LOCUS       NM_001008522            4484 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Rattus norvegicus aldehyde oxidase 2 (Aox2), mRNA.
ACCESSION   NM_001008522 XM_237171
VERSION     NM_001008522.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4484)
  AUTHORS   Kurosaki,M., Bolis,M., Fratelli,M., Barzago,M.M., Pattini,L.,
            Perretta,G., Terao,M. and Garattini,E.
  TITLE     Structure and evolution of vertebrate aldehyde oxidases: from gene
            duplication to gene suppression
  JOURNAL   Cell Mol Life Sci 70 (10), 1807-1830 (2013)
   PUBMED   23263164
REFERENCE   2  (bases 1 to 4484)
  AUTHORS   Kurosaki,M., Terao,M., Barzago,M.M., Bastone,A., Bernardinello,D.,
            Salmona,M. and Garattini,E.
  TITLE     The aldehyde oxidase gene cluster in mice and rats. Aldehyde
            oxidase homologue 3, a novel member of the molybdo-flavoenzyme
            family with selective expression in the olfactory mucosa
  JOURNAL   J Biol Chem 279 (48), 50482-50498 (2004)
   PUBMED   15383531
  REMARK    GeneRIF: selectively expressed in Bowman's glands of the olfactory
            mucosa.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Dec 3, 2020 this sequence version replaced NM_001008522.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY665588.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000009.1  67322598-67322746
            150-207             JAXUCZ010000009.1  67325617-67325674
            208-304             JAXUCZ010000009.1  67327085-67327181
            305-413             JAXUCZ010000009.1  67328435-67328543
            414-540             JAXUCZ010000009.1  67330597-67330723
            541-602             JAXUCZ010000009.1  67332682-67332743
            603-686             JAXUCZ010000009.1  67334808-67334891
            687-767             JAXUCZ010000009.1  67336950-67337030
            768-912             JAXUCZ010000009.1  67339214-67339358
            913-1005            JAXUCZ010000009.1  67340685-67340777
            1006-1157           JAXUCZ010000009.1  67344651-67344802
            1158-1251           JAXUCZ010000009.1  67345462-67345555
            1252-1361           JAXUCZ010000009.1  67348496-67348605
            1362-1546           JAXUCZ010000009.1  67349370-67349554
            1547-1733           JAXUCZ010000009.1  67350119-67350305
            1734-1826           JAXUCZ010000009.1  67350697-67350789
            1827-1996           JAXUCZ010000009.1  67351970-67352139
            1997-2111           JAXUCZ010000009.1  67353069-67353183
            2112-2234           JAXUCZ010000009.1  67355675-67355797
            2235-2331           JAXUCZ010000009.1  67365119-67365215
            2332-2456           JAXUCZ010000009.1  67365896-67366020
            2457-2590           JAXUCZ010000009.1  67367650-67367783
            2591-2678           JAXUCZ010000009.1  67370112-67370199
            2679-2765           JAXUCZ010000009.1  67371660-67371746
            2766-2957           JAXUCZ010000009.1  67372751-67372942
            2958-3185           JAXUCZ010000009.1  67375408-67375635
            3186-3281           JAXUCZ010000009.1  67379194-67379289
            3282-3410           JAXUCZ010000009.1  67382130-67382258
            3411-3485           JAXUCZ010000009.1  67385067-67385141
            3486-3538           JAXUCZ010000009.1  67385988-67386040
            3539-3653           JAXUCZ010000009.1  67387044-67387158
            3654-3719           JAXUCZ010000009.1  67390720-67390785
            3720-3908           JAXUCZ010000009.1  67390869-67391057
