LOCUS       NM_024155               1988 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus annexin A4 (Anxa4), mRNA.
ACCESSION   NM_024155
VERSION     NM_024155.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1988)
  AUTHORS   Xu,Y., Sui,L., Qiu,B., Yin,X., Liu,J. and Zhang,X.
  TITLE     ANXA4 promotes trophoblast invasion via the PI3K/Akt/eNOS pathway
            in preeclampsia
  JOURNAL   Am J Physiol Cell Physiol 316 (4), C481-C491 (2019)
   PUBMED   30673304
  REMARK    GeneRIF: ANXA4 overexpression in placenta alleviated pre-eclampsia
            in an animal model.
REFERENCE   2  (bases 1 to 1988)
  AUTHORS   Arii,Y., Butsusihta,K. and Fukuoka,S.
  TITLE     Role of calcium-binding sites in calcium-dependent membrane
            association of annexin A4
  JOURNAL   Biosci Biotechnol Biochem 79 (6), 978-985 (2015)
   PUBMED   25649809
  REMARK    GeneRIF: role of calcium-binding sites in calcium-dependent
            membrane association of annexin A4
REFERENCE   3  (bases 1 to 1988)
  AUTHORS   Falix,F.A., Weeda,V.B., Labruyere,W.T., Poncy,A., de Waart,D.R.,
            Hakvoort,T.B., Lemaigre,F., Gaemers,I.C., Aronson,D.C. and
            Lamers,W.H.
  TITLE     Hepatic Notch2 deficiency leads to bile duct agenesis perinatally
            and secondary bile duct formation after weaning
  JOURNAL   Dev Biol 396 (2), 201-213 (2014)
   PUBMED   25446530
REFERENCE   4  (bases 1 to 1988)
  AUTHORS   Iwasa,T., Takahashi,R., Nagata,K. and Kobayashi,Y.
  TITLE     Suppression of MIP-2 or IL-8 production by annexins A1 and A4
            during coculturing of macrophages with late apoptotic human
            peripheral blood neutrophils
  JOURNAL   Biochim Biophys Acta 1822 (2), 204-211 (2012)
   PUBMED   22056994
REFERENCE   5  (bases 1 to 1988)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   6  (bases 1 to 1988)
  AUTHORS   Piljic,A. and Schultz,C.
  TITLE     Annexin A4 self-association modulates general membrane protein
            mobility in living cells
  JOURNAL   Mol Biol Cell 17 (7), 3318-3328 (2006)
   PUBMED   16687573
REFERENCE   7  (bases 1 to 1988)
  AUTHORS   Ling,T.Y., Chen,C.L., Huang,Y.H., Liu,I.H., Huang,S.S. and
            Huang,J.S.
  TITLE     Identification and characterization of the acidic pH binding sites
            for growth regulatory ligands of low density lipoprotein
            receptor-related protein-1
  JOURNAL   J Biol Chem 279 (37), 38736-38748 (2004)
   PUBMED   15226301
REFERENCE   8  (bases 1 to 1988)
  AUTHORS   Willshaw,A., Grant,K., Yan,J., Rockliffe,N., Ambavarapu,S.,
            Burdyga,G., Varro,A., Fukuoka,S. and Gawler,D.
  TITLE     Identification of a novel protein complex containing annexin A4,
            rabphilin and synaptotagmin
  JOURNAL   FEBS Lett 559 (1-3), 13-21 (2004)
   PUBMED   14960300
  REMARK    GeneRIF: the rabphilin C2B domain interacts directly with the
            N-terminus of annexin A4 and mediates the co-complexing of these
            two proteins which co-localise at the plasma membrane annexin; A4
            may play a role in synaptic exocytosis.
REFERENCE   9  (bases 1 to 1988)
  AUTHORS   Fukuoka,S., Kern,H., Kazuki-Sugino,R. and Ikeda,Y.
  TITLE     Cloning and characterization of ZAP36, an annexin-like, zymogen
            granule membrane associated protein, in exocrine pancreas
  JOURNAL   Biochim Biophys Acta 1575 (1-3), 148-152 (2002)
   PUBMED   12020832
REFERENCE   10 (bases 1 to 1988)
  AUTHORS   Blackwood,R.A. and Ernst,J.D.
  TITLE     Characterization of Ca2(+)-dependent phospholipid binding, vesicle
            aggregation and membrane fusion by annexins
  JOURNAL   Biochem J 266 (1), 195-200 (1990)
   PUBMED   2138016
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085688.1.
