LOCUS       NM_001008527            4334 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Rattus norvegicus aldehyde oxidase 3 (Aox3), mRNA.
ACCESSION   NM_001008527 XM_579193
VERSION     NM_001008527.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4334)
  AUTHORS   Kurosaki,M., Bolis,M., Fratelli,M., Barzago,M.M., Pattini,L.,
            Perretta,G., Terao,M. and Garattini,E.
  TITLE     Structure and evolution of vertebrate aldehyde oxidases: from gene
            duplication to gene suppression
  JOURNAL   Cell Mol Life Sci 70 (10), 1807-1830 (2013)
   PUBMED   23263164
REFERENCE   2  (bases 1 to 4334)
  AUTHORS   Neumeier,M., Weigert,J., Schaffler,A., Weiss,T.S., Schmidl,C.,
            Buttner,R., Bollheimer,C., Aslanidis,C., Scholmerich,J. and
            Buechler,C.
  TITLE     Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is
            downregulated by adiponectin and fenofibric acid in hepatocytes in
            vitro
  JOURNAL   Biochem Biophys Res Commun 350 (3), 731-735 (2006)
   PUBMED   17022944
  REMARK    GeneRIF: The current data indicate that adiponectin reduces AOX1 by
            activating PPAR-alpha whereas fatty liver disease is associated
            with elevated hepatic AOX1.
REFERENCE   3  (bases 1 to 4334)
  AUTHORS   Kurosaki,M., Terao,M., Barzago,M.M., Bastone,A., Bernardinello,D.,
            Salmona,M. and Garattini,E.
  TITLE     The aldehyde oxidase gene cluster in mice and rats. Aldehyde
            oxidase homologue 3, a novel member of the molybdo-flavoenzyme
            family with selective expression in the olfactory mucosa
  JOURNAL   J Biol Chem 279 (48), 50482-50498 (2004)
   PUBMED   15383531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 5, 2021 this sequence version replaced NM_001008527.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY665586.1, SRR26643290.32574.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000009.1  67159000-67159147
            149-206             JAXUCZ010000009.1  67160628-67160685
            207-303             JAXUCZ010000009.1  67164688-67164784
            304-412             JAXUCZ010000009.1  67165595-67165703
            413-539             JAXUCZ010000009.1  67167110-67167236
            540-601             JAXUCZ010000009.1  67171312-67171373
            602-682             JAXUCZ010000009.1  67173876-67173956
            683-763             JAXUCZ010000009.1  67178163-67178243
            764-908             JAXUCZ010000009.1  67181229-67181373
            909-1001            JAXUCZ010000009.1  67182289-67182381
            1002-1153           JAXUCZ010000009.1  67185688-67185839
            1154-1247           JAXUCZ010000009.1  67186521-67186614
            1248-1357           JAXUCZ010000009.1  67189336-67189445
            1358-1539           JAXUCZ010000009.1  67193380-67193561
            1540-1702           JAXUCZ010000009.1  67193837-67193999
            1703-1795           JAXUCZ010000009.1  67194302-67194394
            1796-1965           JAXUCZ010000009.1  67198272-67198441
            1966-2080           JAXUCZ010000009.1  67199109-67199223
            2081-2203           JAXUCZ010000009.1  67199710-67199832
            2204-2300           JAXUCZ010000009.1  67203178-67203274
            2301-2425           JAXUCZ010000009.1  67206431-67206555
            2426-2559           JAXUCZ010000009.1  67207736-67207869
            2560-2647           JAXUCZ010000009.1  67209995-67210082
            2648-2734           JAXUCZ010000009.1  67212003-67212089
            2735-2926           JAXUCZ010000009.1  67213238-67213429
            2927-3154           JAXUCZ010000009.1  67213615-67213842