            3909-4076           JAXUCZ010000009.1  67393961-67394128
            4077-4151           JAXUCZ010000009.1  67407930-67408004
            4152-4484           JAXUCZ010000009.1  67410031-67410363
FEATURES             Location/Qualifiers
     source          1..4484
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..4484
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /note="aldehyde oxidase 2"
                     /db_xref="GeneID:316421"
                     /db_xref="RGD:1359668"
     exon            1..149
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..4130
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /EC_number="1.2.3.1"
                     /note="aldehyde oxidase 2 pseudogene; aldehyde oxidase
                     3-like 1; aldehyde oxidase homolog 3; azaheterocycle
                     hydroxylase 2"
                     /codon_start=1
                     /product="aldehyde oxidase 2"
                     /protein_id="NP_001008522.2"
                     /db_xref="GeneID:316421"
                     /db_xref="RGD:1359668"
                     /translation="MPCPSQSSDELEFFVNGKKVTEKNVDPEVTLLAFLRKNLRLTGT
                     KYACGTGSCGACTVMVSQHDPVCKKTRHFSVMACLVPLCSLHGAAVTTVEGVGSIKTR
                     LHPVQERLAKSHGTQCGFCSPGMVMSMYALLRNHPQPSEEQLLEALGGNLCRCTGYRP
                     ILESGRTFCMESDGCLQKGTGQCCLDQKEGDSSGSKSDICTELFVKDEFQPLDPTQEL
                     IFPPELLRMAENPEKQTLTFYGERITWIAPGTLQELLVLKAKYPEAPLISGNTALGPA
                     MKSQGHFYPVLLSPARIPDLRMVTKTSGGLTIGACCSLAQVKDVLAESISELPEEKTQ
                     TYRALLKHLRSLAGQQIRNMASLGGHVISRHYYSDLNPILSVGNATLNLLSEEGLRQI
                     PLNGHFLAGLANEDLKPEEILGSVYIPHSQKREFVSAFRQAQCHQNALPDVNAGMRVL
                     FKEGTDIIEELSIAYGGVGPTTVSAHRSCQQLLGRRWNALLLDEACRLLLDEVSLPGS
                     AVGGKVEFRRTLIVSFFFKFYLEVLQELKADKRLLPESTDSQRYPEIADGSRSSLGDF
                     QVTLPQGVQTYQRVNSHQPLQDPVGRPIMHLSGLKHATGEAVFCDDIPRVDKELFMAL
                     VTSTRAHARIISIDSSEVLDLPGVVDVITAEDIPGNNGEEDDKLLAVDKVLCVGQVVC
                     AVVAETDVQAKRATKKIKITYEDLKPVLFTIEDAIQHNSFLCPEKKLEQGNMEEAFEN
                     VDQIVEGKVHVGGQEHFYMETQRVLVIPKTEDKELDMYVSTQDPAHVQKTVSSALNIP
                     LSRITCHVKRVGGGFGGKVGRPAVFGAIAAVGAVKTGRPIRLVLDREDDMLITGGRHP
                     LFAKYKVGFMNSGRIKALDIECYINGGCTLDDSELVTEFLVLKLENAYKIRNLRLRGR
                     ACMTNLPSNTAFRGFGFPQGALVTESCITAVAAKCGLPPEKIREKNMYKTVDKTIYKQ
                     AFNPEPLIRCWNECLDKSSFAIRRTRVDEFNKKSYWRKRGIAVVPMKFSVGFAATSYH
                     QAAALVHIYTDGSVLVAHGGNELGQGIHTKMLQVASRELKIPMSYLHTSETCTAAVPN
                     TIATAASVGADVNGRAVQNACQILLKRLEPVIKKNPEGTWRDWIEAAFEQRISLSATG
                     YFRGYKAFMDWEKGEGDPFPYYVYGAACSEVEIDCLTGAHKKMRTDIVMDACCSLNPA
                     IDVGQIEGAFIQGMGLYTTEELHYSPEGVLYSRSPDKYKIPTVTDVPEQFNVSLLPSS
                     QTPLTIYSSKGLGESGMFLGSSVFFAIADAVAAARRQRDIAEDFTVKSPATPERVRMA
                     CADRFTDMIPRDDPKTFKPWSIPIA"
     exon            150..207
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..304
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..413
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..540
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..602
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..686
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..767
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..912
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1005
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1157
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1251
