LOCUS       NM_019363               4276 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus aldehyde oxidase 1 (Aox1), mRNA.
ACCESSION   NM_019363
VERSION     NM_019363.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4276)
  AUTHORS   Foti,A., Hartmann,T., Coelho,C., Santos-Silva,T., Romao,M.J. and
            Leimkuhler,S.
  TITLE     Optimization of the Expression of Human Aldehyde Oxidase for
            Investigations of Single-Nucleotide Polymorphisms
  JOURNAL   Drug Metab Dispos 44 (8), 1277-1285 (2016)
   PUBMED   26842593
REFERENCE   2  (bases 1 to 4276)
  AUTHORS   Coelho,C., Foti,A., Hartmann,T., Santos-Silva,T., Leimkuhler,S. and
            Romao,M.J.
  TITLE     Structural insights into xenobiotic and inhibitor binding to human
            aldehyde oxidase
  JOURNAL   Nat Chem Biol 11 (10), 779-783 (2015)
   PUBMED   26322824
REFERENCE   3  (bases 1 to 4276)
  AUTHORS   Maia,L.B., Pereira,V., Mira,L. and Moura,J.J.
  TITLE     Nitrite reductase activity of rat and human xanthine oxidase,
            xanthine dehydrogenase, and aldehyde oxidase: evaluation of their
            contribution to NO formation in vivo
  JOURNAL   Biochemistry 54 (3), 685-710 (2015)
   PUBMED   25537183
  REMARK    GeneRIF: These results supported the possibility that XO/XD and AO
            can contribute to nitric oxide generation.
REFERENCE   4  (bases 1 to 4276)
  AUTHORS   Fu,C., Di,L., Han,X., Soderstrom,C., Snyder,M., Troutman,M.D.,
            Obach,R.S. and Zhang,H.
  TITLE     Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative
            characterization of AOX1 expression level and activity relationship
  JOURNAL   Drug Metab Dispos 41 (10), 1797-1804 (2013)
   PUBMED   23857892
REFERENCE   5  (bases 1 to 4276)
  AUTHORS   Swenson,T.L. and Casida,J.E.
  TITLE     Aldehyde oxidase importance in vivo in xenobiotic metabolism:
            imidacloprid nitroreduction in mice
  JOURNAL   Toxicol Sci 133 (1), 22-28 (2013)
   PUBMED   23462233
REFERENCE   6  (bases 1 to 4276)
  AUTHORS   Huang,D.Y., Furukawa,A. and Ichikawa,Y.
  TITLE     Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from
            rabbit and mouse livers and functional expression of recombinant
            mouse retinal oxidase cDNA in Escherichia coli
  JOURNAL   Arch Biochem Biophys 364 (2), 264-272 (1999)
   PUBMED   10190983
REFERENCE   7  (bases 1 to 4276)
  AUTHORS   Wright,R.M., Clayton,D.A., Riley,M.G., McManaman,J.L. and
            Repine,J.E.
  TITLE     cDNA cloning, sequencing, and characterization of male and female
            rat liver aldehyde oxidase (rAOX1). Differences in redox status may
            distinguish male and female forms of hepatic APX
  JOURNAL   J Biol Chem 274 (6), 3878-3886 (1999)
   PUBMED   9920943
REFERENCE   8  (bases 1 to 4276)
  AUTHORS   Berger,R., Mezey,E., Clancy,K.P., Harta,G., Wright,R.M.,
            Repine,J.E., Brown,R.H., Brownstein,M. and Patterson,D.
  TITLE     Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as
            possible candidate genes for autosomal recessive familial
            amyotrophic lateral sclerosis
  JOURNAL   Somat Cell Mol Genet 21 (2), 121-131 (1995)
   PUBMED   7570184
REFERENCE   9  (bases 1 to 4276)
  AUTHORS   Mather,P.B., Duley,J.A. and Holmes,R.S.
  TITLE     Aldehyde oxidase and alcohol dehydrogenase genetics in the mouse.
