LOCUS       NM_022935               2795 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus amine oxidase, copper containing 1 (Aoc1), mRNA.
ACCESSION   NM_022935
VERSION     NM_022935.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2795)
  AUTHORS   Ji,Y., Sakata,Y., Li,X., Zhang,C., Yang,Q., Xu,M., Wollin,A.,
            Langhans,W. and Tso,P.
  TITLE     Lymphatic diamine oxidase secretion stimulated by fat absorption is
            linked with histamine release
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 304 (8), G732-G740 (2013)
   PUBMED   23413254
  REMARK    GeneRIF: DAO secretion may contribute to the catabolism of
            histamine released during fat absorption and this is probably
            mediated through the histamine H(4) receptor.
REFERENCE   2  (bases 1 to 2795)
  AUTHORS   Cai,C., Li,W., Chen,J., Li,X. and Chen,S.
  TITLE     Diamine oxidase as a marker for diagnosis of superior mesenteric
            arterial occlusion
  JOURNAL   Hepatogastroenterology 59 (113), 155-158 (2012)
   PUBMED   22024144
  REMARK    GeneRIF: Measurement of serum diamine oxidase levels might provide
            a marker for early diagnosis of superior mesenteric arterial
            occlusion.
REFERENCE   3  (bases 1 to 2795)
  AUTHORS   Zhang,Y., Li,Y., Qiu,F. and Qiu,Z.
  TITLE     Comprehensive analysis of low-abundance proteins in human urinary
            exosomes using peptide ligand library technology, peptide OFFGEL
            fractionation and nanoHPLC-chip-MS/MS
  JOURNAL   Electrophoresis 31 (23-24), 3797-3807 (2010)
   PUBMED   21082674
REFERENCE   4  (bases 1 to 2795)
  AUTHORS   McGrath,A.P., Hilmer,K.M., Collyer,C.A., Shepard,E.M., Elmore,B.O.,
            Brown,D.E., Dooley,D.M. and Guss,J.M.
  TITLE     Structure and inhibition of human diamine oxidase
  JOURNAL   Biochemistry 48 (41), 9810-9822 (2009)
   PUBMED   19764817
REFERENCE   5  (bases 1 to 2795)
  AUTHORS   Sun,Y.J., Chen,W.M., Zhang,T.Z., Cao,H.J. and Zhou,J.
  TITLE     Effects of cardiopulmonary bypass on tight junction protein
            expressions in intestinal mucosa of rats
  JOURNAL   World J Gastroenterol 14 (38), 5868-5875 (2008)
   PUBMED   18855986
REFERENCE   6  (bases 1 to 2795)
  AUTHORS   Befani,O., Shiozaki,T.S., Turini,P., Gerosa,P. and Mondovi,B.
  TITLE     Inhibition of diamine oxidase activity by metronidazole
  JOURNAL   Biochem Biophys Res Commun 212 (2), 589-594 (1995)
   PUBMED   7626074
REFERENCE   7  (bases 1 to 2795)
  AUTHORS   Verity,K. and Fuller,P.J.
  TITLE     Isolation of a rat amiloride-binding protein cDNA clone: tissue
            distribution and regulation of expression
  JOURNAL   Am J Physiol 266 (6 Pt 1), C1505-C1512 (1994)
   PUBMED   8023885
REFERENCE   8  (bases 1 to 2795)
  AUTHORS   Novotny,W.F., Chassande,O., Baker,M., Lazdunski,M. and Barbry,P.
  TITLE     Diamine oxidase is the amiloride-binding protein and is inhibited
            by amiloride analogues
  JOURNAL   J Biol Chem 269 (13), 9921-9925 (1994)
   PUBMED   8144586
REFERENCE   9  (bases 1 to 2795)
  AUTHORS   Kojima,H., Omoto,Y., Hidaka,H., Aoki,T., Nakamura,T., Kawabata,T.,
            Konaka,K., Kashiwagi,A., Kikkawa,R. and Shigeta,Y.
  TITLE     Increased plasma post-heparin diamine oxidase activity and plant
            sterol levels in streptozotocin diabetic rat
  JOURNAL   Biochem Biophys Res Commun 186 (1), 398-404 (1992)
   PUBMED   1632778
REFERENCE   10 (bases 1 to 2795)
  AUTHORS   Barbry,P., Champe,M., Chassande,O., Munemitsu,S., Champigny,G.,
            Lingueglia,E., Maes,P., Frelin,C., Tartar,A., Ullrich,A. et al.
