LOCUS       NM_013132               1419 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus annexin A5 (Anxa5), mRNA.
ACCESSION   NM_013132
VERSION     NM_013132.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1419)
  AUTHORS   Karimi-Zandi,L., Ghorbandaiepour,T. and Zahmatkesh,M.
  TITLE     The increment of annexin V-positive microvesicles versus annexin
            V-negative microvesicles in CSF of an animal model of Alzheimer's
            disease
  JOURNAL   Neurosci Lett 814, 137446 (2023)
   PUBMED   37595881
  REMARK    GeneRIF: The increment of annexin V-positive microvesicles versus
            annexin V-negative microvesicles in CSF of an animal model of
            Alzheimer's disease.
REFERENCE   2  (bases 1 to 1419)
  AUTHORS   Terashima,R., Laoharatchatathanin,T., Kurusu,S. and Kawaminami,M.
  TITLE     Sequential preovulatory expression of a gonadotropin-releasing
            hormone-inducible gene, Nr4a3, and its suppressor Anxa5 in the
            pituitary gland of female rats
  JOURNAL   J Reprod Dev 67 (3), 217-221 (2021)
   PUBMED   33840679
  REMARK    GeneRIF: Sequential preovulatory expression of a
            gonadotropin-releasing hormone-inducible gene, Nr4a3, and its
            suppressor Anxa5 in the pituitary gland of female rats.
REFERENCE   3  (bases 1 to 1419)
  AUTHORS   Yu,C., Munoz,L.E., Mallavarapu,M., Herrmann,M. and Finnemann,S.C.
  TITLE     Annexin A5 regulates surface alphavbeta5 integrin for retinal
            clearance phagocytosis
  JOURNAL   J Cell Sci 132 (20) (2019)
   PUBMED   31515275
  REMARK    GeneRIF: These results identify a novel role for ANXA5 specifically
            in the recognition and binding step of clearance phagocytosis,
            which is essential to retinal physiology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1419)
  AUTHORS   Dong,R.F., Zhang,B., Tai,L.W., Liu,H.M., Shi,F.K. and Liu,N.N.
  TITLE     The Neuroprotective Role of MiR-124-3p in a
            6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease via the
            Regulation of ANAX5
  JOURNAL   J Cell Biochem 119 (1), 269-277 (2018)
   PUBMED   28543594
  REMARK    GeneRIF: further analysis showed that miR-124-3p enhanced the
            viability of 6-OHDA-treated PC12 or SH-SY5Y cells by targeting
            ANXA5, which was associated with the stimulation of the ERK
            pathway.
REFERENCE   5  (bases 1 to 1419)
  AUTHORS   Sohma,H., Imai,S., Takei,N., Honda,H., Matsumoto,K., Utsumi,K.,
            Matsuki,K., Hashimoto,E., Saito,T. and Kokai,Y.
  TITLE     Evaluation of annexin A5 as a biomarker for Alzheimer's disease and
            dementia with lewy bodies
  JOURNAL   Front Aging Neurosci 5, 15 (2013)
   PUBMED   23576984
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1419)
  AUTHORS   Kawaminami,M., Tanaka,K., Asawa,T., Osugi,S., Kawauchi,H.,
            Kurusu,S. and Hashimoto,I.
  TITLE     Association of annexin V with prolactin in the rat anterior
            pituitary gland
  JOURNAL   Biochem Biophys Res Commun 186 (2), 894-898 (1992)
   PUBMED   1386737
REFERENCE   7  (bases 1 to 1419)
  AUTHORS   Giambanco,I., Pula,G., Ceccarelli,P., Bianchi,R. and Donato,R.
  TITLE     Immunohistochemical localization of annexin V (CaBP33) in rat
            organs
  JOURNAL   J Histochem Cytochem 39 (9), 1189-1198 (1991)
   PUBMED   1833446
REFERENCE   8  (bases 1 to 1419)
  AUTHORS   Goldberg,M., Feinberg,J., Rainteau,D., Lecolle,S., Kaetzel,M.A.,
            Dedman,J.R. and Weinman,S.
  TITLE     Annexins I-VI in secretory ameloblasts and odontoblasts of rat
            incisor
  JOURNAL   J Biol Buccale 18 (4), 289-298 (1990)
   PUBMED   2151331
REFERENCE   9  (bases 1 to 1419)
  AUTHORS   Seaton,B.A., Head,J.F., Kaetzel,M.A. and Dedman,J.R.
  TITLE     Purification, crystallization, and preliminary X-ray diffraction
            analysis of rat kidney annexin V, a calcium-dependent
            phospholipid-binding protein
  JOURNAL   J Biol Chem 265 (8), 4567-4569 (1990)
   PUBMED   2307675
REFERENCE   10 (bases 1 to 1419)
  AUTHORS   Blackwood,R.A. and Ernst,J.D.
