LOCUS       NM_001004071            2742 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus anoctamin 7 (Ano7), mRNA.
ACCESSION   NM_001004071 XM_346077
VERSION     NM_001004071.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2742)
  AUTHORS   Suzuki,J., Fujii,T., Imao,T., Ishihara,K., Kuba,H. and Nagata,S.
  TITLE     Calcium-dependent phospholipid scramblase activity of TMEM16
            protein family members
  JOURNAL   J Biol Chem 288 (19), 13305-13316 (2013)
   PUBMED   23532839
REFERENCE   2  (bases 1 to 2742)
  AUTHORS   Tian,Y., Schreiber,R. and Kunzelmann,K.
  TITLE     Anoctamins are a family of Ca2+-activated Cl- channels
  JOURNAL   J Cell Sci 125 (Pt 21), 4991-4998 (2012)
   PUBMED   22946059
REFERENCE   3  (bases 1 to 2742)
  AUTHORS   Duran,C., Qu,Z., Osunkoya,A.O., Cui,Y. and Hartzell,H.C.
  TITLE     ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are
            intracellular proteins
  JOURNAL   Am J Physiol Cell Physiol 302 (3), C482-C493 (2012)
   PUBMED   22075693
REFERENCE   4  (bases 1 to 2742)
  AUTHORS   Scudieri,P., Sondo,E., Ferrera,L. and Galietta,L.J.
  TITLE     The anoctamin family: TMEM16A and TMEM16B as calcium-activated
            chloride channels
  JOURNAL   Exp Physiol 97 (2), 177-183 (2012)
   PUBMED   21984732
REFERENCE   5  (bases 1 to 2742)
  AUTHORS   Schreiber,R., Uliyakina,I., Kongsuphol,P., Warth,R., Mirza,M.,
            Martins,J.R. and Kunzelmann,K.
  TITLE     Expression and function of epithelial anoctamins
  JOURNAL   J Biol Chem 285 (10), 7838-7845 (2010)
   PUBMED   20056604
REFERENCE   6  (bases 1 to 2742)
  AUTHORS   Bera,T.K., Das,S., Maeda,H., Beers,R., Wolfgang,C.D., Kumar,V.,
            Hahn,Y., Lee,B. and Pastan,I.
  TITLE     NGEP, a gene encoding a membrane protein detected only in prostate
            cancer and normal prostate
  JOURNAL   Proc Natl Acad Sci U S A 101 (9), 3059-3064 (2004)
   PUBMED   14981236
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK004074.1.
            
            On Sep 3, 2004 this sequence version replaced XM_346077.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK004074.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132263,
                                           SAMD00132285 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..2742
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /note="anoctamin 7"
                     /db_xref="GeneID:367318"
                     /db_xref="RGD:1302987"
     exon            1..150
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            151..265
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2740
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /note="transmembrane protein 16G; anoctamin-7-like"
                     /codon_start=1
                     /product="anoctamin-7"
                     /protein_id="NP_001004071.1"
                     /db_xref="GeneID:367318"
                     /db_xref="RGD:1302987"
                     /translation="MLRKQAGEEDSVVLIDMTSPEAGNGCSYGSTAQASEAGKQQVAP
                     SRVGSSANPPIDFVLVWEEDLRSRENPTQDKTDTHEIWRETFLENLRVAGLKIDQRDV
                     QDEAAAVHYILLSAPWAVLCYYAEDLRLKLPLQELPNQASNWSATLLEWLGIPNILLE
                     NVPDTPPEYYSCQFKASKLQWFLGSDNQDTFFTSTKRHQILFEILAKTPYGHQKKGLF
                     GIDQLLAEGVFSAAFPLHDGPFSVVPESSQVLGLTQRQVLFKHWARWGKWRKYQPLDH
                     VRRYFGEKVALYFAWLGFYTGWLLPAAVVGTVVFLAGCFLVFSDVPTQELCHSSDTFD
                     MCPLCSDCSFWLLSSACTLAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKNATLAY
                     RWDCSDYEDIEERPRPQFAATAPMTALNPITGEDEPYFPEKNRVRRMLAGSVVLLMMV
                     AVVIMCLVSIILYRAVMAIIVSKSNNAFLSAWASRIASLTGSVVNLVFILILSKVYVI
                     LAQVLTRWEMHRTQTAFEDAFTLKVFIFQFVNFYASPVYIAFFKGRFVGYPGNYHTLF
                     GVRNEECPAGGCLSELAQELLVIMVGKQIINNVQEVLVPKLKGCWQKLCSRRKKAGMG
                     ANPAPWEADYELLPCEGLFHEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDA
                     RKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRVYYSWTRAP
                     DLRGFLNFTLARAPPTFTSAHNRTCRYRAFRDDDGHYSPTYWTLLAIRLAFVIVFEHV
                     VFSTGRFLDLLVPDIPESVEIKVKREYYLAKQALADNEALLGATGVKGEQPPSSEPSL
                     GLPA"
     exon            266..323
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            324..454
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            455..562
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            563..699
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            700..757
