM_080583               5411 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus adaptor related protein complex 2 subunit beta 1
            (Ap2b1), mRNA.
ACCESSION   NM_080583 XM_347144
VERSION     NM_080583.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5411)
  AUTHORS   Catsburg,L.A., Westra,M., van Schaik,A.M. and MacGillavry,H.D.
  TITLE     Dynamics and nanoscale organization of the postsynaptic endocytic
            zone at excitatory synapses
  JOURNAL   Elife 11, e74387 (2022)
   PUBMED   35072626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5411)
  AUTHORS   Taoufiq,Z., Ninov,M., Villar-Briones,A., Wang,H.Y., Sasaki,T.,
            Roy,M.C., Beauchain,F., Mori,Y., Yoshida,T., Takamori,S., Jahn,R.
            and Takahashi,T.
  TITLE     Hidden proteome of synaptic vesicles in the mammalian brain
  JOURNAL   Proc Natl Acad Sci U S A 117 (52), 33586-33596 (2020)
   PUBMED   33376223
REFERENCE   3  (bases 1 to 5411)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   4  (bases 1 to 5411)
  AUTHORS   Marcello,E., Saraceno,C., Musardo,S., Vara,H., de la Fuente,A.G.,
            Pelucchi,S., Di Marino,D., Borroni,B., Tramontano,A.,
            Perez-Otano,I., Padovani,A., Giustetto,M., Gardoni,F. and Di
            Luca,M.
  TITLE     Endocytosis of synaptic ADAM10 in neuronal plasticity and
            Alzheimer's disease
  JOURNAL   J Clin Invest 123 (6), 2523-2538 (2013)
   PUBMED   23676497
REFERENCE   5  (bases 1 to 5411)
  AUTHORS   Matsuda,S., Kakegawa,W., Budisantoso,T., Nomura,T., Kohda,K. and
            Yuzaki,M.
  TITLE     Stargazin regulates AMPA receptor trafficking through adaptor
            protein complexes during long-term depression
  JOURNAL   Nat Commun 4, 2759 (2013)
   PUBMED   24217640
REFERENCE   6  (bases 1 to 5411)
  AUTHORS   Takei,K., Mundigl,O., Daniell,L. and De Camilli,P.
  TITLE     The synaptic vesicle cycle: a single vesicle budding step involving
            clathrin and dynamin
  JOURNAL   J Cell Biol 133 (6), 1237-1250 (1996)
   PUBMED   8682861
REFERENCE   7  (bases 1 to 5411)
  AUTHORS   Page,L.J. and Robinson,M.S.
  TITLE     Targeting signals and subunit interactions in coated vesicle
            adaptor complexes
  JOURNAL   J Cell Biol 131 (3), 619-630 (1995)
   PUBMED   7593184
REFERENCE   8  (bases 1 to 5411)
  AUTHORS   Gallusser,A. and Kirchhausen,T.
  TITLE     The beta 1 and beta 2 subunits of the AP complexes are the clathrin
            coat assembly components
  JOURNAL   EMBO J 12 (13), 5237-5244 (1993)
   PUBMED   8262066
REFERENCE   9  (bases 1 to 5411)
  AUTHORS   Ponnambalam,S., Robinson,M.S., Jackson,A.P., Peiperl,L. and
            Parham,P.
  TITLE     Conservation and diversity in families of coated vesicle adaptins
  JOURNAL   J Biol Chem 265 (9), 4814-4820 (1990)
   PUBMED   1969413
REFERENCE   10 (bases 1 to 5411)
  AUTHORS   Kirchhausen,T., Nathanson,K.L., Matsui,W., Vaisberg,A., Chow,E.P.,
            Burne,C., Keen,J.H. and Davis,A.E.
