LOCUS       NM_001012346            3878 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus aminopeptidase O (Aopep), mRNA.
ACCESSION   NM_001012346 XM_225111
VERSION     NM_001012346.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3878)
  AUTHORS   Axton,R., Wallis,J.A., Taylor,H., Hanks,M. and Forrester,L.M.
  TITLE     Aminopeptidase O contains a functional nucleolar localization
            signal and is implicated in vascular biology
  JOURNAL   J Cell Biochem 103 (4), 1171-1182 (2008)
   PUBMED   17803194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jul 23, 2021 this sequence version replaced NM_001012346.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.56821.1,
                                           SRR26360172.1253657.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000017.1  2132877-2132979     c
            104-1041            JAXUCZ010000017.1  2082078-2083015     c
            1042-1208           JAXUCZ010000017.1  2066267-2066433     c
            1209-1365           JAXUCZ010000017.1  2040990-2041146     c
            1366-1611           JAXUCZ010000017.1  2030376-2030621     c
            1612-1801           JAXUCZ010000017.1  1947353-1947542     c
            1802-1908           JAXUCZ010000017.1  1943112-1943218     c
            1909-2011           JAXUCZ010000017.1  1923488-1923590     c
            2012-2119           JAXUCZ010000017.1  1922847-1922954     c
            2120-2163           JAXUCZ010000017.1  1913791-1913834     c
            2164-2224           JAXUCZ010000017.1  1903256-1903316     c
            2225-2293           JAXUCZ010000017.1  1878869-1878937     c
            2294-2368           JAXUCZ010000017.1  1878694-1878768     c
            2369-2485           JAXUCZ010000017.1  1837692-1837808     c
            2486-2572           JAXUCZ010000017.1  1822995-1823081     c
            2573-2717           JAXUCZ010000017.1  1821120-1821264     c
            2718-3878           JAXUCZ010000017.1  1817001-1818161     c
FEATURES             Location/Qualifiers
     source          1..3878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..3878
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /note="aminopeptidase O"
                     /db_xref="GeneID:290963"
                     /db_xref="RGD:1309592"
     exon            1..103
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            104..1041
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..2713
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /note="AP-O"
                     /codon_start=1
                     /product="aminopeptidase O"
                     /protein_id="NP_001012346.2"
                     /db_xref="GeneID:290963"
                     /db_xref="RGD:1309592"
                     /translation="MDINLDPSRDDLPLMANTSHLLVKHYVLDLDVDFGSRVLEGNIV
                     LFFGDGNRCKKQSSSSQETFQMESEEAYILRTAEPCHVPKMDSNTFSPKMGHREFAVF
                     GKSDQDAFDNDGNHDNKEHDSESSSSKYCCDTGNHGREDFLLVLDCCDLSVLKVEEVD
                     VAAVPDLEKFTKAPNLTAAPEKRRCEIVRDLVALPADAWREQLDCYTRCSQAPGCGEL
                     LFDSDKWSLQIRKKGVPTAADFPHAIRIWYKTKPEGQSVTWTSDQDGRPCVYTMGSPI
                     NNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGEKSAKPTPLREGYMSWHYYVTMPM
