LOCUS       NP_001012346             822 aa            linear   ROD 01-MAY-2025
DEFINITION  aminopeptidase O [Rattus norvegicus].
ACCESSION   NP_001012346 XP_225111
VERSION     NP_001012346.2
DBSOURCE    REFSEQ: accession NM_001012346.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 822)
  AUTHORS   Axton,R., Wallis,J.A., Taylor,H., Hanks,M. and Forrester,L.M.
  TITLE     Aminopeptidase O contains a functional nucleolar localization
            signal and is implicated in vascular biology
  JOURNAL   J Cell Biochem 103 (4), 1171-1182 (2008)
   PUBMED   17803194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jul 23, 2021 this sequence version replaced NP_001012346.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.56821.1,
                                           SRR26360172.1253657.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     Protein         1..822
                     /product="aminopeptidase O"
                     /note="AP-O"
                     /calculated_mol_wt=93301
     Region          <244..640
                     /region_name="GluZincin"
                     /note="Gluzincin Peptidase family (thermolysin-like
                     proteinases, TLPs) which includes peptidases M1, M2, M3,
                     M4, M13, M32 and M36 (fungalysins); cl14813"
                     /db_xref="CDD:472708"
     Site            587
                     /site_type="other"
                     /note="Transition state stabilizer.
                     /evidence=ECO:0000250|UniProtKB:P15144; propagated from
                     UniProtKB/Swiss-Prot (P69527.2)"
     Region          692..702
                     /region_name="Nucleolar localization signal.
                     /evidence=ECO:0000250|UniProtKB:Q8BXQ6"
                     /note="propagated from UniProtKB/Swiss-Prot (P69527.2)"
     Region          709..821
                     /region_name="Leuk-A4-hydro_C"
                     /note="Leukotriene A4 hydrolase, C-terminal; pfam09127"
                     /db_xref="CDD:462686"
     CDS             1..822
                     /gene="Aopep"
                     /gene_synonym="Apo; Npepo; RGD1309592"
                     /coded_by="NM_001012346.2:245..2713"
                     /db_xref="GeneID:290963"
                     /db_xref="RGD:1309592"
ORIGIN      
        1 mdinldpsrd dlplmantsh llvkhyvldl dvdfgsrvle gnivlffgdg nrckkqssss
       61 qetfqmesee ayilrtaepc hvpkmdsntf spkmghrefa vfgksdqdaf dndgnhdnke
      121 hdsessssky ccdtgnhgre dfllvldccd lsvlkveevd vaavpdlekf tkapnltaap
      181 ekrrceivrd lvalpadawr eqldcytrcs qapgcgellf dsdkwslqir kkgvptaadf
      241 phairiwykt kpegqsvtwt sdqdgrpcvy tmgspinnra lfpcqeppva mstwqatvra
      301 aasfvvlmsg eksakptplr egymswhyyv tmpmpastft iavgcwtemk pktsplddlt
      361 ehtlplrpsd adfrygntcs hmeypcrfqs asaatqniip yrvfapvcle gacreallwl
      421 ipsclsaahs vlgthpfsrl dilivptnfp slgmasphii flsqstltgt shlcgtrlch
      481 eiahawfgla igardwteew lsegfathle difwaeaqql pphealeqqe lraclrwhrl
      541 qdelqnspeg mqvlrpnkek tghvsasgas vvknglnpek gfmqvhylkg yfllrflart
      601 lgeetyfpfl rkfvhlfhgq lilsqdflqm llesipenkr fglsvenivg dwlecpgipk
      661 alqeerkakd cspsrlvrqv gsevakwirv nrrpgkrqrr kreaafekls pdqivlllew
      721 lleqktlspq tlhrlqqtyh lqeqdaevrh rwcelvikhk ytkaydqvkr flqedqamgi
      781 ylygelmvse darlqqlahr cfelvkghmd kasaqvvtem lf
//