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1361
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1546
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1733
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1826
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1996
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2111
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2234
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2331
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2456
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2590
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2678
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2765
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2957
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3185
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3281
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3410
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3411..3485
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3538
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3653
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3654..3719
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3720..3908
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..4076
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4151
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4152..4484
                     /gene="Aox2"
                     /gene_synonym="Aox2p; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgagggtc caggctgcct gcttctacct cgattctttg tcttcacttc agtagctggg
       61 atcagagcca ggaggccaag ctcaccagag ccatgccttg cccatcccag agctccgatg
      121 agttggagtt ctttgtgaac gggaagaagg tgacagagaa gaatgtggac ccagaagtca
      181 ctctgctggc cttcctgaga aagaacttac gcctcacggg gactaagtat gcctgtggga
      241 caggaagctg cggggcctgc actgtgatgg tgtcccagca cgatccggtg tgcaagaaga
      301 caagacactt ctctgtcatg gcatgcctgg tgcccctgtg ctccctgcat ggggctgctg
      361 tcaccaccgt ggaaggtgtg ggaagcatca agaccaggct acaccccgtg caggagagac
      421 tcgccaagag ccacggcacc cagtgtggat tctgcagccc tgggatggtg atgtccatgt
      481 atgctctgct caggaaccac ccgcagccct cagaggagca gctcctggaa gccttgggag
      541 gtaatctctg tcggtgtact gggtatcggc cgattctgga gagtggcaga accttctgca
      601 tggagtcaga tggttgtctg cagaaaggaa caggacagtg ttgcttggat cagaaggaag
      661 gtgactcatc tggaagcaaa agtgatattt gcacggagct atttgtgaaa gacgagttcc
      721 agcccttgga cccaacccag gagctcatat ttcccccaga actcctgagg atggctgaga
      781 acccagagaa gcaaacacta accttttatg gagagagaat tacctggatc gccccaggaa
      841 ccctccaaga actcttggtg ctgaaagcca agtaccctga agcccctctc atctcaggca
      901 acacggctct gggaccagcc atgaagtctc aaggacactt ttacccagtt ctcctgtccc
      961 ctgctagaat tcctgatcta agaatggtga ctaaaaccag tggtggactg accataggtg
     1021 cctgctgcag cctggctcag gtgaaagacg tcttagctga gagcatctct gagctcccag
     1081 aggagaaaac tcagacctac cgagctctcc tgaaacacct ccgtagcttg gcgggacagc
     1141 agatccggaa catggcgtcc ttaggtggac atgttataag caggcattac tactcggacc
     1201 tgaatcccat cctctctgtg ggcaacgcca cactcaatct gctgtcagaa gaaggcctga
     1261 ggcagattcc cctcaatgga cattttcttg ctgggttggc aaatgaagac ctgaagcctg
     1321 aagagattct ggggtcggtg tacatccccc actctcagaa gcgggagttt gtgtctgcct
     1381 tccggcaggc ccagtgccat cagaacgcct tgcctgatgt aaatgctggc atgagagtcc
     1441 tgttcaaaga aggcacagac atcattgagg agctgagcat tgcctatgga ggggtggggc
     1501 ccaccaccgt cagtgcacac agatcctgcc agcagctcct gggccggcgt tggaacgcac
     1561 tgctgctaga cgaggcttgc agactgctcc tggacgaagt ctccctccca ggctcagccg