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            758..868
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1034
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1125
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1222
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1366
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1504
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1603
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1706
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1818
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1873
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1971
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2105
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2311
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2454
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2545
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2665
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2742
                     /gene="Ano7"
                     /gene_synonym="Ngep; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtggcaag ggcaggtgag tggctgccac agctcagggc ccgagggaca gggctggctg
       61 gccctgactt gctcctgctt gaaccagtct tgtgttgatg gtctgtctgt gaactctgag
      121 gtctcttctg gaagccactg tgccggccag gagtgagatg ctgcggaagc aagctggaga
      181 agaagacagc gtggtgctga tcgacatgac ctcccctgaa gcagggaatg ggtgctccta
      241 tgggagcaca gcccaagcct cagaggcagg taaacagcag gtggccccca gcagagttgg
      301 gagctctgcc aaccccccaa ttgattttgt tcttgtttgg gaagaagacc tgaggagccg
      361 agagaacccc actcaggaca agacagacac acatgaaatc tggcgggaga cctttctgga
      421 aaatctccgt gtggctggcc tgaaaataga tcagcgcgat gtccaggacg aggccgctgc
      481 agtacattac atcctcctca gtgcaccctg ggctgtactc tgctactacg cagaagacct
      541 gcgcctgaag ctgcctctgc aggagttacc caaccaagct tccaactggt cggccaccct
      601 tctggagtgg ctgggcatcc ccaatattct gctggagaat gtgcctgaca cgccccctga
      661 gtattactcc tgccagttca aagcgagcaa gctgcaatgg ttccttggga gtgacaacca
      721 ggacaccttc ttcaccagca ccaagaggca ccagattcta tttgagatcc tggccaagac
      781 tccatatggc caccagaaga aaggcttgtt tgggattgat cagctgctgg cagaaggtgt
      841 attcagtgca gccttccctc tgcatgatgg cccgttctct gtagtcccag agagttcaca
      901 ggtcctgggt ctcacccagc gccaagtcct attcaagcac tgggctcgct ggggcaagtg
      961 gaggaagtac cagccactgg accatgtgcg aaggtacttc ggggagaagg tggctctcta
     1021 ctttgcctgg cttgggttct acactggttg gctcctgccc gcggcagtcg tgggcacagt
     1081 ggtcttcctg gcgggctgtt tcctggtgtt ctcagatgta ccaacgcagg agctgtgcca
     1141 cagctcggac accttcgaca tgtgcccact gtgctccgac tgctcctttt ggctgctctc
     1201 cagtgcctgc accctggccc aggctgggcg gctcttcgac cacggtggca ctgtcttctt
     1261 cagtttgttc atggcactgt gggcggtgct gcttctggag tactggaagc ggaaaaacgc
     1321 cacgttggcc taccgctggg actgctctga ctacgaggac attgaggaga ggcctcggcc
     1381 ccagttcgct gcaacagcac ccatgacagc cctgaacccc atcacggggg aagatgagcc
     1441 ttactttccc gagaagaatc gtgtacgccg catgctggcc ggttctgtgg tgctcttgat
     1501 gatggtggct gtggtgatta tgtgtcttgt atctatcatc ctgtaccggg ccgtgatggc
     1561 tatcatcgtg tccaagtcga acaacgcctt cctctcggcc tgggcttcac gaattgccag
     1621 cctcacaggg tccgtggtga accttgtctt catcctcatc ctctccaagg tctatgtgat
     1681 cctggcccag gtcctaacaa gatgggagat gcaccggacg cagaccgcgt ttgaggacgc
     1741 cttcaccctc aaggtgttca tctttcagtt tgtgaacttc tacgcctcgc ctgtgtacat
     1801 tgccttcttc aagggcaggt ttgtgggata cccaggcaac taccacacct tgtttggagt
     1861 ccgaaatgag gagtgtccag ctggaggctg cctcagtgag ctggcacagg agctcctggt
     1921 catcatggtc ggcaagcaga tcatcaataa cgtgcaggag gttcttgtcc caaagctgaa
     1981 aggctgctgg cagaagttgt gctcccggag gaagaaagct ggcatggggg ccaacccagc
     2041 accttgggag gctgactatg agttgctgcc ttgtgagggg ctatttcatg aataccttga
     2101 aatggtgctg cagtttgggt tcgtcactat ctttgtggcc gcctgcccgc tggcgccgct
     2161 ttttgcccta ctcaacaact gggtggagat ccgcctggat gcgcgcaagt ttgtgtgcga
     2221 gtaccggcgt cccgtagcgg agcgcgccca ggacatcggc atctggttcc acatcctagc
     2281 gggcctcacc catctcgcgg tcatcagcaa tgctttccta ctggcctttt cctccgactt
     2341 cctgccgcgt gtctactaca gctggacgcg cgcccctgac ctgcgtggct tcctcaattt
     2401 cacgctggcg cgtgcgccgc ccaccttcac ctcggcacac aaccgcactt gccggtaccg
     2461 ggctttccgg gatgatgacg gacactattc cccaacttac tggactctcc tggccatccg
     2521 cctggccttt gtcatcgtgt ttgagcatgt ggtgttctct actggccgtt tcctggatct
     2581 cttggttcct gacatcccag aatctgtgga aatcaaggtg aagcgggaat actacttggc
     2641 taaacaggca ctggctgata atgaggctct ccttggagca acaggagtga agggtgagca
     2701 gcctccaagc tcagagccca gtctgggtct tccagcctag gg
//
