LOCUS       XM_017600473            6234 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus aminopeptidase O (Aopep), transcript
            variant X8, mRNA.
ACCESSION   XM_017600473
VERSION     XM_017600473.2
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051352.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_017600473.3.
            
            On Jan 21, 2021 this sequence version replaced XM_017600473.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6234
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..6234
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /note="aminopeptidase O; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 5
                     mRNAs, 44 ESTs, 5 long SRA reads, 9 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 17 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:290963"
                     /db_xref="RGD:1309592"
     CDS             283..2751
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /codon_start=1
                     /product="aminopeptidase O isoform X2"
                     /protein_id="XP_017455962.1"
                     /db_xref="GeneID:290963"
                     /db_xref="RGD:1309592"
                     /translation="MDINLDPSRDDLPLMANTSHLLVKHYVLDLDVDFGSRVLEGNIV
                     LFFGDGNRCKKQSSSSQETFQMESEEAYILRTAEPCHVPKMDSNTFSPKMGHREFAVF
                     GKSDQDAFDNDGNHDNKEHDSESSSSKYCCDTGNHGREDFLLVLDCCDLSVLKVEEVD
                     VAAVPDLEKFTKAPNLTAAPEKRRCEIVRDLVALPADAWREQLDCYTRCSQAPGCGEL
                     LFDSDKWSLQIRKKGVPTAADFPHAIRIWYKTKPEGQSVTWTSDQDGRPCVYTMGSPI
                     NNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGEKSAKPTPLREGYMSWHYYVTMPM
                     PASTFTIAVGCWTEMKPKTSPLDDLTEHTLPLRPSDADFRYGNTCSHMEYPCRFQSAS
                     AATQNIIPYRVFAPVCLEGACREALLWLIPSCLSAAHSVLGTHPFSRLDILIVPTNFP
                     SLGMASPHIIFLSQSTLTGTSHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATH
                     LEDIFWAEAQQLPPHEALEQQELRACLRWHRLQDELQNSPEGMQVLRPNKEKTGHVSA
                     SGASVVKNGLNPEKGFMQVHYLKGYFLLRFLARTLGEETYFPFLRKFVHLFHGQLILS
                     QDFLQMLLESIPENKRFGLSVENIVGDWLECPGIPKALQEERKAKDCSPSRLVRQVGS
                     EVAKWIRVNRRPGKRQRRKREAAFEKLSPDQIVLLLEWLLEQKTLSPQTLHRLQQTYH
                     LQEQDAEVRHRWCELVIKHKYTKAYDQVKRFLQEDQAMGIYLYGELMVSEDARLQQLA
                     HRCFELVKGHMDKASAQVVTEMLF"
ORIGIN      
        1 tgtagtttta cataagaatt gctcttttga aacaaggact gtgtccctta gcagcttaga
       61 agtcagtaat gtggcttctc tcctgtcaga aagatgatcc ttcactcttc cctgagcagc
      121 tgccaccttg tggattgcta gggaattgga agttgtggaa agacaaccta tgccagtggg
      181 tgcttcttat ttggtaagcc agccatttgt gattctgagc tgctagagga gataagaagc
      241 ctcagctgcg attcagcaaa gctaccaact gcaaactaca ccatggacat aaacctggac
      301 ccttctcggg atgatctgcc tctcatggcc aacaccagcc acctgcttgt gaagcactac
      361 gtactggatt tggatgtgga ctttggaagt cgagtccttg agggcaacat agtgcttttc
      421 tttggagatg gaaacagatg taaaaaacaa tcgagttcct cccaggaaac cttccagatg
      481 gagtcagagg aagcctacat acttaggaca gctgaaccct gccatgttcc aaagatggat
      541 tcaaatactt tctcacctaa gatgggacat agagaatttg cagtctttgg taaaagtgat
      601 caagatgcct ttgataatga tggtaaccat gacaacaagg aacatgattc tgagagctct
      661 agctcaaagt actgctgtga cacagggaat catgggagag aggatttctt gctagtgttg
      721 gactgctgtg atttgtctgt gctaaaggta gaggaggtgg atgtagctgc tgtgccagat