  TITLE     Human kidney amiloride-binding protein: cDNA structure and
            functional expression
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7347-7351 (1990)
   PUBMED   2217167
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100144.1.
            
            On Apr 7, 2007 this sequence version replaced NM_022935.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100144.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2795
                     /gene="Aoc1"
                     /gene_synonym="Abp; Abp1"
                     /note="amine oxidase, copper containing 1"
                     /db_xref="GeneID:65029"
                     /db_xref="RGD:61296"
     exon            1..172
                     /gene="Aoc1"
                     /gene_synonym="Abp; Abp1"
                     /inference="alignment:Splign:2.1.0"
     exon            173..1746
                     /gene="Aoc1"
                     /gene_synonym="Abp; Abp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..2432
                     /gene="Aoc1"
                     /gene_synonym="Abp; Abp1"
                     /EC_number="1.4.3.22"
                     /note="amiloride-sensitive amine oxidase; DAO;
                     histaminase; diamine oxidase; amiloride binding protein 1
                     (amine oxidase, copper-containing); amiloride-binding
                     protein 1; amine oxidase copper domain-containing protein
                     1"
                     /codon_start=1
                     /product="diamine oxidase [copper-containing] precursor"
                     /protein_id="NP_075224.2"
                     /db_xref="GeneID:65029"
                     /db_xref="RGD:61296"
                     /translation="MRLAQMCLAFGWAAVILVLQTVDTASAVRTPYDKARVFADLSPQ
                     EIKAVHSFLMNREELGLQPSKEPTLAKNSVFLIEMLLPKKKHVLKFLDEGRKGPNREA
                     RAVIFFGAQDYPNVTEFAVGPLPRPYYIRALSPRPGHHLSWSSRPISTAEYDLLYHTL
                     KRATMPLHQFFLDTTGFSFLGCDDRCLTFTDVAPRGVASGQRRSWFIVQRYVEGYFLH
                     PTGLEILLDHGSTDVQDWRVEQLWYNGKFYNNPEELARKYAVGEVDTVVLEDPLPNGT
                     EKPPLFSSYKPRGEFHTPVNVAGPHVVQPSGPRYKLEGNTVLYGGWSFSYRLRSSSGL
                     QIFNVLFGGERVAYEVSVQEAVALYGGHTPAGMQTKYIDVGWGLGSVTHELAPGIDCP
                     ETATFLDAFHYYDSDGPVHYPHALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGYVL
                     VLRTTSTVYNYDYIWDFIFYSNGVMEAKMHATGYVHATFYTPEGLRHGTRLQTHLLGN
                     IHTHLVHYRVDMDVAGTKNSFQTLTMKLENLTNPWSPSHSLVQPTLEQTQYSQEHQAA
                     FRFGQTLPKYLLFSSPQKNCWGHRRSYRLQIHSMAEQVLPPGWQEERAVTWARYPLAV
                     TKYRESERYSSSLYNQNDPWDPPVVFEEFLRNNENIEDEDLVAWVTVGFLHIPHSEDV
                     PNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPQDKGLNRVQRWIPEDRRCLVSP
                     PFSYNGTYKPV"
     exon            1747..2032
                     /gene="Aoc1"
                     /gene_synonym="Abp; Abp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2165
                     /gene="Aoc1"
                     /gene_synonym="Abp; Abp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2765
                     /gene="Aoc1"
                     /gene_synonym="Abp; Abp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcactgga gaggctagaa aagggtgtca gatcgagttg tgaaccacta tgtgagtgcc
       61 aggactgaac cttggtcctc tgggagaaca gcaactgctt ttaaccactg agccatctct
