LOCUS       NM_019905               1395 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus annexin A2 (Anxa2), mRNA.
ACCESSION   NM_019905
VERSION     NM_019905.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1395)
  AUTHORS   Liu,B., Xing,Z., Song,F., Li,D., Zhao,B., Xu,C., Xia,W. and Ji,H.
  TITLE     METTL3-mediated ANXA2 inhibition confers neuroprotection in
            ischemic stroke: Evidence from in vivo and in vitro studies
  JOURNAL   FASEB J 37 (7), e22974 (2023)
   PUBMED   37249328
  REMARK    GeneRIF: METTL3-mediated ANXA2 inhibition confers neuroprotection
            in ischemic stroke: Evidence from in vivo and in vitro studies.
REFERENCE   2  (bases 1 to 1395)
  AUTHORS   Li,D.W., Qi,X.D., Zhang,C.H. and Sun,W.P.
  TITLE     Annexin A2 degradation contributes to dopaminergic cell apoptosis
            via regulating p53 in neurodegenerative conditions
  JOURNAL   Neuroreport 32 (15), 1263-1268 (2021)
   PUBMED   34494994
  REMARK    GeneRIF: Annexin A2 degradation contributes to dopaminergic cell
            apoptosis via regulating p53 in neurodegenerative conditions.
REFERENCE   3  (bases 1 to 1395)
  AUTHORS   Wang,Y., Xu,W., Zu,M. and Xu,H.
  TITLE     Circular RNA circ_0021093 regulates miR-432/Annexin A2 pathway to
            promote hepatocellular carcinoma progression
  JOURNAL   Anticancer Drugs 32 (5), 484-495 (2021)
   PUBMED   33675609
REFERENCE   4  (bases 1 to 1395)
  AUTHORS   Fahling,M., Paliege,A., Jonsson,S., Becirovic-Agic,M.,
            Melville,J.M., Skogstrand,T. and Hultstrom,M.
  TITLE     NFAT5 regulates renal gene expression in response to angiotensin II
            through Annexin-A2-mediated posttranscriptional regulation in
            hypertensive rats
  JOURNAL   Am J Physiol Renal Physiol 316 (1), F101-F112 (2019)
   PUBMED   30332317
  REMARK    GeneRIF: ANGII increases Annexin-A2 nucleic acid-binding activity
            and elevates protein levels of the NFAT5 transcription factor in
            kidneys of hypertensive rats.
REFERENCE   5  (bases 1 to 1395)
  AUTHORS   Liao,L., Zheng,B., Yi,B., Liu,C., Chen,L., Zeng,Z. and Gao,J.
  TITLE     Annexin A2-modulated proliferation of pulmonary arterial smooth
            muscle cells depends on caveolae and caveolin-1 in hepatopulmonary
            syndrome
  JOURNAL   Exp Cell Res 359 (1), 266-274 (2017)
   PUBMED   28729092
  REMARK    GeneRIF: Cav-1 participates upstream of ANXA2 in the activation of
            ERK1/2 and NF-kappaB.
REFERENCE   6  (bases 1 to 1395)
  AUTHORS   Takahashi,S., Reddy,S.V., Chirgwin,J.M., Devlin,R., Haipek,C.,
            Anderson,J. and Roodman,G.D.
  TITLE     Cloning and identification of annexin II as an autocrine/paracrine
            factor that increases osteoclast formation and bone resorption
  JOURNAL   J Biol Chem 269 (46), 28696-28701 (1994)
   PUBMED   7961821
REFERENCE   7  (bases 1 to 1395)
  AUTHORS   Upton,A.L. and Moss,S.E.
  TITLE     Molecular cloning of a novel N-terminal variant of annexin II from
            rat basophilic leukaemia cells
  JOURNAL   Biochem J 302 (Pt 2) (Pt 2), 425-428 (1994)
   PUBMED   8092993
REFERENCE   8  (bases 1 to 1395)
  AUTHORS   Mizutani,A., Usuda,N., Tokumitsu,H., Minami,H., Yasui,K.,
            Kobayashi,R. and Hidaka,H.
  TITLE     CAP-50, a newly identified annexin, localizes in nuclei of cultured
            fibroblast 3Y1 cells
  JOURNAL   J Biol Chem 267 (19), 13498-13504 (1992)
   PUBMED   1618851
REFERENCE   9  (bases 1 to 1395)
  AUTHORS   Blackwood,R.A. and Ernst,J.D.