            
            On Nov 15, 2004 this sequence version replaced NM_024155.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085688.1, SRR8487226.130126.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1988
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1988
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /note="annexin A4"
                     /db_xref="GeneID:79124"
                     /db_xref="RGD:621171"
     exon            1..47
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
     exon            48..94
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1051
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /note="ZAP36; annexin-4; annexin IV; lipocortin IV; 36 kDa
                     zymogen granule membrane-associated protein; ZAP
                     36/annexin IV"
                     /codon_start=1
                     /product="annexin A4"
                     /protein_id="NP_077069.3"
                     /db_xref="GeneID:79124"
                     /db_xref="RGD:621171"
                     /translation="METKGGTVKAASGFNATEDAQVLRKAMKGLGTDEDAIIGVLACR
                     NTAQRQEIRTAYKSTIGRDLLEDLKSELSSNFEQVILGMMTPTVLYDVQELRRAMKGA
                     GTDEGCLIEILASRNPEEIRRINQTYQQQYGRSLEEDICSDTSFMFQRVLVSLTAGGR
                     DEGNYLDDALVKQDAQDLYEAGEKRWGTDEVKFLSILCSRNRNHLLHVFDEYKRISQK
                     DIEQSIKSETSGSFEDALLAIVKCMRNKPAYFAERLYKSMKGLGTDDSTLIRVMVSRA
                     EIDMLDIRANFKRLYGKSLYSFIKGDTSGDYRKVLLILCGGDD"
     exon            95..182
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
     exon            183..277
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
     exon            278..391
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
     exon            392..482
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
     exon            483..562
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
     exon            563..619
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
     exon            620..713
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
     exon            714..809
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
     exon            810..868
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
     exon            869..991
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1958
                     /gene="Anxa4"
                     /gene_synonym="Anx4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagggtgtg gtcgcagtcg tagactcagc ctgtctccgc aggagaggag cttctgctgg
       61 cgtgactgaa ctctgaacgt tagctagagc catggaaacc aaaggaggaa ctgtgaaagc
      121 tgcttcagga ttcaatgcaa ctgaagatgc ccaggtcctg aggaaggcca tgaaaggtct
      181 gggtactgac gaagatgcca ttatcggagt cttagcctgc cggaacactg cccaacgcca
      241 ggaaatcagg acggcctaca agagcaccat tggcagggac ctgcttgagg acttgaagtc
      301 ggagctgagc agcaacttcg agcaggtgat cctgggcatg atgacgccca cagtgctgta
      361 tgacgtgcag gagctccgga gggctatgaa gggagctggc acggacgagg gctgtctgat
      421 tgagatcctg gcctctcgca accctgagga gatccgtcgc atcaaccaga cataccagca
      481 gcaatatgga aggagccttg aagaggacat ctgctctgac acatccttca tgttccagcg
      541 agtactggtg tccctgacag cgggtggcag ggatgaagga aattacctcg atgatgcgct
      601 cgtgaagcag gatgcccagg atctgtatga ggctggagag aagagatggg ggacggatga
      661 agtgaagttc ctaagcattc tctgttcccg gaaccggaac cacctgctcc atgtgtttga
      721 tgaatacaaa cggatctcac agaaggacat tgaacagagc attaagtctg agacatctgg
      781 aagctttgaa gatgctctgc tggctatagt gaagtgcatg aggaataaac ctgcctattt
      841 tgctgaaagg ctttataaat ccatgaaggg cttaggcact gacgacagca ccctcatcag
      901 agtgatggtg tctcgagcag agattgacat gctggacatc cgggcaaact tcaagaggct
      961 ctacgggaag tctttgtact cttttatcaa gggcgacact tctggagact acaggaaggt
     1021 tctgctcatt ctctgtggag gagatgatta aaagcaaggt gcaggacgga aggcttctta
     1081 acactgattt tgtttttaac ttcatttttc tgcactgcta ttaacattat ctcaaatgct
     1141 tatttccaat taaaacgcct ccagttgcct cctaggatcc agactgttat tatcgtctat
     1201 aattagtcat tttgatgcct taaacttgta ctttcaaagc ttttaagaca tacgtggaga
     1261 tttagaatta gaaattaaaa tgtgctccat gtctttatca gattatttcc tcgtttgtgt
     1321 tttgtagaga tttgaatgca ctaaatcctt ctagattttc tttttttggt acgaacagaa
     1381 cagaagagaa gccattttct tccctgggaa gtcagtcatt tctttatgtg ggaccatcag
     1441 cgtctcttac tgagattagc catctggtct cctattttac acagatccaa agttctcatg
     1501 agcccccttt ctttggcttt gcctgtcatg ttagctgaca gttgctgagc ctggtagggg
     1561 caggcttcat ctcattgtac cctgccacca ttttctactc gtgaggtgta acaaagtaac
     1621 cagcacatca aacaagttca atttcaagcg tggctaggca gaccacgtgt gtttgtcagt
     1681 catgctgaac attcctcagt tttagggtta ctaccctaat cttgctcaag tgatggtcaa
     1741 gagtggactc ggccaaggtt gtcctggtaa tgagatgctc tgggtgtggc ttgcctaaga
     1801 agagtttttt tctgctaaaa atagttcatc tctctgaacc gtttatttga tccccactgt
     1861 gcccttttga tcttattcag aaactgtgct tgcatgtaat cctcaagttt ggtttgtata
     1921 caacatgaga catttttaat taaaaatggt ggctttaaaa aaaaaaaaaa aaaaaaaaaa
     1981 aaaaaaaa
//
