LOCUS       NM_001108331            1302 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus adaptor related protein complex 1 subunit sigma 1
            (Ap1s1), mRNA.
ACCESSION   NM_001108331 XM_001076842 XM_341052
VERSION     NM_001108331.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1302)
  AUTHORS   Jain,S., Farias,G.G. and Bonifacino,J.S.
  TITLE     Polarized sorting of the copper transporter ATP7B in neurons
            mediated by recognition of a dileucine signal by AP-1
  JOURNAL   Mol Biol Cell 26 (2), 218-228 (2015)
   PUBMED   25378584
  REMARK    GeneRIF: Data indicate dileucine-dependent binding of the
            C-terminal tail of copper transporter ATP7B to sigma1 subunit of
            the clathrin adaptor AP-1.
REFERENCE   2  (bases 1 to 1302)
  AUTHORS   Baltes,J., Larsen,J.V., Radhakrishnan,K., Geumann,C., Kratzke,M.,
            Petersen,C.M. and Schu,P.
  TITLE     sigma1B adaptin regulates adipogenesis by mediating the sorting of
            sortilin in adipose tissue
  JOURNAL   J Cell Sci 127 (Pt 16), 3477-3487 (2014)
   PUBMED   24928897
REFERENCE   3  (bases 1 to 1302)
  AUTHORS   Glyvuk,N., Tsytsyura,Y., Geumann,C., D'Hooge,R., Huve,J.,
            Kratzke,M., Baltes,J., Boening,D., Klingauf,J. and Schu,P.
  TITLE     AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling,
            learning and memory
  JOURNAL   EMBO J 29 (8), 1318-1330 (2010)
   PUBMED   20203623
  REMARK    Erratum:[EMBO J. 2010 Jun 2;29(11):1941. Boning, Daniel [corrected
            to Boening, Daniel]]
REFERENCE   4  (bases 1 to 1302)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1302)
  AUTHORS   Montpetit,A., Cote,S., Brustein,E., Drouin,C.A., Lapointe,L.,
            Boudreau,M., Meloche,C., Drouin,R., Hudson,T.J., Drapeau,P. and
            Cossette,P.
  TITLE     Disruption of AP1S1, causing a novel neurocutaneous syndrome,
            perturbs development of the skin and spinal cord
  JOURNAL   PLoS Genet 4 (12), e1000296 (2008)
   PUBMED   19057675
REFERENCE   6  (bases 1 to 1302)
  AUTHORS   Leong,W.F. and Chow,V.T.
  TITLE     Transcriptomic and proteomic analyses of rhabdomyosarcoma cells
            reveal differential cellular gene expression in response to
            enterovirus 71 infection
  JOURNAL   Cell Microbiol 8 (4), 565-580 (2006)
   PUBMED   16548883
REFERENCE   7  (bases 1 to 1302)
  AUTHORS   Page,L.J., Sowerby,P.J., Lui,W.W. and Robinson,M.S.
  TITLE     Gamma-synergin: an EH domain-containing protein that interacts with
            gamma-adaptin
  JOURNAL   J Cell Biol 146 (5), 993-1004 (1999)
   PUBMED   10477754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Sep 20, 2008 this sequence version replaced NM_001108331.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB579199.1, BC169070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000012.1  25262036-25262114
            80-258              JAXUCZ010000012.1  25264929-25265107
            259-367             JAXUCZ010000012.1  25266100-25266208
            368-505             JAXUCZ010000012.1  25269831-25269968
            506-1302            JAXUCZ010000012.1  25271687-25272483
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1302
                     /gene="Ap1s1"
                     /note="adaptor related protein complex 1 subunit sigma 1"
                     /db_xref="GeneID:360785"
                     /db_xref="RGD:1305911"
     exon            1..79
                     /gene="Ap1s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..553
                     /gene="Ap1s1"
                     /note="adaptor protein complex AP-1, sigma 1"
                     /codon_start=1
                     /product="adaptor-related protein complex 1, sigma 1
                     subunit"
                     /protein_id="NP_001101801.2"
                     /db_xref="GeneID:360785"
                     /db_xref="RGD:1305911"
                     /translation="MMRFMLLFSRQGKLRLQKWYLATSDKERKKMVRELMQVVLARKP
                     KMCSFLEWRDLKVVYKRYASLYFCCAIEGQDNELITLELIHRYVELLDKYFGSVCELD
                     IIFNFEKAYFILDEFLMGGDVQDTSKKSVLKAIEQADLLQEEDESPRSVLEEMGLA"
     exon            80..258
                     /gene="Ap1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..367
                     /gene="Ap1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..505
                     /gene="Ap1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..1302
                     /gene="Ap1s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaaagaat ccgactggga gtggagctgg cttctacggt ggccggagag ggacgcaccg
       61 ggccggaggc tgcaggatga tgcgattcat gctactgttc agccggcagg gaaaacttcg
      121 gctacaaaaa tggtacctgg ccacctcaga caaggagagg aagaaaatgg tccgagagct
      181 catgcaggtc gttctggctc gaaagcccaa aatgtgcagc ttcctggagt ggagggacct
      241 caaagttgtc tataagagat atgccagtct ctatttctgc tgcgccatcg aaggccaaga
      301 caatgagctg atcaccctgg agctgatcca ccgatacgta gagctcttgg acaagtactt
      361 cggcagcgta tgcgagttgg acatcatctt caactttgag aaagcgtact tcatcctgga
      421 tgagtttctg atgggcgggg acgtccagga cacatccaag aagagtgtcc tcaaggctat
      481 cgagcaggct gacctgctgc aggaggagga tgagtcgccg cgcagtgtcc tggaggagat
      541 gggcctggca tagccccgtc agccagcggg gggccctgtg gaaccggggg aagacaagac
      601 aagagacagc acttggggct gtttcctctc acctctcccc cagacccctt ctcgtggagg
      661 gacccggccg cttttcctcg gccacctcac ctacttagaa ggagctgtgg ctccagccct
      721 acatacaaac attccctccc tccaggtctt cctcccccac caccgtccgt tcccactgaa
      781 ggctttaggg gctagaaggg aggggaatgt gaccggatgg ggatgcccag tggctttcat
      841 tctccttcct ttgaagaagc aatggcaacc ccagccgtcc ttcgtcctcc ctgtgtcccg
      901 aattgctgta aatatataaa tatgtcaggt taaagggaaa aggtttccag ggctcttttc
      961 tcccctctgc ccccaaacct acctccatcc ctccccagaa ccagtcaggg cagcctctct
     1021 gcctcggagg gaggggcttt cttctcctgg gccccacttc ctcctgggct cagtgtctag
     1081 ccagagccag gggaggagcc acacagttaa tgtttttcta accttgctac ttggagggaa
     1141 gggaaggttg gggaaggacc tgctttctgg gacactgacc ctgtccccct tcctcctctc
     1201 cacgttatgg gtgtggcagg agccaagcgg gtggggtggg ccaagtggct gcctttattt
     1261 cctttcttct gaaataaaag gaaaaagtgt ttctggactt ga
//