  TITLE     Characterization of Ca2(+)-dependent phospholipid binding, vesicle
            aggregation and membrane fusion by annexins
  JOURNAL   Biochem J 266 (1), 195-200 (1990)
   PUBMED   2138016
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013132.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M21730.1, BC081855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000002.1  121272660-121272696 c
            38-71               JAXUCZ010000002.1  121272517-121272550 c
            72-156              JAXUCZ010000002.1  121260266-121260350 c
            157-251             JAXUCZ010000002.1  121257971-121258065 c
            252-365             JAXUCZ010000002.1  121255525-121255638 c
            366-456             JAXUCZ010000002.1  121254088-121254178 c
            457-536             JAXUCZ010000002.1  121250352-121250431 c
            537-593             JAXUCZ010000002.1  121249882-121249938 c
            594-687             JAXUCZ010000002.1  121246328-121246421 c
            688-783             JAXUCZ010000002.1  121245087-121245182 c
            784-842             JAXUCZ010000002.1  121243395-121243453 c
            843-965             JAXUCZ010000002.1  121243073-121243195 c
            966-1419            JAXUCZ010000002.1  121242151-121242604 c
FEATURES             Location/Qualifiers
     source          1..1419
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..1419
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /note="annexin A5"
                     /db_xref="GeneID:25673"
                     /db_xref="RGD:2120"
     exon            1..37
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
     exon            38..71
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1028
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /note="PP4; CBP-I; PAP-I; VAC-alpha; annexin-5; anchorin
                     CII; endonexin II; lipocortin V; calphobindin I;
                     thromboplastin inhibitor; vascular anticoagulant-alpha;
                     placental anticoagulant protein 4; placental anticoagulant
                     protein I; Annexin V"
                     /codon_start=1
                     /product="annexin A5"
                     /protein_id="NP_037264.2"
                     /db_xref="GeneID:25673"
                     /db_xref="RGD:2120"
                     /translation="MALRGTVTDFSGFDGRADAEVLRKAMKGLGTDEDSILNLLTARS
                     NAQRQQIAEEFKTLFGRDLVNDMKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAG
                     TDEKVLTEIIASRTPEELRAIKQVYEEEYGSNLEDDVVGDTSGYYQRMLVVLLQANRD
                     PDTAIDDAQVELDAQALFQAGELKWGTDEEKFITILGTRSVSHLRRVFDKYMTISGFQ
                     IEETIDRETSGNLENLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVIVSRSE
                     IDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGGEDD"
     exon            72..156
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
     exon            157..251
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
     exon            252..365
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
     exon            366..456
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
     exon            457..536
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
     exon            537..593
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
     exon            594..687
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
     exon            688..783
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
     exon            784..842
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
     exon            843..965
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1419
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I; LC5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctgctct caaccgcagc ctgcgcccta ccttctgcag ctccagccta ctcctgaccg
       61 acagcatcat ggctctcaga ggcaccgtga ctgacttctc tggattcgac ggcagggctg
      121 atgccgaagt tcttcggaag gccatgaaag gcttgggcac cgacgaggac agcatcctga
      181 acctgttgac agcccggagc aacgctcagc gccagcagat tgctgaggag tttaagactc
      241 tgtttggcag ggaccttgtg aatgacatga agtctgaact gacaggaaag tttgagaagt
      301 taattgtggc tttgatgaag ccctcccggc tctacgacgc ctacgagctg aaacacgctc
      361 ttaagggagc tgggacagat gagaaagtgt tgactgaaat cattgcctca aggacacctg
      421 aagagctcag ggccataaaa caagtttatg aagaagaata tggttccaac ctggaagatg
      481 atgtggtggg ggatacctca gggtactacc agaggatgtt ggtggtcctc cttcaggcca
      541 atagagaccc tgacactgca attgatgatg ctcaagttga actggatgct caggcattgt
      601 tccaggctgg agagctgaag tgggggacgg atgaagaaaa gttcatcacc atccttggga
      661 cacgcagtgt gtctcattta agaagagtgt ttgacaagta catgacaata tcaggatttc
      721 agattgagga aaccattgac cgagagacct cagggaactt ggagaactta ctcctggctg
      781 tcgtgaagtc tattcggagc atacctgcct accttgcaga gaccctctac tatgctatga
      841 agggtgctgg gacggacgat cacaccctca tcagagtcat agtgtcgagg agtgagattg
      901 atctgtttaa catcaggaag gagtttagga agaacttcgc cacgtccctg tactctatga
      961 tcaagggcga cacatctgga gactataaga aggccctgct gctcctctgt ggaggcgagg
     1021 atgactgagg agctgcctgg agtgccctgg gcccgcctgc tgcccaccat cagcttcctt
     1081 cagcaccacg cctacttacg ttcaatgcct gcctgcctgc cacgctgcct tactcacacg
     1141 agtgtgtgct aatgaccaaa gctgtctcga atgaaagcag tgttctgctg ttctgtctga
     1201 catagacctt cccacgtctc tcagtctagt atctctaagt tgcgttttct atcctcttct
     1261 aaagcttcat ttatattaag ttaataacca tattaccttg aacggaacct tagccatgaa
     1321 attgtgaact cttggaagtg ctgtcaatca agcttagtgc tctagctgac ctgaaaaatt
     1381 aagatggtcg taatatcaga aacgttgccg acaaataaa
//
