LOCUS       NM_001107564            4645 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Rattus norvegicus anoctamin 1 (Ano1), mRNA.
ACCESSION   NM_001107564 XM_001066475 XM_219695
VERSION     NM_001107564.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4645)
  AUTHORS   Martinez-Magana,C.J., Munoz-Castillo,P.A. and Murbartian,J.
  TITLE     Spinal bestrophin-1 and anoctamin-1 channels have a pronociceptive
            role in the tactile allodynia induced by REM sleep deprivation in
            rats
  JOURNAL   Brain Res 1834, 148915 (2024)
   PUBMED   38582414
  REMARK    GeneRIF: Spinal bestrophin-1 and anoctamin-1 channels have a
            pronociceptive role in the tactile allodynia induced by REM sleep
            deprivation in rats.
REFERENCE   2  (bases 1 to 4645)
  AUTHORS   Kudo,W., Mitsui,R. and Hashitani,H.
  TITLE     Involvement of ANO1 currents in pacemaking of PDGFRalpha-positive
            specialised smooth muscle cells in rat caudal epididymis
  JOURNAL   Cell Tissue Res 397 (1), 1-12 (2024)
   PUBMED   38587529
  REMARK    GeneRIF: Involvement of ANO1 currents in pacemaking of
            PDGFRalpha-positive specialised smooth muscle cells in rat caudal
            epididymis.
REFERENCE   3  (bases 1 to 4645)
  AUTHORS   Chen,Q., Kong,L., Xu,Z., Cao,N., Tang,X., Gao,R., Zhang,J.,
            Deng,S., Tan,C., Zhang,M., Wang,Y., Zhang,L., Ma,K., Li,L. and
            Si,J.
  TITLE     The Role of TMEM16A/ERK/NK-1 Signaling in Dorsal Root Ganglia
            Neurons in the Development of Neuropathic Pain Induced by Spared
            Nerve Injury (SNI)
  JOURNAL   Mol Neurobiol 58 (11), 5772-5789 (2021)
   PUBMED   34406600
  REMARK    GeneRIF: The Role of TMEM16A/ERK/NK-1 Signaling in Dorsal Root
            Ganglia Neurons in the Development of Neuropathic Pain Induced by
            Spared Nerve Injury (SNI).
REFERENCE   4  (bases 1 to 4645)
  AUTHORS   Guo,P., Liu,Y., Xu,X., Ma,G., Hou,X., Fan,Y. and Zhang,M.
  TITLE     Coronary hypercontractility to acidosis owes to the greater
            activity of TMEM16A/ANO1 in the arterial smooth muscle cells
  JOURNAL   Biomed Pharmacother 139, 111615 (2021)
   PUBMED   34243598
  REMARK    GeneRIF: Coronary hypercontractility to acidosis owes to the
            greater activity of TMEM16A/ANO1 in the arterial smooth muscle
            cells.
REFERENCE   5  (bases 1 to 4645)
  AUTHORS   Tian,X.Q., Tan,C.Y., Li,N.N., Chang,Y.Q., Zhang,A.M., Zhou,Y.,
            Ma,K.T. and Si,J.Q.
  TITLE     [Expression of ANO1 during cardiac fibroblasts differentiation and
            its electrophysiological characteristics as calcium-activated
            chloride channel protein]
  JOURNAL   Zhongguo Ying Yong Sheng Li Xue Za Zhi 36 (4), 358-362 (2020)
   PUBMED   33167099
  REMARK    GeneRIF: [Expression of ANO1 during cardiac fibroblasts
            differentiation and its electrophysiological characteristics as
            calcium-activated chloride channel protein].
REFERENCE   6  (bases 1 to 4645)
  AUTHORS   Liu,B., Linley,J.E., Du,X., Zhang,X., Ooi,L., Zhang,H. and
            Gamper,N.
  TITLE     The acute nociceptive signals induced by bradykinin in rat sensory
            neurons are mediated by inhibition of M-type K+ channels and
            activation of Ca2+-activated Cl- channels
  JOURNAL   J Clin Invest 120 (4), 1240-1252 (2010)
   PUBMED   20335661
REFERENCE   7  (bases 1 to 4645)
  AUTHORS   Schreiber,R., Uliyakina,I., Kongsuphol,P., Warth,R., Mirza,M.,
            Martins,J.R. and Kunzelmann,K.
