LOCUS       NM_001031654            1856 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus annexin A8 (Anxa8), mRNA.
ACCESSION   NM_001031654 XM_224698
VERSION     NM_001031654.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Lee,M.J., Yu,G.R., Yoo,H.J., Kim,J.H., Yoon,B.I., Choi,Y.K. and
            Kim,D.G.
  TITLE     ANXA8 down-regulation by EGF-FOXO4 signaling is involved in cell
            scattering and tumor metastasis of cholangiocarcinoma
  JOURNAL   Gastroenterology 137 (3), 1138-1150 (2009)
   PUBMED   19376120
REFERENCE   2  (bases 1 to 1856)
  AUTHORS   Goebeler,V., Poeter,M., Zeuschner,D., Gerke,V. and Rescher,U.
  TITLE     Annexin A8 regulates late endosome organization and function
  JOURNAL   Mol Biol Cell 19 (12), 5267-5278 (2008)
   PUBMED   18923148
REFERENCE   3  (bases 1 to 1856)
  AUTHORS   Karanjawala,Z.E., Illei,P.B., Ashfaq,R., Infante,J.R., Murphy,K.,
            Pandey,A., Schulick,R., Winter,J., Sharma,R., Maitra,A., Goggins,M.
            and Hruban,R.H.
  TITLE     New markers of pancreatic cancer identified through differential
            gene expression analyses: claudin 18 and annexin A8
  JOURNAL   Am J Surg Pathol 32 (2), 188-196 (2008)
   PUBMED   18223320
REFERENCE   4  (bases 1 to 1856)
  AUTHORS   Goebeler,V., Ruhe,D., Gerke,V. and Rescher,U.
  TITLE     Annexin A8 displays unique phospholipid and F-actin binding
            properties
  JOURNAL   FEBS Lett 580 (10), 2430-2434 (2006)
   PUBMED   16638567
REFERENCE   5  (bases 1 to 1856)
  AUTHORS   Rety,S., Sopkova-de Oliveira Santos,J., Dreyfuss,L., Blondeau,K.,
            Hofbauerova,K., Raguenes-Nicol,C., Kerboeuf,D., Renouard,M.,
            Russo-Marie,F. and Lewit-Bentley,A.
  TITLE     The crystal structure of annexin A8 is similar to that of annexin
            A3
  JOURNAL   J Mol Biol 345 (5), 1131-1139 (2005)
   PUBMED   15644210
REFERENCE   6  (bases 1 to 1856)
  AUTHORS   Hauptmann,R., Maurer-Fogy,I., Krystek,E., Bodo,G., Andree,H. and
            Reutelingsperger,C.P.
  TITLE     Vascular anticoagulant beta: a novel human Ca2+/phospholipid
            binding protein that inhibits coagulation and phospholipase A2
            activity. Its molecular cloning, expression and comparison with
            VAC-alpha
  JOURNAL   Eur J Biochem 185 (1), 63-71 (1989)
   PUBMED   2530088
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099106.1.
            
            On Aug 12, 2005 this sequence version replaced XM_224698.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099106.1, CF110971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p15"
     gene            1..1856
                     /gene="Anxa8"
                     /note="annexin A8"
                     /db_xref="GeneID:306283"
                     /db_xref="RGD:1307719"
     exon            1..37
                     /gene="Anxa8"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1000
                     /gene="Anxa8"
                     /note="annexin-8; annexin VIII"
                     /codon_start=1
                     /product="annexin A8"
                     /protein_id="NP_001026824.1"
                     /db_xref="GeneID:306283"
                     /db_xref="RGD:1307719"
                     /translation="MAWWKAWVEQEGVSVKGSSHFNPDPDAETLYKAMKGIGTNEQAI
                     IDVLTKRSNVQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKEL
                     HDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSTLEEDIQGDTSGYLERILV
                     CLLQGCRDDVSGFVDPGLALQDAQDLHAAGEKILGTDEMKFITILCTRSATHLMRVFE
                     EYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTRNVHSYFAERLYYAMKGAGTLDGTL