  TITLE     Characterization of Ca2(+)-dependent phospholipid binding, vesicle
            aggregation and membrane fusion by annexins
  JOURNAL   Biochem J 266 (1), 195-200 (1990)
   PUBMED   2138016
REFERENCE   10 (bases 1 to 1395)
  AUTHORS   Huang,K.S., Wallner,B.P., Mattaliano,R.J., Tizard,R., Burne,C.,
            Frey,A., Hession,C., McGray,P., Sinclair,L.K., Chow,E.P. et al.
  TITLE     Two human 35 kd inhibitors of phospholipase A2 are related to
            substrates of pp60v-src and of the epidermal growth factor
            receptor/kinase
  JOURNAL   Cell 46 (2), 191-199 (1986)
   PUBMED   3013422
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X66871.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66871.1, BC059136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1395
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1395
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /note="annexin A2"
                     /db_xref="GeneID:56611"
                     /db_xref="RGD:621170"
     exon            1..29
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
     exon            30..90
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1062
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /note="p36; PAP-IV; annexin-2; protein I; lipocortin II;
                     chromobindin-8; placental anticoagulant protein IV;
                     calpactin-1 heavy chain; calpactin I heavy chain"
                     /codon_start=1
                     /product="annexin A2"
                     /protein_id="NP_063970.1"
                     /db_xref="GeneID:56611"
                     /db_xref="RGD:621170"
                     /translation="MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIET
                     AIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELPSAMKSALSGHLETVMLGL
                     LKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDII
                     SDTSGEFRKLLVALAKGKRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMT
                     ERSVCHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYD
                     SMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYFIQQDTKGDYQKALLYL
                     CGGDD"
     exon            91..190
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
     exon            191..285
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
     exon            286..399
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..490
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..570
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..630
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..724
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..820
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
     exon            821..879
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1002
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1337
                     /gene="Anxa2"
                     /gene_synonym="ANX2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctctctg caataggtgc ccggcccagc ttttttttca aaatgtctac tgtccacgaa
       61 atcctgtgca agctcagctt ggagggtgat cattctacac ccccaagtgc ctatgggtcg
      121 gtcaaaccct acaccaactt cgacgctgag agggatgctt tgaacattga aacagcaatc
      181 aagaccaaag gcgtggacga ggtcaccatt gtcaacattc tgactaaccg cagcaatgca
      241 cagaggcagg acattgcctt cgcctaccag aggaggacca aaaaggaact gccatcggcg
      301 atgaagtcgg ccttgtctgg tcacctggag accgtgatgt taggcctgtt gaagacacct
      361 gctcagtacg atgcctctga gctcaaagcc tccatgaagg gcctggggac tgatgaggac
      421 tccctcatcg agatcatctg ctcaagaacc aaccaggagc tgcaggagat taaccgagtg
      481 tataaggaaa tgtacaagac cgatctggag aaggacatca tctctgacac atctggagaa
      541 ttccgaaagc tgttggtcgc ccttgcaaag ggtaaacggg cagaggatgg ttctgttatt
      601 gactacgagc tgattgacca ggatgcccgg gagctctatg atgctggggt gaagaggaaa
      661 ggaaccgatg tccccaagtg gatcagcatc atgactgagc gcagtgtgtg ccacctccag
      721 aaagtgttcg aaaggtacaa gagctacagt ccttatgaca tgctggagag catcaggaaa
      781 gaggtcaaag gagacctgga gaacgccttc ctgaacctgg ttcagtgcat tcagaacaag
      841 cccctgtact ttgctgaccg gctgtatgac tccatgaagg gcaaggggac tcgagacaag
      901 gtcctgatta gaatcatggt ctctcgcagt gaagtggaca tgttgaaaat cagatctgaa
      961 ttcaagagga aatatggcaa atccctgtac tacttcatcc agcaagacac taagggtgac
     1021 taccagaagg cgctgctgta cctgtgtggt ggggacgact gaagggcttg gcatggtgga
     1081 ttgcccagaa gtggccctac ctgtgcccca acctaatgtt ctagagaatc agcctgccac
     1141 taatggaccc ctgaactcct ccctgtgaag atgacgacag agctgccgac ccatccccca
     1201 tcttagctgc ctttgcctgg ctttcccctc attctctcct ttatgccaaa gaaatgaaca
     1261 ttccagggag ttggacgtac cgtctgtgac atgagacact tcctcatatg tgtcgtgaat
     1321 aaaccatttt tactttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1381 aaaaaaaaaa aaaaa
//
