LOCUS       NM_031008               3258 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus adaptor related protein complex 2 subunit alpha 2
            (Ap2a2), mRNA.
ACCESSION   NM_031008
VERSION     NM_031008.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3258)
  AUTHORS   Capella,P., Asensio,J., Troncoso,M., Sosa,M.A. and Seltzer,A.M.
  TITLE     Evidence on differential role for alpha 1 and alpha 2 subtypes of
            AP-2 adaptin in the central nervous system
  JOURNAL   Neurosci Lett 808, 137282 (2023)
   PUBMED   37127089
  REMARK    GeneRIF: Evidence on differential role for alpha 1 and alpha 2
            subtypes of AP-2 adaptin in the central nervous system.
REFERENCE   2  (bases 1 to 3258)
  AUTHORS   Taoufiq,Z., Ninov,M., Villar-Briones,A., Wang,H.Y., Sasaki,T.,
            Roy,M.C., Beauchain,F., Mori,Y., Yoshida,T., Takamori,S., Jahn,R.
            and Takahashi,T.
  TITLE     Hidden proteome of synaptic vesicles in the mammalian brain
  JOURNAL   Proc Natl Acad Sci U S A 117 (52), 33586-33596 (2020)
   PUBMED   33376223
REFERENCE   3  (bases 1 to 3258)
  AUTHORS   Marcello,E., Saraceno,C., Musardo,S., Vara,H., de la Fuente,A.G.,
            Pelucchi,S., Di Marino,D., Borroni,B., Tramontano,A.,
            Perez-Otano,I., Padovani,A., Giustetto,M., Gardoni,F. and Di
            Luca,M.
  TITLE     Endocytosis of synaptic ADAM10 in neuronal plasticity and
            Alzheimer's disease
  JOURNAL   J Clin Invest 123 (6), 2523-2538 (2013)
   PUBMED   23676497
REFERENCE   4  (bases 1 to 3258)
  AUTHORS   Duncker,S.V., Franz,C., Kuhn,S., Schulte,U., Campanelli,D.,
            Brandt,N., Hirt,B., Fakler,B., Blin,N., Ruth,P., Engel,J.,
            Marcotti,W., Zimmermann,U. and Knipper,M.
  TITLE     Otoferlin couples to clathrin-mediated endocytosis in mature
            cochlear inner hair cells
  JOURNAL   J Neurosci 33 (22), 9508-9519 (2013)
   PUBMED   23719817
REFERENCE   5  (bases 1 to 3258)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3258)
  AUTHORS   Takei,K., Mundigl,O., Daniell,L. and De Camilli,P.
  TITLE     The synaptic vesicle cycle: a single vesicle budding step involving
            clathrin and dynamin
  JOURNAL   J Cell Biol 133 (6), 1237-1250 (1996)
   PUBMED   8682861
REFERENCE   7  (bases 1 to 3258)
  AUTHORS   Voglmaier,S.M., Keen,J.H., Murphy,J.E., Ferris,C.D.,
            Prestwich,G.D., Snyder,S.H. and Theibert,A.B.
  TITLE     Inositol hexakisphosphate receptor identified as the clathrin
            assembly protein AP-2
  JOURNAL   Biochem Biophys Res Commun 187 (1), 158-163 (1992)
   PUBMED   1325787
REFERENCE   8  (bases 1 to 3258)
  AUTHORS   Bahler,M., Klein,R.L., Wang,J.K., Benfenati,F. and Greengard,P.
  TITLE     A novel synaptic vesicle-associated phosphoprotein: SVAPP-120
  JOURNAL   J Neurochem 57 (2), 423-430 (1991)
   PUBMED   2072093
  REMARK    Erratum:[J Neurochem 1991 Dec;57(6):2155]
REFERENCE   9  (bases 1 to 3258)
  AUTHORS   Tucker,K.L., Nathanson,K. and Kirchhausen,T.
  TITLE     Sequence of the rat alpha c large chain of the clathrin associated
            protein complex AP-2
  JOURNAL   Nucleic Acids Res 18 (17), 5306 (1990)
   PUBMED   2402467
REFERENCE   10 (bases 1 to 3258)
  AUTHORS   Kirchhausen,T., Nathanson,K.L., Matsui,W., Vaisberg,A., Chow,E.P.,
            Burne,C., Keen,J.H. and Davis,A.E.
  TITLE     Structural and functional division into two domains of the large
            (100- to 115-kDa) chains of the clathrin-associated protein complex
            AP-2
  JOURNAL   Proc Natl Acad Sci U S A 86 (8), 2612-2616 (1989)
   PUBMED   2495531
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081786.1.
