LOCUS       NM_031582               3937 bp    mRNA    linear   ROD 14-APR-2024
DEFINITION  Rattus norvegicus amine oxidase, copper containing 3 (Aoc3), mRNA.
ACCESSION   NM_031582 XM_220990
VERSION     NM_031582.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3937)
  AUTHORS   Yan,L., Sun,C., Zhang,Y., Zhang,P., Chen,Y., Deng,Y., Er,T.,
            Deng,Y., Wang,Z. and Ma,H.
  TITLE     The Biological Implication of Semicarbazide-Sensitive Amine Oxidase
            (SSAO) Upregulation in Rat Systemic Inflammatory Response under
            Simulated Aerospace Environment
  JOURNAL   Int J Mol Sci 24 (4), 3666 (2023)
   PUBMED   36835077
  REMARK    GeneRIF: The Biological Implication of Semicarbazide-Sensitive
            Amine Oxidase (SSAO) Upregulation in Rat Systemic Inflammatory
            Response under Simulated Aerospace Environment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3937)
  AUTHORS   Kubota,R., Reid,M.J., Lieu,K.L., Orme,M., Diamond,C., Tulberg,N.
            and Henry,S.H.
  TITLE     Comparison of Inhibitor and Substrate Selectivity between Rodent
            and Human Vascular Adhesion Protein-1
  JOURNAL   Mediators Inflamm 2020, 3270513 (2020)
   PUBMED   32410850
  REMARK    GeneRIF: Comparison of Inhibitor and Substrate Selectivity between
            Rodent and Human Vascular Adhesion Protein-1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3937)
  AUTHORS   Sahin,A., Altay,D.A., Demir,S., Yulug,E., Mentese,A., Tatli,O.,
            Karaca,Y., Ardic,S., Gunduz,A. and Turedi,S.
  TITLE     Comparison of the diagnostic values of vascular adhesion protein-1
            and intestinal fatty acid-binding protein in the diagnosis of acute
            mesenteric ischemia
  JOURNAL   Eur J Trauma Emerg Surg 45 (3), 545-553 (2019)
   PUBMED   29600311
  REMARK    GeneRIF: In acute mesenteric ischemia, Vap-1 levels are
            significantly increased and correlated with ischemic changes.
REFERENCE   4  (bases 1 to 3937)
  AUTHORS   Ke,M., Zhang,Y. and Deng,Y.
  TITLE     Alteration of SSAO interactome reveals weakened cell adhesion and
            motor function of adipocytes in T2D
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 49 (9), 845-847 (2017)
   PUBMED   28910971
  REMARK    GeneRIF: Data show that 35 potential amine oxidase copper
            containing 3 (SSAO)-interacting proteins were found to be altered
            in type 2 Diabetes (T2D).
REFERENCE   5  (bases 1 to 3937)
  AUTHORS   Tanaka,S., Tanaka,T., Kawakami,T., Takano,H., Sugahara,M.,
            Saito,H., Higashijima,Y., Yamaguchi,J., Inagi,R. and Nangaku,M.
  TITLE     Vascular adhesion protein-1 enhances neutrophil infiltration by
            generation of hydrogen peroxide in renal ischemia/reperfusion
            injury
  JOURNAL   Kidney Int 92 (1), 154-164 (2017)
   PUBMED   28318627
  REMARK    GeneRIF: VAP-1 plays a critical role in the pathophysiology of
            renal ischemia/reperfusion injury by enhancement of neutrophil
            infiltration generating a local hydrogen peroxide gradient.
REFERENCE   6  (bases 1 to 3937)
  AUTHORS   Smith,D.J., Salmi,M., Bono,P., Hellman,J., Leu,T. and Jalkanen,S.
  TITLE     Cloning of vascular adhesion protein 1 reveals a novel
            multifunctional adhesion molecule
  JOURNAL   J Exp Med 188 (1), 17-27 (1998)
   PUBMED   9653080
REFERENCE   7  (bases 1 to 3937)
  AUTHORS   Morris,N.J., Ducret,A., Aebersold,R., Ross,S.A., Keller,S.R. and
            Lienhard,G.E.
  TITLE     Membrane amine oxidase cloning and identification as a major
            protein in the adipocyte plasma membrane
  JOURNAL   J Biol Chem 272 (14), 9388-9392 (1997)
   PUBMED   9083076
REFERENCE   8  (bases 1 to 3937)
  AUTHORS   Jochen,A., Guven,S. and Hays,J.
  TITLE     The major integral membrane glycoprotein in adipocytes is a novel
            200-kDa heterodimer
  JOURNAL   Mol Membr Biol 12 (3), 277-281 (1995)
   PUBMED   8520629
REFERENCE   9  (bases 1 to 3937)
  AUTHORS   Hayes,B.E. and Clarke,D.E.
  TITLE     Semicarbazide-sensitive amine oxidase activity in streptozotocin
            diabetic rats
  JOURNAL   Res Commun Chem Pathol Pharmacol 69 (1), 71-83 (1990)
   PUBMED   2218072
REFERENCE   10 (bases 1 to 3937)
  AUTHORS   Cao Danh,H., Strolin Benedetti,M., Mousset,A. and
            Pasquier-Bechet,P.