  TITLE     Structural and functional division into two domains of the large
            (100- to 115-kDa) chains of the clathrin-associated protein complex
            AP-2
  JOURNAL   Proc Natl Acad Sci U S A 86 (8), 2612-2616 (1989)
   PUBMED   2495531
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_080583.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M77246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000010.1  68600723-68600839
            118-177             JAXUCZ010000010.1  68606021-68606080
            178-283             JAXUCZ010000010.1  68613615-68613720
            284-419             JAXUCZ010000010.1  68617738-68617873
            420-665             JAXUCZ010000010.1  68620322-68620567
            666-856             JAXUCZ010000010.1  68629453-68629643
            857-1078            JAXUCZ010000010.1  68631865-68632086
            1079-1199           JAXUCZ010000010.1  68632815-68632935
            1200-1295           JAXUCZ010000010.1  68633054-68633149
            1296-1411           JAXUCZ010000010.1  68635579-68635694
            1412-1577           JAXUCZ010000010.1  68637975-68638140
            1578-1676           JAXUCZ010000010.1  68639357-68639455
            1677-1936           JAXUCZ010000010.1  68642753-68643012
            1937-2129           JAXUCZ010000010.1  68646895-68647087
            2130-2171           JAXUCZ010000010.1  68660229-68660270
            2172-2318           JAXUCZ010000010.1  68661061-68661207
            2319-2464           JAXUCZ010000010.1  68663457-68663602
            2465-2594           JAXUCZ010000010.1  68664709-68664838
            2595-2679           JAXUCZ010000010.1  68687436-68687520
            2680-2766           JAXUCZ010000010.1  68688451-68688537
            2767-2921           JAXUCZ010000010.1  68695874-68696028
            2922-5411           JAXUCZ010000010.1  68700054-68702543
FEATURES             Location/Qualifiers
     source          1..5411
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..5411
                     /gene="Ap2b1"
                     /note="adaptor related protein complex 2 subunit beta 1"
                     /db_xref="GeneID:140670"
                     /db_xref="RGD:71048"
     exon            1..117
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..177
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2996
                     /gene="Ap2b1"
                     /note="AP105B; beta-adaptin; beta2-adaptin; adaptor
                     protein complex AP-2 subunit beta; adapter-related protein
                     complex 2 beta subunit; clathrin assembly protein complex
                     2 beta large chain; plasma membrane adaptor HA2/AP2
                     adaptin beta subunit; adaptor-related protein complex 2,
                     beta 1 subunit; beta-2-adaptin; AP-2 complex subunit
                     beta-like; adapter-related protein complex 2 subunit beta;
                     adaptor-related protein complex 2 subunit beta; AP-1
                     complex subunit beta-1-like"
                     /codon_start=1
                     /product="AP-2 complex subunit beta"
                     /protein_id="NP_542150.1"
                     /db_xref="GeneID:140670"
                     /db_xref="RGD:71048"
                     /translation="MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVG
                     KDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLI
                     RALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQG
                     FLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWG
                     QIFILDCLSNYNPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDY
                     YNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPIYV
                     KLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCV
                     STLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIW
                     IVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLS
                     LATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELICH
                     IGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTTATNLEQPQVIPSQ
                     GDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLGSDLGGGIGGSPAVGQSF
                     IPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKAKGLEIS
                     GTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQSIDV
                     SLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLFVEDGKMERQVFLATWK
                     DIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWIL
                     AELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN"
     exon            178..283
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..419
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..665
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..856
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1078
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1199
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1295
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1411
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1577
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1676
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1936
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2129
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2171
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2318
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2464
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2594
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2679
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2766
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2921
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..5411
                     /gene="Ap2b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaattgggtt ttgcgcagtg tcttagatct agagagaatc gtgacgggca ggaaaccatt
       61 acaccacctt cccggctgtg ctctctgact gccgccgcca ccccgccctt gcctccggtt
      121 cacgctgaag atccagaatc atgactgact ccaagtactt cacaaccaat aagaagggag
      181 aaatctttga attaaaagct gaactcaaca atgaaaagaa agaaaagagg aaggaggctg
      241 tgaagaaagt gattgctgct atgaccgtgg ggaaggatgt gagctctctc ttcccagatg
      301 tggtgaactg tatgcagact gacaacctgg aactaaagaa gcttgtgtac ctctatctga
      361 tgaactatgc caagagtcag ccagacatgg ccatcatggc tgtcaacagc tttgtgaagg
      421 attgtgaaga ccccaatcct ttgattcgag ccttggcagt tagaaccatg ggatgcatcc
      481 gggtggacaa gattacagag tatctctgtg aacccctccg caagtgcttg aaggatgaag
      541 acccctatgt tcggaaaaca gcagcagtat gcgtggcaaa actccatgat atcaatgccc
      601 agatggtgga agatcaggga tttctggatt ctctgcggga tctcatagca gattcaaacc
      661 caatggtggt ggctaatgct gtagcagcat tgtctgagat cagtgagtct cacccaaaca
      721 gcaacttact tgatctgaac cctcagaata tcaataagct gctcacagcc ctgaatgagt
      781 gcactgagtg gggccagatt ttcatcttgg actgcctgtc taattacaac cctaaagatg
      841 accgggaagc tcagagcatc tgtgagcgag tgacgcctcg gctctctcat gccaattctg
      901 cagtggtgct ttcagcagta aaagttctga tgaagtttct agagttgtta cccaaggact
      961 ctgactacta caatatgctg ctaaagaagc tagcgcctcc acttgtcact ttgctctctg
     1021 gggagccaga agtgcagtat gttgccctga ggaacatcaa cctaattgtc cagaaaaggc
     1081 ctgaaatctt gaagcaggaa atcaaggtct tctttgtgaa gtacaatgat cctatctatg
     1141 ttaaactaga gaagttagac atcatgattc gtcttgcatc ccaagccaac attgctcagg
     1201 ttctggcaga actgaaggaa tatgccactg aagttgatgt ggactttgtt cgcaaagctg
     1261 tgagggccat tggacggtgt gccatcaaag tggagcaatc agcagaacgc tgtgtgagca
     1321 cactgcttga tctaatccag accaaagtaa attatgtggt ccaagaggca attgttgtca
     1381 tcagggacat cttccgaaaa taccccaaca agtatgagag cattatcgcc acgctgtgtg
     1441 agaacttgga ctccctggat gaacccgatg cccgagcggc tatgatttgg attgtaggag
     1501 agtatgctga aagaatcgat aatgccgatg agttactaga gagcttcctg gaaggttttc
     1561 atgatgaaag cacccaggtg cagctcacgt tgcttaccgc catagtgaaa ctgtttctca
     1621 agaagccatc agaaacacag gagctggtcc aacaggtctt gagcttggcc acacaggatt
     1681 ctgataatcc tgaccttcga gatcggggtt atatttattg gcgccttctt tcaactgacc
     1741 ctgtgacagc caaagaagta gtgttgtctg agaagccatt gatctctgag gaaacagacc
     1801 tcattgaacc taccctcctg gatgagctca tctgccacat tggttctttg gcctccgtgt
     1861 accataaacc tccgaatgct tttgtggaag ggagccatgg cattcatcgc aaacacttgc
     1921 caattcacca tgggagcact gatgcaggtg atagccctgt tggcaccacc actgcaacca
     1981 acctggaaca gcctcaggtc atcccctctc aaggtgacct tctgggggat cttttaaatc