            
            On Dec 8, 2007 this sequence version replaced NM_031008.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081786.1, SRR8487227.332266.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3258
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..3258
                     /gene="Ap2a2"
                     /note="adaptor related protein complex 2 subunit alpha 2"
                     /db_xref="GeneID:81637"
                     /db_xref="RGD:71015"
     exon            1..147
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2900
                     /gene="Ap2a2"
                     /note="adaptor protein complex AP-2, alpha 2 subunit;
                     alpha2-adaptin; alpha-adaptin C; 100 kDa coated vesicle
                     protein C; adaptor protein complex AP-2 subunit alpha-2;
                     adaptor-related protein complex 2, alpha 2 subunit;
                     adapter-related protein complex 2 alpha-2 subunit;
                     clathrin assembly protein complex 2 alpha-C large chain;
                     plasma membrane adaptor HA2/AP2 adaptin alpha C subunit;
                     adapter-related protein complex 2 subunit alpha-2"
                     /codon_start=1
                     /product="AP-2 complex subunit alpha-2"
                     /protein_id="NP_112270.2"
                     /db_xref="GeneID:81637"
                     /db_xref="RGD:71015"
                     /translation="MPAVSKGEGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKF
                     KGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLV
                     NSNSELIRLINNAIKNDLASRNPTFMGLALHCIANVGSREMAEAFAGEIPKILVAGDT
                     MDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKN
                     PEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDPAV
                     RGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQL
                     GQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDL
                     LYAMCDRSNAQQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLI
                     RIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFG
                     NLIAGDPRSSPLIQFNLLHSKFHLCSVPTRALLLSTYIKFVNLFPEVKATIQDVLRSD
                     SQLKNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPST
                     VTDLEETKRERSIDVNGGPEPVPASTSAASTPSPSADLLGLGAVPPAPTGPPPTSGGG
                     LLVDVFSDSASAVAPLAPGSEDNFARFVCKNNGVLFENQLLQIGLKSEFRQNLGRMFI
                     FYGNKTSTQFLNFTPTLICADDLQTNLNLQTKPVDPTVDGGAQVQQVVNIECISDFTE
                     APVLNIQFRYGGTFQNVSVKLPITLNKFFQPTEMASQDFFQRWKQLSNPQQEVQNIFK
                     AKHPMDTEITKAKIIGFGSALLEEVDPNPANFVGAGIIHTKTTQIGCLLRLEPNLQAQ
                     MYRLTLRTSKDTVSQRLCELLSEQF"
     exon            148..216
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..359
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..553
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..683
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..785
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..894
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1045
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1214
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1352
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1535
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1633
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1865
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2039
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2203
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2286
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2376
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2500
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2617
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2687
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2822
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..3230
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgctccag ggctactcgg cgtgacggcc gcgcccgttc tgttccagcc cgccgccgag
