LOCUS       NM_012904               1401 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus annexin A1 (Anxa1), mRNA.
ACCESSION   NM_012904
VERSION     NM_012904.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1401)
  AUTHORS   Zheng,F., Li,W., Su,S. and Hui,Q.
  TITLE     Annexin A1 conveys neuroprotective function via inhibiting
            oxidative stress in diffuse axonal injury of rats
  JOURNAL   Neuroreport 35 (7), 466-475 (2024)
   PUBMED   38526918
  REMARK    GeneRIF: Annexin A1 conveys neuroprotective function via inhibiting
            oxidative stress in diffuse axonal injury of rats.
REFERENCE   2  (bases 1 to 1401)
  AUTHORS   He,Y., Zhang,Y., Wu,H., Luo,J., Cheng,C. and Zhang,H.
  TITLE     The role of annexin A1 peptide in regulating PI3K/Akt signaling
            pathway to reduce lung injury after cardiopulmonary bypass in rats
  JOURNAL   Perfusion 38 (2), 320-329 (2023)
   PUBMED   34951334
  REMARK    GeneRIF: The role of annexin A1 peptide in regulating PI3K/Akt
            signaling pathway to reduce lung injury after cardiopulmonary
            bypass in rats.
REFERENCE   3  (bases 1 to 1401)
  AUTHORS   Flores,J.J., Ding,Y., Sherchan,P., Zhang,J.H. and Tang,J.
  TITLE     Annexin A1 upregulates hematoma resolution via the
            FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix
            hemorrhage
  JOURNAL   Exp Neurol 359, 114257 (2023)
   PUBMED   36279933
  REMARK    GeneRIF: Annexin A1 upregulates hematoma resolution via the
            FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix
            hemorrhage.
REFERENCE   4  (bases 1 to 1401)
  AUTHORS   Zhao,B., Huang,J., Lou,X., Yao,K., Ye,M., Mou,Q., Wen,Z., Duan,Q.,
            Zhang,H. and Zhao,Y.
  TITLE     Endothelial CYP2J2 overexpression restores the BRB via
            METTL3-mediated ANXA1 upregulation
  JOURNAL   FASEB J 36 (11), e22619 (2022)
   PUBMED   36269280
  REMARK    GeneRIF: Endothelial CYP2J2 overexpression restores the BRB via
            METTL3-mediated ANXA1 upregulation.
REFERENCE   5  (bases 1 to 1401)
  AUTHORS   Fungbun,N., Sasaki,H., Terashima,R., Murata,T., Chiba,S., Kurusu,S.
            and Kawaminami,M.
  TITLE     Changes in the expression of annexin A1 in the anterior pituitary
            gland after ovariectomy in rats
  JOURNAL   J Vet Med Sci 84 (9), 1288-1291 (2022)
   PUBMED   35896374
  REMARK    GeneRIF: Changes in the expression of annexin A1 in the anterior
            pituitary gland after ovariectomy in rats.
REFERENCE   6  (bases 1 to 1401)
  AUTHORS   Koshimoto,H.N., Tokuda,M., Matsui,H., Itano,T., Hasegawa,E. and
            Hatase,O.
  TITLE     Involvement of lipocortin I in development of galactose-induced
            cataracts in rat
  JOURNAL   Exp Eye Res 54 (5), 817-820 (1992)
   PUBMED   1385581
REFERENCE   7  (bases 1 to 1401)
  AUTHORS   Kovacic,R.T., Tizard,R., Cate,R.L., Frey,A.Z. and Wallner,B.P.
  TITLE     Correlation of gene and protein structure of rat and human
            lipocortin I
  JOURNAL   Biochemistry 30 (37), 9015-9021 (1991)
   PUBMED   1832554
REFERENCE   8  (bases 1 to 1401)
  AUTHORS   Relton,J.K., Strijbos,P.J., O'Shaughnessy,C.T., Carey,F.,
            Forder,R.A., Tilders,F.J. and Rothwell,N.J.
  TITLE     Lipocortin-1 is an endogenous inhibitor of ischemic damage in the
            rat brain
  JOURNAL   J Exp Med 174 (2), 305-310 (1991)
   PUBMED   1830327
REFERENCE   9  (bases 1 to 1401)
  AUTHORS   Blackwood,R.A. and Ernst,J.D.
  TITLE     Characterization of Ca2(+)-dependent phospholipid binding, vesicle
            aggregation and membrane fusion by annexins
  JOURNAL   Biochem J 266 (1), 195-200 (1990)
   PUBMED   2138016
REFERENCE   10 (bases 1 to 1401)
  AUTHORS   Shohat,M., Korenberg,J.R., Schwabe,A.D. and Rotter,J.I.
