LOCUS       NM_001308298            4021 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus adaptor related protein complex 1 subunit beta 1
            (Ap1b1), mRNA.
ACCESSION   NM_001308298 NM_017277
VERSION     NM_001308298.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4021)
  AUTHORS   Piccoli,G., Condliffe,S.B., Bauer,M., Giesert,F., Boldt,K., De
            Astis,S., Meixner,A., Sarioglu,H., Vogt-Weisenhorn,D.M., Wurst,W.,
            Gloeckner,C.J., Matteoli,M., Sala,C. and Ueffing,M.
  TITLE     LRRK2 controls synaptic vesicle storage and mobilization within the
            recycling pool
  JOURNAL   J Neurosci 31 (6), 2225-2237 (2011)
   PUBMED   21307259
REFERENCE   2  (bases 1 to 4021)
  AUTHORS   Evers,D.M., Matta,J.A., Hoe,H.S., Zarkowsky,D., Lee,S.H.,
            Isaac,J.T. and Pak,D.T.
  TITLE     Plk2 attachment to NSF induces homeostatic removal of GluA2 during
            chronic overexcitation
  JOURNAL   Nat Neurosci 13 (10), 1199-1207 (2010)
   PUBMED   20802490
REFERENCE   3  (bases 1 to 4021)
  AUTHORS   Nijboer,C.H., Heijnen,C.J., Groenendaal,F., van Bel,F. and
            Kavelaars,A.
  TITLE     Alternate pathways preserve tumor necrosis factor-alpha production
            after nuclear factor-kappaB inhibition in neonatal cerebral
            hypoxia-ischemia
  JOURNAL   Stroke 40 (10), 3362-3368 (2009)
   PUBMED   19628795
  REMARK    GeneRIF: Our data indicate that the switch to JNK/AP-1 activation
            preserves HI-induced TNF-alpha expression and thereby might
            contribute to the neuroprotective effect of TAT-NBD possibly
            through a TNF-R2 dependent mechanism.
REFERENCE   4  (bases 1 to 4021)
  AUTHORS   Jung,K.J., Lee,E.K., Kim,J.Y., Zou,Y., Sung,B., Heo,H.S., Kim,M.K.,
            Lee,J., Kim,N.D., Yu,B.P. and Chung,H.Y.
  TITLE     Effect of short term calorie restriction on pro-inflammatory NF-kB
            and AP-1 in aged rat kidney
  JOURNAL   Inflamm Res 58 (3), 143-150 (2009)
   PUBMED   19199090
  REMARK    GeneRIF: Results suggest that 10-day calorie restriction can
            attenuate the altered signal transduction for inflammatory
            processes which is mediated through reactive species-induced NF-kB
            and AP-1 in aged kidney.
REFERENCE   5  (bases 1 to 4021)
  AUTHORS   Kim,K.S., Kim,H.Y., Joe,E.H. and Jou,I.
  TITLE     Matrix metalloproteinase-3 induction in rat brain astrocytes: focus
            on the role of two AP-1 elements
  JOURNAL   Biochem J 410 (3), 605-611 (2008)
   PUBMED   18072934
  REMARK    GeneRIF: results indicate that AP-1 could control MMP-3 induction
            in brain astrocytes and that its regulation through specific AP-1
            elements could be exploited in the treatment of brain pathologies
            in which increased expression of MMP-3 plays crucial roles
REFERENCE   6  (bases 1 to 4021)
  AUTHORS   Helmig,S., Schuckenbohmer,P., Heger,J., Euler,G., Piper,H.M. and
            Schluter,K.D.
  TITLE     Direct effects of the angiotensin-converting enzyme inhibitor
            ramiprilat on adult rat ventricular cardiomyocytes
  JOURNAL   Acta Physiol (Oxf) 191 (4), 267-274 (2007)
   PUBMED   17825088
  REMARK    GeneRIF: Ramiprilat exerts direct, bradykinin-receptor independent
            effects on cardiomyocytes that improve cellular function without a
            corresponding effect on AP-1 activation or induction of AP-1
            dependent effects.