       61 gccgctcccg ggtcgcaaag atgccggccg tatccaaggg ggaggggatg cgaggcctag
      121 cggtcttcat ctccgatatc cgtaactgta aaagtaaaga agctgaaata aagaggataa
      181 ataaggagct ggcaaatatt agatcaaaat ttaaaggtga caaggctctt gatggctaca
      241 gtaagaagaa gtatgtctgc aagttactct tcatctttct ccttggtcat gacattgact
      301 ttggacacat ggaagctgtg aatcttctga gctcaaacag atacacggaa aagcagatcg
      361 gctacctttt catctctgta ttggtgaatt caaatagtga actgatccgg ttgattaaca
      421 atgccatcaa gaatgacctg gccagccgca atcctacatt tatgggtctg gccctgcact
      481 gcatcgccaa tgtgggtagc cgtgagatgg cagaggcctt cgctggagag atccccaaga
      541 tcctggtggc aggagatacc atggacagtg tgaagcagag cgcagccctg tgcttgttgc
      601 gcctgtacag gacgtcacct gacctagttc ctatgggcga ctggacatcc cgtgtggtac
      661 acctcctcaa tgaccagcac ttgggtgtag tgactgccgc aactagcctc atcaccacac
      721 tggcccagaa gaatcctgag gagttcaaga cctctgtctc tctagctgtc tctcgactga
      781 gcagaattgt gacgtccgcg tcaacagatc ttcaggatta tacttactac tttgtcccgg
      841 ctccttggct gtcagtcaaa cttctgagac tgctgcagtg ctacccaccc ccagaagacc
      901 ctgcggtgcg tggccgcctg actgagtgct tggagaccat cctgaataag gcccaggagc
      961 cccccaagtc caagaaagtc cagcattcaa atgccaagaa cgctgtgctg tttgaggcca
     1021 tcagcctcat catccaccat gacagtgagc ccaacctcct ggtccgtgcc tgcaaccagc
     1081 tgggccagtt cctgcagcat cgggagacaa acctgcgcta cctggctctg gagagcatgt
     1141 gcacactggc cagctctgag ttctctcacg aggctgtcaa gacccacatc gagactgtca
     1201 tcaatgcctt gaagacggaa cgagatgtga gtgtgcggca gcgggcagtg gacctgctct
     1261 acgccatgtg cgaccgaagc aacgcccagc agattgtggc tgagatgctg agctacctag
     1321 aaacagctga ctactccatc cgggaggaaa ttgtgctgaa ggtggccatc cttgctgaga
     1381 agtatgcagt ggactacact tggtatgtgg acaccatcct caacctcatc cgcattgcag
     1441 gcgactatgt gagcgaagag gtgtggtacc gcgtcatcca gattgtcatc aatcgcgatg
     1501 atgtgcaggg ttatgctgcc aagacggtgt ttgaggcatt gcaggctcca gcatgtcatg
     1561 agaacttggt caaagtgggc ggctacatcc tgggcgagtt tggaaacttg atagcgggag
     1621 acccacgatc cagccctctg atccagttca acctgctcca ctccaagttc cacttgtgca
     1681 gcgtccccac tcgggcactc ctgctgtcca cctacatcaa gttcgtgaac ctctttccag
     1741 aggtaaaggc taccattcag gacgtgctgc gcagtgacag ccaactgaag aacgcagatg
     1801 tggagctgca gcagcgggct gtggagtacc tgcgactgag tactgttgcc agcactgata
     1861 tcctggcaac tgtcctggaa gaaatgccac ccttccctga gcgtgagtcc tccatcttgg
     1921 ccaagctgaa gaagaagaag ggcccaagca cagtgactga cctggaggag accaagcgtg
     1981 agcgaagcat cgatgtgaat gggggccccg aacccgttcc agccagcacc agtgctgcgt
     2041 ccacaccttc tccatcagca gacctgctgg gtctgggggc cgttccccct gctcccacag
     2101 ggccccctcc cacctctggc ggtgggttac tggtggacgt gttctcagac tcagcttctg
     2161 cagttgcacc tcttgcaccc ggctctgaag acaactttgc caggtttgtt tgtaaaaaca
     2221 atggtgtgtt gtttgaaaac cagctgcttc aaattggact gaagtcagaa tttcggcaga
     2281 atttaggtcg aatgttcata ttttatggta acaagacctc cacgcagttc ctaaacttca
     2341 ctccaacact aatctgtgct gacgaccttc agactaatct gaacctgcag actaagcccg
     2401 tggacccaac tgtggatggg ggcgcacagg tgcaacaggt ggtcaacatt gagtgtatat
     2461 ctgatttcac agaggcacct gtcctcaaca tccagttcag gtatggtggt accttccaga
     2521 atgtgtctgt taagcttccc atcactctca acaaattttt ccagcccaca gaaatggctt
     2581 ctcaggattt ctttcaacgt tggaagcagt tgagcaatcc acagcaagaa gtgcagaata
     2641 tcttcaaagc aaagcatccg atggacacag aaatcactaa agcgaagatt attggatttg
     2701 gttctgcgct cctggaagaa gttgatccaa accctgcaaa ttttgtgggt gctggcataa
     2761 tacataccaa aaccacccag atcggctgct tgttgcgcct ggagccaaac ctgcaagctc
     2821 agatgtacag actcaccttg cgtaccagca aagacaccgt ctctcagaga ctatgtgaat
     2881 tgctgtcgga acagttctaa tccacagacc agaagatcag gctctttgtt tgtgcgtctc
     2941 tctcgtctct ctcgtttgtc tttgtaccac actgcagata aacacccctt gtctgaaaac
     3001 tgccattcaa ggcacctcca gtcctacacc tacagccagc ccctgggtgt ggagggaatg
     3061 caggacacag tttgagaagg gctgcagcag gcctgccccg tcaaagaagg gtgcctgggc
     3121 ctgggaaatc aaggcagtcc tgtggttcaa cctacaaatt aaagggaaat tagaaatttg
     3181 aacgaaagtg gaaattttgt tcaaatttta ttaaaatgcc actggttcaa aaaaaaaaaa
     3241 aaaaaaaaaa aaaaaaaa
//
