LOCUS       NM_001401001            5633 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus anoctamin 6 (Ano6), mRNA.
ACCESSION   NM_001401001 XM_008765736
VERSION     NM_001401001.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5633)
  AUTHORS   Zhang,Y., Li,H., Li,X., Wu,J., Xue,T., Wu,J., Shen,H., Li,X.,
            Shen,M. and Chen,G.
  TITLE     TMEM16F Aggravates Neuronal Loss by Mediating Microglial
            Phagocytosis of Neurons in a Rat Experimental Cerebral Ischemia and
            Reperfusion Model
  JOURNAL   Front Immunol 11, 1144 (2020)
   PUBMED   32733436
  REMARK    GeneRIF: TMEM16F Aggravates Neuronal Loss by Mediating Microglial
            Phagocytosis of Neurons in a Rat Experimental Cerebral Ischemia and
            Reperfusion Model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5633)
  AUTHORS   Alvadia,C., Lim,N.K., Clerico Mosina,V., Oostergetel,G.T.,
            Dutzler,R. and Paulino,C.
  TITLE     Cryo-EM structures and functional characterization of the murine
            lipid scramblase TMEM16F
  JOURNAL   Elife 8, e44365 (2019)
   PUBMED   30785399
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5633)
  AUTHORS   Ousingsawat,J., Wanitchakool,P., Schreiber,R., Wuelling,M.,
            Vortkamp,A. and Kunzelmann,K.
  TITLE     Anoctamin-6 controls bone mineralization by activating the calcium
            transporter NCX1
  JOURNAL   J Biol Chem 290 (10), 6270-6280 (2015)
   PUBMED   25589784
REFERENCE   4  (bases 1 to 5633)
  AUTHORS   Ousingsawat,J., Wanitchakool,P., Kmit,A., Romao,A.M.,
            Jantarajit,W., Schreiber,R. and Kunzelmann,K.
  TITLE     Anoctamin 6 mediates effects essential for innate immunity
            downstream of P2X7 receptors in macrophages
  JOURNAL   Nat Commun 6, 6245 (2015)
   PUBMED   25651887
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5633)
  AUTHORS   Huang,F., Wang,X., Ostertag,E.M., Nuwal,T., Huang,B., Jan,Y.N.,
            Basbaum,A.I. and Jan,L.Y.
  TITLE     TMEM16C facilitates Na(+)-activated K+ currents in rat sensory
            neurons and regulates pain processing
  JOURNAL   Nat Neurosci 16 (9), 1284-1290 (2013)
   PUBMED   23872594
REFERENCE   6  (bases 1 to 5633)
  AUTHORS   Schreiber,R., Uliyakina,I., Kongsuphol,P., Warth,R., Mirza,M.,
            Martins,J.R. and Kunzelmann,K.
  TITLE     Expression and function of epithelial anoctamins
  JOURNAL   J Biol Chem 285 (10), 7838-7845 (2010)
   PUBMED   20056604
REFERENCE   7  (bases 1 to 5633)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 5633)
  AUTHORS   Teckchandani,A., Toida,N., Goodchild,J., Henderson,C., Watts,J.,
            Wollscheid,B. and Cooper,J.A.
