LOCUS       NM_024156               2625 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus annexin A6 (Anxa6), mRNA.
ACCESSION   NM_024156 XM_346392
VERSION     NM_024156.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2625)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   2  (bases 1 to 2625)
  AUTHORS   Cui,L., Rashdan,N.A., Zhu,D., Milne,E.M., Ajuh,P., Milne,G.,
            Helfrich,M.H., Lim,K., Prasad,S., Lerman,D.A., Vesey,A.T.,
            Dweck,M.R., Jenkins,W.S., Newby,D.E., Farquharson,C. and
            Macrae,V.E.
  TITLE     End stage renal disease-induced hypercalcemia may promote aortic
            valve calcification via Annexin VI enrichment of valve interstitial
            cell derived-matrix vesicles
  JOURNAL   J Cell Physiol 232 (11), 2985-2995 (2017)
   PUBMED   28369848
  REMARK    GeneRIF: Annexin VI is enriched in calcifying valve interstitial
            cell derived-matrix vesicles from patients with end stage renal
            disease-induced hypercalcemia and aortic valve calcification.
REFERENCE   3  (bases 1 to 2625)
  AUTHORS   Banerjee,P. and Bandyopadhyay,A.
  TITLE     Cytosolic dynamics of annexin A6 trigger feedback regulation of
            hypertrophy via atrial natriuretic peptide in cardiomyocytes
  JOURNAL   J Biol Chem 289 (9), 5371-5385 (2014)
   PUBMED   24403064
  REMARK    GeneRIF: the present study delivers a cooperative mechanism where
            Anxa6 potentiates ANP-dependent counterhypertrophic responses in
            cardiomyocytes by facilitating regulated traffic of pro-ANP.
REFERENCE   4  (bases 1 to 2625)
  AUTHORS   Alvares,K., Stern,P.H. and Veis,A.
  TITLE     Dentin phosphoprotein binds annexin 2 and is involved in calcium
            transport in rat kidney ureteric bud cells
  JOURNAL   J Biol Chem 288 (18), 13036-13045 (2013)
   PUBMED   23525114
REFERENCE   5  (bases 1 to 2625)
  AUTHORS   Domon,M.M., Besson,F., Tylki-Szymanska,A., Bandorowicz-Pikula,J.
            and Pikula,S.
  TITLE     Interaction of AnxA6 with isolated and artificial lipid
            microdomains; importance of lipid composition and calcium content
  JOURNAL   Mol Biosyst 9 (4), 668-676 (2013)
   PUBMED   23360953
REFERENCE   6  (bases 1 to 2625)
  AUTHORS   Chow,A., Davis,A.J. and Gawler,D.J.
  TITLE     Identification of a novel protein complex containing annexin VI,
            Fyn, Pyk2, and the p120(GAP) C2 domain
  JOURNAL   FEBS Lett 469 (1), 88-92 (2000)
   PUBMED   10708762
REFERENCE   7  (bases 1 to 2625)
  AUTHORS   Fan,H., Josic,D., Lim,Y.P. and Reutter,W.
  TITLE     cDNA cloning and tissue-specific regulation of expression of rat
            calcium-binding protein 65/67. Identification as a homologue of
            annexin VI
  JOURNAL   Eur J Biochem 230 (2), 741-751 (1995)
   PUBMED   7607247
REFERENCE   8  (bases 1 to 2625)
  AUTHORS   Doubell,A.F., Lazure,C., Charbonneau,C. and Thibault,G.
  TITLE     Identification and immunolocalisation of annexins V and VI, the
            major cardiac annexins, in rat heart
  JOURNAL   Cardiovasc Res 27 (7), 1359-1367 (1993)
   PUBMED   8252600
REFERENCE   9  (bases 1 to 2625)
  AUTHORS   Mizutani,A., Usuda,N., Tokumitsu,H., Minami,H., Yasui,K.,
            Kobayashi,R. and Hidaka,H.
