LOCUS       NM_001108996            1698 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus adaptor related protein complex 1 subunit mu 2
            (Ap1m2), mRNA.
ACCESSION   NM_001108996 XM_001071847 XM_001071879
VERSION     NM_001108996.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1698)
  AUTHORS   Efendiev,R., Krmar,R.T., Ogimoto,G., Zwiller,J., Tripodi,G.,
            Katz,A.I., Bianchi,G., Pedemonte,C.H. and Bertorello,A.M.
  TITLE     Hypertension-linked mutation in the adducin alpha-subunit leads to
            higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase
            trafficking in response to GPCR signals and intracellular sodium
  JOURNAL   Circ Res 95 (11), 1100-1108 (2004)
   PUBMED   15528469
  REMARK    GeneRIF: Expression of the hypertensive rat or human variant of
            adducin into normal renal epithelial cells recreates the
            hypertensive phenotype with higher Na+,K+-ATPase activity,
            adaptin-2 mu2-subunit hyperphosphorylation, and impaired
            Na+,K+-ATPase endocytosis.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000190.1.
            
            [WARNING] On Mar 30, 2024 this sequence was replaced by
            NM_001108996.4.
            
            On Nov 27, 2020 this sequence version replaced NM_001108996.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167082.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JACYVU010000190.1  4660599-4660673     c
            76-232              JACYVU010000190.1  4657949-4658105     c
            233-300             JACYVU010000190.1  4657675-4657742     c
            301-431             JACYVU010000190.1  4653429-4653559     c
            432-579             JACYVU010000190.1  4653190-4653337     c
            580-706             JACYVU010000190.1  4652978-4653104     c
            707-849             JACYVU010000190.1  4650479-4650621     c
            850-921             JACYVU010000190.1  4650313-4650384     c
            922-1080            JACYVU010000190.1  4646634-4646792     c
            1081-1206           JACYVU010000190.1  4645328-4645453     c
            1207-1282           JACYVU010000190.1  4643715-4643790     c
            1283-1698           JACYVU010000190.1  4642770-4643185     c
FEATURES             Location/Qualifiers
     source          1..1698
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..1698
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /note="adaptor related protein complex 1 subunit mu 2"
                     /db_xref="GeneID:367038"
                     /db_xref="RGD:1561490"
     exon            1..75
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1305
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /note="adaptor-related protein complex 1, mu 2 subunit;
                     mu-adaptin 2; mu1B-adaptin; AP-mu chain family member
                     mu1B; adaptor protein complex AP-1 subunit mu-2; Golgi
                     adaptor HA1/AP1 adaptin mu-2 subunit; clathrin assembly
                     protein complex 1 mu-2 medium chain 2"
                     /codon_start=1
                     /product="AP-1 complex subunit mu-2"
                     /protein_id="NP_001102466.1"
                     /db_xref="GeneID:367038"
                     /db_xref="RGD:1561490"
                     /translation="MSASAVFILDVKGKPLISRNYKGDVPMTEIDHFMPLLMQREEEG
                     MLAPLLSHGRVHFLWIKHSNLYLVATTLKNANASLVYSFLYKTVEVFCEYFKELEEES
                     IRDNFVIVYELLDELMDFGFPQTTDSKILQEYITQQGNKLETGKSRVPPTVTNAVSWR
                     SEGIKYKKNEVFIDVIESVNLLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRV
                     LFELTGRSKNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPL
                     IWIESVIEKFSHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKY
                     VPEKNVVIWSIKSFPGGKEYLMRAHFGLPSVETEEVEGRPPIGVKFEIPYFTVSGIQV
                     RYMKIIEKSGYQALPWVRYITQSGDYQLRTS"
     exon            76..232
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /inference="alignment:Splign:2.1.0"
     exon            233..300
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /inference="alignment:Splign:2.1.0"
     exon            301..431
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /inference="alignment:Splign:2.1.0"
     exon            432..579
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /inference="alignment:Splign:2.1.0"
     exon            580..706
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /inference="alignment:Splign:2.1.0"
     exon            707..849
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /inference="alignment:Splign:2.1.0"
     exon            850..921
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1080
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1206
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1282
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1698
                     /gene="Ap1m2"
                     /gene_synonym="RGD1561490"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctctcgcc tcctagcttc accgggcgcc accatgtcgg cctcggcagt cttcattctg
       61 gacgtcaagg gcaagcctct gattagccga aactacaaag gcgatgtgcc catgacggag
      121 attgaccact tcatgcctct gcttatgcaa cgggaggagg agggtatgct ggccccgctg
      181 ctgagccacg gccgagtgca cttcttgtgg atcaaacaca gcaatctcta cttggtggcc
      241 accacactga agaacgccaa tgcctctctg gtgtactcct ttctgtacaa gactgtggag
      301 gtcttctgcg agtactttaa ggagctggag gaggagagca tccgagacaa ctttgtcatt
      361 gtgtacgagc tgctggacga gctgatggac ttcggctttc cgcagaccac ggacagcaag
      421 atcctgcagg agtacatcac acagcagggc aacaagctgg agaccggcaa gtctcgagtg
      481 ccaccgacag tcaccaatgc tgtgtcctgg cgctccgagg gcatcaagta caaaaagaac
      541 gaggtcttca ttgatgtcat cgagtctgtt aaccttctgg tgaatgctaa tgggagtgtc
      601 ttgctcagcg agattgtggg caccatcaag ctgaaggtgt ttctgtctgg gatgccagag
      661 ctgcggctgg gcctcaatga ccgagtgctc tttgagctta ctggccgcag caagaacaag
      721 tctgtggagc tggaagatgt gaaattccac cagtgtgtga ggctttcacg cttcgacaac
      781 gaccgcacca tctccttcat acccccggat ggggacttcg aactcatgtc ctaccgtctc
      841 agcacccagg tcaaacctct gatctggatc gagtcagtca ttgagaaatt ctcccacagc
      901 cgagtggaga tcatggtgaa ggccaagggt cagtttaaga agcagtcggt ggccaacggc
      961 gtggaaatct ctgtgcctgt acctagcgat gcagattctc cacgcttcaa gaccagtgtg
     1021 ggcagtgcca agtatgtgcc tgagaagaat gtcgtcattt ggagcatcaa gtctttccct
     1081 gggggcaagg agtacttgat gcgtgcccat tttggcctcc ccagcgtgga aactgaggag
     1141 gtagagggcc ggccacccat cggtgtcaag tttgagattc catactttac tgtttccggc
     1201 atccaggtcc gttacatgaa gatcatcgag aaaagcgggt accaggccct gccctgggtc
     1261 cgctacatca cccagagtgg tgattatcaa cttcggacca gctagaaggg agaagtgagg
     1321 cttccatcac cccagatacc agccgcagac tttaaagagc tgtgtgtgtg tgtgtgtgtg
     1381 tgtgtgtgtg tgtgtgtgtc tgcacattca gggttaggca ctgacttaac acatcctggc
     1441 tgcctgcacc taaccccctt cacctctcaa ctgtctgggg tggtttctct gtgtccctcg
     1501 cccctggagc tgtcccacac tgattttata tgaagaaata taagagggcc tggaccgcgc
     1561 tacccctccc ccacgagtgc cttcttgcag tgaactgccg ggcagatcta gggcccacct
     1621 tttatagctg ctgagccgag gccgctggcc ctccacctgg gttttagggt gtcattaaaa
     1681 tgagtctaac aactgtga
//