  TITLE     Quantitative proteomics identifies a Dab2/integrin module
            regulating cell migration
  JOURNAL   J Cell Biol 186 (1), 99-111 (2009)
   PUBMED   19581412
REFERENCE   9  (bases 1 to 5633)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   10 (bases 1 to 5633)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 1, 2022 this sequence version replaced XM_008765736.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1645345.1,
                                           SRR26360172.783816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000007.1  128813131-128813379
            250-332             JAXUCZ010000007.1  128887174-128887256
            333-461             JAXUCZ010000007.1  128914102-128914230
            462-527             JAXUCZ010000007.1  128931930-128931995
            528-812             JAXUCZ010000007.1  128933117-128933401
            813-926             JAXUCZ010000007.1  128933651-128933764
            927-1042            JAXUCZ010000007.1  128935728-128935843
            1043-1177           JAXUCZ010000007.1  128939434-128939568
            1178-1283           JAXUCZ010000007.1  128947846-128947951
            1284-1344           JAXUCZ010000007.1  128952045-128952105
            1345-1487           JAXUCZ010000007.1  128960948-128961090
            1488-1565           JAXUCZ010000007.1  128962860-128962937
            1566-1791           JAXUCZ010000007.1  128966542-128966767
            1792-1961           JAXUCZ010000007.1  128967839-128968008
            1962-2059           JAXUCZ010000007.1  128968210-128968307
            2060-2190           JAXUCZ010000007.1  128973843-128973973
            2191-2396           JAXUCZ010000007.1  128980056-128980261
            2397-2599           JAXUCZ010000007.1  128983892-128984094
            2600-2705           JAXUCZ010000007.1  128985481-128985586
            2706-5633           JAXUCZ010000007.1  128989878-128992805
FEATURES             Location/Qualifiers
     source          1..5633
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     gene            1..5633
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /note="anoctamin 6"
                     /db_xref="GeneID:315272"
                     /db_xref="RGD:1304765"
     exon            1..249
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..2912
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /note="transmembrane protein 16F"
                     /codon_start=1
                     /product="anoctamin-6"
                     /protein_id="NP_001387930.1"
                     /db_xref="GeneID:315272"
                     /db_xref="RGD:1304765"
                     /translation="MQMMTRNVLLNMELEEDDDEDGDIVLENFDQTIVCSTFGSLESQ
                     EDFRTPEFEEFNGKPDSLFFTDGQRRIDFVLVYEDESKKENNKKGTNEKQKRKRQAYE
                     SNLISHGLQLEATRSVSDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKTRSTFD
                     TFNWFTKVLRVNESVIKPEQEFFTAPFEKSRMNDFYILDRDSFFNPATRSRIVYFILS
                     RVKYQVMNNVNKFGINRLVSSGIYKAAFPLHDCKFNYKSEDPNCPSERYLLYREWAHP
                     RSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWS
                     KEVCDPDIGGQILMCPQCDRLCPFWRLNITCESSKKLCIFDSFGTLIFAVFMGVWVTL
                     FLEFWKRRQAELEYEWDTVELQQEEQPRPEYEAQCNHVVINEITQEEERIPFTTCGKC
                     IRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSTTLPKNPNGTDPIQKYLTPQMA
                     TSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSS
                     CFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQE
                     VLLPWVMNLIGRYKRVSGSEKITPRWEQDYHLQPMGRLGLFYEYLEMIIQFGFVTLFV
                     ASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIGAWQPIMQGIAILAVVTN
                     AMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINNTLSVFNITDFKNTDKENPY
                     IGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYA
                     IPDVSKITKSKIKREKYLTQKLLHESHLKDLTKNMGLIAERIGGVADSSVRPKLE"
     exon            250..332
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            333..461