      121 tcagccccaa tttccccttg atctgaagaa gaaagagcca ggtctctaac agagctatga
      181 ggcttgcaca aatgtgtctg gccttcggct gggcagctgt catattggtt ctacagacgg
      241 tagacacggc atctgctgtg aggactcctt atgacaaagc gagggtattt gcagacctga
      301 gcccccagga gataaaggct gttcacagct tcctgatgaa cagggaggag ctggggctgc
      361 agccgtccaa ggaaccgact ttggccaaaa actctgtgtt tctcattgag atgctactgc
      421 ccaagaagaa gcatgtgttg aaatttctgg atgaaggaag aaaaggtcct aaccgggaag
      481 ctagggctgt catcttcttc ggtgcccagg actaccccaa tgtcactgag tttgctgtgg
      541 ggcccctgcc acggccctac tatattcgag cactatcccc caggccaggg caccatctgt
      601 cctggtcatc caggcccatc tccacagcag agtacgacct cctctaccac acgctgaaga
      661 gagccaccat gcctctgcac cagtttttcc ttgacaccac tggcttctca ttcctaggct
      721 gtgacgaccg atgcttgact tttactgacg tagctccacg tggtgtggcg tctggtcagc
      781 gtagaagctg gtttattgtg cagcgctatg tggaaggcta tttccttcat cctacagggc
      841 tggagatcct attggatcat gggagcacag atgtccagga ctggagagtg gagcagctct
      901 ggtataacgg caagttctac aacaacccag aggaactggc tcggaaatac gcagttggag
      961 aagtggacac ggtggtcctc gaggacccac tgcccaatgg cacagagaag cccccactct
     1021 tttcttccta caaaccccgg ggggaattcc atacaccagt caatgttgct ggcccccacg
     1081 ttgtccagcc cagcggcccc cgatataaac tagagggcaa cactgtgctc tatggaggtt
     1141 ggagcttctc ttatcggcta agatcctctt ctgggctgca gatcttcaat gtgctctttg
     1201 gaggtgagcg tgttgcctac gaggtcagtg tgcaggaggc tgtggcactg tatggaggac
     1261 acacacctgc aggcatgcag actaagtaca ttgatgttgg ctggggcctg ggcagtgtca
     1321 ctcacgagtt ggcccctggc attgactgtc cagagactgc tactttcctg gatgccttcc
     1381 actattacga cagcgatggc cctgtccatt atccacatgc tctgtgcctc tttgagatgc
     1441 ccacaggggt gcccctgagg cgccacttta actcaaactt taaaggtggc ttcaacttct
     1501 atgcgggttt gaagggatat gtgctggtgc tacggacgac atcaactgtc tataattatg
     1561 attacatctg ggatttcatc ttctactcta acggggtgat ggaggccaag atgcacgcca
     1621 ctggctatgt ccatgcgacc ttctacactc ctgagggact gcgccatggc actcgcttac
     1681 aaacccacct gcttggtaac atccacaccc acctggtgca ctaccgtgtt gacatggacg
     1741 tggcaggcac caagaacagc ttccagacac tgacgatgaa gctggaaaac ctcaccaatc
     1801 cctggagccc aagtcactcc ctggtccagc ccacactcga gcagacccag tactcccagg
     1861 agcaccaggc tgcattccgc ttcggacaga ctctgcccaa gtacctgctc tttagcagcc
     1921 cccaaaagaa ctgctggggt cacaggcgca gctaccgcct gcagatccat tctatggctg
     1981 agcaggtgct gccaccaggt tggcaggagg agcgggctgt cacttgggcc aggtatcctt
     2041 tggctgtaac aaagtatcgg gaatctgagc gctacagcag cagcctctac aaccagaatg
     2101 acccctggga tccccccgtg gtctttgagg agttccttcg gaacaacgag aacattgaag
     2161 atgaggattt ggtggcctgg gtgacagtgg gcttcctgca catccctcac tcagaagatg
     2221 tccccaacac agccacacct ggaaactctg tgggcttctt gctccggccc ttcaacttct
     2281 tcccagagga cccatccctg gcttctagag acactgtgat agtgtggccc caggacaagg
     2341 gcctcaaccg tgtccagcgc tggatccctg aggacaggcg ctgcttggtg tctcctcctt
     2401 tcagctataa tgggacctac aagcctgtgt gatgggtcag accccagcct ctgcagcaca
     2461 gccccagagc ctcacaaaga cagggaaaac aaacaaacga aacttctgtc tctaccctgt
     2521 atgctacctt ttagctctac tcgtgtttca ttaccatacc tgccacagac ttccaagacc
     2581 attgcaaagg aaggaccaca attttctgcc ggtggttcgg tggtttggag ggtggtgttt
     2641 tttaaatatt tgaggtgttt atcttcctat caggagactt tagagaaatt gtctcacctc
     2701 agtgatggga gggagtaagg aaactgtcat atgaaaatct aataaaatga cacctttgct
     2761 ctttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