            New alleles for the Aox-2 and Adh-3 loci
  JOURNAL   Anim Blood Groups Biochem Genet 14 (4), 279-286 (1983)
   PUBMED   6372555
REFERENCE   10 (bases 1 to 4276)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics, ontogeny, and testosterone inducibility of aldehyde
            oxidase isozymes in the mouse: evidence for two genetic loci (Aox-I
            and Aox-2) closely linked on chromosome 1
  JOURNAL   Biochem Genet 17 (5-6), 517-527 (1979)
   PUBMED   518535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 18, 2021 this sequence version replaced NM_019363.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF110478.1, AF110477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000009.1  67073891-67073983
            94-151              JAXUCZ010000009.1  67088305-67088362
            152-248             JAXUCZ010000009.1  67092424-67092520
            249-357             JAXUCZ010000009.1  67095493-67095601
            358-484             JAXUCZ010000009.1  67097486-67097612
            485-546             JAXUCZ010000009.1  67101310-67101371
            547-636             JAXUCZ010000009.1  67102316-67102405
            637-717             JAXUCZ010000009.1  67103866-67103946
            718-862             JAXUCZ010000009.1  67105057-67105201
            863-955             JAXUCZ010000009.1  67105852-67105944
            956-1107            JAXUCZ010000009.1  67106772-67106923
            1108-1201           JAXUCZ010000009.1  67107088-67107181
            1202-1311           JAXUCZ010000009.1  67108877-67108986
            1312-1496           JAXUCZ010000009.1  67109817-67110001
            1497-1659           JAXUCZ010000009.1  67111228-67111390
            1660-1752           JAXUCZ010000009.1  67113079-67113171
            1753-1922           JAXUCZ010000009.1  67116744-67116913
            1923-2037           JAXUCZ010000009.1  67117215-67117329
            2038-2160           JAXUCZ010000009.1  67118643-67118765
            2161-2257           JAXUCZ010000009.1  67125131-67125227
            2258-2382           JAXUCZ010000009.1  67126201-67126325
            2383-2516           JAXUCZ010000009.1  67127704-67127837
            2517-2604           JAXUCZ010000009.1  67128812-67128899
            2605-2691           JAXUCZ010000009.1  67131924-67132010
            2692-2883           JAXUCZ010000009.1  67132424-67132615
            2884-3111           JAXUCZ010000009.1  67134396-67134623
            3112-3207           JAXUCZ010000009.1  67140449-67140544
            3208-3336           JAXUCZ010000009.1  67142287-67142415
            3337-3411           JAXUCZ010000009.1  67143007-67143081
            3412-3464           JAXUCZ010000009.1  67144798-67144850
            3465-3579           JAXUCZ010000009.1  67145719-67145833
            3580-3645           JAXUCZ010000009.1  67149215-67149280
            3646-3834           JAXUCZ010000009.1  67151028-67151216
            3835-4002           JAXUCZ010000009.1  67151648-67151815
            4003-4276           JAXUCZ010000009.1  67152707-67152980
FEATURES             Location/Qualifiers
     source          1..4276
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..4276
                     /gene="Aox1"
                     /note="aldehyde oxidase 1"
                     /db_xref="GeneID:54349"
                     /db_xref="RGD:620528"
     exon            1..93
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..4053
                     /gene="Aox1"
                     /EC_number="1.2.3.1"
                     /note="aldehyde oxidase (female form); azaheterocycle
                     hydroxylase 1"
                     /codon_start=1
                     /product="aldehyde oxidase 1"
                     /protein_id="NP_062236.3"
                     /db_xref="GeneID:54349"
                     /db_xref="RGD:620528"
                     /translation="MDPPQLLFYVNGQKVVENNVDPEMMLLPYLRKNLRLTGTKYGCG
                     GGGCGACTVMISRYNPSTKSIRHHPVNACLTPICSLYGTAVTTVEGIGNTRTRLHPVQ
                     ERIAKCHGTQCGFCTPGMVMSMYALLRNHPEPSLDQLTDALGGNLCRCTGYRPIIDAC
                     KTFCRASGCCESKENGVCCLDQGINGSAEFQEGDETSPELFSEKEFQPLDPTQELIFP
                     PELMRIAEKQPPKTRVFYSNRMTWISPVTLEELVEAKFKYPGAPIVMGYTSVGPEVKF
                     KGVFHPIIISPDRIEELSIINQTGDGLTLGAGLSLDQVKDILTDVVQKLPEETTQTYR
                     ALLKHLRTLAGSQIRNMASLGGHIVSRHLDSDLNPLLAVGNCTLNLLSKDGKRQIPLS