            3155-3250           JAXUCZ010000009.1  67217390-67217485
            3251-3379           JAXUCZ010000009.1  67218262-67218390
            3380-3454           JAXUCZ010000009.1  67220064-67220138
            3455-3507           JAXUCZ010000009.1  67221331-67221383
            3508-3622           JAXUCZ010000009.1  67224161-67224275
            3623-3688           JAXUCZ010000009.1  67226675-67226740
            3689-3877           JAXUCZ010000009.1  67228535-67228723
            3878-4045           JAXUCZ010000009.1  67237505-67237672
            4046-4334           JAXUCZ010000009.1  67243314-67243602
FEATURES             Location/Qualifiers
     source          1..4334
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..4334
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /note="aldehyde oxidase 3"
                     /db_xref="GeneID:493909"
                     /db_xref="RGD:1359328"
     exon            1..148
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..4099
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /EC_number="1.2.3.1"
                     /note="aldehyde oxidase homolog 1; azaheterocycle
                     hydroxylase 3"
                     /codon_start=1
                     /product="aldehyde oxidase 3"
                     /protein_id="NP_001008527.2"
                     /db_xref="GeneID:493909"
                     /db_xref="RGD:1359328"
                     /translation="MSRSKESDELIFFVNGKKVIERNADPEVNLLFYLRKIIQLTGTK
                     YGCGGGDCGACTVMISRYNPISKKISHFSAAACLVPICSLHGAAVTTVEGIGSTKTRI
                     HPVQERIAKGHGTQCGFCTPGMVMSIYTLLRNHPEPSTEQIMETLGGNLCRCTGYRPI
                     VESARSFSPNSACCPMNEKWKCCLDEGKNEPERKNSVCTKLYEKEEFQPLDPTQELIF
                     PPELMRMAEDSPNTVLTFRGERTTWIAPGTLNDLLELKMEYPSAPLVIGNTCLGLDMK
                     FKDVSYPIIISPARILELFVVTNTNEGLTLGAGLSLTQVKNILSDVVSRLPKERTQTY
                     RALLKHLRTLAGQQIRNVASLGGHIISRLPTSDLNPIFGVGNCKLNVASTEGTQQIPL
                     NDHFLAGVPEAILKPEQVLISVFVPLSRKWEFVSAFRQAPRQQNAFAIVNAGMRVAFK
                     EDTNTITDLSILYGGIGATVVSAKSCQQLIGRCWDEEMLDDAGRMIREEVSLLTAAPG
                     GMVEYRKTLAISFLFKFYLDVLKQLKRRNPHRCPDISQKLLQVLEDFPLTMPHGTQSF
                     KDVDSQQPLQDPVGRPIMHQSGIKHATGEAVFCDDMSVLAGELFLAVVTSSKPHARII
                     SLDASEALASPGVVDVITAQDVPGDNGREEESLYAQDEVICVGQIVCAVAADSYARAK
                     QATKKVKIVYEDMEPMIVTVQDALQHESFIGPEKKLEQGNVQLAFQSADQILEGEVHL
                     GGQEHFYMETQSVRVIPKGEDMEMDIYVSSQDAAFTQEMVARTLGIPKNRITCHVKRV
                     GGAFGGKTSKPGLLASVAAVAAQKTGRPIRFILERGDDMLITGGRHPLLGKYRVGFMN
                     NGKIKAADIQLYINGGCTPDDSELVIEYALLKLENAYKIPNLRVRGRVCKTNLPSNTA
                     FRGFGFPQGAFVTETWVSAVAAKCHLPPEKVRELNMYKTIDRTIHKQEFDPTNLIKCW
                     ETCMENSSYYSRKKAVDEFNQQSFWKKRGIAIIPMKFSVGFPKTFYHQAAALVQIYTD
                     GSVLVAHGGVELGQGINTKMIQVASRELKIPMSYIHLDEMNTMTVPNTITTGGSTGAD
                     VNGRAVQNACQILMKRLEPIISQNPNGDWEEWINEAFIQSISLSATGYFRGYQADMDW
                     EKGEGDIYPYFVFGAACSEVEIDCLTGAHKNIRTDIVMDGSFSINPAVDIGQIEGAFV
                     QGLGLYTLEELKYSPEGVLYTRGPHQYKIASVSDIPEEFHVSLLTPTQNPKAIYSSKG
                     LGEAGMFLGSSVFFAIAAAVAAARKERGLPLILAINSPATAEVIRMACEDQFTNLVPK
                     TDSKCCKPWSIPVA"
     exon            149..206
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            207..303
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..412
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..539
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..601
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..682