     1621 tgggaggcaa agtggaattc aggaggactc tcattgtcag cttcttcttc aagttctacc
     1681 tggaggttct acaggaactg aaggctgaca agaggctgct ccctgaatcc accgacagcc
     1741 agcgttatcc agagatcgca gacgggtccc gaagctctct gggagatttc caggtcacgc
     1801 taccccaggg agtccaaaca taccagagag tgaattctca ccaacctctc caagatccag
     1861 ttggacgtcc catcatgcac ctgtcaggtc ttaaacatgc cacgggggaa gctgtatttt
     1921 gtgatgacat ccccagggtg gataaagaac ttttcatggc tttagtgacc agtaccagag
     1981 ctcatgcaag aatcatatcg atcgactcat ctgaggtcct agacctgcct ggtgtggtcg
     2041 atgtgataac agctgaagac atcccgggca acaatggtga agaggatgac aaattactgg
     2101 ctgtagataa ggttctctgt gtgggccagg tcgtctgtgc tgtggtagca gagactgatg
     2161 ttcaggcaaa acgagcaact aagaagataa aaatcaccta cgaggatctg aagcctgtgc
     2221 tcttcaccat cgaggatgcc atacagcaca attcattcct gtgccctgaa aaaaagctgg
     2281 aacaaggaaa catggaggag gcatttgaaa atgtggatca gatagttgaa gggaaggttc
     2341 atgttggagg gcaagaacat ttctacatgg aaacacagag agtgcttgtc attccaaaga
     2401 cagaagacaa agagctggac atgtatgtgt ccacacagga tccagcccat gtgcagaaaa
     2461 cggtgtcctc tgctttaaac atcccgctca gcaggatcac ctgccacgtg aaacgtgtgg
     2521 gtggaggctt tggaggaaag gtggggagac cagctgtgtt cggagcaatt gctgcagtgg
     2581 gggctgtcaa aactggccgt cccattcgtc ttgttctgga ccgtgaggat gacatgttaa
     2641 taactggggg aagacaccca ttatttgcaa aatacaaagt gggattcatg aacagtggac
     2701 gaatcaaagc cctagacatt gaatgctaca tcaatggagg atgcacactg gatgactcgg
     2761 agctggtaac agaatttctt gtactaaaac tggaaaatgc atataaaatc cgcaacctca
     2821 gacttcgagg tcgtgcctgc atgacaaatt taccatccaa tacagccttt cgtgggtttg
     2881 gcttcccaca aggagccctg gtgacagaat cttgcatcac agctgtggca gccaaatgtg
     2941 ggcttccacc agagaagatt agggagaaaa acatgtacaa aacagttgat aaaaccatct
     3001 acaaacaagc gttcaacccc gaacccctga taaggtgctg gaacgagtgt ctggacaagt
     3061 cttcctttgc cattagaagg acaagagtgg acgagttcaa taagaagagt tactggagga
     3121 agagaggcat tgcggtcgtc cccatgaagt tttcagttgg ctttgctgcg acaagctatc
     3181 atcaggcagc cgcgctcgtt cacatctaca ccgacggctc tgtgttggtg gcacatggag
     3241 gcaatgagct gggacaaggc attcacacca aaatgttaca ggtggccagc cgtgaattga
     3301 aaatacccat gtcgtacctg cacaccagcg aaacatgcac agcagcggtg cccaatacaa
     3361 ttgctacggc cgcgtccgtc ggagccgatg tcaatggcag agctgtgcag aatgcctgtc
     3421 agatccttct caaacgtctt gagcccgtca ttaagaaaaa cccggaaggg acatggagag
     3481 actggataga agcagccttt gaacaaagga tcagtctttc agccaccgga tacttcaggg
     3541 gctacaaggc cttcatggac tgggagaagg gagagggaga cccattccca tactatgtct
     3601 atggagctgc gtgttctgag gttgaaatcg actgcctgac aggtgctcac aagaaaatga
     3661 gaaccgacat tgtcatggat gcctgttgca gcctgaatcc agccatcgac gttgggcaga
     3721 tcgaaggtgc gtttattcaa ggaatgggcc tttataccac agaggagctg cactactctc
     3781 cagagggcgt cctgtactct cggagcccgg acaagtacaa aatcccaact gtcactgatg
     3841 tcccggagca gtttaatgtg tccttgctgc catcatctca gactccgctc accatctact
     3901 cgtcaaaggg cctcggggag tccgggatgt tcctagggtc atccgtattt ttcgccattg
     3961 ctgatgcggt ggctgcggca cggagacaaa gagacatagc cgaggacttc acagtgaaga
     4021 gcccagcaac cccagagcgg gtgcggatgg cctgtgcaga ccggttcacc gacatgatcc
     4081 cgagagatga cccaaagaca tttaaacctt ggtctatacc tatagcttaa tctgctctca
     4141 tttcctagga gatattttag tagtcaagtg aaaagccggc ttcctaatcc tgactggact
     4201 ccaaactgta ttcatgtgct gttgggtggg agggagggtg agctctgtca caaaatttag
     4261 agtcacgatt cacatctaac cacattaatg agatgaagca tttcttataa attatttact
     4321 tagtgttctc agcctagaga ctgccagaca agcactgcag tgtttgaagc tcctttaatg
     4381 atttgtcttt gaaaaagaca gagtaaatgg tactgcggaa ggagcagaaa ggagacctgg
     4441 tgtgcagatg gcagagccat cttttcctga aagaccctcc atca
//
