LOCUS       NM_130416               1885 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus annexin A7 (Anxa7), mRNA.
ACCESSION   NM_130416 XM_346470
VERSION     NM_130416.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1885)
  AUTHORS   Li H, Liu S, Sun X, Yang J, Yang Z, Shen H, Li X, Liu Y and Chen G.
  TITLE     Critical role for Annexin A7 in secondary brain injury mediated by
            its phosphorylation after experimental intracerebral hemorrhage in
            rats
  JOURNAL   Neurobiol Dis 110, 82-92 (2018)
   PUBMED   29196215
  REMARK    GeneRIF: our findings suggest that ANXA7 contributed to secondary
            brain injury at least partially through regulating glutamate
            toxicity after intracerebral hemorrhage
REFERENCE   2  (bases 1 to 1885)
  AUTHORS   Li H, Huang S, Wang S, Wang L, Qi L, Zhang Y, Zhang S, Zhao B and
            Miao J.
  TITLE     Relationship between annexin A7 and integrin beta4 in autophagy
  JOURNAL   Int J Biochem Cell Biol 45 (11), 2605-2611 (2013)
   PUBMED   24007983
REFERENCE   3  (bases 1 to 1885)
  AUTHORS   Chander A, Gerelsaikhan T, Vasa PK and Holbrook K.
  TITLE     Annexin A7 trafficking to alveolar type II cell surface: possible
            roles for protein insertion into membranes and lamellar body
            secretion
  JOURNAL   Biochim Biophys Acta 1833 (5), 1244-1255 (2013)
   PUBMED   23434680
  REMARK    GeneRIF: our studies support in vivo association between surfactant
            secretion and cell surface A7 occurring by insertion into plasma
            membrane and by fusion of A7 containing lamellar bodies.
REFERENCE   4  (bases 1 to 1885)
  AUTHORS   Gerelsaikhan T, Vasa PK and Chander A.
  TITLE     Annexin A7 and SNAP23 interactions in alveolar type II cells and in
            vitro: a role for Ca(2+) and PKC
  JOURNAL   Biochim Biophys Acta 1823 (10), 1796-1806 (2012)
   PUBMED   22713544
  REMARK    GeneRIF: Annexin A7 may function in co-ordination with SNARE
            proteins and that protein kinase activation may be required for
            annexin A7 trafficking.
REFERENCE   5  (bases 1 to 1885)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 1885)
  AUTHORS   Satoh H, Nakano Y, Shibata H and Maki M.
  TITLE     The penta-EF-hand domain of ALG-2 interacts with amino-terminal
            domains of both annexin VII and annexin XI in a Ca2+-dependent
            manner
  JOURNAL   Biochim Biophys Acta 1600 (1-2), 61-67 (2002)
   PUBMED   12445460
REFERENCE   7  (bases 1 to 1885)
  AUTHORS   Srivastava M, Bubendorf L, Srikantan V, Fossom L, Nolan L, Glasman
            M, Leighton X, Fehrle W, Pittaluga S, Raffeld M, Koivisto P, Willi
            N, Gasser TC, Kononen J, Sauter G, Kallioniemi OP, Srivastava S and
            Pollard HB.
  TITLE     ANX7, a candidate tumor suppressor gene for prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 98 (8), 4575-4580 (2001)
   PUBMED   11287641
REFERENCE   8  (bases 1 to 1885)
  AUTHORS   Srivastava M, Atwater I, Glasman M, Leighton X, Goping G, Caohuy H,
            Miller G, Pichel J, Westphal H, Mears D, Rojas E and Pollard HB.
  TITLE     Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+)
            signaling, and insulin secretion in the anx7(+/-) knockout mouse
  JOURNAL   Proc Natl Acad Sci U S A 96 (24), 13783-13788 (1999)
   PUBMED   10570150
REFERENCE   9  (bases 1 to 1885)
  AUTHORS   Clemen CS, Hofmann A, Zamparelli C and Noegel AA.
  TITLE     Expression and localisation of annexin VII (synexin) isoforms in
            differentiating myoblasts
  JOURNAL   J Muscle Res Cell Motil 20 (7), 669-679 (1999)
   PUBMED   10672515
REFERENCE   10 (bases 1 to 1885)
  AUTHORS   Brownawell AM and Creutz CE.
  TITLE     Calcium-dependent binding of sorcin to the N-terminal domain of
            synexin (annexin VII)
  JOURNAL   J Biol Chem 272 (35), 22182-22190 (1997)
   PUBMED   9268363
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070896.1.