  TITLE     CAP-50, a newly identified annexin, localizes in nuclei of cultured
            fibroblast 3Y1 cells
  JOURNAL   J Biol Chem 267 (19), 13498-13504 (1992)
   PUBMED   1618851
REFERENCE   10 (bases 1 to 2625)
  AUTHORS   Blackwood,R.A. and Ernst,J.D.
  TITLE     Characterization of Ca2(+)-dependent phospholipid binding, vesicle
            aggregation and membrane fusion by annexins
  JOURNAL   Biochem J 266 (1), 195-200 (1990)
   PUBMED   2138016
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB585592.1 and BC072523.1.
            
            On Mar 14, 2007 this sequence version replaced NM_024156.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072523.1, SRR8487227.28378.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                CB585592.1         19-69
            52-2625             BC072523.1         1-2574
FEATURES             Location/Qualifiers
     source          1..2625
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2625
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /note="annexin A6"
                     /db_xref="GeneID:79125"
                     /db_xref="RGD:621172"
     exon            1..80
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            81..124
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..2128
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /note="lipocortin VI; chromobindin-20; 67 kDa calelectrin;
                     calphobindin-II; calcium-binding protein CATA 65/67; CBP
                     65/67; annexin-6; calcium-binding protein 65/67; annexin
                     VI"
                     /codon_start=1
                     /product="annexin A6"
                     /protein_id="NP_077070.2"
                     /db_xref="GeneID:79125"
                     /db_xref="RGD:621172"
                     /translation="MAKIAQGAMYRGSVHDFADFDANQDAEALYTAMKGFGSDKESIL
                     ELITSRSNKQRQEICQSYKSLYGKDLIADLKYELTGKFERLIVNLMRPLAYCDAKEIK
                     DAISGIGTDEKCLIEILASRTNEQIHQLVAAYKDAYERDLESDIIGDTSGHFQKMLVV
                     LLQGTRENDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEY
                     LKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIR
                     IMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKALLKLCGGDDDAAGQFFPE
                     AAQVAYQMWELSAVSRVELKGTVRAANDFNPDADAKALRKAMKGIGTDEATIIDIITQ
                     RSNAQRQQIRQTFKSHFGRDLMADLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEG
                     AGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFKRILISLATGN
                     REEGGENRDQAQEDAQVAAEILEIADTPSGDKTSLETRFMTVLCTRSYPHLRRVFQEF
                     IKKTNYDIEHVIKKEMSGDVKDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTR
                     VMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFMKALLALCGGED"
     exon            125..215
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            216..310
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            311..424
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            425..515
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            516..595
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            596..652
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            653..746
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            747..842
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            843..901
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1024
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1083
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1162
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1244
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1339
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1453
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1544
