LOCUS       NP_001385845             487 aa            linear   ROD 30-MAR-2024
DEFINITION  anthrax toxin receptor 2 precursor [Rattus norvegicus].
ACCESSION   NP_001385845 XP_038948584
VERSION     NP_001385845.1
DBSOURCE    REFSEQ: accession NM_001398916.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 487)
  AUTHORS   Liu,Y., Xie,C., Li,T., Lu,C., Fan,L., Zhang,Z., Peng,S., Lv,N. and
            Lu,D.
  TITLE     PCGEM1 promotes cell proliferation and migration in endometriosis
            by targeting miR-124-3p-mediated ANTXR2 expression
  JOURNAL   BMC Womens Health 23 (1), 104 (2023)
   PUBMED   36915057
  REMARK    GeneRIF: PCGEM1 promotes cell proliferation and migration in
            endometriosis by targeting miR-124-3p-mediated ANTXR2 expression.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 487)
  AUTHORS   Liu,X., Yuan,W., Li,J., Yang,L. and Cai,J.
  TITLE     ANTXR2 Knock-Out Does Not Result in the Development of Hypertension
            in Rats
  JOURNAL   Am J Hypertens 30 (2), 182-187 (2017)
   PUBMED   28077422
  REMARK    GeneRIF: ANTXR2 might not be associated with hypertension and thus
            further functional analysis is warranted to identify the causal
            gene at this locus.
REFERENCE   3  (residues 1 to 487)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   4  (residues 1 to 487)
  AUTHORS   Liu,S., Crown,D., Miller-Randolph,S., Moayeri,M., Wang,H., Hu,H.,
            Morley,T. and Leppla,S.H.
  TITLE     Capillary morphogenesis protein-2 is the major receptor mediating
            lethality of anthrax toxin in vivo
  JOURNAL   Proc Natl Acad Sci U S A 106 (30), 12424-12429 (2009)
   PUBMED   19617532
REFERENCE   5  (residues 1 to 487)
  AUTHORS   Scobie,H.M., Wigelsworth,D.J., Marlett,J.M., Thomas,D.,
            Rainey,G.J., Lacy,D.B., Manchester,M., Collier,R.J. and Young,J.A.
  TITLE     Anthrax toxin receptor 2-dependent lethal toxin killing in vivo
  JOURNAL   PLoS Pathog 2 (10), e111 (2006)
   PUBMED   17054395
  REMARK    Erratum:[PLoS Pathog. 2008
            Oct;4(10).doi:10.1371/annotation/08c1bcf0-da65-4abd-97c7-
            5df86b1120b5]
REFERENCE   6  (residues 1 to 487)
  AUTHORS   Hanks,S., Adams,S., Douglas,J., Arbour,L., Atherton,D.J., Balci,S.,
            Bode,H., Campbell,M.E., Feingold,M., Keser,G., Kleijer,W.,
            Mancini,G., McGrath,J.A., Muntoni,F., Nanda,A., Teare,M.D.,
            Warman,M., Pope,F.M., Superti-Furga,A., Futreal,P.A. and Rahman,N.
  TITLE     Mutations in the gene encoding capillary morphogenesis protein 2
            cause juvenile hyaline fibromatosis and infantile systemic
            hyalinosis
  JOURNAL   Am J Hum Genet 73 (4), 791-800 (2003)
   PUBMED   14508707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Dec 28, 2021 this sequence version replaced XP_038948584.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.53973.1,
                                           SRR26643297.42855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     Protein         1..487
                     /product="anthrax toxin receptor 2 precursor"
                     /note="anthrax toxin receptor 2"
                     /calculated_mol_wt=49802
     sig_peptide     1..33
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3439
     Region          39..221
                     /region_name="vWA_ATR"
                     /note="ATR (Anthrax Toxin Receptor): Anthrax toxin is a
                     key virulence factor for Bacillus anthracis, the causative
                     agent of anthrax. ATR is the cellular receptor for the
                     anthrax protective antigen and facilitates entry of the
                     toxin into cells. The VWA domain in...; cd01474"
                     /db_xref="CDD:238751"
     Site            order(50,52,54,118,148)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238751"
     Region          216..317
                     /region_name="Anth_Ig"
                     /note="Anthrax receptor extracellular domain; pfam05587"
                     /db_xref="CDD:461684"
     Region          394..485
                     /region_name="Ant_C"
                     /note="Anthrax receptor C-terminus region; pfam05586"
                     /db_xref="CDD:461683"
     CDS             1..487
                     /gene="Antxr2"
                     /coded_by="NM_001398916.1:594..2057"
                     /db_xref="GeneID:305633"
                     /db_xref="RGD:1561294"
ORIGIN      
        1 mvagrsrars pgswlfpglw lltvggpgsl lqaqeqpsck kafdlyfvld ksgsvannwi
       61 eiynfvhqlt erfvspemrl sfivfssqat iilpltgdry kiskgledlk avqpvgetyi
      121 heglklaneq iqnagglkts siiialtdgk ldglvpsyae keakksrslg asvycvgvld
      181 feqaqleria dskdqvfpvk ggfqalkgii nsilaqscte ilelspssvc vgetfqvvls
      241 gravmsirdd gsvlctftan stytknekpv svqpgsilcp apvlnkaget levsiafndg
      301 ksavsrslti tatecsngia aiiailvlll llgaalmwwf wplcckvvik dpppppsppk
      361 eeeeeeplpn kkwptvdasy yggrgvggik rmevrwgdkg steegarlek aknavvmipe
      421 eeipvpsrpp rpkpthqapq tkwytpikgr ldalwalilk qydrvslmrp qegdegrcin
      481 fsrvphq
//