REFERENCE   7  (bases 1 to 4021)
  AUTHORS   Peyrard,M., Fransson,I., Xie,Y.G., Han,F.Y., Ruttledge,M.H.,
            Swahn,S., Collins,J.E., Dunham,I., Collins,V.P. and Dumanski,J.P.
  TITLE     Characterization of a new member of the human beta-adaptin gene
            family from chromosome 22q12, a candidate meningioma gene
  JOURNAL   Hum Mol Genet 3 (8), 1393-1399 (1994)
   PUBMED   7987321
REFERENCE   8  (bases 1 to 4021)
  AUTHORS   Gallusser,A. and Kirchhausen,T.
  TITLE     The beta 1 and beta 2 subunits of the AP complexes are the clathrin
            coat assembly components
  JOURNAL   EMBO J 12 (13), 5237-5244 (1993)
   PUBMED   8262066
REFERENCE   9  (bases 1 to 4021)
  AUTHORS   Kirchhausen,T., Nathanson,K.L., Matsui,W., Vaisberg,A., Chow,E.P.,
            Burne,C., Keen,J.H. and Davis,A.E.
  TITLE     Structural and functional division into two domains of the large
            (100- to 115-kDa) chains of the clathrin-associated protein complex
            AP-2
  JOURNAL   Proc Natl Acad Sci U S A 86 (8), 2612-2616 (1989)
   PUBMED   2495531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jan 18, 2018 this sequence version replaced NM_017277.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.57817.1,
                                           SRR26643298.55282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000014.1  84093572-84093706
            136-201             JAXUCZ010000014.1  84106698-84106763
            202-264             JAXUCZ010000014.1  84113018-84113080
            265-370             JAXUCZ010000014.1  84116112-84116217
            371-506             JAXUCZ010000014.1  84118602-84118737
            507-752             JAXUCZ010000014.1  84119585-84119830
            753-943             JAXUCZ010000014.1  84121374-84121564
            944-1165            JAXUCZ010000014.1  84122406-84122627
            1166-1286           JAXUCZ010000014.1  84124970-84125090
            1287-1382           JAXUCZ010000014.1  84126205-84126300
            1383-1498           JAXUCZ010000014.1  84127184-84127299
            1499-1664           JAXUCZ010000014.1  84127917-84128082
            1665-1763           JAXUCZ010000014.1  84132881-84132979
            1764-2023           JAXUCZ010000014.1  84133567-84133826
            2024-2225           JAXUCZ010000014.1  84134370-84134571
            2226-2246           JAXUCZ010000014.1  84135189-84135209
            2247-2399           JAXUCZ010000014.1  84135662-84135814
            2400-2545           JAXUCZ010000014.1  84139435-84139580
            2546-2675           JAXUCZ010000014.1  84141197-84141326
            2676-2760           JAXUCZ010000014.1  84141566-84141650
            2761-2847           JAXUCZ010000014.1  84142107-84142193
            2848-3002           JAXUCZ010000014.1  84142278-84142432
            3003-4021           JAXUCZ010000014.1  84143817-84144835
FEATURES             Location/Qualifiers
     source          1..4021
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4021
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /note="adaptor related protein complex 1 subunit beta 1"
                     /db_xref="GeneID:29663"
                     /db_xref="RGD:2064"
     exon            1..135
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            136..201
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..264
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..3077
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /note="beta-adaptin 1; golgi adaptor HA1/AP1 adaptin beta
                     subunit; clathrin assembly protein complex 1 beta large
                     chain; adaptor-related protein complex AP-1 beta 1
                     subunit; adaptor-related protein complex 1, beta 1
                     subunit"
                     /codon_start=1
                     /product="AP-1 complex subunit beta-1"