      781 cttgagaaat ttacaaaagc tccaaacctc acagctgctc ctgagaagcg caggtgtgag
      841 attgtccgtg accttgtggc tctgcctgca gatgcttgga gggagcagtt agactgctac
      901 actcgctgca gccaggctcc tggctgtggg gagctcttgt ttgactctga caagtggagc
      961 ttacagatca ggaagaaggg ggttccgaca gctgctgact ttcctcatgc catcaggata
     1021 tggtataaaa ctaaacctga ggggcagtca gtgacttgga cctcagacca ggatggcagg
     1081 ccatgtgttt atactatggg atcccccatc aacaacaggg ccctttttcc atgccaggaa
     1141 ccaccggttg ccatgtcaac atggcaggct acagttcgag cagctgcatc ttttgttgtt
     1201 ttaatgagtg gggaaaagtc tgccaagccc acaccacttc gagaaggata catgagctgg
     1261 cattactatg tgaccatgcc aatgcctgcc tctaccttca caattgcagt gggatgctgg
     1321 acagaaatga agcccaagac atccccatta gatgatctga ctgagcacac cctccccctc
     1381 cgaccatcag acgctgactt caggtatggt aacacctgca gtcatatgga atacccctgc
     1441 cggttccaga gtgcgtctgc tgccacccag aacatcattc cttatcgagt gtttgcccca
     1501 gtgtgccttg agggtgcctg ccgagaggcc ctgctgtggc tgatcccctc ttgcctctca
     1561 gctgcacact ctgtcctggg aacacaccct ttctccaggc tggacatact tattgtcccc
     1621 accaacttcc caagtctggg aatggccagc ccacacatca tcttcctctc tcagagcacc
     1681 ttgacaggca caagccatct ctgcgggacc cgtctttgcc atgaaattgc tcatgcctgg
     1741 tttggcctag ccataggggc ccgagactgg acagaggagt ggctcagcga aggatttgcc
     1801 actcacttgg aagatatatt ttgggctgaa gcacagcagc tgcccccaca tgaggccctg
     1861 gagcagcaag agctgagggc ttgcctgcgc tggcaccgcc tgcaggatga gcttcagaac
     1921 tccccagagg gaatgcaggt gttaagaccc aacaaagaga agactggtca cgtgagtgct
     1981 tcaggtgcct ctgttgtcaa gaatggactc aacccagaga agggcttcat gcaggttcat
     2041 tacttaaagg gctacttcct tcttcgattc ctagccagaa cacttggaga ggaaacttat
     2101 tttccatttt taagaaaatt tgtgcacctg tttcatgggc agttgattct ttcccaggat
     2161 tttcttcaaa tgctgttgga gagcattcca gaaaacaaaa ggttcggcct gtctgttgag
     2221 aacatcgtcg gtgattggct tgagtgtccc ggaataccca aggcactgca ggaggagcgc
     2281 aaggccaagg actgctcgcc gagtaggctg gtacggcaag tgggctccga ggtggccaaa
     2341 tggattcgag tgaaccgaag acccggaaaa cgccaacgaa ggaaacgtga agccgccttt
     2401 gaaaagcttt ctccagacca gatcgtgttg cttttggagt ggctcttaga gcagaagacc
     2461 ctgagccccc agacattgca tcgtctccag cagacgtacc atctccagga gcaggatgca
     2521 gaggttcgcc atcgatggtg tgaactggtt attaagcaca agtacacaaa ggcatatgat
     2581 caggtcaaga ggttcctaca ggaggatcag gccatgggca tatacctcta cggggagctg
     2641 atggtgagtg aggatgccag gctgcagcag cttgcccacc ggtgctttga gctggtaaag
     2701 ggacacatgg acaaagcatc cgcccaggtg gtgaccgaaa tgctgttcta aagaggtaat
     2761 tttctttctt tctcctccta accctccatg ttgatttgaa agccacagat gagccaaggc
     2821 cgccacagca ccagagggct gccaagcggt cttggggagc aagcagggtg ggtccccaag
     2881 aacaggaagg ctcaggatct ctggagccac ctcgtcttct ggatatactg gtgtaaaaca
     2941 ggttcctact aaaggaggaa cagccccctg gtaccttgga ttctgcacag atccacaggc
     3001 ttctcagggt caaggtcagc acagtggtcc gcagcctcgc tgctccaagc ttcggcctgc
     3061 aggcgtttct cctagaggct gtgtaaacct gagactcctt ggcctcttgt ctccccgacc
     3121 tgtaaagtag gcagcagcgt gttcttacac atcccccttg ctcagtgacc ggtgaggtag
     3181 acagcaggtc ttctttgcct gtccacccag gtgacactgg catcctaagg gcaagtctgt
     3241 ttccatctgg tgctggaaca gggtttaccc tggctcccag agtccttgcc tgtgctgtta
     3301 ccttccccct ctagccaact tgttgaccag tagtgtagtt gagccacaaa gcatggagtt
     3361 ctgggacaca agtgtgggtt agtgtgtttc tttcacagtc atgtcatctc tgcatcttct
     3421 ttctcagtta ttgtcatggt ggtacatatg atgtttactt ttcgtatatt ttttaaattt
     3481 tacatcaatc actgtgttac tgttgttctc tgtgagtact attatgaatg tttagaattg