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..763
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..908
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1001
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1153
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1247
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1357
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1539
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1702
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1795
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1965
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2080
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2203
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2300
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2425
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2559
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2647
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2734
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2926
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3154
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3250
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3379
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3454
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3507
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3622
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3688
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            3689..3877
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            3878..4045
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4334
                     /gene="Aox3"
                     /gene_synonym="Aoh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagcgga gcgtagcact tcatctgaga ggtggacttg tcaacagacg ccttaggcac
       61 aactgcacag agtgtgggca gctgtcctca agtaatgtct cgttctaagg agtcagatga
      121 gctcattttc tttgtgaatg ggaaaaaagt cattgagagg aatgcagacc ctgaggttaa
      181 tttattgttc tatttgagaa aaatcatcca actcacaggg acaaagtatg gctgtggagg
      241 aggtgactgt ggcgcctgca cagtgatgat ctcaagatac aaccccatct ccaaaaagat
      301 cagtcatttc tccgccgctg cctgcctggt ccccatctgc tctctccatg gggctgctgt
      361 cactacagta gaaggcatag gaagcaccaa aaccagaata caccctgtcc aggaaaggat
      421 tgctaaaggc catggtaccc agtgtggatt ctgcactccc gggatggtga tgagcatcta
      481 cactctcctg agaaaccacc cggagccctc cacggaacag ataatggaaa ccttgggtgg
      541 gaatctatgc cgttgcactg gatacaggcc cattgtggag agtgcgagaa gtttcagccc
      601 taactcagct tgctgcccga tgaatgagaa atggaaatgt tgcttggatg aaggaaaaaa
      661 cgagcctgag agaaaaaaca gtgtttgcac caagttatat gaaaaagaag aatttcaacc
      721 cttggaccca actcaggagc ttatatttcc acctgaactg atgagaatgg cagaggattc
      781 cccaaataca gttctgactt tccgtgggga aaggacgacc tggattgccc caggaaccct
      841 aaatgacctt ctggaactga aaatggagta ccccagtgct ccgctcgtga tcggcaacac
      901 gtgtcttggg cttgatatga agttcaaaga cgtttcttat ccaattatca tctctcctgc
      961 aaggatctta gaattatttg tggtgactaa tacaaatgaa gggctgacac tgggcgctgg
     1021 cctcagcctg acccaggtga agaatatctt gtctgatgtg gtctccaggc tcccgaagga
     1081 gaggacgcag acataccgtg ctctcctgaa gcacctgagg actctggctg ggcagcagat
     1141 caggaatgtg gcttccttag gtggtcatat tatcagtaga ctgccgacct ctgacctcaa
     1201 ccctattttc ggtgtaggca attgcaaact caatgttgct tcaacagaag gaacacagca
     1261 aatccctctg aacgatcatt ttctcgctgg agtcccagag gccatcctga agccagagca
     1321 agtgctcatc tcggttttcg tgcccctctc caggaagtgg gagttcgtat cagctttcag
     1381 acaggccccg cgtcagcaaa atgcgtttgc gatagtgaat gctggaatgc gagtcgcttt