                     PASTFTIAVGCWTEMKPKTSPLDDLTEHTLPLRPSDADFRYGNTCSHMEYPCRFQSAS
                     AATQNIIPYRVFAPVCLEGACREALLWLIPSCLSAAHSVLGTHPFSRLDILIVPTNFP
                     SLGMASPHIIFLSQSTLTGTSHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATH
                     LEDIFWAEAQQLPPHEALEQQELRACLRWHRLQDELQNSPEGMQVLRPNKEKTGHVSA
                     SGASVVKNGLNPEKGFMQVHYLKGYFLLRFLARTLGEETYFPFLRKFVHLFHGQLILS
                     QDFLQMLLESIPENKRFGLSVENIVGDWLECPGIPKALQEERKAKDCSPSRLVRQVGS
                     EVAKWIRVNRRPGKRQRRKREAAFEKLSPDQIVLLLEWLLEQKTLSPQTLHRLQQTYH
                     LQEQDAEVRHRWCELVIKHKYTKAYDQVKRFLQEDQAMGIYLYGELMVSEDARLQQLA
                     HRCFELVKGHMDKASAQVVTEMLF"
     exon            1042..1208
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1365
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1611
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1801
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1908
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2011
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2119
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2163
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2224
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2293
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2368
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2485
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2572
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2717
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..3878
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtgtag ctgcagcacg gtggccgaca ggtaacccgc agctcggctg tcaaccagcc
       61 actccgggtt atggggatcg gcgacctctg atgaggtgag cagggaattg gaagttgtgg
      121 aaagacaacc tatgccagtg ggtgcttctt atttggtaag ccagccattt gtgattctga
      181 gctgctagag gagataagaa gcctcagctg cgattcagca aagctaccaa ctgcaaacta
      241 caccatggac ataaacctgg acccttctcg ggatgatctg cctctcatgg ccaacaccag
      301 ccacctgctt gtgaagcact acgtactgga tttggatgtg gactttggaa gtcgagtcct
      361 tgagggcaac atagtgcttt tctttggaga tggaaacaga tgtaaaaaac aatcgagttc
      421 ctcccaggaa accttccaga tggagtcaga ggaagcctac atacttagga cagctgaacc
      481 ctgccatgtt ccaaagatgg attcaaatac tttctcacct aagatgggac atagagaatt
      541 tgcagtcttt ggtaaaagtg atcaagatgc ctttgataat gatggtaacc atgacaacaa
      601 ggaacatgat tctgagagct ctagctcaaa gtactgctgt gacacaggga atcatgggag
      661 agaggatttc ttgctagtgt tggactgctg tgatttgtct gtgctaaagg tagaggaggt
      721 ggatgtagct gctgtgccag atcttgagaa atttacaaaa gctccaaacc tcacagctgc
      781 tcctgagaag cgcaggtgtg agattgtccg tgaccttgtg gctctgcctg cagatgcttg
      841 gagggagcag ttagactgct acactcgctg cagccaggct cctggctgtg gggagctctt
      901 gtttgactct gacaagtgga gcttacagat caggaagaag ggggttccga cagctgctga
      961 ctttcctcat gccatcagga tatggtataa aactaaacct gaggggcagt cagtgacttg
     1021 gacctcagac caggatggca ggccatgtgt ttatactatg ggatccccca tcaacaacag
     1081 ggcccttttt ccatgccagg aaccaccggt tgccatgtca acatggcagg ctacagttcg
     1141 agcagctgca tcttttgttg ttttaatgag tggggaaaag tctgccaagc ccacaccact
     1201 tcgagaagga tacatgagct ggcattacta tgtgaccatg ccaatgcctg cctctacctt
     1261 cacaattgca gtgggatgct ggacagaaat gaagcccaag acatccccat tagatgatct