  TITLE     Age-related changes in the activities of the amine metabolizing
            enzymes of rat eye
  JOURNAL   J Pharm Pharmacol 37 (5), 357-361 (1985)
   PUBMED   2862249
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031582.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100613.1, AB195675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1680              JAXUCZ010000010.1  86773018-86774697
            1681-1966           JAXUCZ010000010.1  86777509-86777794
            1967-2096           JAXUCZ010000010.1  86778115-86778244
            2097-3937           JAXUCZ010000010.1  86779121-86780961
FEATURES             Location/Qualifiers
     source          1..3937
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..3937
                     /gene="Aoc3"
                     /gene_synonym="SSAO"
                     /note="amine oxidase, copper containing 3"
                     /db_xref="GeneID:29473"
                     /db_xref="RGD:62058"
     exon            1..1680
                     /gene="Aoc3"
                     /gene_synonym="SSAO"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2372
                     /gene="Aoc3"
                     /gene_synonym="SSAO"
                     /EC_number="1.4.3.21"
                     /note="membrane primary amine oxidase;
                     semicarbazide-sensitive amine oxidase; VP97; VAP-1; copper
                     amine oxidase; vascular adhesion protein 1"
                     /codon_start=1
                     /product="amine oxidase [copper-containing] 3"
                     /protein_id="NP_113770.2"
                     /db_xref="GeneID:29473"
                     /db_xref="RGD:62058"
                     /translation="MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGRLSQPLHCPSV
                     LPSVQPQTHPGQSQPFADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQ
                     LPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERH
                     GGPLPYYRRPVLTREYQDIQEMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGL
                     QSGDRATWFGIYYNLSGAGFYPHPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQ
                     LEDMFEAGLVNVVLVPDNGTGGSWSLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSL
                     WAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYMDGSFGIG
                     KYSTPLTRGVDCPYLATYVDWHFLLESQTPKTLRDAFCVFEQNQGLPLRRHHSDFYSH
                     YFGGVVETVLVVRSVATLLNYDYVWDMVFHSNGAIEVKFHATGYITSAFFFGAGEKFG
                     NRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAWAEDLAFVPMNVPWQPEFQMQRLQVTR
                     KLLETEEEAAFPLGNATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKA
                     FTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDFTDFISNETIAGEDLVAWVTAGF
                     LHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSPDSIYFRKDQDVTDCEVNSLA
                     CLSQTANCVPDLPAFSHGGFTYK"
     exon            1681..1966
                     /gene="Aoc3"
                     /gene_synonym="SSAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2096
                     /gene="Aoc3"
                     /gene_synonym="SSAO"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..3937
                     /gene="Aoc3"
                     /gene_synonym="SSAO"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgctcgg cctagcgcct gggcgacccc agccaggagg agtccgtttc tggtagaagc
       61 ctgtccagcc tcaaggaaca atgacccaga agaccaccct agtgctcctc gccctggctg
      121 tcatcaccat cttcgctttg gtttgcgtct tgctagctgg caggagcgga gatgggggca
      181 gactgagcca acctcttcat tgcccttccg ttcttcctag cgtccagccc cagacacacc
      241 ctggccagag ccagccgttt gcagacctga gccctgagga gctgacagct gtgatgagct
      301 ttctgatcaa gcacctgggg ccagggctgg tggacgcagc ccaggctcga ccctcggaca
      361 actgtgtctt ctcagtagag ttgcagctgc ctgccaaggc tgcagccctg gcccacctgg
      421 acagaggggg gcccccacct gtgcgggagg cactggccat catcttcttt ggtggacaac
      481 ccaagcctaa tgtgagcgag ctggtggtgg ggcccctgcc tcacccctca tacatgcggg
      541 atgtgactgt ggagcgtcat ggcggccccc tgccctatta ccggcgtcct gtgctgacca
      601 gagagtatca ggatatccag gagatgatct tccacagaga gctgccccaa gcgtctggtc