                     EQFLRKCPDSDLKPQEVLVSVNIPCSRKWEFVSAFRQAQRQQNALAIVNSGMRVLFRE
                     GGGVIKELSILYGGVGPTTIGAKNSCQKLIGRPWNEEMLDTACRLVLDEVTLAGSAPG
                     GKVEFKRTLIISFLFKFYLEVLQGLKREDPGHYPSLTNNYESALEDLHSKHHWRTLTH
                     QNVDSMQLPQDPIGRPIMHLSGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIV
                     SIDLSEALSLPGVVDIITADHLQDTTTFGTETLLATDKVHCVGQLVCAVIADSETRAK
                     QAAKHVKVVYRDLEPLILTIEEAIQHKSFFESERKLECGNVDEAFKIADQILEGEIHI
                     GGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKHIQDIVAATLKLSVNKVMCHVRRV
                     GGAFGGKVGKTSIMAAITAFAASKHGRAVRCTLERGEDMLITGGRHPYLGKYKVGFMR
                     DGRIVALDVEHYCNGGSSLDESLWVIEMGLLKMDNAYKFPNLRCRGWACRTNLPSNTA
                     LRGFGFPQAGLVTEACVTEVAIRCGLSPEQVRTINMYKQIDNTHYKQEFSAKTLFECW
                     RECMAKCSYSERKTAVGKFNAENSWKKRGMAVIPLKFPVGVGSVAMGQAAALVHIYLD
                     GSALVSHGGIEMGQGVHTKMIQVVSRELKMPMSSVHLRGTSTETVPNTNASGGSVVAD
                     LNGLAVKDACQTLLKRLEPIISKNPQGTWKDWAQTAFDQSVSLSAVGYFRGYESNINW
                     EKGEGHPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGHSINPALDIGQVEGAFI
                     QGMGLYTIEELSYSPQGILYSRGPNQYKIPAICDIPTEMHISFLPPSEHSNTLYSSKG
                     LGESGVFLGCSVFFAIHDAVRAARQERGISGPWKLTSPLTPEKIRMACEDKFTKMIPR
                     DEPGSYVPWNIPV"
     exon            94..151
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            152..248
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..357
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..484
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..546
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..636
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..717
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..862
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..955
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1107
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1201
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1311
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1496
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1659
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1752
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1922
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2037
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2160
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2257
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2382
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2516
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2604
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2691
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2883
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3111
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3207
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3336
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3411
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3464
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3579
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3580..3645
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..3834
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..4002
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4276
                     /gene="Aox1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctagggacc cgctagggat ctactaggga cctgctaggg acctcgtcgt catggatccc
       61 ccgcagctgc tcttctacgt gaatggccag aaggtggtag aaaacaatgt tgatcctgag
      121 atgatgcttt taccgtacct gaggaagaac ctccgactca cgggaactaa gtatggctgt
      181 ggaggcggcg gctgcggtgc ctgcacagtg atgatctcac ggtacaaccc cagcaccaag
      241 agcatcaggc atcatcctgt caatgcctgt ctgaccccca tctgctctct gtacggtaca
      301 gcagtcacca cagtagaggg cataggcaac accaggacca gacttcatcc tgttcaggag
      361 aggatcgcca agtgtcacgg cacccagtgt gggttctgta cccctgggat ggtgatgtcc
      421 atgtatgctc tgctcaggaa ccacccagag ccctctctag atcagttaac tgatgccctt
      481 ggggggaatc tgtgccgctg taccggatac aggcccataa ttgacgcttg caagactttc
      541 tgtagagctt ctggttgctg tgaaagtaaa gaaaatgggg tgtgctgttt ggatcaagga
      601 ataaatggat cggcagaatt tcaggaagga gatgagacaa gtccagaact gttctcggaa
      661 aaggaatttc agccactgga cccaacccaa gagctgatat ttcctccaga gctaatgaga
      721 atagccgaga aacagccacc aaagaccaga gtgttctaca gtaatagaat gacatggatc