  TITLE     Expression and function of epithelial anoctamins
  JOURNAL   J Biol Chem 285 (10), 7838-7845 (2010)
   PUBMED   20056604
REFERENCE   8  (bases 1 to 4645)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   9  (bases 1 to 4645)
  AUTHORS   Yang,Y.D., Cho,H., Koo,J.Y., Tak,M.H., Cho,Y., Shim,W.S.,
            Park,S.P., Lee,J., Lee,B., Kim,B.M., Raouf,R., Shin,Y.K. and Oh,U.
  TITLE     TMEM16A confers receptor-activated calcium-dependent chloride
            conductance
  JOURNAL   Nature 455 (7217), 1210-1215 (2008)
   PUBMED   18724360
REFERENCE   10 (bases 1 to 4645)
  AUTHORS   Rock,J.R., Futtner,C.R. and Harfe,B.D.
  TITLE     The transmembrane protein TMEM16A is required for normal
            development of the murine trachea
  JOURNAL   Dev Biol 321 (1), 141-149 (2008)
   PUBMED   18585372
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219695.4, XM_001066475.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132276, SAMD00132281
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4645
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..4645
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /note="anoctamin 1"
                     /db_xref="GeneID:309135"
                     /db_xref="RGD:1310786"
     exon            1..186
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..3173
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /note="transmembrane protein 16A; anoctamin 1, calcium
                     activated chloride channel"
                     /codon_start=1
                     /product="anoctamin-1"
                     /protein_id="NP_001101034.1"
                     /db_xref="GeneID:309135"
                     /db_xref="RGD:1310786"
                     /translation="MQDTQDSDISLEGLTREGAPADRECQRGPETIVHEAQDAGTPNS
                     GDATGAVDGEREATMRVPEKYSTLPAEDRSVHIVNICAIEDLGYLPSEGTLLNSLSVD
                     PDAECKYGLYFRDGKRKVDYILVYHHKRASGSRTLARRGLQNDMVLGTRSVRQDQPLP
                     GKGSPVDVGSPEAPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHA
                     PWHVLCREAEFLKLKMPTKKVYHISETRGLLKTINSVLQKITDPIQPKVAEHRPQTTK
                     RLSYPFSREKQHLFDLTDRDSFFDSKTRSTIVYEILKRTTCTKAKYSMGQGEGRRKDS
                     ALLSKRRKCGKYGITSLLANGVYSAAYPLHDGDYEGDNVEFNDRKLLYEEWASYGVFY
                     KYQPIDLVRKYFGEKVGLYFAWLGAYTQMLIPASIVGVIVFLYGCATVDENIPSMEMC
                     DQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWK
                     RKQMRLNYRWDLTGFEEEEVSSCDHPRAEYEARVLEKSLRKESRNKETDKVKLTWRDR
                     FPAYFTNLVSIIFMIAVTFAIVLGVIIYRISTAAALAMNSSPSVRSNIRVTVTATAVI
                     INLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLTFKAFLLKFVNSYTPIFYVAFF
                     KGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKM
                     KKFIRYLKLRRQSPSDREEYIKRKQRYEVDFNLEPFAGLTPEYMEMIIQFGFVTLFVA
                     SFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAIRAKDIGIWYNILRGVGKLAVIINA
                     FVISFTSDFIPRLVYLYMYSQNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQ
                     ICRYKDYREPPWSEHKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKD
                     ISQQIHKEKVLMVELFMREEQGKQQLLDTWMEKEKPRDVPCNNHSPTAHPEAGDSSPV
                     PSYEYHGGAL"
     exon            187..332
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            333..665
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            666..764
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            765..916
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            917..971