                     /protein_id="NP_001295227.1"
                     /db_xref="GeneID:29663"
                     /db_xref="RGD:2064"
                     /translation="MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVG
                     KDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLI
                     RALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQG
                     FLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWG
                     QIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDY
                     YATLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYV
                     KLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCV
                     STLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIW
                     IVGEYAERIDNADELLESFLDGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLS
                     LATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICY
                     IGTLASVYHKPPNAFVEGGRGVVHKSLPPRTASSESTESPEAAPAGAPASDQPDVIPA
                     QGDLLGDLLNLDLGPPVSGPPLAASSVQMGAVDLLGGGLDSLMGDEPEGIGDSNFGAP
                     PASVAAAAPARLGAPVSSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGT
                     FTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHAPLSPNQTVEISL
                     PLNTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHVLFVEDGKMDRQMFLATWKDI
                     PNENEAQFQIRDCPLNTEAASSKLQSSNIFTVAKRTVEGQDMLYQSLKLTNGIWVLAE
                     LRIQPGNPSFTLSLKCRAPEVSQHVYQAYETILKN"
     exon            265..370
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..506
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..752
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..943
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1165
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1286
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1382
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1498
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1664
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1763
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2023
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2225
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2246
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2399
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2545
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2675
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2760
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2847
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..3002
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..4021
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtgacagc ggtggggctt ggagcggccg gctgctgctg ctgcgacgca ccggcggaga
       61 gggaggagga ggctgcggac attttgctgc tgaagcgagc cgagccgcgg caccaggagc
      121 cgtttggatt tgtggacagg gtttctctgt gtagccgtgg ctgtccgaaa ctccctttgt
      181 agaccaggct gactgggaaa gagtctggcc acagataaag gaccgaaatg actgactcaa
      241 aatacttcac aacaaccaag aaaggggaga tcttcgagtt gaaggcagag cttaacagtg
      301 acaagaagga gaagaagaag gaggcagtaa agaaagtgat tgcatcaatg accgtgggca
      361 aagatgtcag tgctctcttc cctgatgtgg tgaactgcat gcagacagac aacctggagc
      421 taaagaagct ggtgtacctg tacttgatga actatgccaa gagtcagcct gacatggcca
      481 ttatggctgt caacaccttc gtgaaggact gtgaggaccc caaccccctt atccgggccc
      541 tggctgtgag gactatgggc tgcatccgag ttgacaagat cacagagtac ttgtgtgaac
      601 cactccggaa atgcctgaag gatgaagacc catatgtgcg caagacagca gctgtgtgtg
      661 tagccaagct ccacgacatc aacgcccagc tggtagagga ccagggtttc ctggacacac
      721 tcaaagacct catctctgac tctaacccca tggtggtagc aaatgcagtg gctgccctgt
      781 cagagatcgc tgagtctcac cccagtagca acctgcttga cttgaaccca cagtctatca
      841 acaagctgct gacagccctt aatgagtgca ccgagtgggg ccagatcttc attctggact
      901 gtctggcgaa ctacatgccc aaggatgacc gtgaggccca gagcatctgc gagcgggtca