     1321 gactgagcac accctccccc tccgaccatc agacgctgac ttcaggtatg gtaacacctg
     1381 cagtcatatg gaatacccct gccggttcca gagtgcgtct gctgccaccc agaacatcat
     1441 tccttatcga gtgtttgccc cagtgtgcct tgagggtgcc tgccgagagg ccctgctgtg
     1501 gctgatcccc tcttgcctct cagctgcaca ctctgtcctg ggaacacacc ctttctccag
     1561 gctggacata cttattgtcc ccaccaactt cccaagtctg ggaatggcca gcccacacat
     1621 catcttcctc tctcagagca ccttgacagg cacaagccat ctctgcggga cccgtctttg
     1681 ccatgaaatt gctcatgcct ggtttggcct agccataggg gcccgagact ggacagagga
     1741 gtggctcagc gaaggatttg ccactcactt ggaagatata ttttgggctg aagcacagca
     1801 gctgccccca catgaggccc tggagcagca agagctgagg gcttgcctgc gctggcaccg
     1861 cctgcaggat gagcttcaga actccccaga gggaatgcag gtgttaagac ccaacaaaga
     1921 gaagactggt cacgtgagtg cttcaggtgc ctctgttgtc aagaatggac tcaacccaga
     1981 gaagggcttc atgcaggttc attacttaaa gggctacttc cttcttcgat tcctagccag
     2041 aacacttgga gaggaaactt attttccatt tttaagaaaa tttgtgcacc tgtttcatgg
     2101 gcagttgatt ctttcccagg attttcttca aatgctgttg gagagcattc cagaaaacaa
     2161 aaggttcggc ctgtctgttg agaacatcgt cggtgattgg cttgagtgtc ccggaatacc
     2221 caaggcactg caggaggagc gcaaggccaa ggactgctcg ccgagtaggc tggtacggca
     2281 agtgggctcc gaggtggcca aatggattcg agtgaaccga agacccggaa aacgccaacg
     2341 aaggaaacgt gaagccgcct ttgaaaagct ttctccagac cagatcgtgt tgcttttgga
     2401 gtggctctta gagcagaaga ccctgagccc ccagacattg catcgtctcc agcagacgta
     2461 ccatctccag gagcaggatg cagaggttcg ccatcgatgg tgtgaactgg ttattaagca
     2521 caagtacaca aaggcatatg atcaggtcaa gaggttccta caggaggatc aggccatggg
     2581 catatacctc tacggggagc tgatggtgag tgaggatgcc aggctgcagc agcttgccca
     2641 ccggtgcttt gagctggtaa agggacacat ggacaaagca tccgcccagg tggtgaccga
     2701 aatgctgttc taaagaggac agatcacagt gagattctct ttcatacacc ttctcctagc
     2761 cctggtgggg ccaggactgc attgaccctg gacatcaaag ggaagattat gtggctgcta
     2821 aggccatcag cccacagcag cggttggtcc agcttgggct tctggctccc agagcccggg
     2881 ctcccgtggc atatataaaa ggcggagcct cataaactgt tgcacctggc agctgccttt
     2941 gtccccagtc ctagagaccg agtctacaca ctggaattga gctgtgactt gaaggcagtc
     3001 cttcaaaaga atgaaggata ccctccccta ggcagatgga gaaccgactg cctgcttcct
     3061 gtgattgcaa gcactagctg ccatgctctg ggactgcaga atcacatgac acctcctgtg
     3121 gctggccccc aaggactctg cagagaccct ttgatgtgtt cagtcaatag agcattcctg
     3181 tttttgaaaa tgcagggaag cctaagatgt cttaataaag taccggattt gctggtgttc
     3241 cagtttgcct ctgaatttga tgttccttaa aaacaaggaa gaccgtatgt cagaacaggc
     3301 tctgtccaca cacagtatcc tttcctacct ctgggtaatg ttaactgaga aggcggaagt
     3361 aaagggagat tagtatggca caggattctg ctctcttcca aatgtggagt ctcggccagc
     3421 ctggtactag gggagtctct ggtgagaatc tgttccttct ctttgaatat taatgtacag
     3481 aacaagctct aagaagcttc cagtttatgt ctagagaaag atgcttgaga ttgtgccatc
     3541 ggtgcagtca cgtgagcccg gacagggctg agctgtgtga aaaggaaccg gaaggagtat
     3601 tccactgcct ggcctggctt ctgcattcag acctgctggg cgaggaaggc tctaggacag
     3661 acttgagagg agtgtcctca gcagattacc attgggtttc agagcctggg ctgtaccagt
     3721 gactgcattt ggatagttgt gggggacagc gaatggttat ctgctgtgta tgccacgatg
     3781 gtagaagtat caagatgtgt taattccact taatagtaca ctgctttctg tgaagacttg
     3841 aaataaatgg ctgagtctat ggctccctat tctcagaa
//