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1023
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1089
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1145
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1187
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1252
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1387
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1548
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1643
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1715
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1790
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1992
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2104
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2162
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2263
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2409
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2562
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2615
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2800
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2906
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..4645
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctctgccg gtccctctgc tggacccagg gagtccggag cgaacacatc atgcaggaca
       61 cacaggacag cgacatcagc ctggagggct tgacccgaga gggagcccct gcggaccgag
      121 agtgccagag gggaccggaa acaatcgtac acgaggcaca ggacgcagga acccccaact
      181 caggtgacgc caccggggct gtggatgggg agcgcgaggc caccatgagg gtccccgaga
      241 agtactcgac gctcccagcg gaggaccgca gcgtccacat cgtgaacatc tgcgccatcg
      301 aggacctggg ctacctgccg tccgagggca cgttgctcaa ctctctgtcc gtggaccctg
      361 acgccgaatg caagtatggc ctatacttca gggatggcaa acgcaaggtg gactacatct
      421 tggtgtacca tcacaagaga gcctcgggta gcaggactct ggccaggaga ggactacaaa
      481 atgacatggt cctggggacc cgcagtgtca ggcaggacca gccccttccc gggaagggga
      541 gtcctgtgga tgtgggctca ccggaagccc ccatggatta ccacgaagat gacaagcgct
      601 tcagaaggga ggagtacgag ggcaacctgt tggaggcagg cctggagctg gaacgtgacg
      661 aggataccaa aatccatggt gtcgggtttg tgaagatcca tgcgccctgg catgtgctct
      721 gcagggaagc tgagtttttg aaactgaaga tgcccacgaa gaaggtgtac cacatcagtg
      781 agacccgagg cctcctgaaa accatcaact ccgttctgca gaagatcaca gaccccatcc
      841 agcccaaggt ggctgagcac agaccacaga ccacaaagag gctctcctac cccttctcca
      901 gggagaagca acacttattc gacctgactg acagggactc ttttttcgac agcaaaaccc
      961 ggagcacaat agtctatgaa atcctgaaga gaacaacgtg caccaaggcc aagtacagca
     1021 tggggcaagg agagggaaga aggaaggact ctgcccttct aagtaaacgg cggaagtgtg
     1081 ggaaatacgg tatcaccagc ctcctggcca atggcgtgta ctcagctgcg taccctctgc
     1141 acgatggtga ctatgaaggt gacaacgttg agttcaacga caggaaactc ctgtatgagg
     1201 aatgggcaag ctatggagtc ttctacaaat accagcccat tgacctggtc aggaaatact
     1261 ttggagaaaa ggttggcctg tactttgcct ggcttggagc ctacacccag atgctcatcc
     1321 ctgcctccat tgtgggtgtc attgtctttc tctacggatg tgccaccgtg gacgaaaaca
     1381 tccccagcat ggagatgtgt gaccagagac acaacatcac catgtgtcct ctgtgtgaca
     1441 agacctgcag ctactggaag atgagctcag cctgtgccac agcgcgtgcc agtcacctct
     1501 ttgacaatcc tgccactgtc ttcttttctg tgtttatggc cctctgggct gccaccttca
     1561 tggagcactg gaaacggaag cagatgagac tcaactaccg ctgggacctc acgggcttcg
     1621 aggaagagga ggtgagtagc tgtgatcatc ccagagcaga gtatgaagcc agagtcttag
     1681 agaagtcact gagaaaagaa tccagaaaca aagagactga caaggtgaag ttgacctgga
     1741 gggaccgatt cccagcctat ttcaccaatc ttgtctccat catcttcatg atcgcagtga
     1801 catttgcaat cgttcttgga gttatcatct atagaatctc cacagctgca gccttggcca