  TITLE     Hypothesis: familial Mediterranean fever--a genetic disorder of the
            lipocortin family?
  JOURNAL   Am J Med Genet 34 (2), 163-167 (1989)
   PUBMED   2530899
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y00446.1.
            
            On Aug 31, 2012 this sequence version replaced NM_012904.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00446.1, FQ213489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680422, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1401              Y00446.1           2-1402
FEATURES             Location/Qualifiers
     source          1..1401
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..1401
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /note="annexin A1"
                     /db_xref="GeneID:25380"
                     /db_xref="RGD:2118"
     exon            1..46
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
     exon            47..126
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1101
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /note="annexin I; annexin-1; calpactin II; chromobindin-9;
                     phospholipase A2 inhibitory protein; calpactin-2; Annexin
                     1 (p35) (Lipocortin 1); lipocortin 1; lipocortin I"
                     /codon_start=1
                     /product="annexin A1"
                     /protein_id="NP_037036.1"
                     /db_xref="GeneID:25380"
                     /db_xref="RGD:2118"
                     /translation="MAMVSEFLKQACYIEKQEQEYVQAVKSYKGGPGSAVSPYPSFNP
                     SSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQETGKPLDETLKKALTG
                     HLEEVVLAMLKTPAQFDADELRAAMKGLGTDEDTLIEILTTRSNQQIREITRVYREEL
                     KRDLAKDITSDTSGDFRNALLALAKGDRCEDMSVNQDLADTDARALYEAGERRKGTDV
                     NVFNTILTTRSYPHLRKVFQNYRKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPA
                     FFAEKLYEAMKGAGTRHKTLIRIMVSRSEIDMNEIKVFYQKKYGIPLCQAILDETKGD
                     YEKILVALCGGN"
     exon            127..235
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
     exon            236..330
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
     exon            331..444
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
     exon            445..535
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
     exon            536..615
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
     exon            616..672
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
     exon            673..766
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
     exon            767..862
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
     exon            863..921
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1044
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1388
                     /gene="Anxa1"
                     /gene_synonym="Anx1; p35"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcaaagct tctcttcagt tccctggaag acaaggcaat acaaagatac tttattaaaa
       61 atggcaatgg tatcagaatt cctcaagcag gcctgctata ttgaaaagca agagcaggaa
      121 tatgttcaag ctgtaaaatc ctacaaaggt ggtcctggat cagcagtgag cccctaccct
      181 tccttcaatc cgtcctcgga tgttgctgcc ttgcacaaag ctatcatggt taaaggtgtg
      241 gatgaggcaa ccatcattga catccttacc aagagaacca atgctcagcg ccagcagatc
      301 aaggcagcat acttacagga gactgggaag cccctggatg aaaccttgaa aaaagccctt
      361 acgggccacc tggaggaggt tgttttggct atgctcaaga ccccagctca gtttgatgca
      421 gatgaactcc gtgctgccat gaagggactt ggaacagatg aagacactct cattgagatt
      481 ttgacaacaa gatctaacca gcaaatcaga gagattacta gagtctacag agaagagctg
      541 aaaagagatc tggccaaaga catcacttcg gacacatctg gagactttcg taatgccttg
      601 cttgctctcg ccaagggtga tcgctgtgag gatatgagtg tgaatcaaga tttggctgat
      661 acagatgcca gggctttgta tgaagctgga gaaaggagaa aggggacaga cgtgaatgtg
      721 ttcaatacaa ttttgaccac aagaagctat cctcatcttc ggaaagtgtt tcagaattat
      781 agaaagtaca gtcaacatga catgaacaaa gccctggatc tggaactgaa gggtgacatt
      841 gagaagtgcc tcacaaccat tgtgaagtgt gccaccagca ctccagcttt ctttgctgag
      901 aaactgtatg aagccatgaa gggtgctgga actcgccata agacattgat caggattatg
      961 gtctcccgtt cggaaattga catgaatgaa atcaaagtat tttaccagaa gaagtacgga
     1021 atccctctct gccaagccat cctggatgaa accaaaggag actatgaaaa aatcctggtg
     1081 gctctgtgtg gaggaaacta aacatcccaa ctgctctgta agattccgag gagaacatct
     1141 cttagccgtt gttttcttcc tattgcaagg cttaagtagg aaagttgctt tgtcagtaag
     1201 tctaattacc ttctttgaat aatgtagcct ataaatatgt tttagatcat tcatctgtac
     1261 aatagagaaa tacttgtttt gttaattatg tttatcccaa attataaatc cctgtaagca
     1321 agtcactttg gtaccattcc tgagaaagaa gtttacatag aataaaataa aacaatttta
     1381 taagacaaaa aaaaaaaaaa a
//