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1624
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1678
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1696
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1790
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1886
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1945
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2068
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2625
                     /gene="Anxa6"
                     /gene_synonym="Anx6; CPB-II"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcgctgcg gctgctgcta ggctaacggg cttcgagctg cgtctatctg tctgccctga
       61 tccgaggcct ccccagagcg tggtttctgc tgcagaacct gagaccatgg ccaaaatagc
      121 acagggtgcc atgtaccgag gctctgtcca cgacttcgca gactttgatg caaatcagga
      181 tgccgaggct ttgtacacag ccatgaaggg cttcggcagt gacaaggagt ccatattgga
      241 gctgatcacc tcccgcagca acaagcagag gcaggagatc tgccagagtt acaagtccct
      301 ctatggcaag gacctcatcg cagacttgaa gtatgagttg acagggaagt tcgagcgact
      361 gatagtgaac ctgatgaggc cgcttgccta ttgtgacgcc aaagagatta aagacgctat
      421 ctcgggcatt ggcactgatg agaagtgcct cattgaaatt ttggcttccc ggaccaatga
      481 gcagatacac cagctggtgg ccgcatacaa agatgcctat gagagagacc tggagtctga
      541 catcattgga gacacttcag gccacttcca gaagatgctg gtggtactgc tccagggaac
      601 ccgggagaat gacgatgttg tgagtgagga cttggtccag caggatgtcc aggacctgta
      661 tgaggcaggg gaattgaaat ggggaacaga tgaggcccag ttcatctata tcttgggaaa
      721 ccgtagcaaa cagcacctac gattggtgtt tgatgagtac ctgaagacca cagggaagcc
      781 catcgaagcc agtatcagag gggagctgtc tggagacttt gagaagctga tgttggccgt
      841 ggtgaagtgc atccgaagta ccccggagta ttttgctgaa aggctgttca aagccatgaa
      901 gggcctgggg actcgagaca acactctgat ccgtatcatg gtctccagga gcgaactgga
      961 tatgcttgac atccgggaga tcttccggac caagtatgag aagtcactct acagcatgat
     1021 caagaatgat acctctggtg aatacaagaa ggctttgctg aagctatgtg gaggggacga
     1081 tgatgccgct ggccagttct tcccggaggc agcacaggtg gcctatcaga tgtgggaact
     1141 tagtgcagtg tcccgagtcg agctgaaggg taccgtgcgt gcggccaacg atttcaaccc
     1201 cgatgctgat gccaaggccc tgcggaaagc catgaaggga attggaaccg acgaagccac
     1261 catcatcgac atcatcacac agcgcagcaa cgcccagcgg cagcagatcc ggcagacctt
     1321 caaatctcac tttggccggg atttaatggc cgacctgaag tccgagatct caggagacct
     1381 ggcaaggctg atcctggggc tcatgatgcc acctgcccat tacgatgcta agcagctgaa
     1441 gaaagctatg gagggagccg gcacagatga aaaggctctt atagaaatcc tggccacccg
     1501 gaccaatgct gaaatccgag ccatcaatga ggcctacaag gaggattatc acaagtccct
     1561 ggaggatgcc ctgagctcgg acacatctgg ccacttcaaa aggatcctca tttctctggc
     1621 cacagggaat cgagaggaag gaggagaaaa ccgggaccag gctcaggaag atgctcaggt
     1681 ggctgctgag atcttggaaa tagcagacac acccagtgga gacaaaacct ccttggagac
     1741 tcgattcatg accgtcctgt gcacccgtag ctatccccac ctgcgcagag tcttccagga
     1801 gttcatcaag aaaaccaact atgacataga gcatgtcatc aagaaggaga tgtctgggga
     1861 cgtcaaggac gcatttgtgg ccatcgttca gagtgtcaag aacaagcctc tcttctttgc
     1921 tgacaaactg tacaagtcca tgaagggtgc cggcacggat gagaagaccc tcaccagggt
     1981 gatggtgtcc cggagtgaga tagacctgct caacatccgg agggaattca ttgagaaata
     2041 tgacaagtct ctacaccaag ccattgaagg tgacacctct ggagacttca tgaaggcttt
     2101 gctggcgctc tgtggtggag aagactaaaa ctcatggcct tggagggtcc cccctgccat
     2161 gcagtggcca accgcaccag ccaccgtgac ctgaccaagc cattgctcca gcttcagaga
     2221 ctaaggaaga agtgaggggt ggagttggac tgtgatccgg ctggggtgct ctcttgccat
     2281 tgagggtccc aggcggtccc ttctgttatc cctcctgctc atggctaagt ggctggtgaa
     2341 ccacagccat atatgcattc aaccctgctc cccgtctgcc tcctcctccg cccaccctag
     2401 cttccatccc tccacacaat ccctgcctga tttaagcttt gtcacatctc taaacacacc
     2461 aaacctctgt ctacgaagtg agtgacgtgt atgctttgga gggtgggctg tggtacctgg
     2521 tgccaggcat gcattctggg atagcggaga tgatgaatta atttgataga gaggtgatct
     2581 ccccggccgt caccattcaa tctgataaaa gtaccgagct cggaa
//