     1861 tgaactcctc cccatctgtg cggtccaaca tccgggttac agtcacggcc actgctgtca
     1921 tcattaacct cgtggtcatc attctgctgg atgaagttta cggctgcatt gccaggtggc
     1981 tcaccaagat tgaggtcccg aagacagaga agagctttga ggagaggcta accttcaagg
     2041 ccttcctgct caagtttgtg aactcctata ctcccatctt ctatgtcgcc ttcttcaaag
     2101 gccggtttgt tggtcggcct ggtgactacg tttatatctt ccgctctttc cggatggagg
     2161 agtgtgcccc aggcggctgc ctcatggagc tctgtatcca gctgagcatc atcatgctgg
     2221 gcaagcagct aatccagaac aatctcttcg agatcggcat cccgaagatg aaaaaattca
     2281 tccgctacct gaagctgcgc aggcagagcc cctcggaccg cgaggagtac ataaagcgga
     2341 agcagcgcta tgaggtggac ttcaacctcg aacccttcgc cggcctcacg cccgagtaca
     2401 tggaaatgat cattcagttc ggcttcgtca ccctgttcgt tgcgtccttc cctctggccc
     2461 cactcttcgc cctgctgaac aacatcattg agatccgcct ggatgccaaa aagtttgtca
     2521 ccgagctacg gagaccagta gccatcagag ccaaagacat cggcatctgg tataacattc
     2581 tcagaggtgt cgggaagctg gctgtcatca ttaatgcctt tgtgatctcc ttcacgtctg
     2641 acttcatccc tcgcctggta tacctctaca tgtacagtca aaacgggacc atgcacggct
     2701 tcgtcaacca cacgctctcc tccttcaatg tcagcgactt ccagaatggc acagcaccca
     2761 atgacccact ggacctgggc tacgaggttc agatctgcag gtataaagat taccgggagc
     2821 ccccgtggtc agaacacaag tatgatatct ccaaagactt ctgggctgtc ctggccgccc
     2881 ggctggcatt cgtcattgtc ttccagaacc tggtgatgtt catgagtgac tttgtggact
     2941 gggtgatccc tgatatcccc aaagacatca gccagcagat ccacaaggag aaggttctca
     3001 tggtggagtt gttcatgcgt gaggagcagg gcaagcagca gctactggac acatggatgg
     3061 agaaggagaa gccaagggat gtgccttgta acaaccacag tcccacagcc cacccagagg
     3121 caggtgacag cagcccagtc cccagctacg agtaccatgg gggcgcgctg tagccatgat
     3181 ggcaggccag caggccagca ggcttctgac catcaccaag tgaccactcg gtttcctcca
     3241 gagccagtac ttctagcccc accagggctt gtggctcttg ggtcgtctag atgtgtggag
     3301 ggccactctg atgtgacaac ggtcttcttt cttctttctg tttcttctca tttttgcaca
     3361 aggccattat gcagggaagt ttttatcttt agtattcaat gccaaggatg gctggtgatg
     3421 gggatgaaca gggtgagggc atgttccaca gacctatgag ggaacataga gacccccacc
     3481 ccaacccccc gcatcagtaa ggagccaagg tccagagtca gcatccttag tctgaaggat
     3541 gccctgggat agatgcagaa tggtgtccag gaacctgcta acattttgca gaaggatgaa
     3601 cgacttagat ttctaaagat gttacctgct ctagttggac aagctggaag actccactgt
     3661 ctttccttct gggagctcag aagttcaggc ccagggtcag aaataagcct ggcctggcca
     3721 cccacagagc acacacacac acacacacac acacacacac acacacacac acacacacac
     3781 acagtggctt cacattctgc tccagtaacc aaggagtaca ggggccccag ttgaccagcg
     3841 cccttggcat ccctggcagg ctccacacca gccactcaag ggcccctcac atgaggctga
     3901 tgtcctcctt gtgagacagg ctgtggtgac gggcaggaca tctttaaaca ggctggaggg
     3961 cttcaccaag ccccagagcc tctgtgggct catttttcgc tcttttagac catctattgg
     4021 tttttgtcta aaaatcaata gtatgatgga tttgagggat tttctttctg tagctcaagg
     4081 tggaaggagt ttatttcatt agttagccaa atactgagag gaaattaaaa tatcgttact
     4141 accaaagatt tttctcaata aaagcttcta ttttggtaac acacctatat tttcactcat
     4201 ggggatatga ggtcctcagc acttaccatt gtaatagctt cgaaaacaag cctcgtgggc
     4261 cagcttcttt ggatgtgcta gccagctgtg caaagcctct cagcaccagt gccagcaggg
     4321 cctcgcccag gctggaaaag gcaactcctt ctctcgtctg agggcgcggc agacagtcct
     4381 gcagttggca gctggggtcc aagtcttggg cttcaaaggt tttcactgtt ggctaaaatc
     4441 atgagatctg atgcttctgt cttcttctgt gcagtgacgt ggtttccgat gatgttttgt
     4501 atatagctac cgtatccaaa attagataat taccaaaaat tcttttacag aaaccatttt
     4561 ttaaaaaaaa aacaaaactg aatgtataca cacccacagg agtctgtggc tgagcgttca
     4621 tcaaaataaa tttgaataca caacc
//