            
            On Jun 3, 2007 this sequence version replaced NM_130416.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070896.1, SRR8487231.152843.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..1885
                     /gene="Anxa7"
                     /note="annexin A7"
                     /db_xref="GeneID:155423"
                     /db_xref="RGD:621173"
     exon            1..168
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
     exon            169..223
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1561
                     /gene="Anxa7"
                     /codon_start=1
                     /product="annexin A7"
                     /protein_id="NP_569100.2"
                     /db_xref="GeneID:155423"
                     /db_xref="RGD:621173"
                     /translation="MSYPGYPPTGYPPFPGYPPAGQESSFPTSGQYPYPSGFPPMGGG
                     AYPPAPSGGYPGAGGYPSPGGYPAPGGYPGTLNPGGPPSYPGGQGFGAPPGGAGFSGY
                     PQPPAQSYGGGPAQVPVPGGFPGGQMPSQYPGGQSPYPGQPAAMTQGTQGTIRPASNF
                     DAMRDAEILRKAMKGFGTDEQAIVDVVSNRSNDQRQQIKAAFKTMYGKDLIKDLKSEL
                     SGNMEELILALFMPPTYYDAWSLRKAIQGAGTQERVLIEILCTRTNQEIRDIVRCYQL
                     EFGRELERDIRSDTSGHFERLLVSMCQGNRDESPSINHQMAQEDAQRLYQAGEGRLGT
                     DESCFNMILATRSFPQLRATMEAYSRMANRDLLSSVSREFSGYVESGLKTILQCALNR
                     PAFFAERLYYSMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFTQMYQKTLSTMIASDTS
                     GDYRKLLLAIVGQ"
     exon            224..428
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
     exon            429..530
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
     exon            531..595
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
     exon            596..698
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
     exon            699..793
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
     exon            794..907
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1078
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1249
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1325
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1438
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1861
                     /gene="Anxa7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgttaaaa ccagcagagc cacctgaggg gcgcagggtc ccgcccgggc ttgggggcgg
       61 tccaggcagc cagcatcctc gcgccgccca tgcgccacgc cctccggccc tccctggctc
      121 catattgcag gaaagcgggc tagggtgtga cgctgctttc tggttcagaa tgtcataccc
      181 aggctacccc ccgacaggct acccaccttt ccctggatat cctcctgcag gtcaggagtc
      241 ctctttcccc acttcgggtc agtatccgta ccctagtggc tttccaccaa tgggaggagg
      301 tgcttaccca ccagctccaa gtggtggcta cccaggagct ggaggctacc cctcacctgg
      361 aggttatcca gcccctgggg gctatcctgg aaccctaaat ccagggggtc ctccatccta
      421 tcctggaggt caaggctttg gggccccacc tggtggggca ggcttttctg gctatccaca
      481 gccacctgca cagtcttacg gcggtggacc agcccaggtt ccagtcccag gtggctttcc
      541 tggagggcag atgccgtctc agtaccccgg aggacagtct ccctaccctg gccagcctgc
      601 tgcgatgact cagggcaccc aaggaacaat ccgcccagcc tccaacttcg atgctatgag
      661 agatgcagag attctccgca aagcaatgaa ggggtttggg actgatgagc aagcgattgt
      721 ggatgtcgtg tctaaccgtt ccaatgacca gaggcaacaa attaaagcag cttttaagac
      781 catgtatggc aaggatttaa ttaaagatct caagtcagag ttgagtggaa acatggaaga
      841 attaatcctt gccctgttca tgcctcctac atactatgat gcctggagtt tgcggaaggc
      901 gatacaggga gcaggaactc aagagcgtgt gttgatagag attttgtgca caagaacaaa
      961 tcaagaaatc cgagacattg ttagatgcta tcaattagaa tttggacgcg agctcgagag
     1021 ggacattaga tcggatacct caggacattt cgaacggctc ctcgtgtcca tgtgccaggg
     1081 aaaccgtgac gagagcccaa gtataaacca ccagatggcc caggaagatg cccagcgcct
     1141 ctatcaggct ggggagggga ggctagggac agacgaatcc tgtttcaaca tgatcctcgc
     1201 cacaaggagc ttccctcagc tgagagccac catggaggct tattccagga tggctaatcg
     1261 agatttgcta agcagtgtga gccgggaatt ttccggatac gttgaaagcg gtttgaagac
     1321 catattgcag tgcgccctca accgccctgc cttcttcgcc gagcgactct actattccat
     1381 gaaaggcgct ggaacagatg actccaccct ggtcaggatt gtggtcactc ggagtgagat
     1441 tgacctcgtt cagataaaac agatgttcac ccagatgtat cagaagactc taagcacgat
     1501 gattgcaagt gacaccagtg gagattacag gaagctgctc ctggccatcg ttggccagtg
     1561 acggggattt ttttcccttt aaggaatgaa gctcttcagg gcctatcttt ctgagcaatg
     1621 agacctgcat gcagccacgt cagacaccaa ctgaccagag tgcttttcca ctgaggcctg
     1681 tcagggggtg tgctgcgttt gcacatgttg tcactgcctt aattctaatg ttagtctctt
     1741 tctttctgta tccaatcagt gtaaaagcca tgtcaatgac atagtaatgt aaatttgtaa
     1801 agcttcactc ccactgcttt cactttaatc cggatttcaa attaaaaaaa attcacagca
     1861 aaaaaaaaaa aaaaaaaaaa aaaaa
//