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            462..527
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            528..812
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            813..926
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1042
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1177
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1283
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1344
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1487
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1565
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1791
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1961
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2059
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2190
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2396
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2599
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2705
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..5633
                     /gene="Ano6"
                     /gene_synonym="Tmem16f"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagtggcg gtgtccctct gggcatgctc agttgcacag ctgagcagcg cttgccgaag
       61 cagagcgcgg gcgtagcgaa gcggggctgt gctgagaggg ctgagtggag cttgcggccc
      121 gagccgagcg gagccgagca gagccgagag cagccgagcg gcggtctcgg ggagacatgc
      181 agatgatgac taggaacgtc ctgctgaaca tggagctgga agaggacgac gatgaggatg
      241 gagacattgt gctggaaaac ttcgaccaga ccatagtctg ctccaccttt ggatcactgg
      301 agagccagga ggacttccgc actccagagt ttgaagagtt taacggaaag cctgactcgc
      361 tctttttcac cgatggccag agacggatcg acttcgtcct cgtgtacgaa gacgagagca
      421 agaaggagaa caataagaaa gggacaaatg agaaacagaa gaggaaaagg caagcatacg
      481 aatctaacct catcagccac ggcctgcagc tggaagccac aagatctgtt tctgatgaca
      541 agcttgtgtt cgtcaaagtg catgcgccct gggaagtgct gtgcacctat gctgagatca
      601 tgcacatcaa gctcccacta aagcccaatg acctgaagac tcgttccacc tttgacacct
      661 tcaactggtt caccaaggtc ctccgtgtga acgagagtgt catcaagccg gagcaggagt
      721 tcttcactgc cccctttgag aagagccgga tgaatgactt ctacatcctt gacagagact
      781 ccttcttcaa tcccgccacc agaagtcgca ttgtttattt catcctctct cgggtcaaat
      841 accaagtgat gaacaacgtt aacaaatttg ggattaatag actggtcagt tctggcatct
      901 acaaagcagc gttccctctg cacgactgca aattcaacta taagtcggaa gaccccaact
      961 gtcctagcga gcgttacctc ctgtacaggg aatgggctca ccctcggagt atatacaaga
     1021 aacagccctt ggatcttatc aggaagtatt acggagagaa gattggaatc tacttcgcgt
     1081 ggctgggcta ttatacgcag atgctccttc tagcagctgt ggtgggcgtg gcctgcttcc
     1141 tctatggata tcttaatcag gataactgca cttggagcaa agaggtctgt gatcctgaca
     1201 tcggtggcca gatcctgatg tgtccccagt gtgacaggtt gtgtccgttc tggaggctga
     1261 atatcacctg tgaatcctct aagaaattgt gcatctttga cagttttgga accctgatct
     1321 tcgctgtatt tatgggagtg tgggttacat tgtttttgga gttctggaag cggcgccaag
     1381 cagagcttga gtatgaatgg gacactgttg agctacagca agaggaacag ccccggccag
     1441 agtatgaggc ccagtgcaat cacgtggtaa taaacgagat cactcaggag gaggagcgta
     1501 tcccatttac cacctgtggg aagtgtatcc ggatcaccct gtgtgcgagc gctgtcttct
     1561 tctggatcct gctcatcatc gcctctgtga ttgggatcat tgtctacagg ctgtccgtgt
     1621 tcatcgtgtt ctccacgacg ctccccaaga accccaatgg gacagaccca atccagaagt
     1681 acctgacccc acagatggcc acgtccatca cggcttccat tattagtttc atcatcatca
     1741 tgatcctcaa cacgatctac gagaaggtgg ccatcatgat caccaacttt gaactcccaa
     1801 ggacccagac tgattatgag aacagcctga ccatgaagat gttcttgttc cagtttgtca
     1861 actactactc ctcctgcttc tacatcgcat tcttcaaggg caaatttgtc ggctatccgg
     1921 gggacccggt gtactggctg ggcaaataca gaaacgaaga gtgtgacccg gggggctgcc
     1981 tccttgaact gactacacag ctgacgatca tcatgggggg aaaggcgatc tggaacaaca
     2041 tacaagaagt tctgctcccg tgggttatga atctaattgg acgatataaa agagtctcgg
     2101 gatcagaaaa gataacccca cgatgggaac aggattacca tctgcagccc atgggcaggc
     2161 tgggattgtt ctatgagtac cttgaaatga ttattcagtt tgggttcgtc accttatttg
     2221 tggcctcttt cccactggct cccctgctgg ccctggtgaa caatatactg gagataagag
     2281 tggatgcgtg gaagcttaca acacagtttc gacgcatggt gccagagaaa gcccaggata
     2341 tcggcgcgtg gcagcccatc atgcaaggaa tagccatcct ggccgtggtg accaacgcca