      961 ctcctaggct ttcccatgcc aactctgctg tggtgctgtc cgcagtgaag gtcctgatga
     1021 agttcatgga gatgctgtct aaggacctgg actactatgc cacactactc aagaagctgg
     1081 cccctcccct ggtcacactg ctgtcagcag agccagagtt gcagtatgtg gctctgcgca
     1141 atattaacct cattgtacag aaaaggccag agattttgaa gcatgaaatg aaggttttct
     1201 ttgtgaagta caatgacccc atctatgtga agctggagaa actggacatt atgatccgcc
     1261 tggcctccca ggccaacatt gcccaggttt tggcagaact caaagagtac gcgacagaag
     1321 tagatgtgga ttttgtacgg aaggcagtgc gtgccattgg ccgctgtgcc atcaaggtgg
     1381 agcaatctgc agagcgctgt gtgagcacat tgcttgatct catccagacc aaggtcaact
     1441 atgtggtcca ggaagccatt gtggtcatta aagacatctt ccgcaagtac cccaacaagt
     1501 acgagagtgt gatagccaca ctgtgtgaga atctggactc gctggatgag cctgaggctc
     1561 gcgctgctat gatctggata gtgggcgagt atgctgagcg gattgacaat gcggacgagc
     1621 tgcttgagag cttcctcgac ggcttccatg acgagagcac ccaggtccag ctacagctgc
     1681 tgacagccat tgtgaagctc ttcctgaaga agccaacaga gacgcaggag ctggtgcagc
     1741 aggtcctcag tttggccact caggactcgg acaatccaga ccttcgggac cgtggctaca
     1801 tctactggcg cctgctctcc acggaccctg tagctgccaa agaggtggta ctggctgaga
     1861 agcccctcat ctcagaagag acagacctta ttgagcccac actgctggat gaactcatct
     1921 gctacattgg cacactggcc tctgtctacc acaagccacc caatgccttt gtggagggcg
     1981 gccggggagt ggtgcacaag agtctgccac ctcgcactgc ctcgagcgaa agcacagaga
     2041 gccctgaggc agcccctgcc ggagcacctg ctagtgacca gcctgatgtc attcctgccc
     2101 agggtgacct gttaggtgac ctcctcaacc tggaccttgg gcccccagtg agtggcccac
     2161 ccttggctgc ctcctcagtg cagatgggag ctgtggatct tcttggtggt ggcctcgaca
     2221 gcctgatggg ggatgagcct gaagggattg gagacagcaa ctttggggca cctccagcat
     2281 cagtggcggc ggcagcacca gccagacttg gagcacccgt cagcagtggc ttaagtgacc
     2341 tctttgacct gaccagtgga gtgggcaccc tctcagggtc ctatgtcgct cccaaagcag
     2401 tttggctccc tgccatgaag gccaaggggc tggaaatctc tggcaccttc acccggcagg
     2461 ttggctccat ctccatggat ctgcagctga ctaacaaggc cctgcaggtc atgacagatt
     2521 tcgctatcca gtttaatcgg aacagctttg gcttggcccc cgctgcgcca ctccaagtgc
     2581 acgccccact gagccccaac cagacggtgg agatctccct gcctcttaac acggtgggct
     2641 cagtcatgaa gatggagcct ctgaacaatc ttcaggtggc tgtgaagaac aacattgacg
     2701 tcttctactt cagcactttg tacccactgc atgtcctctt cgtggaggac gggaagatgg
     2761 accggcagat gttcctggcc acatggaagg acattcccaa cgagaatgaa gcccagttcc
     2821 agatcagaga ctgcccgctg aacacagagg ctgcaagcag caagctgcaa agcagtaaca
     2881 ttttcactgt cgccaagagg actgtggagg gccaggacat gctctaccaa tctctgaagt
     2941 tgaccaatgg catctgggtg ctggcagagc tgcggatcca gccaggcaac cccagtttca
     3001 cgctgtccct gaagtgtcga gcgccagagg tgtcccagca tgtataccag gcctacgaga
     3061 ccatcctcaa gaactgaagt ccctctcgca tccaccccag ccttctgcca gcccagccat
     3121 ggaaccctgt ggtggcagca cctcctcctt tctttgggga gaagccaggt gggctcctga
     3181 cccacccagg aggctcccct gatcctaact gagggcctgg agcagggcca cgtctcctag
     3241 agtgaaatct ccgtgcatct ccagtggctg cttttttcta ttgctgttga tgtgggatca
     3301 aaggaagtgg atccagcaca gcatcagaag ctggacgggg gccacagggt gctcttcctt
     3361 ctgctctcct gggcgtgaac atggaaccct cctggggtcc cagcccataa tccctgccct
     3421 gtctcctcag tgagcctgtc tgggtagagt cctctgggtg ccaatattac tgtttgggac
     3481 tctgagagct ggaggtggtg atggacagac atgagcccag gggagcaacc tgggctggca
     3541 ctgtctgccc catataacac cagttggtgc tctgtgacca cctgcatggc ccagagccca
     3601 tctaggattc tgttccctta ggccctggag gatggtcact gcctaccaaa cattcctcgg
     3661 tgtcctctct gtgagtccag ggctctcaga ccagaagtgg ggtgaaaggt ggggcaaggg
     3721 gcagtgggac cgcttctagt gtgagctcct gcacccactg gctgccctgg ctccccagtc
     3781 tgtgtgtgac agtgacaggt tgatctgtcg ctactgtttg ataataaaga gattctgctt
     3841 ttggcaatca tgcgcatttc ttcccctcta caaaaaaagg ccagcctaag aaactgctct
     3901 gatagccggg gatagtatct gaccctgcag tgattatatc taatgcatat aaatgaaaat
     3961 atatattgta tatttaccct tattttcaaa agagaaagca aataaaaaat gatgatgtta
     4021 a
//