      661 tcctccatca ctgttgcttc tacaaacgcc aaggacacaa cctgctaaaa atgactacag
      721 ccccccgtgg tttgcaatca ggggaccggg ccacctggtt tggcatatat tacaatctct
      781 caggggctgg gttttaccct caccccattg gcttagagct tctggtagat cacaaggccc
      841 tggatcctgc cctgtggacc atccagaagg tattctacca aggccgttac tatgagagtc
      901 tgactcagct ggaggacatg tttgaggctg gcctggtgaa tgtggttttg gtcccagaca
      961 atggcacagg tgggtcctgg tctctgaagt cttcagtgcc accaggccga gctcctcctc
     1021 tgcagttcca tcctgaggga ccccgtttca gcgtccaggg gagtcaagtg agatcctcct
     1081 tgtgggcttt ttcttttggt cttggagctt tcagtggccc aaggatcttt gatatccgct
     1141 ttcaagggga gagggtggcc tatgaaatca gtgtccagga ggccatagcc ctctatggtg
     1201 gtaattcccc ggcatcaatg tcgacctgct atatggacgg aagctttggc attggcaaat
     1261 actctacccc gctgacccga ggggtagact gtccatacct tgccacctat gtggactggc
     1321 acttccttct ggagtctcag acccccaaga cactacgtga tgcgttttgc gtgtttgaac
     1381 agaaccaggg cctcccgctc cggcgacacc actcagattt ctactcccac tattttgggg
     1441 gcgttgtgga gacagtgctt gtggtcagat ccgtggctac cttgctcaat tatgactatg
     1501 tgtgggacat ggttttccac tccaatgggg ccatagaagt caaattccac gccacgggct
     1561 atatcacctc ggctttcttc ttcggtgctg gcgagaagtt tgggaaccga gttgccgagc
     1621 acacactggg cacggtacac acccacaacg ctcacttcaa agtggacttg gatgtggcag
     1681 ggttgaagaa ctgggcctgg gcagaggatt tggcttttgt ccctatgaat gtaccttggc
     1741 aaccggagtt ccagatgcag aggctgcagg tgactcggaa gctgctggag acagaagagg
     1801 aggctgcctt cccactggga aatgccaccc cacgctacct gtacctggcc agtaaccaca
     1861 gcaacaagtg gggtcacagg cgaggctacc gcatccagat actcagcttt gctgggaagc
     1921 cactgcccca ggaaagcccc atagagaaag ccttcacctg gggcaggtat cacttggctg
     1981 tgacccagag gaaggaggag gagcccagca gttctagcat ctacaaccag aatgacccgt
     2041 ggacccccac tgtggacttc actgacttta tcagcaatga gaccattgct ggcgaggact
     2101 tggtagcctg ggtgacagct ggctttttgc acatcccaca tgcggaagac attcccaaca
     2161 cggtgaccgt agggaacggg gtgggtttct tcctccggcc gtataacttc tttgatgagg
     2221 acccctcctt ctactcaccc gactccatct atttccggaa ggaccaggat gtcacagact
     2281 gtgaggtcaa ctccctggct tgcctgtctc agactgccaa ctgtgtcccc gacctccctg
     2341 ccttctccca tgggggcttt acttataaat aagtgtcccc aagatggaca gtctagccaa
     2401 gagctgggga atagagcatc agctgggctg tgcacagggc aatctggttt cttctgttcc
     2461 cgcatctctg atgtcccctc tcatgctgcc ctccttgtct ctccctccct gcttggagca
     2521 tcctgagccc atggatgcct aacacacagg gacattgagt tttgttggtc gtgcctgtgc
     2581 tgagttcctg ctttgggaga agactagcct tgttaggagc ctggagtaat ggctatgggt
     2641 gttttgtttt gttttgtttt aaagatggtc ccccccccca atctggcttt cattaacaat
     2701 tttataatag ctttgagatc tctgcaatga agaaactctc tagagacccc aaagtagggt
     2761 ctccctgagt cttgcacatc cacagatgag cttggaccca agtctatgga aatctcaaag
     2821 atgtgatgga aagtctcact ggaaaggacc aggcttgttt gtctcctaag gtttctcaca
     2881 tatcggacag gagtaggact tgtccctgct acagccccgc cttgccctct ttacaagcag
     2941 atggtcatag agacagccgg tggcttgact ggttatttta tcccactgct ctgctcgact
     3001 gcagctctgg cctctgtgca gtagcctgcc ttagctagtt tgtgacagtg agctaggaac
     3061 catgtgtggg cattaaaggt gagaaactga aaaccttggt aacaccgccc ccaccaccta
     3121 actctgggtc tgtccaatca gaagctaact cggggtctgt ccaatcagaa gcaggcatgc
     3181 aaatgagcct gagtctgttc caagatgggt ctggattggt cggacctgct tcagcatttc
     3241 tccttgctgc ttgtctttac tgagatctgg acagggaagt ggtacaagtg actaaaaaca
     3301 acagacacat cattccctag cagtctggcc agccccattg ttaactaatg ttattactgt
     3361 tattaatgaa agaaaggtgc tggaaaaata taagtgcgta ttggttttgt agggaaccca
     3421 ggttcctttc ccagcatcat tattaggtgc tcacgactat ctataaatcc aggagatcca
     3481 atggcctttc agggcaccta cactcaagca cataccttca cacagacaca gacacacaaa
     3541 taaaaataaa agaatttagc cttatgtggt gacacataac attaatccca gcattgggag
     3601 gcagaagcag gaggatctct gagcttgagg ccagcctggt ctacggagtg agttccagga
     3661 tagccagagc tacacagaga agccctgttt tgcaaaacaa aacaaaacag aaacaaacag
     3721 agttctttaa agacaaaaag agaagctaac aatgaatagg ctataagtgt atatctgttt
     3781 atttctgcat tctttgagaa ctaacaccgg ttacctctgg ggaggaagac gggtgagaga
     3841 gagagagaga gaatagggtt ctgcgtgtcc ttctggacat cctgaattgg aatcatgtga
     3901 ccatattgtc aaaataaata agtcagttaa acacaaa
//