     2401 tgatcattgc cttcacctca gacatgatcc cccgcctggt gtactattgg tccttctcca
     2461 tccctcccta tggggaccac acttactaca ccatggacgg ctacatcaac aacactctct
     2521 cggtcttcaa catcaccgac ttcaaaaata cagacaaaga aaacccgtac attgggcttg
     2581 gcaactacac cctgtgcagg taccgtgact tccgaaaccc acccgggcac ccacaagagt
     2641 ataaacacaa catctactat tggcacgtga ttgccgccaa gctggctttt atcattgtta
     2701 tggagcacgt catctactct gtgaagttct tcatttcgta cgcaattccg gatgtgtcga
     2761 agatcacgaa aagcaagatc aagagggaga aatacctcac acagaagctg cttcacgaga
     2821 gtcacctcaa agacctgacc aaaaacatgg ggctcatcgc cgagaggata ggaggagtgg
     2881 ctgacagcag cgtgaggccg aaactcgaat gagagagcgc tttacggtcc tgagaagcac
     2941 tttaaaagta attagctgtc aggcgtgttg tgaatcacta gagaggacgg tgcaaatgga
     3001 gtcctcgcct tacccatttc cgccctatat ggttgttttt cagtttcagc tagcaacgca
     3061 ggaactggag aagggaaaaa ctttgatcag gaagggcata aaaccgccta cctggaggac
     3121 ctgactctgt cccctccttt gataaattgg taacagagaa agcctccagg tgggcccaag
     3181 tcctctcagg gggaggggag gaggctttgc tttcctgacc tcaggtgcag agttcctttt
     3241 ctgttcttaa ttttgccaaa tctatcccag acctatttca tccggatggc accgccacca
     3301 aagaccaggc agacctcagc cttaatcgca tttgtgttat caacaacagc cagctcagga
     3361 ttgagtttgg atgctgttgg gaggtgccag gtagactcca gagttcacag tacttcgcgt
     3421 cttactgtac cccagggaag gagactccgc tgcctatgga gccgcttctg tatctcttca
     3481 gccttccacc tccaagaaaa gctcgtcttc gattgccgtg aagatggagg gcattgaatg
     3541 aagcctgtct ccgtcacccc gcggggacat ctgctttcta gcagtactcc cagcatgctc
     3601 tgggcctgac caatgatgac tggctttcag atcttaaggg agtaagagga gaaggtagta
     3661 aactcttact gatctgaacg gttaatttac ctcttcttga tatgtaagtt tcttggtagg
     3721 atgataatca aatgatcatg actgtaccgt cctcaacaga atgggctggg aagcccatca
     3781 acttcatgca gaaggcaggc actaccaatc accaagcgcc ttctgcccgt ctcgctgaga
     3841 agactggtgg cctgacgacg ctgggcatag tcagagcagc agccagtaac ccaatcacta
     3901 gccatgtcct gtgatccttc tgcggtcccg cgtcactcac agggattccc actgccttct
     3961 ctgcttgccg ctgtgaccag cttccttgcg ggctctgtcc ctttcctagg cctgctaact
     4021 cattgtaatc acaactgtgc cagagacaag tctaccccga tcgttgccca ggattcgatt
     4081 tgagccccaa gcctcctctc aggccatcag ggagattctg ggaaggctgg tttatctgct
     4141 ggtggctcgc tgctaagcct tagcttcctg gtgccctccc tccctgttgc ttgactgaag
     4201 tttctccgca gcctatacat gcccggcctt tcctccatta cctctgatat ctcgcaccct
     4261 ggactgataa cagaggtcag ggcagggtga agaagggagg ccctgcctca caccatttcg
     4321 ggattgggcc tctgctgact ggcatggtgg gaaatggctt gggtgaccag gagccgagcc
     4381 aaggaaagtg aatggtttga gaggctgccg tctcaacact gagctgaagc agctctaatt
     4441 cctggtttta aatgcccacc gggaatggct tactagagaa tcaacatgat taatcaaaac
     4501 agtgttctga gttcagcgga aacatttccc ctcctctctt gtcctgggag tccaggacct
     4561 gccatacagt gtctaaccac agttaagcta agatagaaat gactgccttc ccccaccctc
     4621 aaggaaggtt ctcactccac agctaaaacc aggtgccact ccctgccctt cctcccccca
     4681 cccccggccc catcccaact gccctggagt tcctgctccc ttcgttacct cttctccaga
     4741 gcctgtgctc accttcagtc acacttcaca ccataggaaa ggagatcttt cctctcataa
     4801 ctctcccctt cctttctttg tacatacaaa gaaaacatcg aatttaaaaa gtgcatttat
     4861 ccacgtgtac ccccagccaa gaactccctt cacagtgcag aaagtaccac tgtggacaga
     4921 agaaaccaaa caaaccctgc gtctctgaag ggaacgttca tggcgtctga tgctaccaga
     4981 atgctgaccg gcaaagttgc cgtgggctaa agggtcccac ggcatcagta tcattcctgt
     5041 gagacctgtg ccaagttggc gacggagagg acatctgcgg tggcagtgag ataacccccc
     5101 ccccaccccc agccccagga aagccaaggg catgactgtg agggaagatc tggccaccca
     5161 cctgtctagc atgaaccact agagaaagtc tgtccttttg taatgccttt gcgttttaat
     5221 ggatgaaatc agtagaccca gtactcaggg gatttttctt taaatgttcc ttggttgttt
     5281 taggtgtccc attagaagta gaaggccacg gtttgtcttg aaattaaatg aggccacctg
     5341 gtaatgagtc tgtcaaggtt tcccctttgc ggggcacatg ggtcttgagt ttcatggggc
     5401 actcatttgt gaggggggca gagtggggtg tgttggtccc atacttgtct gctccttgtg
     5461 tccgctccaa ttacgtctga gaagtggaga cagtgctcac agctaagcta agacagaact
     5521 gaggctcatg atgcttcctg tatcctgtgt aatgtttgta actgatgttc gttcatttct
     5581 atgcctttta atatttttaa tgagcatttt aataaattct gttttacaaa caa
//