                     IRNIVSRSEIDLNLIKSQFQKMYGKTLSSMIMGDTSGYYKTALLNLVGTDL"
     exon            38..128
                     /gene="Anxa8"
                     /inference="alignment:Splign:2.1.0"
     exon            129..223
                     /gene="Anxa8"
                     /inference="alignment:Splign:2.1.0"
     exon            224..337
                     /gene="Anxa8"
                     /inference="alignment:Splign:2.1.0"
     exon            338..428
                     /gene="Anxa8"
                     /inference="alignment:Splign:2.1.0"
     exon            429..508
                     /gene="Anxa8"
                     /inference="alignment:Splign:2.1.0"
     exon            509..568
                     /gene="Anxa8"
                     /inference="alignment:Splign:2.1.0"
     exon            569..662
                     /gene="Anxa8"
                     /inference="alignment:Splign:2.1.0"
     exon            663..758
                     /gene="Anxa8"
                     /inference="alignment:Splign:2.1.0"
     exon            759..817
                     /gene="Anxa8"
                     /inference="alignment:Splign:2.1.0"
     exon            818..940
                     /gene="Anxa8"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1834
                     /gene="Anxa8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtgaggca cacaggatgg cctggtggaa agcctgggtt gaacaagagg gcgtcagtgt
       61 gaagggtagt tctcatttca acccagaccc tgatgcagag accctctaca aagccatgaa
      121 ggggatcgga accaacgagc aggccatcat agacgtgctc accaagagga gcaatgtgca
      181 gaggcagcag attgccaagt ccttcaaggc tcaatttgga aaggacctca ctgagaccct
      241 aaagtcagag ctgagtggca aattcgagag gctcatcgtg gccctcatgt acccgccata
      301 cagatatgag gccaaggagc tgcacgacgc tatgaagggc ttaggaacca aagaaggagt
      361 catcattgag atcctggctt ctcggaccaa gaaccagctg agagagataa tgaaggccta
      421 tgaggaagac tacggatcta ccctggaaga agacatccaa ggagacacga gtggctatct
      481 ggagcggatt ctggtgtgtc ttctgcaggg ctgcagagat gacgtgagtg gttttgtgga
      541 cccaggactg gcccttcaag atgcacagga cctgcatgca gcaggtgaga agattctggg
      601 gactgatgag atgaagttca tcaccatcct gtgtacacgc agtgccactc atctgatgag
      661 agtgttcgag gaatatgaaa agattgccaa caagagcatt gaggatagca tcaagagtga
      721 gacccatggt tcactggagg aggccatgct cactgtggtg aaatgcaccc ggaacgtcca
      781 cagctacttt gcagagagac tgtactatgc catgaaggga gcagggacac ttgatgggac
      841 gctgatcagg aacattgttt ccaggagtga gattgactta aaccttatca agagtcagtt
      901 tcagaagatg tacggcaaga ctctcagcag catgatcatg ggcgacacca gcggttacta
      961 caagactgcc ctgctgaacc ttgtgggtac tgacctctga aaatgtcaaa aaatcaaaca
     1021 agggcaagaa gggtcagcac agcccctgtg gcttcagccc tgaccccatg ggtgaggtgg
     1081 gggtaaggga cacctcatgt ggcttttaat cttctgtctc ccggtttctg atgcttctca
     1141 tccaatgctt ctgacccaga aggtgagacc agcctgggtt tcccttccac ctctcccctg
     1201 agtcatttct aatgcccacc ctagcattac ctctgagcaa acagaaacaa catgaagaag
     1261 cttgcaggaa cctgtgggcc attccttccc tgcacaaaag ctcctgggta caggtcacac
     1321 tctgccttgg ctctgagtca tccactgaat cagggtcttt ggaggaggaa ccaaccatgg
     1381 atttctagca gtcgtcttag ctgataagca tcattatcag gcagccagtg agcaagtggg
     1441 agagcacggc tatgagagaa cacagccgtg ggaactgaga aagggtcaca gagctgtgcc
     1501 aagtgggatg tctgtgacac tcatttaaca gaaattgtta ggctgtaggt ggaggaagat
     1561 tcttacgcca tcctaatagc aagaattaga ttggattgca aatccctgtc ctgacccaag
     1621 tacaccatgg cccgagagcg tcaggcttgt ccagccattg gccaaatcag atgttcgttc
     1681 cctccatgct gaagcttgca gactaggaag ccccccaacc ctgagcatga atcctaacct
     1741 ccgatcgtgg tctccaagcc tgaagaacat gacagaactc tccctaatat tcattgggct
     1801 ttcagaatca taaacgtttg tactttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