      781 tccccggtga ccctggagga acttgtggaa gctaagttca agtatcctgg ggcccccatt
      841 gtcatggggt acacctctgt ggggcctgaa gtaaagttta aaggtgtctt ccaccccatc
      901 ataatttctc ctgacagaat tgaagagctg agtatcataa accagactgg ggatgggctg
      961 accctgggtg ctggcctcag cctggaccag gtgaaggaca ttctcactga cgtggtccag
     1021 aagcttccag aagagacgac acagacatac cgtgcgctcc tgaagcacct gagaactctg
     1081 gctggctctc agatcaggaa tatggcttct ttagggggcc acatcgtgag cagacatctg
     1141 gactcggatc tgaatcccct tctggctgtg ggtaattgta ccctcaactt actatccaaa
     1201 gatggaaaac ggcagatccc tttaagtgag cagtttctcc gcaagtgtcc tgactcggat
     1261 cttaagcctc aggaagtctt ggtctcagtg aacatcccct gttccaggaa gtgggagttt
     1321 gtgtcagcct tccgacaagc ccagagacag cagaatgcac tagcgattgt caactctgga
     1381 atgagagtcc tttttagaga aggaggtggc gtcattaaag agttatccat tttgtatgga
     1441 ggtgtcggtc caaccaccat cggtgccaag aactcctgtc agaaactcat tggaaggccc
     1501 tggaatgaag agatgctgga cacagcatgc aggctggttt tggatgaagt cacccttgca
     1561 ggttcagctc ctggtgggaa ggtggagttc aagaggaccc tcatcatcag cttccttttc
     1621 aagttctacc tggaggtgct gcagggtctg aagagggagg acccaggtca ctatcctagc
     1681 ttgacaaaca attatgagag tgctttagaa gatctccatt caaaacatca ctggagaaca
     1741 ttaacccacc agaacgtgga ctcgatgcag cttcctcagg acccaattgg ccgtcccatc
     1801 atgcaccttt ctggtattaa gcacgctacc ggcgaggcca tctactgtga cgacatgcct
     1861 gcagtagacc gggagctttt cctgactttt gtaacaagtt caagagcaca cgctaagatt
     1921 gtgtccattg atctgtcaga agctctcagc ctgccaggcg tggtggacat cattactgcg
     1981 gatcatcttc aggacacaac caccttcggc acagagacgc ttctggccac agataaggtc
     2041 cactgcgtgg gccaacttgt ctgtgccgtg attgcggatt ctgagacacg ggcaaagcaa
     2101 gcggcgaagc acgtgaaggt ggtctaccga gacttggagc ctctgatcct aactattgag
     2161 gaagctatac aacacaagtc cttcttcgag tcagaacgga agctggagtg tggaaatgtt
     2221 gatgaagcgt ttaaaattgc tgatcaaatt cttgaaggtg agatacacat aggcggccag
     2281 gaacattttt atatggaaac ccaaagcatg cttgttgtcc ccaaaggaga ggacggagag
     2341 attgacatct atgtgtccac acagttcccc aagcatatac aggatatagt tgctgcaacc
     2401 ttgaagcttt cagtcaacaa ggtcatgtgt catgtaaggc gtgttggtgg ggcgttcgga
     2461 gggaaggtag gcaagaccag catcatggcg gccatcactg cattcgctgc cagcaaacac
     2521 ggtcgcgcgg tccgctgcac tctggaacga ggggaagaca tgttaataac tgggggccgc
     2581 catccttacc ttggaaagta taaagttgga ttcatgaggg acggcagaat cgtggccctg
     2641 gatgtggagc actattgcaa tggagggagc tccctggatg agtccttatg ggtgatagaa
     2701 atggggcttc tgaagatgga caacgcttac aagtttccca atctacgctg ccggggctgg
     2761 gcctgcagaa ccaacctccc gtccaacact gctctgcgtg ggtttggctt tcctcaggca
     2821 gggctggtca ccgaagcctg tgtcacagaa gtggcaatca gatgtggcct gtcccctgag
     2881 caggttcgaa ccataaatat gtacaagcaa attgataata cccattacaa gcaagaattc
     2941 agcgccaaga ccctctttga gtgctggaga gaatgcatgg ccaagtgttc ctactctgag
     3001 aggaaaacgg ctgtaggaaa attcaatgca gagaattcct ggaagaagag gggaatggcc
     3061 gtgattccat tgaagtttcc tgtgggtgtt ggctcagtag ccatgggaca ggcggctgcc
     3121 ctggtccata tttatcttga tggctctgca ctggtctctc acggtgggat tgagatgggg
     3181 cagggtgtcc acactaaaat gatccaggtg gtcagccggg aattaaagat gccaatgtcg
     3241 agtgtccacc tgcgtgggac aagcacagaa accgtcccca acaccaatgc atctggaggc
     3301 tctgtggtgg cagatctcaa tggattggca gtaaaggatg cttgccagac ccttctaaaa
     3361 cgccttgagc ccatcatcag caagaacccc cagggaactt ggaaggattg ggcccagact
     3421 gcttttgacc agagcgtcag tctctcggct gttggatatt tcaggggcta cgagtcgaat
     3481 ataaactggg agaaagggga aggccatccc ttcgaatact ttgtgtatgg agctgcctgc
     3541 tcagaggttg aaatagactg cctgaccggg gaccataaga atatcagaac agacatcgtg
     3601 atggatgttg gccacagcat aaacccagcc cttgacatag gccaggttga aggtgcattt
     3661 attcaaggaa tgggacttta cacgatagag gagctgagct actctcctca gggcattctg
     3721 tacagtcgtg gtccaaacca gtacaagatc cctgccatct gcgacatccc caccgagatg
     3781 cacatttctt ttttgccccc atccgaacac tcaaacaccc tgtattcatc taagggtctg
     3841 ggagagtctg gggtgttcct gggctgttcg gtattttttg ccatccatga cgcagtgagg
     3901 gcagcgcggc aggagagagg catctctgga ccatggaagc tcactagtcc tctgactcca
     3961 gagaaaatca gaatggcttg tgaagataag ttcacaaaaa tgattccaag agatgaacct
     4021 ggatcctatg ttccctggaa catacctgtg tgagtgaaat atgaacttct gaaaggattg
     4081 gctcaacaac tacagaacgc acctcccggt ctctctgctc taagatgcta aatatgaaag
     4141 ccagagtttc acagcccaga atcatccaca gcactgcttt actgattcgg aagtttctct
     4201 tgaggatact ccagatacac ctgagacatt ataaatcata tatcaaattg cacaaatatt
     4261 aaatcgtttg ctcaga
//