     1441 caaagaggat acaaacacca ttacagactt gagcatctta tatggaggga ttggtgccac
     1501 tgtagtcagc gccaagtcct gccagcagct gattggaagg tgttgggatg aggaaatgct
     1561 ggatgacgct ggccggatga ttcgtgaaga agtctccctc ctcacagcag cccccggagg
     1621 aatggtggaa taccggaaga cccttgccat cagtttcctc ttcaagtttt acttagatgt
     1681 gttgaagcag ctaaagagga ggaatcccca taggtgccct gacatctcac agaaactcct
     1741 acaggttctg gaagactttc ctttgaccat gcctcatggg acacagtcat ttaaagatgt
     1801 agactcccag cagcctctgc aagacccagt cgggcgtccc atcatgcatc agtctggcat
     1861 caaacacgcc acaggggagg ccgtattttg tgatgatatg tctgtgttgg caggggaact
     1921 cttcttggct gtggtaacca gcagcaagcc acatgctaga atcatctccc tcgatgcctc
     1981 tgaggccttg gcatcacctg gtgtggttga tgtgataaca gctcaagatg tgcctggtga
     2041 caatggcaga gaagaggaaa gcctgtatgc acaggatgag gtgatctgcg tgggtcagat
     2101 tgtctgcgcc gtggctgctg actcgtatgc tcgcgccaag caggccacaa aaaaagtaaa
     2161 gattgtctat gaagacatgg agcccatgat tgtgacggtt caggatgcac tgcaacatga
     2221 atcattcatt ggacctgaaa aaaaactaga acaaggaaat gtccagttag catttcaaag
     2281 tgctgatcaa atcctcgaag gggaagtgca cttgggaggc caggagcatt tttacatgga
     2341 gactcaaagc gtacgagtga tccccaaggg agaggacatg gagatggaca tatatgtgtc
     2401 cagccaggac gcagcgttta cccaggaaat ggtggctcga accttgggca tcccaaagaa
     2461 caggatcacc tgccacgtga aaagggttgg tggagccttc ggagggaaaa cgagcaaacc
     2521 tgggctcctg gcatcggtgg cagctgtggc cgcacagaag accggccgcc caatccgttt
     2581 tattctagag cgtggggatg acatgttgat aacgggagga cgtcacccac tactcgggaa
     2641 atacagggtt ggcttcatga acaatgggaa gatcaaggca gcagacatcc agctttatat
     2701 caacggaggc tgcaccccag atgattctga actggtgata gaatatgctt tgctcaaact
     2761 ggaaaatgcg tacaagatcc ccaacctccg tgtccgaggt cgcgtctgta agaccaactt
     2821 gccatccaat acagcgtttc ggggatttgg ttttccccag ggggcattcg taacagaaac
     2881 ctgggtgtca gctgtggcag ccaaatgcca cttgccacca gagaaggttc gagagttaaa
     2941 catgtacaaa acaatcgaca ggacaattca caagcaagaa tttgacccaa cgaatctgat
     3001 aaagtgctgg gagacatgta tggaaaattc ttcctactac agcagaaaga aggctgtaga
     3061 tgaatttaac cagcagagtt tttggaagaa gagaggaatt gccatcatcc ccatgaagtt
     3121 ctcagttgga tttccaaaga cattttatca tcaggctgct gctttggtcc agatctacac
     3181 agatgggtct gtactagttg ctcatggtgg tgttgaactg ggacaaggta ttaacaccaa
     3241 aatgatacag gtggctagcc gtgaattaaa aataccaatg tcttatatac acctggatga
     3301 aatgaacact atgaccgtcc ccaacacgat taccactgga ggctccactg gtgccgatgt
     3361 caacgggaga gctgttcaga atgcctgtca gatcctcatg aagcgcctgg aacccatcat
     3421 cagccagaat cctaatggtg actgggaaga gtggattaat gaagctttca ttcaaagcat
     3481 tagcctctct gccactggat attttagggg ttaccaagct gacatggact gggagaaggg
     3541 agaaggtgac atttatccct attttgtttt tggagctgcc tgttctgagg ttgaaattga
     3601 ttgtctgacg ggagctcaca agaacatcag aactgacatt gtcatggatg gatctttcag
     3661 tataaaccct gctgtggaca taggccagat cgaaggggca tttgttcaag gtcttggact
     3721 ttatactcta gaggaactga aatattcccc tgaaggagtc ctatacaccc gtggtccaca
     3781 ccagtacaaa atagcatcag ttagcgacat cccagaagaa ttccatgtat cattgttgac
     3841 accaacccaa aaccccaaag ccatctactc ttctaagggc cttggtgaag ctggaatgtt
     3901 tctaggttct tctgtgttct tcgctattgc tgctgccgtg gctgccgccc gcaaggagag
     3961 aggcctgccc ctgattttgg ccataaacag ccctgccaca gcagaagtaa ttcgaatggc
     4021 ctgtgaggac cagtttacaa acctggttcc aaaaacggat tctaaatgct gtaagccatg
     4081 gtccatccca gttgcctgat gcttggggtt tgagcacaaa aacagatatc ctgaagaact
     4141 taaagcttca atgggtcact agaataaaca acttcatcta aaatacatag acaattagag
     4201 gcaattctta aattttcata tttacagaat cttgtaatct ttaatcacgt gtgctacaag
     4261 tagtaacatt tttggagctt cagccaaagg tcacggttag gtcaactaaa cctcatttcc
     4321 cagtgggtga agaa
//