     2041 ttgacctggg tcccccagtg aatgtcccgc aagtgtcctc catgcagatg ggagcagtgg
     2101 atcttttagg aggaggactg gatagcctgc ttggcagtga ccttggcggg ggcattggag
     2161 gaagtccggc agtaggacag tccttcatcc cgtcatcagt gcctgcaacc ttcgctcctt
     2221 cacctactcc tgctgtggtc agcagtggtc tgaatgacct gtttgagctt tccactggga
     2281 taggcatggc acctggcgga tatgtggctc ctaaggcagt ctggctacct gctgtaaagg
     2341 ctaaaggctt ggagatttcg gggacgttta ctcaccgcca agggcacatc tatatggaaa
     2401 tgaacttcac caacaaagct ctgcagcaca tgacggattt tgccatccag tttaacaaga
     2461 atagcttcgg tgtcatcccg agcactccct tggccataca tactccgctg atgccaaacc
     2521 agagcattga tgtgtctctg cctctcaaca ccttgggccc agtcatgaag atggagcctc
     2581 tgaataactt gcaggtggct gttaaaaaca atattgatgt cttctacttc agctgcctca
     2641 tcccactcaa tgtgcttttt gtagaagatg gcaaaatgga acgccaggtc ttccttgcga
     2701 cgtggaagga tattcccaat gaaaatgagc tccaatttca gattaaggag tgtcatttaa
     2761 acgctgacac agtttccagc aagttgcaaa acaacaatgt ttacactatc gccaagagga
     2821 atgtggaggg gcaggacatg ctgtaccagt ccctgaagct cactaatggc atttggattt
     2881 tggcagagct gcggatccag ccaggaaacc ccaattatac gctgtcgctg aagtgtagag
     2941 cccctgaagt ctctcagtac atctatcagg tctacgacag cattttgaaa aactaataaa
     3001 tgggtccagt cagcctgtaa tcagtgcaag ccacgaactc ttaactgaaa gacattgtat
     3061 tgttgtgtag agcctgaacc caaaccctgc ggtacccacc ccggtagtgg ccagtcattt
     3121 tgtgctgata ttagcactca ccccattggt aggttagctt cccgtgacat ctccttccac
     3181 tatcgcccac ctctgccacc tgccgctgct ctctgtcctt agttgtgagt tcctctgtgc
     3241 tgtgccaatg gctagccttt tctacaccct cttttgagtg tagtttgata ttttgtaatc
     3301 gaaagctcat ttcacaagca gaaaaaggca acaagttaat tagagcgagg aagagtgtca
     3361 ctgaaacata cactgcacct tattgtttta tatttttgta cagatgagat agatattgag
     3421 gtagaacgct gagtagaaag ggtgactgac cctcctcaga cacagtctta ttggagacat
     3481 atggccctgg ccccttctgg ggcaaggaga ggcgacccca ctcctggtct tttgcatttt
     3541 caccttggcc acgccttcca gctctcttat gcccatgctc tctcatttgg cgaccacatt
     3601 gatgtttctg agtgcaggga cactggacat gtgagcacag tgctgagaga tggcagagct
     3661 gtgctcgtgt ctacagcgct agcccaggag tcaccctgag gaggctgggt agacatgagt
     3721 aagaacacag cgccctcccc tagcctcctt ccctgttttt cagggctagt tcagatttaa
     3781 agtcagtgtt tgagagttaa gacagacttt agtgacttcc ccaaccctgt ttttctacaa
     3841 agaaaggtga taggggagaa gggtgctgcc aaggtggcct cttggctctt gagtagcaga
     3901 gctgagactg gtcccgacct ccatcagctt ccctatgtgg ccggctcatt attctttcct
     3961 taaagcctct gcctttcctg tgcctgcctg tggctctttg cacactccat actgagtttg
     4021 gtgctccacc cattccctgg cgtccggtgg cagctggcgt ctcagttaca tgagtttgca
     4081 tccaggtaac aagagtgaaa gcggagctga cattcgccag gctgtcctgg agccacagtt
     4141 cggaggctgg ccagtgagca gtgagtatag aagtgtgtag aggtgttgcc aattctcact
     4201 gtccctcacc tcactgatct gccctccatc catggtactc aagctccaaa gcacaggaag
     4261 atcattccag aaggctgtgt agttcttgtc atctcacaga ggactgggga tgggaagtcc
     4321 tctccctaag gaattggtat gagccatcga agaaagcctc atactgtcac cctgcttgag
     4381 atgtggcact tgttgcacag cctggcacct ggtattcagg gtccattcag agtcctatgc
     4441 tcaaggcaga agcatgccag ggtccaaaga cctcatgtag gactcagacc tgacccactg
     4501 gatcccgagg agaaactgga aaaatcaggg tagaaaccag cttcttttaa aagtgtgtct
     4561 ggagtgatcc tatttcctcc caaagtcttt aagaggattg ctggctggca aaaaagaaat
     4621 aacatccctc tctcactctc tcactctctc actcactcac tcactcactc actcactcac
     4681 tcaccatgtg gggagtaaga aatactgcag ggttgtgtgg gaggcaggtg gtatattggg
     4741 tggaaagcaa gttgaccaag ttcccttgtc ggtgccgatt cctggagtca gttggatgtg
     4801 agtggtgtaa gggattccca ctacagacag tgttctcatc tcaaagcaaa ttcccaaaag
     4861 tacatgtgtc agggcaagca gaaaatttta taccagaaca tgtccacccc agaaactaag
     4921 gcctctatca gcccctctac cagtgacaga taccagctgt ggttctctgc tggcctgagc
     4981 ccatccatgc tgtctgactc cctcttgttt ttaccccaag ggagttagga ggaggcaagg
     5041 agctctcctg aagagactct gttgccttcc tgaagcttcc ccttcaggtc agtttcgagc
     5101 ttgactagat tgggagaact ggggtcagtt tatcctgtat ctgctctcct tggctgaagt
     5161 gtgtcgctgt tgaaagctga agtacagagg gcagggaagc aaacccacca gagctctatc
     5221 tggtcagatt ccccacgtgt ttgttcccag cctggtccct attgtgaagc ttgggactgg
     5281 gaccaggtgc ggagagtaaa agctgtccca ggaatgcgta gtttcctgtt ctgtcggggt
     5341 ctgttgttgg ggaggtgggg attggggagc ctttaccttg tgtattcacc aataaactca
     5401 tttacacaaa a
//