     3541 tgttgctaat cttaactctt ggtcaggcat taaatttaca ttttcacatt tcacttttac
     3601 aaaacccact cctgtgtact atgtttattt tgtttatgtg aaagaactaa tcttatgaag
     3661 gggaagcatg tttactgaaa tatgatggtg ttcttgcgga aatgctgggg accgccatag
     3721 ttgagcagag gagagtgtgg ggtggagtaa gcctgcacac cacgacctag gacggtggcc
     3781 tgtgcaagca ggcaggttcg gctgggctcc tctccactgc ctgctgcagg catttctcta
     3841 ggaacttgta agctcaggga ttgttggtgt ggtgtgtaag gtcacaataa agccactatt
     3901 ctgtcttccg gtcctttggc cttcactttg gagagccaga gtcagatagt ggtacgagcg
     3961 actcttctaa gggtattttt ggcccctgtg caagcaaatc ctcaacttcc aagctcccct
     4021 gagaactcta tgctgtaccc cagctcatcc aaccaaatgc ttggtcacag cagctccaga
     4081 aactctctgc acaccatgcc tactgagaag agtttcctat ccaaggggcc catagacatc
     4141 tcaggccatt aaaaatctgc agtttgagaa cagggtgtgt ccccagggtt aaaggtcaca
     4201 tactcagagc gaggattggt catgtagctg ataagtgtgt cctttgtctc ctggttccct
     4261 atgctcctct atacagtgca gctagcatgc tggatgacag caggctacat acactgctag
     4321 cgtggtgggc tcagaggcgg tgtggaggac actcagcgca tgtggatggg agtggttggg
     4381 catggcgctg ccctcacctg ctctggctgc ttgggttcct ggcatgctga tttgtgactt
     4441 gagattaaaa tcacattgcc agggattacc acgcaaccat gaccttggct gctcctgcag
     4501 aaccgtggct actttctctc tgcagtttgg agaacagagg caccttgtgg ctctttggga
     4561 aaaaaaaaaa aaaaaaaaga agccaccagc cttcgaagat gctcaccagc cctttaatta
     4621 tggccggcga tgacctctct aacaaggtgc agagcttagc tgattggtga acagtgattg
     4681 gtttccgctt tgttcacagt ggctaagttc tgcacctgaa gagaaggtga gatggggaca
     4741 gttaacttgc agctgccagg cagaggccac tgcctggtgg tcactccaga ggaggagaga
     4801 ccagcctgcc tcaaggctgt gttgtcaaga gtgcaagcag cgtgctgacc acccttaaat
     4861 gtgcctacag aaaatacaga tctactgcta attagtccac tgtaatatca agtgtattgg
     4921 agtcacagaa aactaaaacc agatgcatca caaaagctga gcggagtctc agctgatgcc
     4981 acacgtgagg gtggggttgg gggtggttct tttgtccctg ctgggcgtgg tgaactcttt
     5041 cttgtatttg cagtccaggt ctccatgtct tcacagtcgc tggcaggatg atgcccaggg
     5101 cacgccagga ggcactgccc agctgtgatt ggacccgccc tccggtgcct actgagctga
     5161 tatcagttct catttcacac actggctcag ttcagcagga acaggagtcg agcccttgag
     5221 caaaaagcct acccatctgt aagtgcctga ggcaggcctc ccacggacaa gaagatgaag
     5281 ggccttgagt gtctggtacc agacccaaca gcagtggtat ccctctgtat gtgctcttga
     5341 ggtggggatt tatagagtgc agatcaaact ttggaaagat tgcattccct agaagtaagg
     5401 cagagcagaa gccgagcgtt tgccatgtgt ttgagacaga gcacaccctg ttgtctgctg
     5461 ccttgagcag tgtgaatgct gtcttaaggg ctttctgtag agccgccttc cattgaatct
     5521 ctctgggctt cacagccctg catggcctat gctgtgactg tgcaccccag gtcgaggatt
     5581 gtgaggcgtg gcttcagtct tgtccctgtc ctccctgaaa gttccctctc aagtggaggt
     5641 cagaggctag gagaactcct gtcagaatga ctgtggtgac tgggtaataa attttattgc
     5701 tgtttccttc acaggacaga tcacagtgag attctctttc atacaccttc tcctagccct
     5761 ggtggggcca ggactgcatt gaccctggac atcaaaggga agattatgtg gctgctaagg
     5821 ccatcagccc acagcagcgg ttggtccagc ttgggcttct ggctcccaga gcccgggctc
     5881 ccgtggcata tataaaaggc ggagcctcat aaactgttgc acctggcagc tgcctttgtc
     5941 cccagtccta gagaccgagt ctacacactg gaattgagct gtgacttgaa ggcagtcctt
     6001 caaaagaatg aaggataccc tcccctaggc agatggagaa ccgactgcct gcttcctgtg
     6061 attgcaagca ctagctgcca tgctctggga ctgcagaatc acatgacacc tcctgtggct
     6121 ggcccccaag gactctgcag agaccctttg atgtgttcag tcaatagagc attcctgttt
     6181 ttgaaaatgc agggaagcct aagatgtctt aataaagtac cggatttgct ggtg
//
